메뉴 건너뛰기




Volumn 336, Issue 3, 2011, Pages 962-972

In vitro and in vivo evidence for anti-inflammatory properties of 2-methoxyestradiol

Author keywords

[No Author keywords available]

Indexed keywords

2 METHOXYESTRADIOL; COLCHICINE; DEXAMETHASONE; ESTRADIOL; GAMMA INTERFERON; GLUCOCORTICOID RECEPTOR; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MIFEPRISTONE; PACLITAXEL; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA;

EID: 79951981414     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.174854     Document Type: Article
Times cited : (30)

References (40)
  • 1
    • 0017260590 scopus 로고
    • Glucocorticoid therapy
    • Axelrod L (1976) Glucocorticoid therapy. Medicine 55:39-65.
    • (1976) Medicine , vol.55 , pp. 39-65
    • Axelrod, L.1
  • 2
    • 0015398836 scopus 로고
    • Glucocorticoid receptors and the role of glucocorticoids in fetal lung development
    • Ballard PL and Ballard RA (1972) Glucocorticoid receptors and the role of glucocorticoids in fetal lung development. Proc Natl Acad Sci USA 69:2668-2672.
    • (1972) Proc Natl Acad Sci USA , vol.69 , pp. 2668-2672
    • Ballard, P.L.1    Ballard, R.A.2
  • 7
    • 0028220858 scopus 로고
    • The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth
    • DOI 10.1038/368237a0
    • Fotsis T, Zhang Y, Pepper MS, Adlercreutz H, Montesano R, Nawroth PP, and Schweigerer L (1994) The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth. Nature 368:237-239. (Pubitemid 24108838)
    • (1994) Nature , vol.368 , Issue.6468 , pp. 237-239
    • Fotsis, T.1    Zhang, Y.2    Pepper, M.S.3    Adlercreutz, H.4    Montesano, R.5    Nawrotht, P.P.6    Schweigerer, L.7
  • 9
    • 0031594466 scopus 로고    scopus 로고
    • Physiological concentrations of 17β-estradiol inhibit the synthesis of nitric oxide synthase in macrophages via a receptor-mediated system
    • DOI 10.1097/00005344-199802000-00016
    • Hayashi T, Yamada K, Esaki T, Muto E, Chaudhuri G, and Iguchi A (1998) Physiological concentrations of 17β-estradiol inhibit the synthesis of nitric oxide synthase in macrophages via a receptor-mediated system. J Cardiovasc Pharmacol 31:292-298. (Pubitemid 28099171)
    • (1998) Journal of Cardiovascular Pharmacology , vol.31 , Issue.2 , pp. 292-298
    • Hayashi, T.1    Yamada, K.2    Esaki, T.3    Muto, E.4    Chaudhuri, G.5    Iguchi, A.6
  • 10
    • 33646838414 scopus 로고    scopus 로고
    • SAR studies of 2-methoxyestradiol and development of its analogs as probes of anti-tumor mechanisms
    • DOI 10.1016/j.bmcl.2006.04.030, PII S0960894X06004240
    • Ho A, Kim YE, Lee H, Cyrus K, Baek SH, and Kim KB (2006) SAR studies of 2-methoxyestradiol and development of its analogs as probes of anti-tumor mechanisms. Bioorg Med Chem Lett 16:3383-3387. (Pubitemid 43777095)
    • (2006) Bioorganic and Medicinal Chemistry Letters , vol.16 , Issue.13 , pp. 3383-3387
    • Ho, A.1    Kim, Y.-E.2    Lee, H.-S.3    Cyrus, K.4    Baek, S.-H.5    Kim, K.-B.6
  • 12
    • 0036232865 scopus 로고    scopus 로고
    • 2-Methoxyestradiol and analogs as novel antiproliferative agents: Analysis of three-dimensional quantitative structure-activity relationships for DNA synthesis inhibition and estrogen receptor binding
    • DOI 10.1124/mol.61.5.1053
    • Hughes RA, Harris T, Altmann E, McAllister D, Vlahos R, Robertson A, Cushman M, Wang Z, and Stewart AG (2002) 2-Methoxyestradiol and analogs as novel antiproliferative agents: analysis of three-dimensional quantitative structure-activity relationships for DNA synthesis inhibition and estrogen receptor binding. Mol Pharmacol 61:1053-1069. (Pubitemid 34441770)
    • (2002) Molecular Pharmacology , vol.61 , Issue.5 , pp. 1053-1069
    • Hughes, R.A.1    Harris, T.2    Altmann, E.3    McAllister, D.4    Vlahos, R.5    Robertson, A.6    Cushman, M.7    Wang, Z.8    Stewart, A.G.9
  • 13
    • 41149126578 scopus 로고    scopus 로고
    • Modulation of adjuvant arthritis in the rat by 2-methoxyestradiol: An effect independent of an anti-angiogenic action
    • Issekutz AC and Sapru K (2008) Modulation of adjuvant arthritis in the rat by 2-methoxyestradiol: an effect independent of an anti-angiogenic action. Int Immunopharmacol 8:708-716.
    • (2008) Int Immunopharmacol , vol.8 , pp. 708-716
    • Issekutz, A.C.1    Sapru, K.2
  • 14
    • 0031872051 scopus 로고    scopus 로고
    • Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle
    • DOI 10.1002/(SICI)1098-1128(199807)18:4<259::AID-MED3>3.0.CO;2-U
    • Jordan A, Hadfield JA, Lawrence NJ, and McGown AT (1998) Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. Med Res Rev 18:259-296. (Pubitemid 28346389)
    • (1998) Medicinal Research Reviews , vol.18 , Issue.4 , pp. 259-296
    • Jordan, A.1    Hadfield, J.A.2    Lawrence, N.J.3    McGown, A.T.4
  • 15
    • 0031036011 scopus 로고    scopus 로고
    • Suppression of type II collagen-induced arthritis by the endogenous estrogen metabolite 2-methoxyestradiol
    • DOI 10.1002/art.1780400120
    • Josefsson E and Tarkowski A (1997) Suppression of type II collagen-induced arthritis by the endogenous estrogen metabolite 2-methoxyestradiol. Arthritis Rheum 40:154-163. (Pubitemid 27044047)
    • (1997) Arthritis and Rheumatism , vol.40 , Issue.1 , pp. 154-163
    • Josefsson, E.1    Tarkowski, A.2
  • 20
    • 0028324365 scopus 로고
    • Effects of a corticosteroid, budesonide, on alveolar macrophage and blood monocyte secretion of cytokines: Differential sensitivity of GM-CSF, IL-1β, and IL-6
    • DOI 10.1006/pulp.1994.1004
    • Linden M and Brattsand R (1994) Effects of a corticosteroid, budesonide, on alveolar macrophage and blood monocyte secretion of cytokines: differential sensitivity of GM-CSF, IL-1β, and IL-6. Pulm Pharmacol 7:43-47. (Pubitemid 24101686)
    • (1994) Pulmonary Pharmacology , vol.7 , Issue.1 , pp. 43-47
    • Linden, M.1    Brattsand, R.2
  • 22
    • 0028324655 scopus 로고
    • Taxol provides a second signal for murine macrophage tumoricidal activity
    • Manthey CL, Perera PY, Salkowski CA, and Vogel SN (1994) Taxol provides a second signal for murine macrophage tumoricidal activity. J Immunol 152:825-831. (Pubitemid 24072987)
    • (1994) Journal of Immunology , vol.152 , Issue.2 , pp. 825-831
    • Manthey, C.L.1    Perera, P.-Y.2    Salkowski, C.A.3    Vogel, S.N.4
  • 23
    • 0020334848 scopus 로고
    • The interaction of cancer chemotherapy agents with mononuclear phagocytes
    • Mantovani A (1982) The interaction of cancer chemotherapy agents with mononuclear phagocytes. Adv Pharmacol Chemother 19:35-66.
    • (1982) Adv Pharmacol Chemother , vol.19 , pp. 35-66
    • Mantovani, A.1
  • 26
    • 1342303482 scopus 로고    scopus 로고
    • Of Mice and Not Men: Differences between Mouse and Human Immunology
    • Mestas J and Hughes CC (2004) Of mice and not men: differences between mouse and human immunology. J Immunol 172:2731-2738. (Pubitemid 38263654)
    • (2004) Journal of Immunology , vol.172 , Issue.5 , pp. 2731-2738
    • Mestas, J.1    Hughes, C.C.W.2
  • 27
    • 0141996464 scopus 로고    scopus 로고
    • Microtubules, microtubule-interfering agents and apoptosis
    • DOI 10.1023/A:1025513106330
    • Mollinedo F and Gajate C (2003) Microtubules, microtubule-interfering agents and apoptosis. Apoptosis 8:413-450. (Pubitemid 37247987)
    • (2003) Apoptosis , vol.8 , Issue.5 , pp. 413-450
    • Mollinedo, F.1    Gajate, C.2
  • 28
    • 0842269204 scopus 로고    scopus 로고
    • Mechanism of action of 2-methoxyestradiol: New developments
    • Mooberry SL (2003) Mechanism of action of 2-methoxyestradiol: new developments. Drug Resist Updat 6:355-361.
    • (2003) Drug Resist Updat , vol.6 , pp. 355-361
    • Mooberry, S.L.1
  • 29
    • 0037180812 scopus 로고    scopus 로고
    • Points of control in inflammation
    • Nathan C (2002) Points of control in inflammation. Nature 420:846-852.
    • (2002) Nature , vol.420 , pp. 846-852
    • Nathan, C.1
  • 30
    • 66649093817 scopus 로고    scopus 로고
    • Disease modifying and antiangiogenic activity of 2-methoxyestradiol in a murine model of rheumatoid arthritis
    • Plum SM, Park EJ, Strawn SJ, Moore EG, Sidor CF, and Fogler WE (2009) Disease modifying and antiangiogenic activity of 2-methoxyestradiol in a murine model of rheumatoid arthritis. BMC Musculoskelet Disord 10:46-58.
    • (2009) BMC Musculoskelet Disord , vol.10 , pp. 46-58
    • Plum, S.M.1    Park, E.J.2    Strawn, S.J.3    Moore, E.G.4    Sidor, C.F.5    Fogler, W.E.6
  • 31
    • 0031253739 scopus 로고    scopus 로고
    • Colchicine Down-Regulates Lipopolysaccharide-Induced Granulocyte- Macrophage Colony-Stimulating Factor Production in Murine Macrophages
    • Rao P, Falk LA, Dougherty SF, Sawada T, and Pluznik DH (1997) Colchicine down-regulates lipopolysaccharide-induced granulocyte-macrophage colony-stimulating factor production in murine macrophages. J Immunol 159:3531-3539. (Pubitemid 127482112)
    • (1997) Journal of Immunology , vol.159 , Issue.7 , pp. 3531-3539
    • Rao, P.1    Falk, L.A.2    Dougherty, S.F.3    Sawada, T.4    Pluznik, D.H.5
  • 32
    • 18244409614 scopus 로고    scopus 로고
    • 17β-estradiol primes elicitation of inducible nitric oxide synthase expression by lipopolysaccharide and interferon-γ in mouse macrophage cell line J774.1
    • DOI 10.1248/jhs.51.62
    • Sakazaki H, Ido R, Ueno H, and Nakamuro K (2005) 17β-estradiol primes elicitation of inducible nitric oxide synthase expression by lipopolysaccharide and interferon-γ in mouse macrophage cell line J774.1. J Health Sci 51:62-69. (Pubitemid 40626944)
    • (2005) Journal of Health Science , vol.51 , Issue.1 , pp. 62-69
    • Sakazaki, H.1    Ido, R.2    Ueno, H.3    Nakamuro, K.4
  • 33
    • 79951988006 scopus 로고    scopus 로고
    • Treatment of asthma and airway diseases
    • inventor; Amrad Operations Pty Ltd, assignee. U.S. patent 5,962,445. 1999 Oct 5
    • Stewart AG (1999) inventor; Amrad Operations Pty Ltd, assignee. Treatment of asthma and airway diseases. U.S. patent 5,962,445. 1999 Oct 5.
    • (1999)
    • Stewart, A.G.1
  • 34
    • 34447106558 scopus 로고    scopus 로고
    • 2-Methoxyestradiol - A unique blend of activities generating a new class of anti-tumour/anti-inflammatory agents
    • DOI 10.1016/j.drudis.2007.05.005, PII S1359644607002231
    • Sutherland TE, Anderson RL, Hughes RA, Altmann E, Schuliga M, Ziogas J, and Stewart AG (2007) 2-Methoxyestradiol-a unique blend of activities generating a new class of anti-tumour/anti-inflammatory agents. Drug Discov Today 12:577-584. (Pubitemid 47031662)
    • (2007) Drug Discovery Today , vol.12 , Issue.13-14 , pp. 577-584
    • Sutherland, T.E.1    Anderson, R.L.2    Hughes, R.A.3    Altmann, E.4    Schuliga, M.5    Ziogas, J.6    Stewart, A.G.7
  • 35
    • 16344381892 scopus 로고    scopus 로고
    • 2-Methoxyestradiol is an estrogen receptor agonist that supports tumor growth in murine xenograft models of breast cancer
    • DOI 10.1158/1078-0432.CCR-04-1789
    • Sutherland TE, Schuliga M, Harris T, Eckhardt BL, Anderson RL, Quan L, and Stewart AG (2005) 2-Methoxyestradiol is an estrogen receptor agonist that supports tumor growth in murine xenograft models of breast cancer. Clin Cancer Res 11:1722-1732. (Pubitemid 40471833)
    • (2005) Clinical Cancer Research , vol.11 , Issue.5 , pp. 1722-1732
    • Sutherland, T.E.1    Schuliga, M.2    Harris, T.3    Eckhardt, B.L.4    Anderson, R.L.5    Quan, L.6    Stewart, A.G.7
  • 36
    • 0031042247 scopus 로고    scopus 로고
    • A murine model of pulmonary damage induced by lipopolysaccharide via intranasal instillation
    • DOI 10.1016/S0022-1759(96)00236-0, PII S0022175996002360
    • Szarka RJ, Wang N, Gordon L, Nation PN, and Smith RH (1997) A murine model of pulmonary damage induced by lipopolysaccharide via intranasal instillation. J Immunol Methods 202:49-57. (Pubitemid 27104267)
    • (1997) Journal of Immunological Methods , vol.202 , Issue.1 , pp. 49-57
    • Szarka, R.J.1    Wang, N.2    Gordon, L.3    Nation, P.N.4    Smith, R.H.5
  • 37
    • 68149181704 scopus 로고    scopus 로고
    • 2-Methoxyestradiol attenuates bleomycin-induced pulmonary hypertension and fibrosis in estrogen-deficient rats
    • Tofovic SP, Zhang X, Jackson EK, Zhu H, and Petrusevska G (2009) 2-Methoxyestradiol attenuates bleomycin-induced pulmonary hypertension and fibrosis in estrogen-deficient rats. Vascul Pharmacol 51:190-197.
    • (2009) Vascul Pharmacol , vol.51 , pp. 190-197
    • Tofovic, S.P.1    Zhang, X.2    Jackson, E.K.3    Zhu, H.4    Petrusevska, G.5
  • 39
    • 33750608081 scopus 로고    scopus 로고
    • 2-methoxyestradiol reduces cerebral vasospasm after 48 hours of experimental subarachnoid hemorrhage in rats
    • DOI 10.1016/j.expneurol.2006.06.009, PII S0014488606003918
    • Yan J, Chen C, Lei J, Yang L, Wang K, Liu J, and Zhou C (2006) 2-Methoxyestradiol reduces cerebral vasospasm after 48 hours of experimental subarachnoid hemorrhage in rats. Exp Neurol 202:348-356. (Pubitemid 44692678)
    • (2006) Experimental Neurology , vol.202 , Issue.2 , pp. 348-356
    • Yan, J.1    Chen, C.2    Lei, J.3    Yang, L.4    Wang, K.5    Liu, J.6    Zhou, C.7
  • 40
    • 0031921942 scopus 로고    scopus 로고
    • Growth and clonogenic assays compared for irradiated MCF-7 and Colo-205 cell lines
    • Yang YY, Olofsson M, Köpf I, and Hultborn R (1998) Growth and clonogenic assays compared for irradiated MCF-7 and Colo-205 cell lines. Anticancer Res 18:53-59. (Pubitemid 28174684)
    • (1998) Anticancer Research , vol.18 , Issue.1 A , pp. 53-59
    • Yang, Y.Y.1    Olofsson, M.2    Kopf, I.3    Hultborn, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.