Physiological concentrations of 17β-estradiol inhibit the synthesis of nitric oxide synthase in macrophages via a receptor-mediated system

Journal of Cardiovascular Pharmacology

Volumn 31, Issue 2, 1998, Pages 292-298

  Hayashi, Toshio ^a   Yamada, Kazuyoshi ^a   Esaki, Teiji ^a   Muto, Emiko ^a   Chaudhuri, Gautam ^b   Iguchi, Akihisa ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Estradiol; Estrogen receptor; Inducible nitric oxide synthase; Macrophage

Indexed keywords

17ALPHA ESTRADIOL; ANTIESTROGEN; ESTRADIOL; ESTROGEN RECEPTOR; FULVESTRANT; GAMMA INTERFERON; LIPOPOLYSACCHARIDE; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; TAMOXIFEN; DRUG DERIVATIVE; EDETIC ACID; INDUCIBLE NITRIC OXIDE SYNTHASE; MONOCLONAL ANTIBODY; NOS2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; ESTROGEN THERAPY; MACROPHAGE; MOUSE; NONHUMAN; POSTMENOPAUSE; PRIORITY JOURNAL; PROTECTION; ANIMAL; BIOSYNTHESIS; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; IMMUNOHISTOCHEMISTRY; METABOLISM; MICROELECTRODE; PHYSIOLOGY; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, MONOCLONAL; BLOTTING, WESTERN; CELL LINE; EDETIC ACID; ESTRADIOL; ESTROGEN ANTAGONISTS; IMMUNOHISTOCHEMISTRY; INTERFERON TYPE II; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICROELECTRODES; NITRATES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; TAMOXIFEN;

EID: 0031594466     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199802000-00016     Document Type: Article

References (29)

1. Williams JK, Adams MR, Klopfenstein HS. Estrogen modulates responses of atherosclerotic coronary arteries. Circulation 1990; 81:1680-7.
2. Stumpfer MJ, Colditz BA. Estrogen replacement therapy and coronary heart disease: a quantitative assessment of the epidemiologic evidence. Prev Med 1991;20:47-63.
3. Walsh BW, Sciff I, Rosner B, Greeenberg L, Ravnikar V, Sacks FM. Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins. N Engl J Med 1991;325:1196-204.
4. Gruchow HW, Anderson AJ, Barboraik JJ, Sobocinski KA. Postmenopausal use of estrogen and occlusion of coronary arteries. Am Heart J 1988;115:954-63.
5. Collins P, Rosano GM, Jiang C, Lindsay D, Sarrel PM, Poole-Wilson PA. Cardiovascular protection by oestrogen: a calcium antagonist effect? Lancet 1993;341:1264-5.
6. Bath PM, Hasall DG, Gladwin AM, Palmer RMJ, Martin JF. Nitric oxide and prostacyclin: divergence of inhibitory effects on monocyte chemotaxis and adhesion to endothelium in vitro. Arterioscler Thromb 1991;11:254-60.
7. Radmski MW, Palmer RMJ, Moncada S. The anti-aggregation properties of vascular endothelium: interactions between prostacyclin and nitric oxide. Br J Pharmacol 1987;92:639-46.
8. Bredt DS, Snyder SH. Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc Natl Acad Sci U S A 1990; 87:682-8.
9. Hayashi T, Fukuto JM, Ignarro LJ, Chaudhuri G. Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis. Proc Natl Acad Sci U S A 1992;89:11259-63.
10. Hayashi T, Fukuto JM, Ignarro LJ, Chaudhuri G. Gender differences in atherosclerosis: possible role of nitric oxide. J Cardiovasc Pharmacol 1995;26:792-802.
11. Hayashi T, Yamada K, Esaki T, et al. Estrogen increases endothelial nitric oxide by a receptor-mediated system. Biochem Biophys Res Commun 1995;214:847-55.
12. Hibbs JJ, Tanitor RR, Varvin Z, Rachlin EM. Nitric oxide: a cytotoxic activated macrophage effector molecule. Biochem Biophys Res Commun 1988;157:87-94.
13. Esaki T, Hayashi T, Mutoh E, Iguchi A. Expression of inducible nitric oxide synthase in T lymphocytes and macrophages of cholesterol-fed rabbits. Atherosclerosis 1997;128:39-46.
14. Yamada K, Nabeshima T. Simultaneous measurement of nitrite and nitrate levels as indices of nitric oxide release in the cerebellum of conscious rats. J Neurochem 1997;68:1234-43.
15. Malinski T, Tana Z. Nitric oxide release from a single cell measured in situ by a porphyrinic-based microsensor. Nature 1992;358:676-8.
16. Ichimori K, Fukahori H, Nakazawa H, Murakami E. Practical nitric oxide measurement employing a nitric oxide-selective electrode. Rev Sci Instrum 1994;65:1-8.
17. Ignarro LJ, Fukuto JM, Griscavage JM, Rogers NM, Byms RE. Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine. Proc Natl Acad Sci U S A 1993;90:8103-7.
18. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-71.
19. Hishikawa K, Nakaki T, Marumo T, Suzuki H, Kato R, Saruta T. Upregulation of nitric oxide synthase by estradiol in human aortic endothelial cells. FEBS Lett 1995;360:291-3.
20. Venema RC, Nishida K, Alexander RW, Harrison DG, Murphy TJ. Organization of the bovine gene encoding the endothelial nitric oxide synthase. Biochim Biophys Acta 1994;1218:413-20.
21. Aeberhard EE, Henderson SA, Arabolos NS, et al. Nonsteroidal anti-inflammatory drugs inhibit expression of the inducible nitric oxide synthase gene. Biochem Biophys Res Commun 1995;208:1053-9.
22. Kopp E, Ghosh S. Inhibition of NF-κB by sodium salicylate and aspirin. Science 1994;265:956-9.
23. Schreck R, Meier B, Männel DN, Dröge WPA. Dithiocarbamates as potent inhibitors of nuclear factor κB activation in intact cells. J Exp Med 1992;175:1181-94.
24. Kuiper GGJM, Enmark E, Pelto-Huiko M, et al. Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc Natl Acad Sci U S A 1996;93:5925-30.
25. Mosselman S, Polman J, Dijkema R. Erb: identification and characterization of a novel human estrogen receptor. FEBS Lett 1996; 392:49-53.
26. Kuiper GGJM, Carlsson B, Grandien KAJ, et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 1997;138:863-70.
27. Frazier-Jessen MR, Kovacs FJ. Estrogen modulation of monocyte chemoattractant protein-1 mRNA expression in murine macrophages. J Immunol 1995;154:1838-45.
28. Nabulsi AA, Folsom AR, White A, et al. Association of hormone-replacement therapy with various cardiovascular risk factors in postmenopausal women. N Engl J Med 1993;328:1069-75.
29. Coffins P, Shay J, Jiang C, Moss J. Nitric oxide accounts for dose-dependent estrogen-mediated coronary relaxation after acute estrogen withdrawal. Circulation 1994;90:1964-8.