The kinetic study of the inhibition of human cholinesterases by demeton-S-methyl shows that cholinesterase-based titration methods are not suitable for this organophosphate

Toxicology in Vitro

Volumn 25, Issue 3, 2011, Pages 754-759

  Bazire, Alexandre ^a   Gillon, Emilie ^a   Lockridge, Oksana ^b   Vallet, Virginie ^a   Nachon, Florian ^a  

^a CENTRE DE RECHERCHES   (France)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Cholinesterase inhibition activity; Demeton S methyl (DSM); Titration; VX surrogate

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE; DEMETON S METHYL; ORGANOPHOSPHATE INSECTICIDE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CONCENTRATION (PARAMETERS); ENZYME ACTIVITY; ENZYME INHIBITION; INHIBITION KINETICS; MASS SPECTROMETRY; QUANTITATIVE ANALYSIS;

ACETYLCHOLINESTERASE; BIOLOGICAL MARKERS; BUTYRYLCHOLINESTERASE; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MASS SPECTROMETRY; ORGANOTHIOPHOSPHORUS COMPOUNDS; THIOPHOSPHORIC ACID ESTERS;

EID: 79952043519     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2011.01.006     Document Type: Article

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