It's never too late: Calorie restriction is effective in older mammals

Rejuvenation Research

Volumn 7, Issue 1, 2004, Pages 3-8

  Rae, Michael ^a  

^a Calorie Restriction Society   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

AGING; CALORIC INTAKE; CALORIC RESTRICTION; GENE EXPRESSION; LIFESPAN; MAMMAL; MORTALITY; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; REVIEW; ANIMAL; LONGEVITY; PHYSIOLOGY; REJUVENATION;

MAMMALIA;

AGING; ANIMALS; CALORIC RESTRICTION; LONGEVITY; MAMMALS; REJUVENATION;

EID: 3843097263     PISSN: 15491684     EISSN: None     Source Type: Journal    
DOI: 10.1089/154916804323105026     Document Type: Review

References (25)

1. Masoro E. Caloric Restriction: a Key to Understanding and Modulating Aging. 2002; Amsterdam: Elsevier.
2. Weindruch R, Walford RL. Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence. Science 1982;215:1415-1418.
3. Lane MA, Mattison J, Ingram DK, Roth GS. Caloric restriction and aging in primates: relevance to humans and possible CR mimetics. Microsc Res Tech 2002;59:335-338.
4. Forster MJ, Sohal BH, Sohal RS. Reversible effects of long-term caloric restriction on protein oxidative damage. J Gerontol A Biol Sci Med Sci 2000;55:B522-B529.
5. Goto S, Takahashi R, Araki S, Nakamoto H. Dietary restriction initiated in late adulthood can reverse age-related alterations of protein and protein metabolism. Ann N Y Acad Sci 2002;959:50-56.
6. Lee CM, Aspnes LE, Chung SS, Weindruch R, Aiken JM. Influences of caloric restriction on age-associated skeletal muscle fiber characteristics and mitochondrial changes in rats and mice. Ann NY Acad Sci 1998;854:182-191.
7. Lass A, Sohal BH, Weindruch R, Forster MJ, Sohal RS. Caloric restriction prevents age-associated accrual of oxidative damage to mouse skeletal muscle mitochondria. Free Radic Biol Med 1998;25:1089-1097.
8. Merry BJ. Oxidative stress and mitochondrial function with aging: the effects of calorie restriction. Aging Cell 2004;3:7-12.
9. Cao SX, Dhahbi JM, Mote PL, Spindler SR. Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice. PNAS 2001;98:10630-10635.
10. http://lists.calorierestriction.org/cgi-bin/wa?AZ= ind0207&L= crsociety&P=R8701 [registration required]
11. Forster MJ, Morris P, Sohal RS. Genotype and age influence the effect of caloric intake on mortality in mice. FASEB J 2003;17:690-692.
12. Dhahbi JM, Kim H-J, Mote PL, Beaver RJ, Spindler SR. Temporal linkage between the phenotypic and genomic responses to caloric restriction. PNAS 2004;101:5524-5529.
13. Miller RA, Harper JM, Dysko RC, Durkee SJ, Austad SN. Longer life spans and delayed maturation in wild-derived mice. Exp Biol Med (Maywood) 2002;227:500-508.
14. Ahuja N, Issa JP. Aging, methylation and cancer. Histol Histopathol 2000;15:835-842.
15. Lee CK, Klopp RG, Weindruch R, Prolla TA. Gene expression profile of aging and its retardation by caloric restriction. Science 1999;285:1390-1393.
16. Lee CK, Weindruch R, Prolla TA. Gene-expression profile of the ageing brain in mice. Nat Genet 2000;25:294-297.
17. http://www.biomarkerinc.com/html/press.htm
18. http://www.calorierestriction.org
19. Merry BJ. Molecular mechanisms linking calorie restriction and longevity. Int J Biochem Cell Biol 2002;34:1340-1354.
20. Weindruch R, Walford RL, Fligiel S, Guthrie D. The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J Nutr 1986;116:641-654.
21. Turturro A, Witt WW, Lewis S, Hass BS, Lipman RD, Hart RW. Growth curves and survival characteristics of the animals used in the Biomarkers of Aging Program. J Gerontol A Biol Sci Med Sci 1999;54:B492-B501.
22. Pugh TD, Oberley TD, Weindruch R. Dietary intervention at middle age: caloric restriction but not dehydroepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice. Cancer Res 1999;59:1642-1648.
23. Mair W, Goymer P, Pletcher SD, Partridge L. Demography of dietary restriction and death in Drosophila. Science 2003;301:1731-1733.
24. de Grey AD, Ames BN, Andersen JK, Bartke A, Campisi J, Reward CB, McCarter RJM, Stock G. Time to talk SENS: critiquing the immutability of human aging. Ann NY Acad Sci 2002;959:452-462.
25. de Grey AD. Challenging but essential targets for genuine anti-ageing drugs. Expert Opin Ther Targets 2003;7:1-5.