The effect of 5-year vitamin C supplementation on serum pepsinogen level and Helicobacter pylori infection

Cancer Science

Volumn 94, Issue 4, 2003, Pages 378-382

  Sasazuki, Shizuka ^a   Sasaki, Satoshi ^a,b   Tsubono, Yoshitaka ^a,c   Okubo, Shunji ^d   Hayashi, Masato ^d   Kakizoe, Tadao ^e   Tsugane, Shoichiro ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b NATIONAL INSTITUTE OF HEALTH AND NUTRITION   (Japan)

^c TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d Hiraka General Hospital   (Japan)

^e NATIONAL CANCER CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; BETA CAROTENE; CAGA PROTEIN; PEPSINOGEN I; PEPSINOGEN II;

ADULT; AGED; ARTICLE; ATROPHIC GASTRITIS; CANCER RISK; CHRONIC GASTRITIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE COURSE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG MEGADOSE; DRUG WITHDRAWAL; FACTORIAL ANALYSIS; FEMALE; FOLLOW UP; HEALTH PROGRAM; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; JAPAN; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MEDICAL EXAMINATION; POPULATION RESEARCH; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STOMACH CANCER; STOMACH MUCOSA; UNITED STATES; VITAMIN SUPPLEMENTATION;

ADMINISTRATION, ORAL; ADULT; AGED; ANTIGENS, BACTERIAL; ASCORBIC ACID; BACTERIAL PROTEINS; CHRONIC DISEASE; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; GASTRITIS, ATROPHIC; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; JAPAN; MALE; MIDDLE AGED; PEPSINOGEN A; PEPSINOGEN C; TIME FACTORS;

EID: 0038527177     PISSN: 13479032     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2003.tb01450.x     Document Type: Article

References (25)

1. Correa P, Malcom G, Schmidt B, Fontham E, Ruiz B, Bravo JC, Bravo LE, Zarama G, Realpe JL. Review article: antioxidant micronutrients and gastric cancer. Aliment Pharmacol Ther 1998; 12 Suppl 1: 73-82.
2. Tannenbaum SR, Wishnok JS, Leaf CD. Inhibition of nitrosamine formation by ascorbic acid. Am J Clin Nutr 1991; 53: 247S-50S.
3. Block G. Vitamin C and cancer prevention: the epidemiologic evidence. Am J Clin Nutr 1991; 53: 270S-82S.
4. Zhang HM, Wakisaka N, Maeda O, Yamamoto T. Vitamin C inhibits the growth of a bacterial risk factor for gastric carcinoma: Helicobacter pylori. Cancer 1997; 80: 1897-903.
5. Jarosz M, Dzieniszewski J, Ufniarz ED, Wartanowicz M, Ziemlanski S, Reed PI. Effects of high dose vitamin C treatment on Helicobacter pylori infection and total vitamin C concentration in gastric juice. Eur J Cancer Prev 1998; 7: 449-54.
6. Miki K, Ichinose M, Shimizu A, Huang SC, Oka H, Furihata C, Matsushima T, Takahashi K. Serum pepsinogens as a screening test of extensive chronic gastritis. Gastroenterol Jpn 1987; 22: 133-41.
7. Tsubono Y, Okubo S, Hayashi M, Kakizoe T, Tsugane S. A randomized controlled trial for chemoprevention of gastric cancer in high-risk Japanese population; study design, feasibility and protocol modification. Jpn J Cancer Res 1997; 88: 344-9.
8. Anonymous. Beta carotene and vitamin A halted in lung cancer prevention trial. National Cancer Institute Press Release, Jan. 18, 1996.
9. Recommended dietary allowance for Japanese. 5th ed. Tokyo: Daiichi Shuppan; 1994 (in Japanese).
10. Levine M, Conry-Cantilena C, Wang Y, Welch RW, Washko PW, Dhariwal KR, Park JB, Lazarev A, Graumlich JF, King J, Cantilena LR. Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci USA 1996; 93: 3704-9.
11. Correa P. Haenszel W, Cuello C, Zavala D, Fontham E, Zarama G, Tannenbaum S, Collazos T, Ruiz B. Gastric precancerous process in a high risk population: cross-sectional studies. Cancer Res 1990; 50: 4731-6.
12. Miki K. The clinical application of serum pepsinogen measurement. Naika 1990; 66: 618-20 (in Japanese).
13. Bodger K, Wyatt JI, Heatley RV. Variation in serum pepsinogen with severity and topography of Helicobacter pylori-associated chronic gastritis in dyspeptic patients referred for endoscopy. Helicobacter 2001; 6: 216-24.
14. El-omar EM, Oien K, El-nujumi A, Gillen D, Wirz A, Dahill S, Williams C, Ardill JES, Mccoll KEL. Helicobacter pylori infection and chronic gastric acid hyposecretion. Gastroenterology 1997; 113: 15-24.
15. Helicobacter and Cancer Collaborative Group. Gastric cancer and Helicobacter pylori: a combined analysis of 12 cases control studies nested within prospective studies. Gut 2001; 49: 347-53.
16. Webb PM, Bates CJ, Palli D, Forman D, the Eurogast Study Group. Gastric cancer, gastritis and plasma vitamin C: results from an international correlation and cross-sectional study. Int J Cancer 1997; 73: 684-9.
17. Sobala GM, Schorah CJ, Sanderson M, Dixon MF, Tompkins DS, Godwin P, Axon ATR. Ascorbic acid in the human stomach. Gastroenterology 1989; 97: 357-63.
18. Sobala GM, Crabtree JE, Dixon MF, Schorah CJ, Taylor JD, Rathbone BJ, Heatley RV, Axon ATR. Acute Helicobacter pylori infection: clinical features, local and systemic immune response, gastric mucosal histology, and gastric juice ascorbic acid concentrations. Gut 1991; 34: 1415-8.
19. Banerjee S, Hawksby C, Miller S, Dahill S, Beattie AD, McColl KEL. Effect of H. pylori and its eradication on gastric juice ascorbic acid. Gut 1994; 35: 317-22.
20. Crabtree JE, Covacci A, Farmery SM, Xiang Z, Tompkins DS, Perry S, Lindley IJ, Rappuoli R. Helicobacter pylori induced interleukin-8 expression in gastric epithelial cells is associated with CagA positive phenotype. J Clin Pathol 1995; 48: 41-5.
21. Cover TL, Glupczynski Y, Lage AP, Burette A, Tummuru MK, Perez-Perez GI, Blaser MJ. Serologic detection of infection with CagA + Helicobacter pylori strains. J Clin Microbiol 1995; 33: 1496-500.
22. Blaser MJ. Intrastrain differences in Helicobacter pylori: a key question in mucosal damage? Ann Med 1995; 27: 559-63.
23. Kuipers EJ, Perez-Perez GI, Meuwissen SG, Blaser MJ. Helicobacter pylori and atrophic gastritis: importance of the CagA status. J Natl Cancer Inst 1995; 87: 1777-80.
24. Blaser MJ, Perez-Perez GI, Kleanthous H, Cover TL, Peek RM, Chyou PH, Stemmermann GN, Nomura A. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res 1995; 55: 2111-5.
25. Correa P. Human gastric carcinogenesis: a multistep and multifactorial process - first American Cancer Society award lecture on cancer epidemiology and prevention. Cancer Res 1992; 52: 6735-40.