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Volumn 2, Issue 9, 2010, Pages 929-949

Reexamination of a meta-analysis of the effect of antioxidant supplementation on mortality and health in randomized trials

Author keywords

Antioxidants; Benefit risk; Meta analysis; Mortality; Supplementation

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; CELECOXIB; DONEPEZIL; METHIONINE; MINERAL; NICOTINIC ACID; OMEGA 3 FATTY ACID; PLACEBO; RETINOL; RILUZOLE; SELEGILINE; SELENIUM; SELENOMETHIONINE; SIMVASTATIN; TRACE ELEMENT;

EID: 79952048150     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu2090929     Document Type: Article
Times cited : (52)

References (95)
  • 1
    • 0026576932 scopus 로고
    • Vitamin C intake and mortality among a sample of the United States population
    • Enstrom, J.E.; Kanim, L.E.; Klein, M.A. Vitamin C intake and mortality among a sample of the United States population. Epidemiology 1992, 3, 194-202.
    • (1992) Epidemiology , vol.3 , pp. 194-202
    • Enstrom, J.E.1    Kanim, L.E.2    Klein, M.A.3
  • 3
    • 0029918290 scopus 로고    scopus 로고
    • Dietary antioxidant vitamins and death from coronary heart disease in postmenopausal women
    • Kushi, L.H.; Folsom, A.R.; Prineas, R.J.; Mink, P.J.; Wu, Y.; Bostick, R.M. Dietary antioxidant vitamins and death from coronary heart disease in postmenopausal women. N. Engl. J. Med. 1996, 334, 1156-1162.
    • (1996) N. Engl. J. Med , vol.334 , pp. 1156-1162
    • Kushi, L.H.1    Folsom, A.R.2    Prineas, R.J.3    Mink, P.J.4    Wu, Y.5    Bostick, R.M.6
  • 4
    • 0030013268 scopus 로고    scopus 로고
    • Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality in older persons: The Established Populations for Epidemiologic Studies of the Elderly
    • Losonczy, K.G.; Harris, T.B.; Havlik, R.J. Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality in older persons: The Established Populations for Epidemiologic Studies of the Elderly. Am. J. Clin. Nutr. 1996, 64, 190-196.
    • (1996) Am. J. Clin. Nutr , vol.64 , pp. 190-196
    • Losonczy, K.G.1    Harris, T.B.2    Havlik, R.J.3
  • 7
    • 0023866516 scopus 로고
    • The World Health Organization MONICA Project (monitoring trends and determinants in cardiovascular disease): A major international collaboration
    • WHO MONICA Project Principal Investigators
    • WHO MONICA Project Principal Investigators. The World Health Organization MONICA Project (monitoring trends and determinants in cardiovascular disease): A major international collaboration. J. Clin. Epidemiol. 1988, 41, 105-114.
    • (1988) J. Clin. Epidemiol , vol.41 , pp. 105-114
  • 8
    • 0027275148 scopus 로고
    • Nutrition intervention trials in Linxian, China: Supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population
    • Blot, W.J.; Li, J.Y.; Taylor, P.R.; Guo, W.; Dawsey, S.; Wang, G.Q.; Yang, C.S.; Zheng, S.F.; Gail, M.; Li, G.Y.; et al. Nutrition intervention trials in Linxian, China: Supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J. Natl. Cancer Inst. 1993, 85, 1483-1492.
    • (1993) J. Natl. Cancer Inst , vol.85 , pp. 1483-1492
    • Blot, W.J.1    Li, J.Y.2    Taylor, P.R.3    Guo, W.4    Dawsey, S.5    Wang, G.Q.6    Yang, C.S.7    Zheng, S.F.8    Gail, M.9    Li, G.Y.10
  • 9
    • 0038116394 scopus 로고    scopus 로고
    • Incidence of cancer and mortality following alpha-tocopherol and beta-carotene supplementation: A postintervention follow-up
    • ATBC Study Group
    • Virtamo, J.; Pietinen, P.; Huttunen, J.K.; Korhonen, P.; Malila, N.; Virtanen, M.J.; Albanes, D.; Taylor, P.R.; Albert, P.; ATBC Study Group. Incidence of cancer and mortality following alpha-tocopherol and beta-carotene supplementation: A postintervention follow-up. J. Am. Med. Assoc. 2003, 290, 476-485.
    • (2003) J. Am. Med. Assoc , vol.290 , pp. 476-485
    • Virtamo, J.1    Pietinen, P.2    Huttunen, J.K.3    Korhonen, P.4    Malila, N.5    Virtanen, M.J.6    Albanes, D.7    Taylor, P.R.8    Albert, P.9
  • 10
    • 0345109256 scopus 로고    scopus 로고
    • Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: Results of the GISSI-Prevenzione trial
    • GISSI (Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardio)
    • GISSI (Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardio). Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: Results of the GISSI-Prevenzione trial. Lancet 1999, 354, 447-455.
    • (1999) Lancet , vol.354 , pp. 447-455
  • 11
    • 0034688195 scopus 로고    scopus 로고
    • Vitamin E supplementation and cardiovascular events in high-risk patients
    • The Heart Outcomes Prevention Evaluation Study Investigators
    • Yusuf, S.; Dagenais, G.; Pogue, J.; Bosch, J.; Sleight, P. Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N. Engl. J. Med. 2000, 342, 154-160.
    • (2000) N. Engl. J. Med , vol.342 , pp. 154-160
    • Yusuf, S.1    Dagenais, G.2    Pogue, J.3    Bosch, J.4    Sleight, P.5
  • 12
    • 20044383911 scopus 로고    scopus 로고
    • Effects of long-term vitamin E supplementation on cardiovascular events and cancer: A randomized controlled trial
    • HOPE and HOPE-TOO Trial Investigators
    • Lonn, E.; Bosch, J.; Yusuf, S.; Sheridan, P.; Pogue, J.; Arnold, J.M.; Ross, C.; Arnold, A.; Sleight, P.; Probstfield, J.; Dagenais, G.R.; HOPE and HOPE-TOO Trial Investigators. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: A randomized controlled trial. J. Am. Med. Assoc. 2005, 293, 1338-1347.
    • (2005) J. Am. Med. Assoc , vol.293 , pp. 1338-1347
    • Lonn, E.1    Bosch, J.2    Yusuf, S.3    Sheridan, P.4    Pogue, J.5    Arnold, J.M.6    Ross, C.7    Arnold, A.8    Sleight, P.9    Probstfield, J.10    Dagenais, G.R.11
  • 14
    • 21444438990 scopus 로고    scopus 로고
    • Vitamin E in the primary prevention of cardiovascular disease and cancer: The Women's Health Study: A randomized controlled trial
    • Lee, I.M.; Cook, N.R.; Gaziano, J.M.; Gordon, D.; Ridker, P.M.; Manson, J.E.; Hennekens, C.H.; Buring, J.E. Vitamin E in the primary prevention of cardiovascular disease and cancer: The Women's Health Study: A randomized controlled trial. J. Am. Med. Assoc. 2005, 294, 56-65.
    • (2005) J. Am. Med. Assoc , vol.294 , pp. 56-65
    • Lee, I.M.1    Cook, N.R.2    Gaziano, J.M.3    Gordon, D.4    Ridker, P.M.5    Manson, J.E.6    Hennekens, C.H.7    Buring, J.E.8
  • 16
    • 36149001299 scopus 로고    scopus 로고
    • A randomized trial of beta carotene supplementation and cognitive function in men: The Physicians' Health Study II
    • Grodstein, F.; Kang, J.H.; Glynn, R.J.; Cook, N.R.; Gaziano, J.M. A randomized trial of beta carotene supplementation and cognitive function in men: The Physicians' Health Study II. Arch. Intern. Med. 2007, 167, 2184-2190.
    • (2007) Arch. Intern. Med , vol.167 , pp. 2184-2190
    • Grodstein, F.1    Kang, J.H.2    Glynn, R.J.3    Cook, N.R.4    Gaziano, J.M.5
  • 17
    • 0034800655 scopus 로고    scopus 로고
    • A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta-carotene, and zinc for age-related macular degeneration and vision loss: Report No. 8
    • Age-Related Eye Disease Study Research Group
    • Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta-carotene, and zinc for age-related macular degeneration and vision loss: Report No. 8. Arch. Ophthalmol. 2001, 119, 1417-1436.
    • (2001) Arch Ophthalmol , vol.119 , pp. 1417-1436
  • 18
    • 0034788401 scopus 로고    scopus 로고
    • A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E and beta-carotene for age-related cataract and vision loss: Report No. 9
    • Age-Related Eye Disease Study Research Group
    • Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E and beta-carotene for age-related cataract and vision loss: Report No. 9. Arch. Ophthalmol. 2001, 119, 1439-1452.
    • (2001) Arch Ophthalmol , vol.119 , pp. 1439-1452
  • 20
    • 34948871565 scopus 로고    scopus 로고
    • Why clinical trials of vitamin E and cardiovascular diseases may be fatally flawed. Commentary on The relationship between dose of vitamin E and suppression of oxidative stress in humans
    • Blumberg, J.B.; Frei, B. Why clinical trials of vitamin E and cardiovascular diseases may be fatally flawed. Commentary on The relationship between dose of vitamin E and suppression of oxidative stress in humans. Free Radic. Biol. Med. 2007, 43, 1374-1376.
    • (2007) Free Radic. Biol. Med , vol.43 , pp. 1374-1376
    • Blumberg, J.B.1    Frei, B.2
  • 21
    • 33947526438 scopus 로고    scopus 로고
    • Are we over oxidized? Oxidative stress, cardiovascular disease, and the future of intervention studies with antioxidants
    • Dusting, G.J.; Triggle, C. Are we over oxidized? Oxidative stress, cardiovascular disease, and the future of intervention studies with antioxidants. Vasc. Health Risk Manag. 2005, 1, 93-97.
    • (2005) Vasc. Health Risk Manag , vol.1 , pp. 93-97
    • Dusting, G.J.1    Triggle, C.2
  • 22
    • 51049085594 scopus 로고    scopus 로고
    • Nutrients, endpoints, and the problem of proof
    • Heaney, R.P. Nutrients, endpoints, and the problem of proof. J. Nutr. 2008, 138, 1591-1595.
    • (2008) J. Nutr , vol.138 , pp. 1591-1595
    • Heaney, R.P.1
  • 24
    • 0037840165 scopus 로고    scopus 로고
    • Use of antioxidant vitamins for the prevention of cardiovascular disease: Meta-analysis of randomised trials
    • Vivekananthan, D.P.; Penn, M.S.; Sapp, S.K.; Hsu, A.; Topol, E.J. Use of antioxidant vitamins for the prevention of cardiovascular disease: Meta-analysis of randomised trials. Lancet 2003, 361, 2017-2023.
    • (2003) Lancet , vol.361 , pp. 2017-2023
    • Vivekananthan, D.P.1    Penn, M.S.2    Sapp, S.K.3    Hsu, A.4    Topol, E.J.5
  • 25
    • 4744372695 scopus 로고    scopus 로고
    • Antioxidant supplements for prevention of gastrointestinal cancers: A systematic review and meta-analysis
    • Bjelakovic, G.; Nikolova, D.; Simonetti, R.G.; Gluud, C. Antioxidant supplements for prevention of gastrointestinal cancers: A systematic review and meta-analysis. Lancet 2004, 364, 1219-1228.
    • (2004) Lancet , vol.364 , pp. 1219-1228
    • Bjelakovic, G.1    Nikolova, D.2    Simonetti, R.G.3    Gluud, C.4
  • 27
    • 33847378451 scopus 로고    scopus 로고
    • Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: Systematic review and meta-analysis
    • Bjelakovic, G.; Nikolova, D.; Gluud, L.L.; Simonetti, R.G.; Gluud, C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: Systematic review and meta-analysis. J. Am. Med. Assoc. 2007, 297, 842-857.
    • (2007) J. Am. Med. Assoc , vol.297 , pp. 842-857
    • Bjelakovic, G.1    Nikolova, D.2    Gluud, L.L.3    Simonetti, R.G.4    Gluud, C.5
  • 28
    • 44949122716 scopus 로고    scopus 로고
    • Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases
    • doi:10.1002/14651858.CD007176
    • Bjelakovic, G.; Nikolova, D.; Gluud, L.L.; Simonetti, R.G.; Gluud, C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst. Rev. 2008, 2, CD007176, doi:10.1002/14651858.CD007176.
    • (2008) Cochrane Database Syst. Rev , vol.2
    • Bjelakovic, G.1    Nikolova, D.2    Gluud, L.L.3    Simonetti, R.G.4    Gluud, C.5
  • 29
    • 0026487750 scopus 로고
    • Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects
    • Chandra, R.K. Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. Lancet 1992, 340, 1124-1127.
    • (1992) Lancet , vol.340 , pp. 1124-1127
    • Chandra, R.K.1
  • 30
    • 33744908294 scopus 로고    scopus 로고
    • Research misconduct: The poisoning of the well
    • Smith, R. Research misconduct: The poisoning of the well. J. R. Soc. Med. 2006, 99, 232-237.
    • (2006) J. R. Soc. Med , vol.99 , pp. 232-237
    • Smith, R.1
  • 34
    • 0033548858 scopus 로고    scopus 로고
    • MIN. VIT. AOX. geriatric network. Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized elderly patients: A randomized controlled trial
    • Girodon, F.; Galan, P.; Monget, A.L.; Boutron-Ruault, M.C.; Brunet-Lecomte, P.; Preziosi, P.; Arnaud, J.; Manuguerra, J.C.; Hercberg, S; MIN. VIT. AOX. geriatric network. Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized elderly patients: A randomized controlled trial. Arch. Intern. Med. 1999, 159, 748-754.
    • (1999) Arch. Intern. Med , vol.159 , pp. 748-754
    • Girodon, F.1    Galan, P.2    Monget, A.L.3    Boutron-Ruault, M.C.4    Brunet-Lecomte, P.5    Preziosi, P.6    Arnaud, J.7    Manuguerra, J.C.8    Hercberg, S.9
  • 35
    • 4043056768 scopus 로고    scopus 로고
    • Vitamin E and respiratory tract infections in elderly nursing home residents: A randomized controlled trial
    • Meydani, S.N.; Leka, L.S.; Fine, B.C.; Dallal, G.E.; Keusch, G.T.; Singh, M.F.; Hamer, D.H. Vitamin E and respiratory tract infections in elderly nursing home residents: A randomized controlled trial. J. Am. Med. Assoc. 2004, 292, 828-836.
    • (2004) J. Am. Med. Assoc , vol.292 , pp. 828-836
    • Meydani, S.N.1    Leka, L.S.2    Fine, B.C.3    Dallal, G.E.4    Keusch, G.T.5    Singh, M.F.6    Hamer, D.H.7
  • 36
    • 0025859057 scopus 로고
    • The effect of dietary supplementation with vitamins A, C and E on cell-mediated immune function in elderly long-stay patients: A randomized controlled trial
    • Penn, N.D.; Purkins, L.; Kelleher, J.; Heatley, R.V.; Mascie-Taylor, B.H.; Belfield, P.W. The effect of dietary supplementation with vitamins A, C and E on cell-mediated immune function in elderly long-stay patients: A randomized controlled trial. Age Ageing 1991, 20, 169-174.
    • (1991) Age Ageing , vol.20 , pp. 169-174
    • Penn, N.D.1    Purkins, L.2    Kelleher, J.3    Heatley, R.V.4    Mascie-Taylor, B.H.5    Belfield, P.W.6
  • 37
    • 0028874148 scopus 로고
    • Effect of vitamin and trace element supplementation on immune indices in healthy elderly
    • Pike, J.; Chandra, R.K. Effect of vitamin and trace element supplementation on immune indices in healthy elderly. Int. J. Vitam. Nutr. Res. 1995, 65, 117-121.
    • (1995) Int. J. Vitam. Nutr. Res , vol.65 , pp. 117-121
    • Pike, J.1    Chandra, R.K.2
  • 38
    • 0017333155 scopus 로고
    • Quantitative evaluation of vitamin E in the treatment of angina pectoris
    • Gillilan, R.E.; Mondell, B.; Warbasse, J.R. Quantitative evaluation of vitamin E in the treatment of angina pectoris. Am. Heart J. 1977, 93, 444-449.
    • (1977) Am. Heart J , vol.93 , pp. 444-449
    • Gillilan, R.E.1    Mondell, B.2    Warbasse, J.R.3
  • 39
    • 0023741133 scopus 로고
    • A randomized trial of vitamins C and E in the prevention of recurrence of colorectal polyps
    • McKeown-Eyssen, G.; Holloway, C.; Jazmaji, V.; Bright-See, E.; Dion, P.; Bruce, W.R. A randomized trial of vitamins C and E in the prevention of recurrence of colorectal polyps. Cancer Res. 1988, 48, 4701-4705.
    • (1988) Cancer Res , vol.48 , pp. 4701-4705
    • McKeown-Eyssen, G.1    Holloway, C.2    Jazmaji, V.3    Bright-See, E.4    Dion, P.5    Bruce, W.R.6
  • 41
    • 0027055591 scopus 로고
    • Impact of Vitamin A Supplementation on the Incidence of Infection in Elderly Nursing-home Residents: A Randomized Controlled Trial
    • Murphy, S.; West, K.P., Jr.; Greenough, W.B., III; Cherot, E.; Katz, J.; Clement, L. Impact of Vitamin A Supplementation on the Incidence of Infection in Elderly Nursing-home Residents: A Randomized Controlled Trial. Age Ageing 1992, 21, 435-439.
    • (1992) Age Ageing , vol.21 , pp. 435-439
    • Murphy, S.1    West Jr., K.P.2    Greenough, W.B.3    Cherot, E.4    Katz, J.5    Clement, L.6
  • 42
    • 0027182552 scopus 로고
    • Nutrition Intervention Trials in Linxian, China: Multiple Vitamin/Mineral Supplementation, Cancer Incidence, and Disease-Specific Mortality Among Adults With Esophageal Dysplasia
    • Li, J.Y.; Taylor, P.R.; Li, B.; Dawsey, S.; Wang, G.Q.; Ershow, A.G.; Guo, W.; Liu, S.F.; Yang, C.S.; Shen, Q.; et al. Nutrition Intervention Trials in Linxian, China: Multiple Vitamin/Mineral Supplementation, Cancer Incidence, and Disease-Specific Mortality Among Adults With Esophageal Dysplasia. J. Natl. Cancer Inst. 1993, 85, 1492-1498.
    • (1993) J. Natl. Cancer Inst , vol.85 , pp. 1492-1498
    • Li, J.Y.1    Taylor, P.R.2    Li, B.3    Dawsey, S.4    Wang, G.Q.5    Ershow, A.G.6    Guo, W.7    Liu, S.F.8    Yang, C.S.9    Shen, Q.10
  • 43
    • 0027490562 scopus 로고
    • Alcohol-induced toxic hepatitis-a free radical associated disease. Lowering fatality by adjuvant antioxidant therapy. Z
    • Wenzel, G.; Kuklinski, B.; Rühlmann, C.; Ehrhardt, D. Alcohol-induced toxic hepatitis-a free radical associated disease. Lowering fatality by adjuvant antioxidant therapy. Z. Gesamte Inn. Med. 1993, 48, 490-496.
    • (1993) Gesamte Inn. Med , vol.48 , pp. 490-496
    • Wenzel, G.1    Kuklinski, B.2    Rühlmann, C.3    Ehrhardt, D.4
  • 46
    • 0028916565 scopus 로고
    • Effects of long-term vitamin E supplementation in alcoholic cirrhotics
    • de la Maza, M.P.; Petermann, M.; Bunout, D.; Hirsch, S. Effects of long-term vitamin E supplementation in alcoholic cirrhotics. J. Am. Coll. Nutr. 1995, 14, 192-196.
    • (1995) J. Am. Coll. Nutr , vol.14 , pp. 192-196
    • de la Maza, M.P.1    Petermann, M.2    Bunout, D.3    Hirsch, S.4
  • 47
    • 0029620317 scopus 로고
    • Randomized clinical trial of ascorbic acid in the treatment of pressure ulcers
    • Ter Riet, G.; Kessels, A.G.; Knipschild, P.G. Randomized clinical trial of ascorbic acid in the treatment of pressure ulcers. J. Clin. Epidemiol. 1995, 48, 1453-1460.
    • (1995) J. Clin. Epidemiol , vol.48 , pp. 1453-1460
    • Ter Riet, G.1    Kessels, A.G.2    Knipschild, P.G.3
  • 50
    • 0029680973 scopus 로고    scopus 로고
    • Multicenter ophthalmic and nutritional age-related macular degeneration study-part 2: Antioxidant intervention and conclusions
    • Richer, S. Multicenter ophthalmic and nutritional age-related macular degeneration study-part 2: Antioxidant intervention and conclusions. J. Am. Optom. Assoc. 1996, 67, 30-49.
    • (1996) J. Am. Optom. Assoc , vol.67 , pp. 30-49
    • Richer, S.1
  • 51
    • 0029925181 scopus 로고    scopus 로고
    • Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)
    • Stephens, N.G.; Parsons, A.; Schofield, P.M.; Kelly, F.; Cheeseman, K.; Mitchinson, M.J. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet 1996, 347, 781-786.
    • (1996) Lancet , vol.347 , pp. 781-786
    • Stephens, N.G.1    Parsons, A.2    Schofield, P.M.3    Kelly, F.4    Cheeseman, K.5    Mitchinson, M.J.6
  • 52
    • 0030775138 scopus 로고    scopus 로고
    • Effect of retinol in preventing squamous cell skin cancer in moderate-risk subjects: A randomized, double-blind, controlled trial. Southwest Skin Cancer Prevention Study Group
    • Moon, T.E.; Levine, N.; Cartmel, B.; Bangert, J.L.; Rodney, S.; Dong, Q.; Peng, Y.M.; Alberts, D.S. Effect of retinol in preventing squamous cell skin cancer in moderate-risk subjects: A randomized, double-blind, controlled trial. Southwest Skin Cancer Prevention Study Group. Cancer Epidemiol. Biomarkers Prev. 1997, 6, 949-956.
    • (1997) Cancer Epidemiol. Biomarkers Prev , vol.6 , pp. 949-956
    • Moon, T.E.1    Levine, N.2    Cartmel, B.3    Bangert, J.L.4    Rodney, S.5    Dong, Q.6    Peng, Y.M.7    Alberts, D.S.8
  • 54
    • 0033612873 scopus 로고    scopus 로고
    • Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: A randomised controlled trial
    • Green, A.; Williams, G.; Neale, R.; Hart, V.; Leslie, D.; Parsons, P.; Marks, G.C.; Gaffney, P.; Battistutta, D.; Frost, C.; et al. Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: A randomised controlled trial. Lancet 1999, 354, 723-729.
    • (1999) Lancet , vol.354 , pp. 723-729
    • Green, A.1    Williams, G.2    Neale, R.3    Hart, V.4    Leslie, D.5    Parsons, P.6    Marks, G.C.7    Gaffney, P.8    Battistutta, D.9    Frost, C.10
  • 59
    • 0035007860 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled randomized clinical trial of alpha-tocopherol (vitamin E) in the treatment of amyotrophic lateral sclerosis
    • ALS riluzole-tocopherol Study Group
    • Desnuelle, C.; Dib, M.; Garrel, C.; Favier, A; ALS riluzole-tocopherol Study Group. A double-blind, placebo-controlled randomized clinical trial of alpha-tocopherol (vitamin E) in the treatment of amyotrophic lateral sclerosis. Amyotroph. Lateral Scler. Other Motor Neuron Disord. 2001, 2, 9-18.
    • (2001) Amyotroph. Lateral Scler. Other Motor Neuron Disord , vol.2 , pp. 9-18
    • Desnuelle, C.1    Dib, M.2    Garrel, C.3    Favier, A.4
  • 61
    • 0034988736 scopus 로고    scopus 로고
    • An intervention trial to inhibit the progression of precancerous gastric lesions: Compliance, serum micronutrients and S-allyl cysteine levels, and toxicity
    • You, W.C.; Chang, Y.S.; Heinrich, J.; Ma, J.L.; Liu, W.D.; Zhang, L.; Brown, L.M.; Yang, C.S.; Gail, M.H.; Fraumeni, J.F., Jr.; Xu, G.W. An intervention trial to inhibit the progression of precancerous gastric lesions: Compliance, serum micronutrients and S-allyl cysteine levels, and toxicity. Eur. J. Cancer Prev. 2001, 10, 257-263.
    • (2001) Eur. J. Cancer Prev , vol.10 , pp. 257-263
    • You, W.C.1    Chang, Y.S.2    Heinrich, J.3    Ma, J.L.4    Liu, W.D.5    Zhang, L.6    Brown, L.M.7    Yang, C.S.8    Gail, M.H.9    Fraumeni Jr., J.F.10    Xu, G.W.11
  • 62
    • 0035852471 scopus 로고    scopus 로고
    • Collaborative Group of the Primary Prevention Project. Low-dose aspirin and vitamin E in people at cardiovascular risk: A randomised trial in general practice
    • de Gaetano, G. Collaborative Group of the Primary Prevention Project. Low-dose aspirin and vitamin E in people at cardiovascular risk: A randomised trial in general practice. Lancet 2001, 357, 89-95.
    • (2001) Lancet , vol.357 , pp. 89-95
    • de Gaetano, G.1
  • 63
    • 0034898806 scopus 로고    scopus 로고
    • Effect of glutathione S-transferase M1 genotype on progression of atherosclerosis in lifelong male smokers
    • de Waart, F.G.; Kok, F.J.; Smilde, T.J.; Hijmans, A.; Wollersheim, H.; Stalenhoef, A.F. Effect of glutathione S-transferase M1 genotype on progression of atherosclerosis in lifelong male smokers. Atherosclerosis 2001, 158, 227-231.
    • (2001) Atherosclerosis , vol.158 , pp. 227-231
    • de Waart, F.G.1    Kok, F.J.2    Smilde, T.J.3    Hijmans, A.4    Wollersheim, H.5    Stalenhoef, A.F.6
  • 64
    • 0036154163 scopus 로고    scopus 로고
    • The Roche European American Cataract Trial (REACT): A randomized clinical trial to investigate the efficacy of an oral antioxidant micronutrient mixture to slow progression of age-related cataract
    • Chylack, L.T., Jr.; Brown, N.P.; Bron, A.; Hurst, M.; Köpcke, W.; Thien, U.; Schalch, W. The Roche European American Cataract Trial (REACT): A randomized clinical trial to investigate the efficacy of an oral antioxidant micronutrient mixture to slow progression of age-related cataract. Ophthalmic Epidemiol. 2002, 9, 49-80.
    • (2002) Ophthalmic Epidemiol , vol.9 , pp. 49-80
    • Chylack Jr., L.T.1    Brown, N.P.2    Bron, A.3    Hurst, M.4    Köpcke, W.5    Thien, U.6    Schalch, W.7
  • 65
    • 0037077492 scopus 로고    scopus 로고
    • Effect of daily vitamin E and multivitamin-mineral supplementation on acute respiratory tract infections in elderly persons: A randomized controlled trial
    • Graat, J.M.; Schouten, E.G.; Kok, F.J. Effect of daily vitamin E and multivitamin-mineral supplementation on acute respiratory tract infections in elderly persons: A randomized controlled trial. J. Am. Med. Assoc. 2002, 288, 715-721.
    • (2002) J. Am. Med. Assoc , vol.288 , pp. 715-721
    • Graat, J.M.1    Schouten, E.G.2    Kok, F.J.3
  • 66
    • 0037031094 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20536 high-risk individuals: A randomised placebo-controlled trial
    • Heart Protection Study Collaborative Group
    • Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20536 high-risk individuals: A randomised placebo-controlled trial. Lancet 2002, 360, 23-33.
    • (2002) Lancet , vol.360 , pp. 23-33
  • 67
    • 0037126049 scopus 로고    scopus 로고
    • Alpha-tocopherol supplementation in healthy individuals reduces low-density lipoprotein oxidation but not atherosclerosis: The Vitamin E Atherosclerosis Prevention Study
    • Hodis, H.N.; Mack, W.J.; LaBree, L.; Mahrer, P.R.; Sevanian, A.; Liu, C.R.; Liu, C.H.; Hwang, J.; Selzer, R.H.; Azen, S.P. Alpha-tocopherol supplementation in healthy individuals reduces low-density lipoprotein oxidation but not atherosclerosis: The Vitamin E Atherosclerosis Prevention Study. Circulation 2002, 106, 1453-1459.
    • (2002) Circulation , vol.106 , pp. 1453-1459
    • Hodis, H.N.1    Mack, W.J.2    Labree, L.3    Mahrer, P.R.4    Sevanian, A.5    Liu, C.R.6    Liu, C.H.7    Hwang, J.8    Selzer, R.H.9    Azen, S.P.10
  • 68
    • 0037145833 scopus 로고    scopus 로고
    • Effects of Hormone Replacement Therapy and Antioxidant Vitamin Supplements on Coronary Atherosclerosis in Postmenopausal Women: A Randomized Controlled Trial
    • Waters, D.D.; Alderman, E.L.; Hsia, J.; Howard, B.V.; Cobb, F.R.; Rogers, W.J.; Ouyang, P.; Thompson, P.; Tardif, J.C.; Higginson, L.; et al. Effects of Hormone Replacement Therapy and Antioxidant Vitamin Supplements on Coronary Atherosclerosis in Postmenopausal Women: A Randomized Controlled Trial. J. Am. Med. Assoc. 2002, 288, 2432-2440.
    • (2002) J. Am. Med. Assoc , vol.288 , pp. 2432-2440
    • Waters, D.D.1    Alderman, E.L.2    Hsia, J.3    Howard, B.V.4    Cobb, F.R.5    Rogers, W.J.6    Ouyang, P.7    Thompson, P.8    Tardif, J.C.9    Higginson, L.10
  • 70
    • 0036896117 scopus 로고    scopus 로고
    • Supplementary vitamin E does not affect the loss of cartilage volume in knee osteoarthritis: A 2 year double blind randomized placebo controlled study
    • Wluka, A.E.; Stuckey, S.; Brand, C.; Cicuttini, F.M. Supplementary vitamin E does not affect the loss of cartilage volume in knee osteoarthritis: A 2 year double blind randomized placebo controlled study. J. Rheumatol. 2002, 29, 2585-2591.
    • (2002) J. Rheumatol , vol.29 , pp. 2585-2591
    • Wluka, A.E.1    Stuckey, S.2    Brand, C.3    Cicuttini, F.M.4
  • 72
    • 0037247881 scopus 로고    scopus 로고
    • Oral antioxidant supplementation for fatigue associated with primary biliary cirrhosis: Results of a multicentre, randomized, placebo-controlled, cross-over trial
    • Prince, M.I.; Mitchison, H.C.; Ashley, D.; Burke, D.A.; Edwards, N.; Bramble, M.G.; James, O.F.; Jones, D.E. Oral antioxidant supplementation for fatigue associated with primary biliary cirrhosis: Results of a multicentre, randomized, placebo-controlled, cross-over trial. Aliment. Pharmacol. Ther. 2003, 17, 137-143.
    • (2003) Aliment. Pharmacol. Ther , vol.17 , pp. 137-143
    • Prince, M.I.1    Mitchison, H.C.2    Ashley, D.3    Burke, D.A.4    Edwards, N.5    Bramble, M.G.6    James, O.F.7    Jones, D.E.8
  • 74
    • 0038527177 scopus 로고    scopus 로고
    • The effect of 5-year vitamin C supplementation on serum pepsinogen level and Helicobacter pylori infection
    • Sasazuki, S.; Sasaki, S.; Tsubono, Y.; Okubo, S.; Hayashi, M.; Kakizoe, T.; Tsugane, S. The effect of 5-year vitamin C supplementation on serum pepsinogen level and Helicobacter pylori infection. Cancer Sci. 2003, 94, 378-382.
    • (2003) Cancer Sci , vol.94 , pp. 378-382
    • Sasazuki, S.1    Sasaki, S.2    Tsubono, Y.3    Okubo, S.4    Hayashi, M.5    Kakizoe, T.6    Tsugane, S.7
  • 76
    • 0347759969 scopus 로고    scopus 로고
    • Can a short period of micronutrient supplementation in older institutionalized people improve response to influenza vaccine? A randomized, controlled trial
    • Allsup, S.J.; Shenkin, A.; Gosney, M.A.; Taylor, S.; Taylor, W.; Hammond, M.; Zambon, M.C. Can a short period of micronutrient supplementation in older institutionalized people improve response to influenza vaccine? A randomized, controlled trial. J. Am. Geriatr. Soc. 2004, 52, 20-24.
    • (2004) J. Am. Geriatr. Soc , vol.52 , pp. 20-24
    • Allsup, S.J.1    Shenkin, A.2    Gosney, M.A.3    Taylor, S.4    Taylor, W.5    Hammond, M.6    Zambon, M.C.7
  • 77
    • 10644263516 scopus 로고    scopus 로고
    • The Beta-Carotene and Retinol Efficacy Trial: Incidence of lung cancer and cardiovascular disease mortality during 6-year follow-up after stopping beta-carotene and retinol supplements
    • Goodman, G.E.; Thornquist, M.D.; Balmes, J.; Cullen, M.R.; Meyskens, F.L., Jr.; Omenn, G.S.; Valanis, B.; Williams, J.H., Jr. The Beta-Carotene and Retinol Efficacy Trial: Incidence of lung cancer and cardiovascular disease mortality during 6-year follow-up after stopping beta-carotene and retinol supplements. J. Natl. Cancer Inst. 2004, 96, 1743-1750.
    • (2004) J. Natl. Cancer Inst , vol.96 , pp. 1743-1750
    • Goodman, G.E.1    Thornquist, M.D.2    Balmes, J.3    Cullen, M.R.4    Meyskens Jr., F.L.5    Omenn, G.S.6    Valanis, B.7    Williams Jr., J.H.8
  • 78
    • 3242731551 scopus 로고    scopus 로고
    • Impact of Vitamin E supplementation on lipoprotein peroxidation and composition in Type 1 diabetic patients treated with Atorvastatin
    • Manuel-Y-Keenoy, B.; Vinckx, M.; Vertommen, J.; van Gaal, L.; de Leeuw, I. Impact of Vitamin E supplementation on lipoprotein peroxidation and composition in Type 1 diabetic patients treated with Atorvastatin. Atherosclerosis 2004, 175, 369-376.
    • (2004) Atherosclerosis , vol.175 , pp. 369-376
    • Manuel-Y-Keenoy, B.1    Vinckx, M.2    Vertommen, J.3    van Gaal, L.4    de Leeuw, I.5
  • 81
    • 2542432254 scopus 로고    scopus 로고
    • Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: The Veterans LAST study (Lutein Antioxidant Supplementation Trial)
    • Richer, S.; Stiles, W.; Statkute, L.; Pulido, J.; Frankowski, J.; Rudy, D.; Pei, K.; Tsipursky, M.; Nyland, J. Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: The Veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry 2004, 75, 216-230.
    • (2004) Optometry , vol.75 , pp. 216-230
    • Richer, S.1    Stiles, W.2    Statkute, L.3    Pulido, J.4    Frankowski, J.5    Rudy, D.6    Pei, K.7    Tsipursky, M.8    Nyland, J.9
  • 82
    • 23444462113 scopus 로고    scopus 로고
    • Effect of multivitamin and multimineral supplements on morbidity from infections in older people (MAVIS trial): Pragmatic, randomised, double blind, placebo controlled trial
    • Avenell, A.; Campbell, M.K.; Cook, J.A.; Hannaford, P.C.; Kilonzo, M.M.; McNeill, G.; Milne, A.C.; Ramsay, C.R.; Seymour, D.G.; Stephen, A.I.; Vale, L.D. Effect of multivitamin and multimineral supplements on morbidity from infections in older people (MAVIS trial): Pragmatic, randomised, double blind, placebo controlled trial. Br. Med. J. 2005, 331, 324-329.
    • (2005) Br. Med. J , vol.331 , pp. 324-329
    • Avenell, A.1    Campbell, M.K.2    Cook, J.A.3    Hannaford, P.C.4    Kilonzo, M.M.5    McNeill, G.6    Milne, A.C.7    Ramsay, C.R.8    Seymour, D.G.9    Stephen, A.I.10    Vale, L.D.11
  • 83
    • 17844387640 scopus 로고    scopus 로고
    • High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: Results of a placebo-controlled double-blind study
    • Graf, M.; Ecker, D.; Horowski, R.; Kramer, B.; Riederer, P.; Gerlach, M.; Hager, C.; Ludolph, A.C.; Becker, G.; Osterhage, J.; et al. High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: Results of a placebo-controlled double-blind study. J. Neural Transm. 2005, 112, 649-660.
    • (2005) J. Neural Transm , vol.112 , pp. 649-660
    • Graf, M.1    Ecker, D.2    Horowski, R.3    Kramer, B.4    Riederer, P.5    Gerlach, M.6    Hager, C.7    Ludolph, A.C.8    Becker, G.9    Osterhage, J.10
  • 84
    • 24144475928 scopus 로고    scopus 로고
    • Randomized, placebo-controlled, esophageal squamous cell cancer chemoprevention trial of selenomethionine and celecoxib
    • Limburg, P.J.; Wei, W.; Ahnen, D.J.; Qiao, Y.; Hawk, E.T.; Wang, G.; Giffen, C.A.; Wang, G.; Roth, M.J.; Lu, N.; et al. Randomized, placebo-controlled, esophageal squamous cell cancer chemoprevention trial of selenomethionine and celecoxib. Gastroenterology 2005, 129, 863-873.
    • (2005) Gastroenterology , vol.129 , pp. 863-873
    • Limburg, P.J.1    Wei, W.2    Ahnen, D.J.3    Qiao, Y.4    Hawk, E.T.5    Wang, G.6    Giffen, C.A.7    Wang, G.8    Roth, M.J.9    Lu, N.10
  • 85
    • 11444266497 scopus 로고    scopus 로고
    • Parkinson Study Group. Survival in Parkinson disease: Thirteen-year follow-up of the DATATOP cohort
    • Marras, C.; McDermott, M.P.; Rochon, P.A.; Tanner, C.M.; Naglie, G.; Rudolph, A.; Lang, A.E.; Parkinson Study Group. Survival in Parkinson disease: Thirteen-year follow-up of the DATATOP cohort. Neurology 2005, 64, 87-93.
    • (2005) Neurology , vol.64 , pp. 87-93
    • Marras, C.1    McDermott, M.P.2    Rochon, P.A.3    Tanner, C.M.4    Naglie, G.5    Rudolph, A.6    Lang, A.E.7
  • 88
    • 13444311600 scopus 로고    scopus 로고
    • Effects of vitamins C and E on oxidative stress markers and endothelial function in patients with systemic lupus erythematosus: A double blind, placebo controlled pilot study
    • Tam, L.S.; Li, E.K.; Leung, V.Y.; Griffith, J.F.; Benzie, I.F.; Lim, P.L.; Whitney, B.; Lee, V.W.; Lee, K.K.; Thomas, G.N.; Tomlinson, B. Effects of vitamins C and E on oxidative stress markers and endothelial function in patients with systemic lupus erythematosus: A double blind, placebo controlled pilot study. J. Rheumatol. 2005, 32, 275-282.
    • (2005) J. Rheumatol , vol.32 , pp. 275-282
    • Tam, L.S.1    Li, E.K.2    Leung, V.Y.3    Griffith, J.F.4    Benzie, I.F.5    Lim, P.L.6    Whitney, B.7    Lee, V.W.8    Lee, K.K.9    Thomas, G.N.10    Tomlinson, B.11
  • 89
    • 27544498373 scopus 로고    scopus 로고
    • The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure
    • Witte, K.K.; Nikitin, N.P.; Parker, A.C.; von Haehling, S.; Volk, H.D.; Anker, S.D.; Clark, A.L.; Cleland, J.G. The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure. Eur. Heart J. 2005, 26, 2238-2244.
    • (2005) Eur. Heart J , vol.26 , pp. 2238-2244
    • Witte, K.K.1    Nikitin, N.P.2    Parker, A.C.3    von Haehling, S.4    Volk, H.D.5    Anker, S.D.6    Clark, A.L.7    Cleland, J.G.8
  • 91
    • 16844379901 scopus 로고    scopus 로고
    • Manganese superoxide dismutase polymorphism, prediagnostic antioxidant status, and risk of clinical significant prostate cancer
    • Li, H.; Kantoff, P.W.; Giovannucci, E.; Leitzmann, M.F.; Gaziano, J.M.; Stampfer, M.J.; Ma, J. Manganese superoxide dismutase polymorphism, prediagnostic antioxidant status, and risk of clinical significant prostate cancer. Cancer Res. 2005, 65, 2498-2504.
    • (2005) Cancer Res , vol.65 , pp. 2498-2504
    • Li, H.1    Kantoff, P.W.2    Giovannucci, E.3    Leitzmann, M.F.4    Gaziano, J.M.5    Stampfer, M.J.6    Ma, J.7
  • 92
    • 62149086225 scopus 로고    scopus 로고
    • Bayesian model averaging in meta-analysis: Vitamin E supplementation and mortality
    • Berry, D.; Wathen, J.K.; Newell, M. Bayesian model averaging in meta-analysis: Vitamin E supplementation and mortality. Clin. Trials 2009, 6, 28-41.
    • (2009) Clin. Trials , vol.6 , pp. 28-41
    • Berry, D.1    Wathen, J.K.2    Newell, M.3
  • 93
    • 65949087685 scopus 로고    scopus 로고
    • Associations between α-tocopherol, β-carotene, and retinol and prostate cancer survival
    • Watters, J.L.; Gail, M.H.; Weinstein, S.J.; Virtamo, J.; Albanes, D. Associations between α-tocopherol, β-carotene, and retinol and prostate cancer survival. Cancer Res. 2009, 69, 3833-3841.
    • (2009) Cancer Res , vol.69 , pp. 3833-3841
    • Watters, J.L.1    Gail, M.H.2    Weinstein, S.J.3    Virtamo, J.4    Albanes, D.5
  • 94
    • 38549138535 scopus 로고    scopus 로고
    • Vitamin E supplementation reduces cardiovascular events in a subgroup of middle-aged individuals with both type 2 diabetes mellitus and the haptoglobin 2-2 genotype: A prospective double-blinded clinical trial
    • Milman, U.; Blum, S.; Shapira, C.; Aronson, D.; Miller-Lotan, R.; Anbinder, Y.; Alshiek, J.; Bennett, L.; Kostenko, M.; Landau, M.; et al. Vitamin E supplementation reduces cardiovascular events in a subgroup of middle-aged individuals with both type 2 diabetes mellitus and the haptoglobin 2-2 genotype: A prospective double-blinded clinical trial. Arterioscler. Thromb. Vasc. Biol. 2008, 28, 341-347.
    • (2008) Arterioscler. Thromb. Vasc. Biol , vol.28 , pp. 341-347
    • Milman, U.1    Blum, S.2    Shapira, C.3    Aronson, D.4    Miller-Lotan, R.5    Anbinder, Y.6    Alshiek, J.7    Bennett, L.8    Kostenko, M.9    Landau, M.10


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