Challenges and new opportunities for clinical nutrition interventions in the aged

Journal of Nutrition

Volumn 141, Issue 3, 2011, Pages 535-541

  Johnson, Mary Ann ^a   Dwyer, Johanna T ^b,c   Jensen, Gordon L ^d   Miller, Joshua W ^e   Speakman, John R ^f   Starke Reed, Pamela ^b   Volpi, Elena ^g  

^a UNIVERSITY OF GEORGIA   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c TUFTS UNIVERSITY   (United States)

^d PENNSYLVANIA STATE UNIVERSITY   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF ABERDEEN   (United Kingdom)

^g University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID;

AGED; AGING; CALORIC RESTRICTION; CONFERENCE PAPER; DIETARY INTAKE; FOOD SECURITY; HUMAN; LIFESPAN; MUSCLE ATROPHY; MUSCLE MASS; NONHUMAN; NUTRITION; OBESITY; PROTEIN INTAKE; UNITED STATES;

AGED; AGED, 80 AND OVER; AGING; ANIMALS; BIOMEDICAL RESEARCH; CALORIC RESTRICTION; FOLIC ACID; HEALTH STATUS; HUMANS; NUTRITION THERAPY; NUTRITIONAL STATUS; OBESITY; SARCOPENIA; SOCIOECONOMIC FACTORS; VITAMIN B 12 DEFICIENCY;

EID: 79951966855     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.110.131425     Document Type: Conference Paper

References (91)

1. Administration on Aging, U.S. Department of Health and Human Services. Minority aging [cited 2010 Jun 3]. Available from: http://www.aoa.gov/AoARoot/ Aging-Statistics/Minority-Aging/index.aspx.
2. Administration on Aging, US Department of Health and Human Services. A profile of older Americans: 2009 [cited 2010 Jun 3]. Available from: http://www.aoa.gov/AoARoot/Aging-Statistics/Profile/2009/docs/2009profile-508. pdf.
3. Cowie CC, Rust KF, Ford ES, Eberhardt MS, Byrd-Holt DD, Li C, Williams DE, Gregg EW, Bainbridge KE, et al. Full accounting of diabetes and pre-diabetes in the U.S. population in 1988-1994 and 2005-2006. Diabetes Care. 2009;32:287-94.
4. Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults, 1999-2008. JAMA. 2010;303:235-41.
5. Institute of Medicine, Committee on Disability in America, Board on Health Sciences Policy. The future of disability in America. Washington, DC: The National Academies Press; 2007.
6. USDA, Agricultural Research Service. What we eat in America [cited 2010 Jun 3]. Available from: http://www.ars.usda.gov/Services/docs.htm?docid=18349.
7. Houston DK, Nicklas BJ, Ding J, Harris TB, Tylavsky FA, Newman AB, Lee JS, Sahyoun NR, Visser M, et al. Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) study. Am J Clin Nutr. 2008;87:150-5.
8. Federal Interagency Forum on Aging-Related Statistics. Older Americans 2008: key indicators of well-being. Washington, DC: US Government Printing Office; 2008 [cited 2010 Jun 3]. Available from: http://www.aoa.gov/ agingstatsdotnet/Main-Site/Data/2008-Documents/OA-2008.pdf.
9. Bailey RL, Dodd KW, Goldman JA, Gahche JJ, Dwyer JT, Moshfegh AJ, Sempos CT, Picciano MF. Total folate and folic acid intake from foods and dietary supplements in the United States: 2003-2006. Am J Clin Nutr. 2010;91:231-7.
10. Nord M, Andrews M, Carlson S. Household food security in the United States, 2008. Washington, DC: U.S. Department of Agriculture Economic Research Service; 2009. Report No. ERR-83.
11. McCay CM, Crowell MF, Maynard LA. The effect of retarded growth upon the length of life and upon the ultimate body size. J Nutr. 1935;10:63-79.
12. Merry BJ. Molecular mechanisms linking calorie restriction and longevity. Int J Biochem Cell Biol. 2002;34:1340-54. (Pubitemid 35245394)
13. Speakman JR, Hambly C. Starving for life: what animal studies can and cannot tell us about the use of caloric restriction to prolong human lifespan. J Nutr. 2007;137:1078-86. (Pubitemid 46596915)
14. Walford R, Weindruch R. The retardation of aging and disease by dietary restriction. Springfield (IL): C.C. Thomas; 1988.
15. Walford RL, Walford L. The anti-aging plan: strategies and recipes for extending your healthy years. New York: Marlowe and Company; 1995.
16. Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, et al. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science. 2009;325:201-4.
17. Cooper TM, Mockett RJ, Sohal BH, Sohal RS, Orr WC. Effect of caloric restriction on life span of the housefly, Musca domestica. FASEB J. 2004;18:1591-3.
18. Liao CY, Rikke BA, Johnson TE, Diaz V, Nelson JF. Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. Aging Cell. 2010;9:92-5.
19. Mattson MP. Genes and behavior interact to determine mortality in mice when food is scarce and competition fierce. Aging Cell. 2010;9:448-9.
20. Shanley DP, Kirkwood TB. Caloric restriction does not enhance longevity in all species and is unlikely to do so in humans. Biogerontology. 2006;7:165-8. (Pubitemid 44151627)
21. Phelan JP, Rose MR. Why dietary restriction substantially increases longevity in animal models but won't in humans. Ageing Res Rev. 2005;4:339-50. (Pubitemid 41134192)
22. Phelan JP, Rose MR. Caloric restriction increases longevity substantially only when the reaction norm is steep. Biogerontology. 2006;7:161-4. (Pubitemid 44151626)
23. Speakman JR. The physiological costs of reproduction in small mammals. Philos Trans R Soc Lond B Biol Sci. 2008;363:375-98. (Pubitemid 350249333)
24. Dhahbi JM, Mote PL, Wingo J, Tillman JB, Walford RL, Spindler SR. Calories and aging alter gene expression for gluconeogenic, glycolytic, and nitrogen-metabolizing enzymes. Am J Physiol. 1999;277:E352-60.
25. Dhahbi JM, Kim HJ, Mote PL, Beaver RJ, Spindler SR. Temporal linkage between the phenotypic and genomic responses to caloric restriction. Proc Natl Acad Sci USA. 2004;101:5524-9. (Pubitemid 38481190)
26. Spindler SR. Calorie restriction enhances the expression of key metabolic enzymes associated with protein renewal during aging. Ann N Y Acad Sci. 2001;928:296-304. (Pubitemid 32386091)
27. Spindler SR. Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restriction. Mech Ageing Dev. 2005;126:960-6. (Pubitemid 41033176)
28. Rae M. It's never too late: calorie restriction is effective in older mammals. Rejuvenation Res. 2004;7:3-8. (Pubitemid 39619802)
29. Hambly C, Mercer JG, Speakman JR. Hunger does not diminish over time in mice under protracted caloric restriction. Rejuvenation Res. 2007;10:533-42.
30. Redman LM, Heilbronn LK, Martin CK, de Jonge L, Williamson DA, Delany JP, Ravussin E, Pennington CALERIE Team. Metabolic and behavioral compensations in response to caloric restriction: implications for the maintenance of weight loss. PLoS ONE. 2009;4:e4377.
31. Fontana L, Klein S, Holloszy JO. Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production. Age (Dordr). 2010;32:97-108.
32. Hambly C, Speakman JR. Contribution of different mechanisms to compensation for energy restriction in the mouse. Obes Res. 2005;13:1548-57.
33. Dhahbi JM, Mote PL, Fahy GM, Spindler SR. Identification of potential caloric restriction mimetics by microarray profiling. Physiol Genomics. 2005;23:343-50. (Pubitemid 44437970)
34. Ingram DK, Anson RM, de Cabo R, Mamczarz J, Zhu M, Mattison J, Lane MA, Roth GS. Development of calorie restriction mimetics as a prolongevity strategy. Ann N Y Acad Sci. 2004;1019:412-23. (Pubitemid 38951347)
35. Ingram DK, Zhu M, Mamczarz J, Zou S, Lane MA, Roth GS, deCabo R. Calorie restriction mimetics: an emerging research field. Aging Cell. 2006;5:97-108.
36. Bjedov I, Toivonen JM, Kerr F, Slack C, Jacobson J, Foley A, Partridge L. Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab. 2010;11:35-46.
37. Cox LS, Mattison JA. Increasing longevity through caloric restriction or rapamycin feeding in mammals: common mechanisms for common outcomes? Aging Cell. 2009;8:607-13.
38. Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature. 2009;460:392-5.
39. Anisimov VN, Berstein LM, Egormin PA, Piskunova TS, Popovich IG, Zabezhinski MA, Tyndyk ML, Yurova MV, Kovalenko IG, et al. Metformin slows down aging and extends life span of female SHR mice. Cell Cycle. 2008;7:2769-73.
40. Onken B, Driscoll M. Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS ONE. 2010;5:e8758.
41. Core indicators of nutritional state for difficult-to-sample populations. J Nutr. 1990;120:1559-600.
42. Ziliak J, Gundersen C. Senior hunger in the United States: differences across states and rural and urban areas; 2009 [cited 2010 Mar 12]. Available from: http://www.mowaa.org/Document.Doc?id=193.
43. Lee JS, Fischer JG, Johnson MA. Food insecurity, food and nutrition programs, and aging: experiences from Georgia. J Nutr Elder. 2010;29:116-49.
44. Brewer DP, Catlett CS, Porter KN, Lee JS, Hausman DB, Reddy S, Johnson MA. Physical limitations contribute to food insecurity and the food insecurity-obesity paradox in older adults at senior centers in Georgia. J Nutr Elder. 2010;29:150-69.
45. Lee JS, Sinnett S, Bengle R, Johnson MA, Brown A. Unmet needs for the Older Americans Act Nutrition Program in Georgia. J Appl Gerontol. In press 2010.
46. Ziliak J, Gundersen C, Haist M. The causes, consequences, and future of senior hunger in America. Lexington (KY): University of Kentucky; 2008 [cited 2010 Mar 10]. Available from: http://216.235.203.153/Document.Doc?id=13.
47. Lee JS, Frongillo EA Jr. Nutritional and health consequences are associated with food insecurity among U.S. elderly persons. J Nutr. 2001;131:1503-9. (Pubitemid 32422974)
48. Nelson K, Cunningham W, Andersen R, Harrison G, Gelberg L. Is food insufficiency associated with health status and health care utilization among adults with diabetes? J Gen Intern Med. 2001;16:404-11.
49. Sullivan AF, Clark S, Pallin DJ, Camargo CA Jr. Food security, health, and medication expenditures of emergency department patients. J Emerg Med. 2010;38:524-8.
50. Seligman HK, Laraia BA, Kushel MB. Food insecurity is associated with chronic disease among low-income NHANES participants. J Nutr. 2010;140:304-10.
51. Gao X, Scott T, Falcon LM, Wilde PE, Tucker KL. Food insecurity and cognitive function in Puerto Rican adults. Am J Clin Nutr. 2009;89:1197-203.
52. Bengle R, Sinnett S, Johnson T, Johnson MA, Brown A, Lee JS. Food insecurity is associated with cost-related medication non-adherence in community-dwelling, low-income older adults in Georgia. J Nutr Elder. 2010;29:170-91.
53. U.S. Administration on Aging. Unofficial compilation of the Older Americans Act of 1965, as amended in 2006 (Public Law 109-365) [cited 2010 Mar 10]. Available from: http://www.aoa.gov/AoARoot/AoA-Programs/OAA/oaa-full.asp.
54. Blumberg SJ, Bialostosky K, Hamilton WL, Briefel RR. The effectiveness of a short form of the Household Food Security Scale. Am J Public Health. 1999;89:1231-4. (Pubitemid 29359579)
55. Finkelstein EA, Trogdon JG, Cohen JW, Dietz W. Annual medical spending attributable to obesity: payer- and service-specific estimates. Health Aff (Millwood). 2009;28:w822-31.
56. Sturm R, Ringel JS, Andreyeva T. Increasing obesity rates and disability trends. Health Aff (Millwood). 2004;23:199-205. (Pubitemid 38471055)
57. Jensen GL, Hsiao PY. Obesity in older adults: relationship to functional limitation. Curr Opin Clin Nutr Metab Care. 2010;13:46-51.
58. Miller SL, Wolfe RR. The danger of weight loss in the elderly. J Nutr Health Aging. 2008;12:487-91.
59. Kulminski AM, Arbeev KG, Kulminskaya IV, Ukraintseva SV, Land K, Akushevich I, Yashin AI. Body mass index and nine-year mortality in disabled and nondisabled older U.S. individuals. J Am Geriatr Soc. 2008;56:105-10.
60. Villareal DT, Apovian CM, Kushner RF, Klein S. Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society. Am J Clin Nutr. 2005;82:923-34. (Pubitemid 43779747)
61. NIH. Clinical guidelines on the identification, evaluation, and treatment of obesity in adults: the evidence report. Bethesda (MD): NIH Publications; 1998.
62. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010;39:412-23.
63. Paddon-Jones D, Short KR, Campbell WW, Volpi E, Wolfe RR. Role of dietary protein in the sarcopenia of aging. Am J Clin Nutr. 2008;87:S1562-6.
64. Fujita S, Volpi E. Amino acids and muscle loss with aging. J Nutr. 2006;136:S277-80.
65. Roubenoff R. The pathophysiology of wasting in the elderly. J Nutr. 1999;129 Suppl 1S:S256-259.
66. Chen Z, Wang Z, Lohman T, Heymsfield SB, Outwater E, Nicholas JS, Bassford T, LaCroix A, Sherrill D, et al. Dual-energy X-ray absorptiometry is a valid tool for assessing skeletal muscle mass in older women. J Nutr. 2007;137:2775-80. (Pubitemid 350255312)
67. Mosoni L, Valluy MC, Serrurier B, Prugnaud J, Obled C, Guezennec CY, Mirand PP. Altered response of protein synthesis to nutritional state and endurance training in old rats. Am J Physiol. 1995;268:E328-35.
68. Volpi E, Mittendorfer B, Rasmussen BB, Wolfe RR. The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly. J Clin Endocrinol Metab. 2000;85:4481-90. (Pubitemid 32157622)
69. Katsanos CS, Kobayashi H, Sheffield-Moore M, Aarsland A, Wolfe RR. Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids. Am J Clin Nutr. 2005;82:1065-73. (Pubitemid 43779766)
70. Katsanos CS, Kobayashi H, Sheffield-Moore M, Aarsland A, Wolfe RR. A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol Endocrinol Metab. 2006;291:E381-7.
71. Paddon-Jones D, Rasmussen BB. Dietary protein recommendations and the prevention of sarcopenia. Curr Opin Clin Nutr Metab Care. 2009;12:86-90.
72. Rasmussen BB, Fujita S, Wolfe RR, Mittendorfer B, Roy M, Rowe VL, Volpi E. Insulin resistance of muscle protein metabolism in aging. FASEB J. 2006;20:768-9. (Pubitemid 46671209)
73. Fujita S, Glynn EL, Timmerman KL, Rasmussen BB, Volpi E. Supraphysiological hyperinsulinaemia is necessary to stimulate skeletal muscle protein anabolism in older adults: evidence of a true age-related insulin resistance of muscle protein metabolism. Diabetologia. 2009;52:1889-98.
74. Timmerman KL, Lee JL, Dreyer HC, Dhanani S, Glynn EL, Fry CS, Drummond MJ, Sheffield-Moore M, Rasmussen BB, et al. Insulin stimulates human skeletal muscle protein synthesis via an indirect mechanism involving endothelial-dependent vasodilation and mammalian target of rapamycin complex 1 signaling. J Clin Endocrinol Metab. 2010;95:3848-57.
75. Fujita S, Rasmussen BB, Cadenas JG, Drummond MJ, Glynn EL, Sattler FR, Volpi E. Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of rapamycin signaling. Diabetes. 2007;56:1615-22. (Pubitemid 46842620)
76. Honein MA, Paulozzi LJ, Mathews TJ, Erickson JD, Wong LYC. Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects. JAMA. 2001;285:2981-6. (Pubitemid 32550116)
77. CDC. Trends in spina bifida, United States, 1991-2005 [cited 2010 Jun 1]. Available from: http://www.cdc.gov/Features/dsSpinaBifida/.
78. Williams LJ, Mai CT, Edmonds LD, Shaw GM, Kirby RS, Hobbs CA, Sever LE, Miller LA, Meaney FJ, et al. Prevalence of spina bifida and anencephaly during the transition to mandatory folic acid fortification in the United States. Teratology. 2002;66:33-9. (Pubitemid 34734388)
79. De Wals P, Tairou F, Van Allen MI, Uh SH, Lowry RB, Sibbald B, Evans JA, Van den Hof MC, Zimmer P, et al. Reduction in neural-tube defects after folic acid fortification in Canada. N Engl J Med. 2007;357:135-42. (Pubitemid 47057731)
80. Jacques PF, Selhub J, Bostom AG, Wilson PW, Rosenberg IH. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med. 1999;340:1449-54. (Pubitemid 29220543)
81. Smith AD, Kim YI, Refsum H. Is folic acid good for everyone? Am J Clin Nutr. 2008;87:517-33.
82. Mason JB, Dickstein A, Jacques PF, Haggarty P, Selhub J, Dallal G, Rosenberg IH. A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis. Cancer Epidemiol Biomarkers Prev. 2007;16:1325-9. (Pubitemid 47076861)
83. Arabelovic S, Sam G, Dallal GE, Jacques PF, Selhub J, Rosenberg IH, Roubenoff R. Preliminary evidence shows that folic acid fortification of the food supply is associated with higher methotrexate dosing in patients with rheumatoid arthritis. J Am Coll Nutr. 2007;26:453-5. (Pubitemid 47512041)
84. Troen AM, Mitchell B, Sorensen B, Wener MH, Johnston A, Wood B, Selhub J, McTiernan A, Yasui Y, et al. Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women. J Nutr. 2006;136:189-94. (Pubitemid 43156507)
85. Reynolds EH. Benefits and risks of folic acid to the nervous system. J Neurol Neurosurg Psychiatry. 2002;72:567-71. (Pubitemid 34462806)
86. Morris MS, Jacques PF, Rosenberg IH, Selhub J. Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr. 2007;85:193-200. (Pubitemid 46067634)
87. Selhub J, Morris MS, Jacques PF. In vitamin B12 deficiency, higher serum folate is associated with increased total homocysteine and methylmalonic acid concentrations. Proc Natl Acad Sci USA. 2007;104:19995-20000.
88. Miller JW, Garrod MG, Allen LH, Haan MN, Green R. Metabolic evidence of vitamin B-12 deficiency, including high homocysteine and methylmalonic acid and low holotranscobalamin, is more pronounced in older adults with elevated plasma folate. Am J Clin Nutr. 2009;90:1586-92.
89. Yajnik CS, Deshpande SS, Jackson AA, Refsum H, Rao S, Fisher DJ, Bhat DS, Naik SS, Coyaji KJ, et al. Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study. Diabetologia. 2008;51:29-38. (Pubitemid 350197985)
90. Kondo H, Osborne ML, Kolhouse JF, Binder MJ, Podell ER, Utley CS, Abrams RS, Allen RH. Nitrous oxide has multiple deleterious effects on cobalamin metabolism and causes decreases in activities of both mammalian cobalamin-dependent enzymes in rats. J Clin Invest. 1981;67:1270-83. (Pubitemid 11099341)
91. Berry RJ, Carter HK, Yang Q. Cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr. 2007;86:265-7. (Pubitemid 47041624)