Consequences and utility of the zinc-dependent metalloprotease activity of anthrax lethal toxin

Toxins

Volumn 2, Issue 5, 2010, Pages 1038-1053

  Bromberg White, Jennifer ^a   Lee, Chih Shia ^a,b   Duesbery, Nicholas ^a  

^a VAN ANDEL RESEARCH INSTITUTE   (United States)

^b Michigan State University   (United States)

Author keywords

Anthrax; Lethal factor; Metalloprotease; Mitogen activated protein kinase kinase; Pathogenesis; Retinal neovascularization; Tumorigenesis

Indexed keywords

ANTHRAX TOXIN; METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; VASCULOTROPIN INHIBITOR; ZINC;

ADAPTIVE IMMUNITY; ANTHRAX; ANTINEOPLASTIC ACTIVITY; BACILLUS ANTHRACIS; CANCER INHIBITION; CARBOXY TERMINAL SEQUENCE; CYTOTOXICITY; DISEASE COURSE; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME MODIFICATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; FIBROSARCOMA; HOST PATHOGEN INTERACTION; HUMAN; IMMUNOMODULATION; INNATE IMMUNITY; MELANOMA; NONHUMAN; PATHOGENESIS; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RETINA MACULA AGE RELATED DEGENERATION; RETINA NEOVASCULARIZATION; REVIEW; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR VASCULARIZATION; VASCULAR DISEASE;

ANIMALS; ANTHRAX; ANTIGENS, BACTERIAL; BACILLUS ANTHRACIS; BACTERIAL TOXINS; HUMANS; METALLOPROTEASES; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; ZINC;

BACILLUS ANTHRACIS; POSIBACTERIA;

EID: 79952060991     PISSN: None     EISSN: 20726651     Source Type: Journal    
DOI: 10.3390/toxins2051038     Document Type: Review

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