메뉴 건너뛰기




Volumn 35, Issue 3, 2011, Pages 323-328

Effect of the nonpeptide thrombopoietin receptor agonist eltrombopag on megakaryopoiesis of patients with lower risk myelodysplastic syndrome

Author keywords

Eltrombopag; Megakaryopoiesis; Myelodysplastic syndrome; Thrombocytopenia; Thrombopoietin

Indexed keywords

ELTROMBOPAG;

EID: 79952101422     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2010.06.029     Document Type: Article
Times cited : (36)

References (27)
  • 1
    • 34848904494 scopus 로고    scopus 로고
    • Myelodysplastic syndrome with isolated deletion of chromosome 20q: an indolent disease with minimal morphological dysplasia and frequent thrombocytopenic presentation
    • Gupta R., Soupir C.P., Johari V., Hasserjian R.P. Myelodysplastic syndrome with isolated deletion of chromosome 20q: an indolent disease with minimal morphological dysplasia and frequent thrombocytopenic presentation. Br J Haematol 2007, 139:265-268.
    • (2007) Br J Haematol , vol.139 , pp. 265-268
    • Gupta, R.1    Soupir, C.P.2    Johari, V.3    Hasserjian, R.P.4
  • 2
    • 34247646400 scopus 로고    scopus 로고
    • The incidence and impact of thrombocytopenia in myelodysplastic syndromes
    • Kantarjian H., Giles F., List A., Lyons R., Sekeres M.A., Pierce S., et al. The incidence and impact of thrombocytopenia in myelodysplastic syndromes. Cancer 2007, 109:1705-1714.
    • (2007) Cancer , vol.109 , pp. 1705-1714
    • Kantarjian, H.1    Giles, F.2    List, A.3    Lyons, R.4    Sekeres, M.A.5    Pierce, S.6
  • 4
    • 18244369756 scopus 로고    scopus 로고
    • Increased peripheral platelet destruction and caspase-3-independent programmed cell death of bone marrow megakaryocytes in myelodysplastic patients
    • Houwerzijl E.J., Blom N.R., van der Want J.J., Louwes H., Esselink M.T., Smit J.W., et al. Increased peripheral platelet destruction and caspase-3-independent programmed cell death of bone marrow megakaryocytes in myelodysplastic patients. Blood 2005, 105:3472-3479.
    • (2005) Blood , vol.105 , pp. 3472-3479
    • Houwerzijl, E.J.1    Blom, N.R.2    van der Want, J.J.3    Louwes, H.4    Esselink, M.T.5    Smit, J.W.6
  • 5
    • 13544266567 scopus 로고    scopus 로고
    • Megakaryocytopoiesis and apoptosis in patients with myelodysplastic syndromes
    • Li X., Pu Q. Megakaryocytopoiesis and apoptosis in patients with myelodysplastic syndromes. Leuk Lymphoma 2005, 46:387-391.
    • (2005) Leuk Lymphoma , vol.46 , pp. 387-391
    • Li, X.1    Pu, Q.2
  • 6
    • 0034981980 scopus 로고    scopus 로고
    • Role of splenectomy in the treatment of myelodysplastic syndromes with peripheral thrombocytopenia: a report on six cases
    • Bourgeois E., Caulier M.T., Rose C., Dupriez B., Bauters F., Fenaux P. Role of splenectomy in the treatment of myelodysplastic syndromes with peripheral thrombocytopenia: a report on six cases. Leukemia 2001, 15:950-953.
    • (2001) Leukemia , vol.15 , pp. 950-953
    • Bourgeois, E.1    Caulier, M.T.2    Rose, C.3    Dupriez, B.4    Bauters, F.5    Fenaux, P.6
  • 7
    • 70449726874 scopus 로고    scopus 로고
    • Effect of the nonpeptide thrombopoietin receptor agonist eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndrome
    • Will B., Kawahara M., Luciano J.P., Bruns I., Parekh S., Erickson-Miller C.L., et al. Effect of the nonpeptide thrombopoietin receptor agonist eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndrome. Blood 2009, 114:3899-3908.
    • (2009) Blood , vol.114 , pp. 3899-3908
    • Will, B.1    Kawahara, M.2    Luciano, J.P.3    Bruns, I.4    Parekh, S.5    Erickson-Miller, C.L.6
  • 8
    • 75749124291 scopus 로고    scopus 로고
    • Safety and efficacy of romiplostim in patients with lower-risk myelodysplastic syndrome and thrombocytopenia
    • Kantarjian H., Fenaux P., Sekeres M.A., Becker P.S., Boruchov A., Bowen D., et al. Safety and efficacy of romiplostim in patients with lower-risk myelodysplastic syndrome and thrombocytopenia. J Clin Oncol 2010, 28(3):437-444.
    • (2010) J Clin Oncol , vol.28 , Issue.3 , pp. 437-444
    • Kantarjian, H.1    Fenaux, P.2    Sekeres, M.A.3    Becker, P.S.4    Boruchov, A.5    Bowen, D.6
  • 9
    • 36549001698 scopus 로고    scopus 로고
    • Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura
    • Bussel J.B., Cheng G., Saleh M.N., Psaila B., Kovaleva L., Meddeb B., et al. Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura. N Engl J Med 2007, 357:2237-2247.
    • (2007) N Engl J Med , vol.357 , pp. 2237-2247
    • Bussel, J.B.1    Cheng, G.2    Saleh, M.N.3    Psaila, B.4    Kovaleva, L.5    Meddeb, B.6
  • 11
    • 0038107361 scopus 로고    scopus 로고
    • Impaired granulocytopoiesis in patients with chronic idiopathic neutropenia is associated with increased apoptosis of bone marrow myeloid progenitor cells
    • Papadaki H.A., Eliopoulos A.G., Kosteas T., Gemetzi C., Damianaki A., Koutala H., et al. Impaired granulocytopoiesis in patients with chronic idiopathic neutropenia is associated with increased apoptosis of bone marrow myeloid progenitor cells. Blood 2003, 101:2591-2600.
    • (2003) Blood , vol.101 , pp. 2591-2600
    • Papadaki, H.A.1    Eliopoulos, A.G.2    Kosteas, T.3    Gemetzi, C.4    Damianaki, A.5    Koutala, H.6
  • 12
    • 0029866409 scopus 로고    scopus 로고
    • The use of 7-amino actinomycin D in identifying apoptosis: simplicity of use and broad spectrum of application compared with other techniques
    • Philpott N.J., Turner A.J., Scopes J., Westby M., Marsh J.C., Gordon-Smith E.C., et al. The use of 7-amino actinomycin D in identifying apoptosis: simplicity of use and broad spectrum of application compared with other techniques. Blood 1996, 87:2244-2251.
    • (1996) Blood , vol.87 , pp. 2244-2251
    • Philpott, N.J.1    Turner, A.J.2    Scopes, J.3    Westby, M.4    Marsh, J.C.5    Gordon-Smith, E.C.6
  • 13
    • 0036493402 scopus 로고    scopus 로고
    • Bone marrow progenitor cell reserve and function and stromal cell function are defective in rheumatoid arthritis: evidence for a tumor necrosis factor alpha-mediated effect
    • Papadaki H.A., Kritikos H.D., Gemetzi C., Koutala H., Marsh J.C., Boumpas D.T., et al. Bone marrow progenitor cell reserve and function and stromal cell function are defective in rheumatoid arthritis: evidence for a tumor necrosis factor alpha-mediated effect. Blood 2002, 99:1610-1619.
    • (2002) Blood , vol.99 , pp. 1610-1619
    • Papadaki, H.A.1    Kritikos, H.D.2    Gemetzi, C.3    Koutala, H.4    Marsh, J.C.5    Boumpas, D.T.6
  • 14
    • 0033761459 scopus 로고    scopus 로고
    • In vitro proliferation and differentiation of megakaryocytic progenitors in patients with aplastic anemia, paroxysmal nocturnal hemoglobinuria, and the myelodysplastic syndromes
    • Cox C.V., Killick S.B., Patel S., Elebute M.O., Marsh J.C., Gordon-Smith E.C., et al. In vitro proliferation and differentiation of megakaryocytic progenitors in patients with aplastic anemia, paroxysmal nocturnal hemoglobinuria, and the myelodysplastic syndromes. Stem Cells 2000, 18:428-434.
    • (2000) Stem Cells , vol.18 , pp. 428-434
    • Cox, C.V.1    Killick, S.B.2    Patel, S.3    Elebute, M.O.4    Marsh, J.C.5    Gordon-Smith, E.C.6
  • 15
    • 33747426275 scopus 로고    scopus 로고
    • Impaired megakaryopoiesis in patients with chronic idiopathic neutropenia is associated with increased transforming growth factor beta1 production in the bone marrow
    • Psyllaki M., Damianaki A., Gemetzi C., Pyrovolaki K., Eliopoulos G.D., Papadaki H.A. Impaired megakaryopoiesis in patients with chronic idiopathic neutropenia is associated with increased transforming growth factor beta1 production in the bone marrow. Br J Haematol 2006, 134:624-631.
    • (2006) Br J Haematol , vol.134 , pp. 624-631
    • Psyllaki, M.1    Damianaki, A.2    Gemetzi, C.3    Pyrovolaki, K.4    Eliopoulos, G.D.5    Papadaki, H.A.6
  • 16
    • 0034024416 scopus 로고    scopus 로고
    • Effect of thrombopoietin on proliferation of blasts from patients with myelodysplastic syndromes
    • Luo S.S., Ogata K., Yokose N., Kato T., Dan K. Effect of thrombopoietin on proliferation of blasts from patients with myelodysplastic syndromes. Stem Cells 2000, 18:112-119.
    • (2000) Stem Cells , vol.18 , pp. 112-119
    • Luo, S.S.1    Ogata, K.2    Yokose, N.3    Kato, T.4    Dan, K.5
  • 17
    • 0033797720 scopus 로고    scopus 로고
    • Alteration of c-mpl-mediated signal transduction in CD34(+) cells from patients with myelodysplastic syndromes
    • Kalina U., Hofmann W.K., Koschmieder S., Wagner S., Kauschat D., Hoelzer D., et al. Alteration of c-mpl-mediated signal transduction in CD34(+) cells from patients with myelodysplastic syndromes. Exp Hematol 2000, 28:1158-1163.
    • (2000) Exp Hematol , vol.28 , pp. 1158-1163
    • Kalina, U.1    Hofmann, W.K.2    Koschmieder, S.3    Wagner, S.4    Kauschat, D.5    Hoelzer, D.6
  • 18
    • 19944432021 scopus 로고    scopus 로고
    • Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist
    • Erickson-Miller C.L., DeLorme E., Tian S.S., Hopson C.B., Stark K., Giampa L., et al. Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist. Exp Hematol 2005, 33:85-93.
    • (2005) Exp Hematol , vol.33 , pp. 85-93
    • Erickson-Miller, C.L.1    DeLorme, E.2    Tian, S.S.3    Hopson, C.B.4    Stark, K.5    Giampa, L.6
  • 19
    • 60249099882 scopus 로고    scopus 로고
    • Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomised, double-blind, placebo-controlled trial
    • Bussel J.B., Provan D., Shamsi T., Cheng G., Psaila B., Kovaleva L., et al. Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomised, double-blind, placebo-controlled trial. Lancet 2009, 373:641-648.
    • (2009) Lancet , vol.373 , pp. 641-648
    • Bussel, J.B.1    Provan, D.2    Shamsi, T.3    Cheng, G.4    Psaila, B.5    Kovaleva, L.6
  • 21
    • 62549153611 scopus 로고    scopus 로고
    • Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist
    • Erickson-Miller C.L., Delorme E., Tian S.S., Hopson C.B., Landis A.J., Valoret E.I., et al. Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist. Stem Cells 2009, 27:424-430.
    • (2009) Stem Cells , vol.27 , pp. 424-430
    • Erickson-Miller, C.L.1    Delorme, E.2    Tian, S.S.3    Hopson, C.B.4    Landis, A.J.5    Valoret, E.I.6
  • 22
    • 66749122752 scopus 로고    scopus 로고
    • Thrombopoietin and thrombopoietin mimetics in the treatment of thrombocytopenia
    • Kuter D.J. Thrombopoietin and thrombopoietin mimetics in the treatment of thrombocytopenia. Annu Rev Med 2009, 60:193-206.
    • (2009) Annu Rev Med , vol.60 , pp. 193-206
    • Kuter, D.J.1
  • 23
    • 67849104655 scopus 로고    scopus 로고
    • Development of thrombopoietin receptor agonists for clinical use
    • Ikeda Y., Miyakawa Y. Development of thrombopoietin receptor agonists for clinical use. J Thromb Haemost 2009, 7(Suppl. 1):239-244.
    • (2009) J Thromb Haemost , vol.7 , Issue.SUPPL. 1 , pp. 239-244
    • Ikeda, Y.1    Miyakawa, Y.2
  • 24
    • 77955271313 scopus 로고    scopus 로고
    • Reduced proliferation of non-megakaryocytic acute myelogenous leukemia and other leukemia and lymphoma cell lines in response to eltrombopag
    • Erickson-Miller C.L., Kirchner J., Aivado M., May R., Payne P., Chadderton A. Reduced proliferation of non-megakaryocytic acute myelogenous leukemia and other leukemia and lymphoma cell lines in response to eltrombopag. Leuk Res 2010, 10.1016/j.leukres.2010.02.005.
    • (2010) Leuk Res
    • Erickson-Miller, C.L.1    Kirchner, J.2    Aivado, M.3    May, R.4    Payne, P.5    Chadderton, A.6
  • 26
    • 68549092703 scopus 로고    scopus 로고
    • Comparative analyses of the small molecule thrombopoietin receptor agonist eltrombopag and thrombopoietin on in vitro platelet function
    • Erhardt J.A., Erickson-Miller C.L., Aivado M., Abboud M., Pillarisetti K., Toomey J.R. Comparative analyses of the small molecule thrombopoietin receptor agonist eltrombopag and thrombopoietin on in vitro platelet function. Exp Hematol 2009, 37:1030-1037.
    • (2009) Exp Hematol , vol.37 , pp. 1030-1037
    • Erhardt, J.A.1    Erickson-Miller, C.L.2    Aivado, M.3    Abboud, M.4    Pillarisetti, K.5    Toomey, J.R.6
  • 27
    • 34249719511 scopus 로고    scopus 로고
    • Phase I clinical study of eltrombopag, an oral, non-peptide thrombopoietin receptor agonist
    • Jenkins J.M., Williams D., Deng Y., Uhl J., Kitchen V., Collins D. Phase I clinical study of eltrombopag, an oral, non-peptide thrombopoietin receptor agonist. Blood 2007, 109:4739-4741.
    • (2007) Blood , vol.109 , pp. 4739-4741
    • Jenkins, J.M.1    Williams, D.2    Deng, Y.3    Uhl, J.4    Kitchen, V.5    Collins, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.