-
2
-
-
70449136457
-
Drug reactions enzymes, andbiochemical genetics
-
Motulsky, A. G. Drug reactions enzymes, andbiochemical genetics.JAMA165, 835-837(1957).
-
(1957)
JAMA
, vol.165
, pp. 835-837
-
-
Motulsky, A.G.1
-
3
-
-
0014403645
-
Genetic control ofdrug levels in man: Antipyrine
-
Vesell, E. S. & Page, J. G. Genetic control ofdrug levels in man: antipyrine.Science161, 72-73 (1968).
-
(1968)
Science
, vol.161
, pp. 72-73
-
-
Vesell, E.S.1
Page, J.G.2
-
4
-
-
84965047512
-
The relationshipbetween dose of succinylcholine and duration of apnea in man
-
Kalow, W. & Gunn, D. R. The relationshipbetween dose of succinylcholine and duration of apnea in man.J. Pharmacol. Exp. Ther.120, 203-214 (1957).
-
(1957)
J. Pharmacol. Exp. Ther
, vol.120
, pp. 203-214
-
-
Kalow, W.1
Gunn, D.R.2
-
5
-
-
0001221024
-
Some statistical dataon atypical cholinesterase of human serum
-
Kalow, W. & Gunn, D. R. Some statistical dataon atypical cholinesterase of human serum.Ann. Hum. Genet.23, 239-250 (1959).
-
(1959)
Ann. Hum. Genet
, vol.23
, pp. 239-250
-
-
Kalow, W.1
Gunn, D.R.2
-
7
-
-
40949127393
-
How to interpreta genome-wide association study
-
Pearson, T. A. & Manolio, T. A. How to interpreta genome-wide association study.JAMA299, 1335-1344 (2008).
-
(2008)
JAMA
, vol.299
, pp. 1335-1344
-
-
Pearson, T.A.1
Manolio, T.A.2
-
8
-
-
0016735879
-
Polymorphic acetylation procainamide in man
-
Reidenberg, M. M., Drayer, D. E., Levy, M. & Warner, H. Polymorphic acetylation procainamide in man.Clin. Pharmacol. Ther. 17, 722-730 (1975).
-
(1975)
Clin. Pharmacol. Ther.
, vol.17
, pp. 722-730
-
-
Reidenberg, M.M.1
Drayer, D.E.2
Levy, M.3
Warner, H.4
-
9
-
-
0014823763
-
&Sakamoto, A. Relationship of acetyl transferaseactivity to antinuclear antibodies and toxicsymptoms in hypertensive patients treatedwith hydralazine
-
Perry, H. M. Jr., Tan, E. M., Carmody, S. &Sakamoto, A. Relationship of acetyl transferaseactivity to antinuclear antibodies and toxicsymptoms in hypertensive patients treated with hydralazine.J. Lab. Clin. Med.76, 114-125(1970).
-
(1970)
J. Lab. Clin. Med
, vol.76
, pp. 114-125
-
-
Perry, H.M.1
Tan, E.M.2
Carmody, S.3
Sakamoto, A.4
-
11
-
-
0018615011
-
Defective N-oxidation of sparteine in man: A new pharmacogeneticdefect
-
Eichelbaum, M., Spannbrucker, N., Steincke, B. & Dengler, H. J. Defective N-oxidation of sparteine in man: a new pharmacogeneticdefect.Eur. J. Clin. Pharmacol.16, 183-187(1979).
-
(1979)
Eur. J. Clin. Pharmacol
, vol.16
, pp. 183-187
-
-
Eichelbaum, M.1
Spannbrucker, N.2
Steincke, B.3
Dengler, H.J.4
-
12
-
-
0020409410
-
S.et al.Oxidation phenotype—amajor determinant of metoprolol metabolismand response
-
Lennard, M. S.et al.Oxidation phenotype—amajor determinant of metoprolol metabolismand response.N. Engl. J. Med.307, 1558-1560(1982).
-
(1982)
N. Engl. J. Med
, vol.307
, pp. 1558-1560
-
-
Lennard, M.1
-
13
-
-
0023954396
-
Human debrisoquine4-hydroxylase (P450IID1): CDNA and deducedamino acid sequence and assignment of theCYP2D locus of chromosome 22
-
Gonzalez, F. J.et al.Human debrisoquine4-hydroxylase (P450IID1): cDNA and deducedamino acid sequence and assignment of theCYP2D locus of chromosome 22.Genomics2, 174-179 (1988).
-
(1988)
Genomics
, vol.2
, pp. 174-179
-
-
Gonzalez, F.J.1
-
14
-
-
0024796958
-
The human debrisoquine4-hydroxylase (CYP2D) locus: Sequence andidentification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene
-
Kimura, S., Umeno, M., Skoda, R. C., Meyer, U. A.& Gonzalez, F. J. The human debrisoquine4-hydroxylase (CYP2D) locus: sequence andidentification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.Am. J. Hum. Genet.45, 889-904 (1989).
-
(1989)
Am. J. Hum. Genet
, vol.45
, pp. 889-904
-
-
Kimura, S.1
Umeno, M.2
Skoda, R.C.3
Meyer, U.A.4
Gonzalez, F.J.5
-
15
-
-
0027136288
-
Inherited amplification of anactive gene in the cytochrome P450 CYP2Dlocus as a cause of ultrarapid metabolism ofdebrisoquine
-
et al
-
Johansson, I.et al.Inherited amplification of anactive gene in the cytochrome P450 CYP2Dlocus as a cause of ultrarapid metabolism ofdebrisoquine.Proc. Natl Acad. Sci. USA 90, 11825-11829 (1993).
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 11825-11829
-
-
Johansson, I.1
-
16
-
-
0030432585
-
Frequent distribution ofultrarapid metabolizers of debrisoquine in anEthiopian population carrying duplicated andmultiduplicated functional CYP2D6 alleles
-
et al
-
Akulli, E.et al.Frequent distribution ofultrarapid metabolizers of debrisoquine in anEthiopian population carrying duplicated andmultiduplicated functional CYP2D6 alleles. J. Pharmacol. Exp. Ther.278, 441-446 (1996).
-
(1996)
J. Pharmacol. Exp. Ther
, vol.278
, pp. 441-446
-
-
Akulli, E.1
-
17
-
-
58749094444
-
Cytochrome p-450polymorphisms and response to clopidogrel
-
Mega, J. L.et al.Cytochrome p-450polymorphisms and response to clopidogrel. N. Engl. J. Med.360, 354-362 (2008).
-
(2008)
N. Engl. J. Med
, vol.360
, pp. 354-362
-
-
Mega, J.L.1
-
18
-
-
3142745348
-
Trends in heart failureincidence and survival in a community-basedpopulation
-
Roger, V. L.et al.Trends in heart failureincidence and survival in a community-basedpopulation.JAMA292, 344-350 (2004).
-
(2004)
JAMA
, vol.292
, pp. 344-350
-
-
Roger, V.L.1
-
19
-
-
19944429413
-
Amiodarone or an implantablecardioverter-defibrillator for congestive heartfailure
-
Bardy G. H.et al.Amiodarone or an implantablecardioverter-defibrillator for congestive heartfailure.N. Engl. J. Med.352, 225-237 (2005).
-
(2005)
N. Engl. J. Med
, vol.352
, pp. 225-237
-
-
Bardy, G.H.1
-
20
-
-
0035978801
-
The Beta-Blocker Evaluation of Survival TrialInvestigators. A trial of the beta-blockerbucindolol in patients with advanced chronicheart failure
-
The Beta-Blocker Evaluation of Survival TrialInvestigators. A trial of the beta-blockerbucindolol in patients with advanced chronicheart failure.N. Engl. J. Med.344, 1659-1667(2001).
-
(2001)
N. Engl. J. Med
, vol.344
, pp. 1659-1667
-
-
-
21
-
-
33847312219
-
Pharmacogenetics of the humanbeta-adrenergic receptors
-
Taylor, M. R. Pharmacogenetics of the humanbeta-adrenergic receptors.Pharmacogenomics J.7, 29-37 (2007).
-
(2007)
Pharmacogenomics J.
, vol.7
, pp. 29-37
-
-
Taylor, M.R.1
-
22
-
-
0033584561
-
Racial differences in the frequencies of cardiac beta(1)-adrenergicreceptor polymorphisms: Analysis of c145A>Gand c1165G>C
-
Moore, J. D., Mason, D. A., Green, S. A., Hsu, J. & Liggett, S. B. Racial differences in the frequencies of cardiac beta(1)-adrenergicreceptor polymorphisms: analysis of c145A>Gand c1165G>C.Hum. Mutat.14, 271 (1999).
-
(1999)
Hum. Mutat
, vol.14
, pp. 271
-
-
Moore, J.D.1
Mason, D.A.2
Green, S.A.3
Hsu, J.4
Liggett, S.B.5
-
23
-
-
33746603033
-
A polymorphism within aconserved beta(1)-adrenergic receptor motifalters cardiac function and beta-blocker response in human heart failure
-
Liggett, S. B.et al.A polymorphism within aconserved beta(1)-adrenergic receptor motifalters cardiac function and beta-blocker response in human heart failure.Proc. NatlAcad. Sci. USA103, 11288-11293 (2006).
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 11288-11293
-
-
Liggett, S.B.1
-
24
-
-
0034725616
-
A four amino aciddeletion polymorphism in the third intracellularloop of the human alpha 2C-adrenergic receptorconfers impaired coupling to multiple effectors
-
Small, K. M., Forbes, S. L., Rahman, F., Bridges, K. M. & Liggett, S. B. A four amino aciddeletion polymorphism in the third intracellularloop of the human alpha 2C-adrenergic receptorconfers impaired coupling to multiple effectors.J. Biol. Chem.275, 23059-23064 (2000).
-
(2000)
J. Biol. Chem
, vol.275
, pp. 23059-23064
-
-
Small, K.M.1
Forbes, S.L.2
Rahman, F.3
Bridges, K.M.4
Liggett, S.B.5
-
25
-
-
0037057235
-
Synergistic polymorphisms of beta1- and alpha2C-adrenergicreceptors and the risk of congestive heart failure
-
Small, K. M., Wagoner, L. E., Levin, A. M., Kardia, S. L. & Liggett, S. B. Synergistic polymorphisms of beta1- and alpha2C-adrenergicreceptors and the risk of congestive heart failure.N. Engl. J. Med.347, 1135-1142 (2002).
-
(2002)
N. Engl. J. Med
, vol.347
, pp. 1135-1142
-
-
Small, K.M.1
Wagoner, L.E.2
Levin, A.M.3
Kardia, S.L.4
Liggett, S.B.5
-
26
-
-
43249124512
-
A GRK5 polymorphism thatinhibits beta-adrenergic receptor signaling isprotective in heart failure
-
Liggett, S. B.et al.A GRK5 polymorphism thatinhibits beta-adrenergic receptor signaling isprotective in heart failure.Nat. Med.14, 510-517 (2008).
-
(2008)
Nat. Med
, vol.14
, pp. 510-517
-
-
Liggett, S.B.1
-
27
-
-
38449106799
-
Medication use leading toemergency department visits for adverse drugevents in older adults
-
Budnitz, D. S., Shehab, N., Kegler, S. R. &Richards, C. L. Medication use leading toemergency department visits for adverse drugevents in older adults.Ann. Intern. Med.147, 755-765 (2007).
-
(2007)
Ann. Intern. Med
, vol.147
, pp. 755-765
-
-
Budnitz, D.S.1
Shehab, N.2
Kegler, S.R.3
Richards, C.L.4
-
28
-
-
0010982679
-
Hereditary transmission of exceptional resistance tocoumarin anticoagulant drugs
-
O’Reilly, R. A., Aggeler, P M., Hoag, M. S., Leong, L. S. & Kropatkin, M. L. Hereditary transmission of exceptional resistance tocoumarin anticoagulant drugs. The first reportedkindred.N. Engl. J. Med.271, 809-815 (1964).
-
(1964)
The first reportedkindred N. Engl. J. Med
, vol.271
, pp. 809-815
-
-
O’Reilly, R.A.1
Aggeler, P.M.2
Hoag, M.S.3
Leong, L.S.4
Kropatkin, M.L.5
-
29
-
-
0037565623
-
Pharmacogenetics oforal anticoagulants
-
Daly, A. K. & King, B. P. Pharmacogenetics oforal anticoagulants.Pharmacogenetics13, 247-252 (2003).
-
(2003)
Pharmacogenetics
, vol.13
, pp. 247-252
-
-
Daly, A.K.1
King, B.P.2
-
30
-
-
0033608466
-
Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin doserequirement and risk of bleeding complications
-
Aithal, G. P, Day, C. P, Kesteven, P J. & Daly, A. K. Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin doserequirement and risk of bleeding complications.Lancet353, 717-719 (1999).
-
(1999)
Lancet
, vol.353
, pp. 717-719
-
-
Aithal, G.P.1
Day, C.P.2
Kesteven, P.J.3
Daly, A.K.4
-
31
-
-
10744228888
-
Mutations in VKORC1 causewarfarin resistance and multiple coagulationfactor deficiency type 2
-
et al
-
Rost, S.et al.Mutations in VKORC1 causewarfarin resistance and multiple coagulationfactor deficiency type 2.Nature427, 537-541(2004).
-
(2004)
Nature
, vol.427
, pp. 537-541
-
-
Rost, S.1
-
32
-
-
21144448879
-
Effect of VKORC1 haplotypeson transcriptional regulation and warfarin dose
-
Rieder, M. J. etal.Effect of VKORC1 haplotypeson transcriptional regulation and warfarin dose.N. Engl. J. Med.352, 2285-2293 (2005).
-
(2005)
N. Engl. J. Med
, vol.352
, pp. 2285-2293
-
-
Rieder, M.J.1
-
33
-
-
40449120615
-
Genetic determinants ofresponse to warfarin during initialanticoagulation
-
Schwarz, U. I.et al.Genetic determinants ofresponse to warfarin during initialanticoagulation.N. Engl. J. Med.358, 999-1008(2008).
-
(2008)
N. Engl. J. Med.
, vol.358
, pp. 999-1008
-
-
Schwarz, U.I.1
-
34
-
-
49949098665
-
The critical path of warfarin dosing:finding an optimal dosing strategy usingpharmacogenetics
-
Lesko, L. J. The critical path of warfarin dosing:finding an optimal dosing strategy usingpharmacogenetics.Clin. Pharmacol. Ther.84, 301-303 (2008).
-
(2008)
Clin. Pharmacol. Ther
, vol.84
, pp. 301-303
-
-
Lesko, L.J.1
-
35
-
-
60849097257
-
Estimation of the warfarindose with clinical and pharmacogenetic data
-
International Warfarin PharmacogeneticsConsortiumet al.Estimation of the warfarindose with clinical and pharmacogenetic data. N. Engl. J. Med.360, 753-764 (2009). http://clinicaltrials.gov/ct2/show/NCT00839657
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 753-764
-
-
-
36
-
-
49949104757
-
SLCO1B1 variants and statin-inducedmyopathy—a genomewide study
-
et al
-
The SEARCH Collaborative Group et al.SLCO1B1 variants and statin-inducedmyopathy—a genomewide study.N. Engl. J. Med.359, 789-799 (2008).
-
(2008)
N. Engl. J. Med
, vol.359
, pp. 789-799
-
-
-
37
-
-
34447338590
-
M.Pharmacogenomics of statin response
-
Mangravite, L. M. & Krauss, R. M.Pharmacogenomics of statin response. Curr. Opin. Lipidol.18, 409-414 (2007).
-
(2007)
Curr. Opin. Lipidol
, vol.18
, pp. 409-414
-
-
Mangravite, L.M.1
Krauss, R.2
-
38
-
-
34047136751
-
Tolerability of statins is notlinked to CYP450 polymorphisms, but reducedCYP2D6 metabolism improves cholesteraemicresponse to simvastatin and fluvastatin
-
et al
-
Zuccaro, Pet al.Tolerability of statins is notlinked to CYP450 polymorphisms, but reducedCYP2D6 metabolism improves cholesteraemicresponse to simvastatin and fluvastatin.Pharmacol. Res.55, 310-317 (2007).
-
(2007)
Pharmacol. Res
, vol.55
, pp. 310-317
-
-
Zuccaro, P.1
-
39
-
-
58149352685
-
Pharmacogenomics: Candidate geneidentification, functional validation andmechanisms
-
Wang, L. & Weinshilboum, R. M.Pharmacogenomics: candidate geneidentification, functional validation andmechanisms.Hum. Mol. Genet.17, R174-R179(2008).
-
(2008)
Hum. Mol. Genet
, vol.17
, pp. R174-R179
-
-
Wang, L.1
Weinshilboum, R.M.2
-
40
-
-
52049100798
-
Gemcitabine and cytosinearabinoside cytotoxicity: Association withlymphoblastoid cell expression
-
et al
-
Li, L.et al.Gemcitabine and cytosinearabinoside cytotoxicity: association withlymphoblastoid cell expression.Cancer Res. 68, 7050-7058 (2008).
-
(2008)
Cancer Res.
, vol.68
, pp. 7050-7058
-
-
Li, L.1
-
41
-
-
84984764751
-
FKBP51 acts as a scaffoldingprotein to regulate Akt phosphorylation
-
Pei, H.et al.FKBP51 acts as a scaffoldingprotein to regulate Akt phosphorylation.CancerCell(in press).
-
-
-
Pei, H.1
-
42
-
-
33845226443
-
Spotlight on molecular profiling:‘Integromic’ analysis of the NCI-60 cancer celllines
-
Weinstein, J. N. Spotlight on molecular profiling:‘Integromic’ analysis of the NCI-60 cancer celllines.Mol. Cancer Ther.5, 2601-2605 (2006).
-
(2006)
Mol. Cancer Ther.
, vol.5
, pp. 2601-2605
-
-
Weinstein, J.N.1
-
43
-
-
35548997972
-
Warfarinpharmacogenetics: Economic considerations
-
Hughes, D. A. & Pirmohamed, M. Warfarinpharmacogenetics: economic considerations.Pharmacoeconomics25, 899-902 (2007).
-
(2007)
Pharmacoeconomics
, vol.25
, pp. 899-902
-
-
Hughes, D.A.1
Pirmohamed, M.2
-
44
-
-
58749095297
-
Cost-effectiveness of using pharmacogenetic information in warfarin dosingfor patients with nonvalvular atrial fibrillation
-
Eckman, M. H., Rosand, J., Greenberg, S. M. & Gage, B. F. Cost-effectiveness of using pharmacogenetic information in warfarin dosingfor patients with nonvalvular atrial fibrillation.Ann. Intern. Med.150, 73-83 (2009).
-
(2009)
Ann. Intern. Med
, vol.150
, pp. 73-83
-
-
Eckman, M.H.1
Rosand, J.2
Greenberg, S.M.3
Gage, B.F.4
-
45
-
-
45549101363
-
Keeping pace with the times—the GeneticInformation Nondiscrimination Act of 2008
-
Hudson, K. L., Holohan, M. K. & Collins, F. S.Keeping pace with the times—the GeneticInformation Nondiscrimination Act of 2008. N. Engl. J. Med.358, 2661-2663 (2008).
-
(2008)
N. Engl. J. Med
, vol.358
, pp. 2661-2663
-
-
Hudson, K.L.1
Holohan, M.K.2
Collins, F.S.3
|