메뉴 건너뛰기




Volumn 6, Issue 10, 2009, Pages 632-638

Cardiovascular pharmacogenomics and individualized drug therapy

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOVASCULAR AGENT;

EID: 79958085599     PISSN: 17595002     EISSN: 17595010     Source Type: Journal    
DOI: 10.1038/nrcardio.2009.154     Document Type: Article
Times cited : (57)

References (46)
  • 2
    • 70449136457 scopus 로고
    • Drug reactions enzymes, andbiochemical genetics
    • Motulsky, A. G. Drug reactions enzymes, andbiochemical genetics.JAMA165, 835-837(1957).
    • (1957) JAMA , vol.165 , pp. 835-837
    • Motulsky, A.G.1
  • 3
    • 0014403645 scopus 로고
    • Genetic control ofdrug levels in man: Antipyrine
    • Vesell, E. S. & Page, J. G. Genetic control ofdrug levels in man: antipyrine.Science161, 72-73 (1968).
    • (1968) Science , vol.161 , pp. 72-73
    • Vesell, E.S.1    Page, J.G.2
  • 4
    • 84965047512 scopus 로고
    • The relationshipbetween dose of succinylcholine and duration of apnea in man
    • Kalow, W. & Gunn, D. R. The relationshipbetween dose of succinylcholine and duration of apnea in man.J. Pharmacol. Exp. Ther.120, 203-214 (1957).
    • (1957) J. Pharmacol. Exp. Ther , vol.120 , pp. 203-214
    • Kalow, W.1    Gunn, D.R.2
  • 5
    • 0001221024 scopus 로고
    • Some statistical dataon atypical cholinesterase of human serum
    • Kalow, W. & Gunn, D. R. Some statistical dataon atypical cholinesterase of human serum.Ann. Hum. Genet.23, 239-250 (1959).
    • (1959) Ann. Hum. Genet , vol.23 , pp. 239-250
    • Kalow, W.1    Gunn, D.R.2
  • 7
    • 40949127393 scopus 로고    scopus 로고
    • How to interpreta genome-wide association study
    • Pearson, T. A. & Manolio, T. A. How to interpreta genome-wide association study.JAMA299, 1335-1344 (2008).
    • (2008) JAMA , vol.299 , pp. 1335-1344
    • Pearson, T.A.1    Manolio, T.A.2
  • 9
    • 0014823763 scopus 로고
    • &Sakamoto, A. Relationship of acetyl transferaseactivity to antinuclear antibodies and toxicsymptoms in hypertensive patients treatedwith hydralazine
    • Perry, H. M. Jr., Tan, E. M., Carmody, S. &Sakamoto, A. Relationship of acetyl transferaseactivity to antinuclear antibodies and toxicsymptoms in hypertensive patients treated with hydralazine.J. Lab. Clin. Med.76, 114-125(1970).
    • (1970) J. Lab. Clin. Med , vol.76 , pp. 114-125
    • Perry, H.M.1    Tan, E.M.2    Carmody, S.3    Sakamoto, A.4
  • 12
    • 0020409410 scopus 로고
    • S.et al.Oxidation phenotype—amajor determinant of metoprolol metabolismand response
    • Lennard, M. S.et al.Oxidation phenotype—amajor determinant of metoprolol metabolismand response.N. Engl. J. Med.307, 1558-1560(1982).
    • (1982) N. Engl. J. Med , vol.307 , pp. 1558-1560
    • Lennard, M.1
  • 13
    • 0023954396 scopus 로고
    • Human debrisoquine4-hydroxylase (P450IID1): CDNA and deducedamino acid sequence and assignment of theCYP2D locus of chromosome 22
    • Gonzalez, F. J.et al.Human debrisoquine4-hydroxylase (P450IID1): cDNA and deducedamino acid sequence and assignment of theCYP2D locus of chromosome 22.Genomics2, 174-179 (1988).
    • (1988) Genomics , vol.2 , pp. 174-179
    • Gonzalez, F.J.1
  • 14
    • 0024796958 scopus 로고
    • The human debrisoquine4-hydroxylase (CYP2D) locus: Sequence andidentification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene
    • Kimura, S., Umeno, M., Skoda, R. C., Meyer, U. A.& Gonzalez, F. J. The human debrisoquine4-hydroxylase (CYP2D) locus: sequence andidentification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.Am. J. Hum. Genet.45, 889-904 (1989).
    • (1989) Am. J. Hum. Genet , vol.45 , pp. 889-904
    • Kimura, S.1    Umeno, M.2    Skoda, R.C.3    Meyer, U.A.4    Gonzalez, F.J.5
  • 15
    • 0027136288 scopus 로고
    • Inherited amplification of anactive gene in the cytochrome P450 CYP2Dlocus as a cause of ultrarapid metabolism ofdebrisoquine
    • et al
    • Johansson, I.et al.Inherited amplification of anactive gene in the cytochrome P450 CYP2Dlocus as a cause of ultrarapid metabolism ofdebrisoquine.Proc. Natl Acad. Sci. USA 90, 11825-11829 (1993).
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 11825-11829
    • Johansson, I.1
  • 16
    • 0030432585 scopus 로고    scopus 로고
    • Frequent distribution ofultrarapid metabolizers of debrisoquine in anEthiopian population carrying duplicated andmultiduplicated functional CYP2D6 alleles
    • et al
    • Akulli, E.et al.Frequent distribution ofultrarapid metabolizers of debrisoquine in anEthiopian population carrying duplicated andmultiduplicated functional CYP2D6 alleles. J. Pharmacol. Exp. Ther.278, 441-446 (1996).
    • (1996) J. Pharmacol. Exp. Ther , vol.278 , pp. 441-446
    • Akulli, E.1
  • 17
    • 58749094444 scopus 로고    scopus 로고
    • Cytochrome p-450polymorphisms and response to clopidogrel
    • Mega, J. L.et al.Cytochrome p-450polymorphisms and response to clopidogrel. N. Engl. J. Med.360, 354-362 (2008).
    • (2008) N. Engl. J. Med , vol.360 , pp. 354-362
    • Mega, J.L.1
  • 18
    • 3142745348 scopus 로고    scopus 로고
    • Trends in heart failureincidence and survival in a community-basedpopulation
    • Roger, V. L.et al.Trends in heart failureincidence and survival in a community-basedpopulation.JAMA292, 344-350 (2004).
    • (2004) JAMA , vol.292 , pp. 344-350
    • Roger, V.L.1
  • 19
    • 19944429413 scopus 로고    scopus 로고
    • Amiodarone or an implantablecardioverter-defibrillator for congestive heartfailure
    • Bardy G. H.et al.Amiodarone or an implantablecardioverter-defibrillator for congestive heartfailure.N. Engl. J. Med.352, 225-237 (2005).
    • (2005) N. Engl. J. Med , vol.352 , pp. 225-237
    • Bardy, G.H.1
  • 20
    • 0035978801 scopus 로고    scopus 로고
    • The Beta-Blocker Evaluation of Survival TrialInvestigators. A trial of the beta-blockerbucindolol in patients with advanced chronicheart failure
    • The Beta-Blocker Evaluation of Survival TrialInvestigators. A trial of the beta-blockerbucindolol in patients with advanced chronicheart failure.N. Engl. J. Med.344, 1659-1667(2001).
    • (2001) N. Engl. J. Med , vol.344 , pp. 1659-1667
  • 21
    • 33847312219 scopus 로고    scopus 로고
    • Pharmacogenetics of the humanbeta-adrenergic receptors
    • Taylor, M. R. Pharmacogenetics of the humanbeta-adrenergic receptors.Pharmacogenomics J.7, 29-37 (2007).
    • (2007) Pharmacogenomics J. , vol.7 , pp. 29-37
    • Taylor, M.R.1
  • 22
    • 0033584561 scopus 로고    scopus 로고
    • Racial differences in the frequencies of cardiac beta(1)-adrenergicreceptor polymorphisms: Analysis of c145A>Gand c1165G>C
    • Moore, J. D., Mason, D. A., Green, S. A., Hsu, J. & Liggett, S. B. Racial differences in the frequencies of cardiac beta(1)-adrenergicreceptor polymorphisms: analysis of c145A>Gand c1165G>C.Hum. Mutat.14, 271 (1999).
    • (1999) Hum. Mutat , vol.14 , pp. 271
    • Moore, J.D.1    Mason, D.A.2    Green, S.A.3    Hsu, J.4    Liggett, S.B.5
  • 23
    • 33746603033 scopus 로고    scopus 로고
    • A polymorphism within aconserved beta(1)-adrenergic receptor motifalters cardiac function and beta-blocker response in human heart failure
    • Liggett, S. B.et al.A polymorphism within aconserved beta(1)-adrenergic receptor motifalters cardiac function and beta-blocker response in human heart failure.Proc. NatlAcad. Sci. USA103, 11288-11293 (2006).
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 11288-11293
    • Liggett, S.B.1
  • 24
    • 0034725616 scopus 로고    scopus 로고
    • A four amino aciddeletion polymorphism in the third intracellularloop of the human alpha 2C-adrenergic receptorconfers impaired coupling to multiple effectors
    • Small, K. M., Forbes, S. L., Rahman, F., Bridges, K. M. & Liggett, S. B. A four amino aciddeletion polymorphism in the third intracellularloop of the human alpha 2C-adrenergic receptorconfers impaired coupling to multiple effectors.J. Biol. Chem.275, 23059-23064 (2000).
    • (2000) J. Biol. Chem , vol.275 , pp. 23059-23064
    • Small, K.M.1    Forbes, S.L.2    Rahman, F.3    Bridges, K.M.4    Liggett, S.B.5
  • 25
    • 0037057235 scopus 로고    scopus 로고
    • Synergistic polymorphisms of beta1- and alpha2C-adrenergicreceptors and the risk of congestive heart failure
    • Small, K. M., Wagoner, L. E., Levin, A. M., Kardia, S. L. & Liggett, S. B. Synergistic polymorphisms of beta1- and alpha2C-adrenergicreceptors and the risk of congestive heart failure.N. Engl. J. Med.347, 1135-1142 (2002).
    • (2002) N. Engl. J. Med , vol.347 , pp. 1135-1142
    • Small, K.M.1    Wagoner, L.E.2    Levin, A.M.3    Kardia, S.L.4    Liggett, S.B.5
  • 26
    • 43249124512 scopus 로고    scopus 로고
    • A GRK5 polymorphism thatinhibits beta-adrenergic receptor signaling isprotective in heart failure
    • Liggett, S. B.et al.A GRK5 polymorphism thatinhibits beta-adrenergic receptor signaling isprotective in heart failure.Nat. Med.14, 510-517 (2008).
    • (2008) Nat. Med , vol.14 , pp. 510-517
    • Liggett, S.B.1
  • 27
    • 38449106799 scopus 로고    scopus 로고
    • Medication use leading toemergency department visits for adverse drugevents in older adults
    • Budnitz, D. S., Shehab, N., Kegler, S. R. &Richards, C. L. Medication use leading toemergency department visits for adverse drugevents in older adults.Ann. Intern. Med.147, 755-765 (2007).
    • (2007) Ann. Intern. Med , vol.147 , pp. 755-765
    • Budnitz, D.S.1    Shehab, N.2    Kegler, S.R.3    Richards, C.L.4
  • 29
    • 0037565623 scopus 로고    scopus 로고
    • Pharmacogenetics oforal anticoagulants
    • Daly, A. K. & King, B. P. Pharmacogenetics oforal anticoagulants.Pharmacogenetics13, 247-252 (2003).
    • (2003) Pharmacogenetics , vol.13 , pp. 247-252
    • Daly, A.K.1    King, B.P.2
  • 30
    • 0033608466 scopus 로고    scopus 로고
    • Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin doserequirement and risk of bleeding complications
    • Aithal, G. P, Day, C. P, Kesteven, P J. & Daly, A. K. Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin doserequirement and risk of bleeding complications.Lancet353, 717-719 (1999).
    • (1999) Lancet , vol.353 , pp. 717-719
    • Aithal, G.P.1    Day, C.P.2    Kesteven, P.J.3    Daly, A.K.4
  • 31
    • 10744228888 scopus 로고    scopus 로고
    • Mutations in VKORC1 causewarfarin resistance and multiple coagulationfactor deficiency type 2
    • et al
    • Rost, S.et al.Mutations in VKORC1 causewarfarin resistance and multiple coagulationfactor deficiency type 2.Nature427, 537-541(2004).
    • (2004) Nature , vol.427 , pp. 537-541
    • Rost, S.1
  • 32
    • 21144448879 scopus 로고    scopus 로고
    • Effect of VKORC1 haplotypeson transcriptional regulation and warfarin dose
    • Rieder, M. J. etal.Effect of VKORC1 haplotypeson transcriptional regulation and warfarin dose.N. Engl. J. Med.352, 2285-2293 (2005).
    • (2005) N. Engl. J. Med , vol.352 , pp. 2285-2293
    • Rieder, M.J.1
  • 33
    • 40449120615 scopus 로고    scopus 로고
    • Genetic determinants ofresponse to warfarin during initialanticoagulation
    • Schwarz, U. I.et al.Genetic determinants ofresponse to warfarin during initialanticoagulation.N. Engl. J. Med.358, 999-1008(2008).
    • (2008) N. Engl. J. Med. , vol.358 , pp. 999-1008
    • Schwarz, U.I.1
  • 34
    • 49949098665 scopus 로고    scopus 로고
    • The critical path of warfarin dosing:finding an optimal dosing strategy usingpharmacogenetics
    • Lesko, L. J. The critical path of warfarin dosing:finding an optimal dosing strategy usingpharmacogenetics.Clin. Pharmacol. Ther.84, 301-303 (2008).
    • (2008) Clin. Pharmacol. Ther , vol.84 , pp. 301-303
    • Lesko, L.J.1
  • 35
    • 60849097257 scopus 로고    scopus 로고
    • Estimation of the warfarindose with clinical and pharmacogenetic data
    • International Warfarin PharmacogeneticsConsortiumet al.Estimation of the warfarindose with clinical and pharmacogenetic data. N. Engl. J. Med.360, 753-764 (2009). http://clinicaltrials.gov/ct2/show/NCT00839657
    • (2009) N. Engl. J. Med. , vol.360 , pp. 753-764
  • 36
    • 49949104757 scopus 로고    scopus 로고
    • SLCO1B1 variants and statin-inducedmyopathy—a genomewide study
    • et al
    • The SEARCH Collaborative Group et al.SLCO1B1 variants and statin-inducedmyopathy—a genomewide study.N. Engl. J. Med.359, 789-799 (2008).
    • (2008) N. Engl. J. Med , vol.359 , pp. 789-799
  • 37
    • 34447338590 scopus 로고    scopus 로고
    • M.Pharmacogenomics of statin response
    • Mangravite, L. M. & Krauss, R. M.Pharmacogenomics of statin response. Curr. Opin. Lipidol.18, 409-414 (2007).
    • (2007) Curr. Opin. Lipidol , vol.18 , pp. 409-414
    • Mangravite, L.M.1    Krauss, R.2
  • 38
    • 34047136751 scopus 로고    scopus 로고
    • Tolerability of statins is notlinked to CYP450 polymorphisms, but reducedCYP2D6 metabolism improves cholesteraemicresponse to simvastatin and fluvastatin
    • et al
    • Zuccaro, Pet al.Tolerability of statins is notlinked to CYP450 polymorphisms, but reducedCYP2D6 metabolism improves cholesteraemicresponse to simvastatin and fluvastatin.Pharmacol. Res.55, 310-317 (2007).
    • (2007) Pharmacol. Res , vol.55 , pp. 310-317
    • Zuccaro, P.1
  • 39
    • 58149352685 scopus 로고    scopus 로고
    • Pharmacogenomics: Candidate geneidentification, functional validation andmechanisms
    • Wang, L. & Weinshilboum, R. M.Pharmacogenomics: candidate geneidentification, functional validation andmechanisms.Hum. Mol. Genet.17, R174-R179(2008).
    • (2008) Hum. Mol. Genet , vol.17 , pp. R174-R179
    • Wang, L.1    Weinshilboum, R.M.2
  • 40
    • 52049100798 scopus 로고    scopus 로고
    • Gemcitabine and cytosinearabinoside cytotoxicity: Association withlymphoblastoid cell expression
    • et al
    • Li, L.et al.Gemcitabine and cytosinearabinoside cytotoxicity: association withlymphoblastoid cell expression.Cancer Res. 68, 7050-7058 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 7050-7058
    • Li, L.1
  • 41
    • 84984764751 scopus 로고    scopus 로고
    • FKBP51 acts as a scaffoldingprotein to regulate Akt phosphorylation
    • Pei, H.et al.FKBP51 acts as a scaffoldingprotein to regulate Akt phosphorylation.CancerCell(in press).
    • Pei, H.1
  • 42
    • 33845226443 scopus 로고    scopus 로고
    • Spotlight on molecular profiling:‘Integromic’ analysis of the NCI-60 cancer celllines
    • Weinstein, J. N. Spotlight on molecular profiling:‘Integromic’ analysis of the NCI-60 cancer celllines.Mol. Cancer Ther.5, 2601-2605 (2006).
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 2601-2605
    • Weinstein, J.N.1
  • 43
    • 35548997972 scopus 로고    scopus 로고
    • Warfarinpharmacogenetics: Economic considerations
    • Hughes, D. A. & Pirmohamed, M. Warfarinpharmacogenetics: economic considerations.Pharmacoeconomics25, 899-902 (2007).
    • (2007) Pharmacoeconomics , vol.25 , pp. 899-902
    • Hughes, D.A.1    Pirmohamed, M.2
  • 44
    • 58749095297 scopus 로고    scopus 로고
    • Cost-effectiveness of using pharmacogenetic information in warfarin dosingfor patients with nonvalvular atrial fibrillation
    • Eckman, M. H., Rosand, J., Greenberg, S. M. & Gage, B. F. Cost-effectiveness of using pharmacogenetic information in warfarin dosingfor patients with nonvalvular atrial fibrillation.Ann. Intern. Med.150, 73-83 (2009).
    • (2009) Ann. Intern. Med , vol.150 , pp. 73-83
    • Eckman, M.H.1    Rosand, J.2    Greenberg, S.M.3    Gage, B.F.4
  • 45
    • 45549101363 scopus 로고    scopus 로고
    • Keeping pace with the times—the GeneticInformation Nondiscrimination Act of 2008
    • Hudson, K. L., Holohan, M. K. & Collins, F. S.Keeping pace with the times—the GeneticInformation Nondiscrimination Act of 2008. N. Engl. J. Med.358, 2661-2663 (2008).
    • (2008) N. Engl. J. Med , vol.358 , pp. 2661-2663
    • Hudson, K.L.1    Holohan, M.K.2    Collins, F.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.