The relationship between methylation of the Syk gene in the promoter region and the genesis of lung cancer

Clinical Laboratory

Volumn 56, Issue 9-10, 2010, Pages 407-416

  Ma, Li ^a   Dong, Shangwen ^a   Zhang, Peng ^a   Xu, Ning ^a   Yan, Huiqin ^a   Liu, Hongyu ^a   Li, Yongwen ^a   Zhou, Qinghua ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

5 aza 2 deoxycytidine; Lung cancer; MSP; Promoter methylation; Syk; Tumor suppressor gene

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; PROTEIN KINASE SYK; PRIMER DNA; PROTEIN TYROSINE KINASE; RNA; SIGNAL PEPTIDE;

ARTICLE; CANCER CELL CULTURE; CANCER INVASION; CANCER PATIENT; CANCER TISSUE; CARCINOGENESIS; CELL LINE A549; CELL LINE L9981; CELL LINE MDA MB 435S; CELL LINE NCI H446; CELL STRAIN MCF 7; CONTROLLED STUDY; DNA METHYLATION; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG CARCINOMA; METHYLATION SPECIFIC POLYMERASE CHAIN REACTION; POLYMERASE CHAIN REACTION; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN METHYLATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; GENE EXPRESSION REGULATION; GENETICS; ISOLATION AND PURIFICATION; LARGE CELL CARCINOMA; LUNG TUMOR; METHYLATION; REFERENCE VALUE; SMALL CELL CARCINOMA; TUMOR CELL LINE;

CARCINOMA, LARGE CELL; CARCINOMA, SMALL CELL; CELL LINE, TUMOR; DNA METHYLATION; DNA PRIMERS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG NEOPLASMS; METHYLATION; PROMOTER REGIONS, GENETIC; PROTEIN-TYROSINE KINASES; REFERENCE VALUES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA;

EID: 79952109284     PISSN: 14336510     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Coopman PJ, Do MTH, Barth M, et al. The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells. Nature 2000;406:742-7.
2. Wang L, Duke L, Zhang PS, et al. Alternative splicing disrupts a nuclear localization signal in spleen tyrosine kinase that is required for invasion suppression in breast cancer. Cancer Res 2003;63:4724-30. (Pubitemid 36951053)
3. Kass SU, Pruss D, Wolffe AP. How does DNA methylation repress transcription? Trends Genet 1997;13:444-9.
4. Razin A, Ceder H. DNA methylation and gene expression. Microbiol Rev 1991;55:451-8. (Pubitemid 21895162)
5. Jones PA, Laird PW. Cancer epigenetics comes of age. Nat Genet 1999;21:163-7. (Pubitemid 29070360)
6. Esteller M, Corn PG, Baylin SB, Herman JG. A gene hypermethylation profile of human cancer. Cancer Res 2001;61:3225-9.
7. Tohyama Y., Yamamura H. Protein tyrosine kinase, syk: a key player in phagocytic cells. J Biochem 2009;145(3):267-73.
8. Mortarino M, Gelain ME, Gioia G, et al. ZAP-70 and Syk expression in canine lymphoid cells and preliminary results on leukaemia cases. Vet Immunol Immunopathol 2009;128(4):395-401.
9. Boelens J, Lust S, Van Bockstaele F, et al. Steroid effects on ZAP-70 and SYK in relation to apoptosis in poor prognosis chronic lymphocytic leukemia. Leuk Res 2009;33(10):1335-43.
10. Geahlen, RL. Syk and pTyr'd: Signaling through the B cell antigen receptor. Biochim Biophys Acta, 2009;1793(7):1115-27.
11. Coopman PJ, Mueller SC. The Syk tyrosine kinase: a new negative regulator in tumor growth and progression. Cancer Lett 2006 Sep 28;241(2):159-73. (Pubitemid 44163045)
12. Ulanova M, Puttagunta L, Marcet-Palacios M, et al. Syk tyrosine kinase participates in beta 1-integrin signaling and inflammatory responses in airway epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol 2005;288:L497-L507.
13. T. Yamada, S. Fujieda, S. Yanagi, et al. Protein-tyrosine kinase Syk expressed in human nasal fibroblasts and its effect on RANTES production. J. Immunol 2001;166:538-43. (Pubitemid 32038474)
14. R. Inatome, S. Yanagi, T. Takano, H. Yamamura, A critical role for Syk in endothelial cell proliferation and migration. Biochem. Biophys. Res. Commun 2001;286:195-9.
15. T. Tsujimura, S. Yanagi, R. Inatome, et al. Syk protein-tyrosine kinase is involved in neuron-like differentiation of embryonal carcinoma P19 cells. FEBS Lett. 2001 ;Feb 2;489(2-3):129-33. (Pubitemid 32126395)
16. S. Tsuchida, S. Yanagi, R. Inatome, J. Ding, P. Hermann, T. Tsujimura, et al. Purification of a 72-kDa protein-tyrosine kinase from rat liver and its identification as Syk: involvement of Syk in signaling events of hepatocytes. J. Biochem 2000;127:321-7. (Pubitemid 30136916)
17. Hoeller C, Thallinger C, Pratscher B, et al. The non-receptor-associated tyrosine kinase Syk is a regulator of metastatic behavior in human melanoma cells. J. Invest Dermatol 2005;124:1293-9. (Pubitemid 40847418)
18. Toyama T, Iwase H, Yamashita H, et al. Reduced expression of the Syk gene is correlated with poor prognosis in human breast cancer. Cancer Lett 2003;189:97-102. (Pubitemid 35351524)
19. Yuan Y, Mendez R, Sahin A, et al. Hypermethylation leads to silencing of the Syk gene in human breast cancer. Cancer Res 2001;61(14):5558-61. (Pubitemid 32694942)
20. Yuan Y, Wang J, Li J, et al. Frequent epigenetic inactivation of spleen tyrosine kinase gene in human hepatocellular carcinoma. Clin Cancer Res 2006 Nov 15;12(22):6687-95. (Pubitemid 44876836)
21. Ding YF, Wu ZY, Wang Shui, et al. Hypermethylation of Syk gene in promoter region is associated with oncogenesis, metastasis of breast carcinoma. Natl Med J China 2004;84(4):290-3.
22. Wang S, Ding YB, Chen GY, et al. Hypermethylation of Syk gene in promoter region associated with oncogenesis and metastasis of gastric carcinoma. World J Gastroenterol 2004;10(12): 1815-8. (Pubitemid 38931212)
23. Liu YX, Ding YB, Yang Li, et al. Relationship between hypermethylation of Syk gene in promoter and oncogenesis, metastasis of gastric carcinoma. ACTA Universitatis Medicinalis Nanjing (Natural Science) 2006;26(3):169-94.
24. Goodman PA, Burkhardt N, Juran B, et al. Hypermethylation of the spleen tyrosine kinase promoter in T-lineage acute lymphoblastic leukemia. Oncogene 2003;22(16):2504-14. (Pubitemid 36560733)
25. Buchholz TA, Wazer DE. Molecular biology and genetics of breast cancer development: a clinical perspective. Semin Radiat Oncol 2002;12:285-95. (Pubitemid 35204819)
26. Ding YB, Chen GY, Xia JG, Zang XW, Yang HY, Yang L. Correlation of tumor-positive ratio and number of perigastric lymph nodes with prognosis of gastric carcinoma in surgically treated patients. World J Gastroenterol 2004;10:182-5. (Pubitemid 38195257)