Molecular biological aspects on canine and human mammary tumors

Veterinary Pathology

Volumn 48, Issue 1, 2011, Pages 132-146

  Rivera, P ^a   von Euler, H ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

BRCA1; BRCA2; Breast cancer; Canine; Dogs; Mammary tumor; Molecular biology

Indexed keywords

ANIMAL; ARTICLE; BREAST TUMOR; DOG; DOG DISEASE; EXPERIMENTAL NEOPLASM; FEMALE; GENETIC PREDISPOSITION; GENETICS; HUMAN;

ANIMALS; BREAST NEOPLASMS; DOG DISEASES; DOGS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MAMMARY NEOPLASMS, ANIMAL;

CANIS FAMILIARIS;

EID: 79951910678     PISSN: 03009858     EISSN: 15442217     Source Type: Journal    
DOI: 10.1177/0300985810387939     Document Type: Article

References (82)

1. Agrawal M., Garg RJ, Cortes J., Quintas-Cardama A.: Tyrosine kinase inhibitors: the first decade. Curr Hematol Malig Rep 5:70-80, 2010.
2. Ahern TE, Bird RC, Bird AE, Wolfe LG: Expression of the oncogene c-erbB-2 in canine mammary cancers and tumor-derived cell lines. Am J Vet Res 57:693-696, 1996.
3. Antoniou A., Pharoah PD, Narod S., Risch HA, Eyfjord JE, Hopper JL, Loman N., Olsson H., Johannsson O., Borg A., Pasini B., Radice P., Manoukian S., Eccles DM, Tang N., Olah E., Anton-Culver H., Warner E., Lubinski J., Gronwald J., Gorski B., Tulinius H., Thorlacius S., Eerola H., Nevanlinna H., Syrjakoski K., Kallioniemi OP, Thompson D., Evans C., Peto J., Lalloo F., Evans DG, Easton DF: Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet 72:1117-1130, 2003.
4. Bergman A., Karlsson P., Berggren J., Martinsson T., Bjorck K., Nilsson S., Wahlstrom J., Wallgren A., Nordling M.: Genomewide linkage scan for breast cancer susceptibility loci in Swedish hereditary non-BRCA1/2 families: suggestive linkage to 10q2332-q25.3. Genes Chromosomes Cancer 46:302-309, 2007.
5. Bueno-de-Mesquita JM, Sonke GS, van de Vijver MJ, Linn SC: Additional value and potential use of the 70-gene prognosis signature in node-negative breast cancer in daily clinical practice [published online ahead of print December 2, 2009]. Ann Oncol.
6. Carey LA: Through a glass darkly: advances in understanding breast cancer biology, 2000-2010. Clin Breast Cancer 10:188-195, 2010.
7. Chen J., Silver DP, Walpita D., Cantor SB, Gazdar AF, Tomlinson G., Couch FJ, Weber BL, Ashley T., Livingston DM, Scully R.: Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol Cell 2:317-328, 1998.
8. Collaborative Group on Hormonal Factors in Breast Cancer: Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58,209 women with breast cancer and 101,986 women without the disease. Lancet 358:1389-1399, 2001.
9. Cox A., Dunning AM, Garcia-Closas M., Balasubramanian S., Reed MW, Pooley KA, Scollen S., Baynes C., Ponder BA, Chanock S., Lissowska J., Brinton L., Peplonska B., Southey MC, Hopper JL, McCredie MR, Giles GG, Fletcher O., Johnson N., dos Santos Silva I., Gibson L., Bojesen SE, Nordestgaard BG, Axelsson CK, Torres D., Hamann U., Justenhoven C., Brauch H., Chang-Claude J., Kropp S., Risch A., Wang-Gohrke S., Schurmann P., Bogdanova N., Dork T., Fagerholm R., Aaltonen K., Blomqvist C., Nevanlinna H., Seal S., Renwick A., Stratton MR, Rahman N., Sangrajrang S., Hughes D., Odefrey F., Brennan P., Spurdle AB, Chenevix-Trench G., Beesley J., Mannermaa A., Hartikainen J., Kataja V., Kosma VM, Couch FJ, Olson JE, Goode EL, Broeks A., Schmidt MK, Hogervorst FB, Van't Veer LJ, Kang D., Yoo KY, Noh DY, Ahn SH, Wedren S., Hall P., Low YL, Liu J., Milne RL, Ribas G., Gonzalez-Neira A., Benitez J., Sigurdson AJ, Stredrick DL, Alexander BH, Struewing JP, Pharoah PD, Easton DF: A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet 39:352-358, 2007.
10. Dobrovic A., Simpfendorfer D.: Methylation of the BRCA1 gene in sporadic breast cancer. Cancer Res 57:3347-3350, 1997.
11. Dunbier AK, Anderson H., Ghazoui Z., Folkerd EJ, A'Hern R., Crowder RJ, Hoog J., Smith IE, Osin P., Nerurkar A., Parker JS, Perou CM, Ellis MJ, Dowsett M.: Relationship between plasma estradiol levels and estrogen-responsive gene expression in estrogen receptor-positive breast cancer in postmenopausal women. J Clin Oncol 28:1161-1167, 2010.
12. Easton DF, Pooley KA, Dunning AM, Pharoah PD, Thompson D., Ballinger DG, Struewing JP, Morrison J., Field H., Luben R., Wareham N., Ahmed S., Healey CS, Bowman R., Meyer KB, Haiman CA, Kolonel LK, Henderson BE, Le Marchand L., Brennan P., Sangrajrang S., Gaborieau V., Odefrey F., Shen CY, Wu PE, Wang HC, Eccles D., Evans DG, Peto J., Fletcher O., Johnson N., Seal S., Stratton MR, Rahman N., Chenevix-Trench G., Bojesen SE, Nordestgaard BG, Axelsson CK, Garcia-Closas M., Brinton L., Chanock S., Lissowska J., Peplonska B., Nevanlinna H., Fagerholm R., Eerola H., Kang D., Yoo KY, Noh DY, Ahn SH, Hunter DJ, Hankinson SE, Cox DG, Hall P., Wedren S., Liu J., Low YL, Bogdanova N., Schurmann P., Dork T., Tollenaar RA, Jacobi CE, Devilee P., Klijn JG, Sigurdson AJ, Doody MM, Alexander BH, Zhang J., Cox A., Brock IW, MacPherson G., Reed MW, Couch FJ, Goode EL, Olson JE, Meijers-Heijboer H., van den Ouweland A., Uitterlinden A., Rivadeneira F., Milne RL, Ribas G., Gonzalez-Neira A., Benitez J., Hopper JL, McCredie M., Southey M., Giles GG, Schroen C., Justenhoven C., Brauch H., Hamann U., Ko YD, Spurdle AB, Beesley J., Chen X., Mannermaa A., Kosma VM, Kataja V., Hartikainen J., Day NE, Cox DR, Ponder BA: Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 447:1087-1093, 2007.
13. Egenvall A., Bonnett BN, Ohagen P., Olson P., Hedhammar A., von Euler H.: Incidence of and survival after mammary tumors in a population of over 80,000 insured female dogs in Sweden from 1995 to 2002. Prev Vet Med 69:109-127, 2005.
14. Evaluation of Genomic Applications in Practice and Prevention Working Group: Recommendations from the EGAPP Working Group: can tumor gene expression profiling improve outcomes in patients with breast cancer? Genet Med 11:66-73, 2009.
15. Ferreira E., Gobbi H., Saraiva BS, Cassali GD: Columnar cell lesions of the canine mammary gland: pathological features and immunophenotypic analysis. BMC Cancer 10:61, 2010.
16. Fong PC, Boss DS, Yap TA, Tutt A., Wu P., Mergui-Roelvink M., Mortimer P., Swaisland H., Lau A., O'Connor MJ, Ashworth A., Carmichael J., Kaye SB, Schellens JH, de Bono JS: Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 361:123-134, 2009.
17. Futreal PA, Kasprzyk A., Birney E., Mullikin JC, Wooster R., Stratton MR: Cancer and genomics. Nature 409:850-852, 2001.
18. Gail MH: Value of adding single-nucleotide polymorphism genotypes to a breast cancer risk model. J Natl Cancer Inst 101:959-963, 2009.
19. Gonzalez-Neira A., Rosa-Rosa JM, Osorio A., Gonzalez E., Southey M., Sinilnikova O., Lynch H., Oldenburg RA, van Asperen CJ, Hoogerbrugge N., Pita G., Devilee P., Goldgar D., Benitez J.: Genomewide high-density SNP linkage analysis of non-BRCA1/ 2 breast cancer families identifies various candidate regions and has greater power than microsatellite studies. BMC Genomics 8:299, 2007.
20. Hsu WL, Huang HM, Liao JW, Wong ML, Chang SC: Increased survival in dogs with malignant mammary tumours overexpressing HER2 protein and detection of a silent single nucleotide polymorphism in the canine HER2 gene. Vet J 180:116-123, 2009.
21. Hsu WL, Huang YH, Chang TJ, Wong ML, Chang SC: Single nucleotide variation in exon 11 of canine BRCA2 in healthy and cancerous mammary tissue. Vet J 184:351-356, 2010.
22. Hughes-Davies L., Huntsman D., Ruas M., Fuks F., Bye J., Chin SF, Milner J., Brown LA, Hsu F., Gilks B., Nielsen T., Schulzer M., Chia S., Ragaz J., Cahn A., Linger L., Ozdag H., Cattaneo E., Jordanova ES, Schuuring E., Yu DS, Venkitaraman A., Ponder B., Doherty A., Aparicio S., Bentley D., Theillet C., Ponting CP, Caldas C., Kouzarides T.: EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. Cell 115:523-535, 2003.
23. Hunter DJ, Kraft P., Jacobs KB, Cox DG, Yeager M., Hankinson SE, Wacholder S., Wang Z., Welch R., Hutchinson A., Wang J., Yu K., Chatterjee N., Orr N., Willett WC, Colditz GA, Ziegler RG, Berg CD, Buys SS, McCarty CA, Feigelson HS, Calle EE, Thun MJ, Hayes RB, Tucker M., Gerhard DS, Fraumeni JF Jr, Hoover RN, Thomas G., Chanock SJ: A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet 39:870-874, 2007.
24. Jordan VC: Tamoxifen (ICI46,474) as a targeted therapy to treat and prevent breast cancer. Br J Pharmacol 147:S269-S276, 2006.
25. Karlsson EK, Baranowska I., Wade CM, Salmon Hillbertz NH, Zody MC, Anderson N., Biagi TM, Patterson N., Pielberg GR, Kulbokas EJ, 3rd, Comstock KE, Keller ET, Mesirov JP, von Euler H., Kampe O., Hedhammar A., Lander ES, Andersson G., Andersson L., Lindblad-Toh K.: Efficient mapping of mendelian traits in dogs through genome-wide association. Nat Genet 39:1321-1328, 2007.
26. Karlsson EK, Lindblad-Toh K.: Leader of the pack: gene mapping in dogs and other model organisms. Nat Rev Genet 9:713-725, 2008.
27. Kato M., Yano K., Matsuo F., Saito H., Katagiri T., Kurumizaka H., Yoshimoto M., Kasumi F., Akiyama F., Sakamoto G., Nagawa H., Nakamura Y., Miki Y.: Identification of Rad51 alteration in patients with bilateral breast cancer. J Hum Genet 45:133-137, 2000.
28. Kaurah P., MacMillan A., Boyd N., Senz J., De Luca A., Chun N., Suriano G., Zaor S., Van Manen L., Gilpin C., Nikkel S., Connolly-Wilson M., Weissman S., Rubinstein WS, Sebold C., Greenstein R., Stroop J., Yim D., Panzini B., McKinnon W., Greenblatt M., Wirtzfeld D., Fontaine D., Coit D., Yoon S., Chung D., Lauwers G., Pizzuti A., Vaccaro C., Redal MA, Oliveira C., Tischkowitz M., Olschwang S., Gallinger S., Lynch H., Green J., Ford J., Pharoah P., Fernandez B., Huntsman D.: Founder and recurrent CDH1 mutations in families with hereditary diffuse gastric cancer. JAMA 297:2360-2372, 2007.
29. Khanna C., Hunter K.: Modeling metastasis in vivo. Carcinogenesis 26:513-523, 2005.
30. Klopfleisch R., Gruber AD: Derlin-1 and stanniocalcin-1 are differentially regulated in metastasizing canine mammary adenocarcinomas. J Comp Pathol 141:113-120, 2009.
31. Klopfleisch R., Gruber AD: Differential expression of cell cycle regulators p21, p27 and p53 in metastasizing canine mammary adenocarcinomas versus normal mammary glands. Res Vet Sci 87:91-96, 2009.
32. Klopfleisch R., Gruber AD: Increased expression of BRCA2 and RAD51 in lymph node metastases of canine mammary adenocarcinomas. Vet Pathol 46:416-422, 2009.
33. Klopfleisch R., Klose P., da Costa A., Brunnberg L., Gruber AD: HEPACAM1 and 2 are differentially regulated in canine mammary adenomas and carcinomas and its lymph node metastases. BMC Vet Res 6:15, 2010.
34. Klopfleisch R., Klose P., Gruber AD: The combined expression pattern of BMP2, LTBP4, and DERL1 discriminates malignant from benign canine mammary tumors. Vet Pathol 47:446-454, 2010.
35. Klopfleisch R., Schutze M., Gruber AD: Downregulation of transforming growth factor beta (TGFbeta) and latent TGFbeta binding protein (LTBP)-4 expression in late stage canine mammary tumours [published online ahead of print October 14, 2009]. Vet J.
36. Klopfleisch R., Schutze M., Gruber AD: Loss of p27 expression in canine mammary tumors and their metastases. Res Vet Sci 88:300-303, 2009.
37. Klopfleisch R., Schutze M., Gruber AD: RAD51 protein expression is increased in canine mammary carcinomas. Vet Pathol 47:98-101, 2010.
38. Klopfleisch R., Schutze M., Linzmann H., Brunnberg L., Gruber AD: Increased Derlin-1 expression in metastases of canine mammary adenocarcinomas. J Comp Pathol 142:79-83, 2009.
39. Lander ES, Linton LM, Birren B., Nusbaum C., Zody MC, Baldwin J., Devon K., Dewar K., Doyle M., FitzHugh W., Funke R., Gage D., Harris K., Heaford A., Howland J., Kann L., Lehoczky J., LeVine R., McEwan P., McKernan K., Meldrim J., Mesirov JP, Miranda C., Morris W., Naylor J., Raymond C., Rosetti M., Santos R., Sheridan A., Sougnez C., Stange-Thomann N., Stojanovic N., Subramanian A., Wyman D., Rogers J., Sulston J., Ainscough R., Beck S., Bentley D., Burton J., Clee C., Carter N., Coulson A., Deadman R., Deloukas P., Dunham A., Dunham I., Durbin R., French L., Grafham D., Gregory S., Hubbard T., Humphray S., Hunt A., Jones M., Lloyd C., McMurray A., Matthews L., Mercer S., Milne S., Mullikin JC, Mungall A., Plumb R., Ross M., Shownkeen R., Sims S., Waterston RH, Wilson RK, Hillier LW, McPherson JD, Marra MA, Mardis ER, Fulton LA, Chinwalla AT, Pepin KH, Gish WR, Chissoe SL, Wendl MC, Delehaunty KD, Miner TL, Delehaunty A., Kramer JB, Cook LL, Fulton RS, Johnson DL, Minx PJ, Clifton SW, Hawkins T., Branscomb E., Predki P., Richardson P., Wenning S., Slezak T., Doggett N., Cheng JF, Olsen A., Lucas S., Elkin C., Uberbacher E., Frazier M., Gibbs RA, Muzny DM, Scherer SE, Bouck JB, Sodergren EJ, Worley KC, Rives CM, Gorrell JH, Metzker ML, Naylor SL, Kucherlapati RS, Nelson DL, Weinstock GM, Sakaki Y., Fujiyama A., Hattori M., Yada T., Toyoda A., Itoh T., Kawagoe C., Watanabe H., Totoki Y., Taylor T., Weissenbach J., Heilig R., Saurin W., Artiguenave F., Brottier P., Bruls T., Pelletier E., Robert C., Wincker P., Smith DR, Doucette-Stamm L., Rubenfield M., Weinstock K., Lee HM, Dubois J., Rosenthal A., Platzer M., Nyakatura G., Taudien S., Rump A., Yang H., Yu J., Wang J., Huang G., Gu J., Hood L., Rowen L., Madan A., Qin S., Davis RW, Federspiel NA, Abola AP, Proctor MJ, Myers RM, Schmutz J., Dickson M., Grimwood J., Cox DR, Olson MV, Kaul R., Shimizu N., Kawasaki K., Minoshima S., Evans GA, Athanasiou M., Schultz R., Roe BA, Chen F., Pan H., Ramser J., Lehrach H., Reinhardt R., McCombie WR, de la Bastide M., Dedhia N., Blocker H., Hornischer K., Nordsiek G., Agarwala R., Aravind L., Bailey JA, Bateman A., Batzoglou S., Birney E., Bork P., Brown DG, Burge CB, Cerutti L., Chen HC, Church D., Clamp M., Copley RR, Doerks T., Eddy SR, Eichler EE, Furey TS, Galagan J., Gilbert JG, Harmon C., Hayashizaki Y., Haussler D., Hermjakob H., Hokamp K., Jang W., Johnson LS, Jones TA, Kasif S., Kaspryzk A., Kennedy S., Kent WJ, Kitts P., Koonin EV, Korf I., Kulp D., Lancet D., Lowe TM, McLysaght A., Mikkelsen T., Moran JV, Mulder N., Pollara VJ, Ponting CP, Schuler G., Schultz J., Slater G., Smit AF, Stupka E., Szustakowski J., Thierry-Mieg D., Thierry-Mieg J., Wagner L., Wallis J., Wheeler R., Williams A., Wolf YI, Wolfe KH, Yang SP, Yeh RF, Collins F., Guyer MS, Peterson J., Felsenfeld A., Wetterstrand KA, Patrinos A., Morgan MJ, de Jong P., Catanese JJ, Osoegawa K., Shizuya H., Choi S., Chen YJ: Initial sequencing and analysis of the human genome. Nature 409:860-921, 2001.
40. Lindblad-Toh K., Wade CM, Mikkelsen TS, Karlsson EK, Jaffe DB, Kamal M., Clamp M., Chang JL, Kulbokas EJ, 3rd, Zody MC, Mauceli E., Xie X., Breen M., Wayne RK, Ostrander EA, Ponting CP, Galibert F., Smith DR, DeJong PJ, Kirkness E., Alvarez P., Biagi T., Brockman W., Butler J., Chin CW, Cook A., Cuff J., Daly MJ, DeCaprio D., Gnerre S., Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., Koepfli KP, Parker HG, Pollinger JP, Searle SM, Sutter NB, Thomas R., Webber C., Baldwin J., Abebe A., Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., Khazanovich D., Kieu AC, Kisner P., Kumar M., Lance K., Landers T., Lara M., Lee W., Leger JP, Lennon N., Leuper L., LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S., Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander ES: Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature 438:803-819, 2005.
41. Litman R., Gupta R., Brosh RM Jr, Cantor SB: BRCA-FA pathway as a target for anti-tumor drugs. Anticancer Agents Med Chem 8:426-430, 2008.
42. Marmorstein LY, Ouchi T., Aaronson SA: The BRCA2 gene product functionally interacts with p53 and RAD51. Proc Natl Acad Sci U S A 95:13869-13874, 1998.
43. Martin de las Mulas J., Ordas J., Millan Y., Fernandez-Soria V., Ramon y Cajal S.: Oncogene HER2 in canine mammary gland carcinomas: an immunohistochemical and chromogenic in situ hybridization study. Breast Cancer Res Treat 80:363-367, 2003.
44. Miki Y., Swensen J., Shattuck-Eidens D., Futreal PA, Harshman K., Tavtigian S., Liu Q., Cochran C., Bennett LM, Ding W., Bell R., Rosenthal J., Hussey C., Tran T., McClure M., Frye C., Hattier T., Phelps R., Haugen-Strano A., Katcher H., Yakumo K., Gholami Z., Shaffer D., Stone S., Bayer S., Wray C., Bogden R., Dayananth P., Ward J., Tonin P., Narod S., Bristow PK, Norris FH, Helvering L., Morrison P., Rosteck P., Lai M., Barrett JC, Lewis C., Neuhausen S., Cannon-Albright L., Goldgar D., Wiseman R., Kamb A., Skolnick MH: A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266:66-71, 1994.
45. Moh MC, Zhang T., Lee LH, Shen S.: Expression of hepaCAM is downregulated in cancers and induces senescence-like growth arrest via a p53/p21-dependent pathway in human breast cancer cells. Carcinogenesis 29:2298-2305, 2008.
46. Mohr S., Bottin MC, Lannes B., Neuville A., Bellocq JP, Keith G., Rihn BH: Microdissection, mRNA amplification and microarray: a study of pleural mesothelial and malignant mesothelioma cells. Biochimie 86:13-19, 2004.
47. Naim V., Rosselli F.: The FANC pathway and mitosis: a replication legacy. Cell Cycle 8:2907-2911, 2009.
48. Nieto A., Perez-Alenza MD, Del Castillo N., Tabanera E., Castano M., Pena L.: BRCA1 expression in canine mammary dysplasias and tumours: relationship with prognostic variables. J Comp Pathol 128:260-268, 2003.
49. Ochiai K., Morimatsu M., Tomizawa N., Syuto B.: Cloning and sequencing full length of canine Brca2 and Rad51 cDNA. J Vet Med Sci 63:1103-1108, 2001.
50. Paoloni M., Khanna C.: Translation of new cancer treatments from pet dogs to humans. Nat Rev Cancer 8:147-156, 2008.
51. Parker JS, Mullins M., Cheang MC, Leung S., Voduc D., Vickery T., Davies S., Fauron C., He X., Hu Z., Quackenbush JF, Stijleman IJ, Palazzo J., Marron JS, Nobel AB, Mardis E., Nielsen TO, Ellis MJ, Perou CM, Bernard PS: Supervised risk predictor of breast cancer based on intrinsic subtypes. J Clin Oncol 27:1160-1167, 2009.
52. Perou CM, Sorlie T., Eisen MB, van de Rijn M., Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H., Akslen LA, Fluge O., Pergamenschikov A., Williams C., Zhu SX, Lonning PE, Borresen-Dale AL, Brown PO, Botstein D.: Molecular portraits of human breast tumours. Nature 406:747-752, 2000.
53. Peto J., Collins N., Barfoot R., Seal S., Warren W., Rahman N., Easton DF, Evans C., Deacon J., Stratton MR: Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer. J Natl Cancer Inst 91:943-949, 1999.
54. Rajan JV, Marquis ST, Gardner HP, Chodosh LA: Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues. Dev Biol 184:385-401, 1997.
55. Rao NA, van Wolferen ME, van den Ham R., van Leenen D., Groot Koerkamp MJ, Holstege FC, Mol JA: cDNA microarray profiles of canine mammary tumour cell lines reveal deregulated pathways pertaining to their phenotype. Anim Genet 39:333-345, 2008.
56. Ripperger T., Gadzicki D., Meindl A., Schlegelberger B.: Breast cancer susceptibility: current knowledge and implications for genetic counselling. Eur J Hum Genet 17:722-731, 2009.
57. Rivera P., Melin M., Biagi T., Fall T., Haggstrom J., Lindblad-Toh K., von Euler H.: Mammary tumor development in dogs is associated with BRCA1 and BRCA2. Cancer Res 69:8770-8774, 2009.
58. Rosa-Rosa JM, Gracia-Aznarez FJ, Hodges E., Pita G., Rooks M., Xuan Z., Bhattacharjee A., Brizuela L., Silva JM, Hannon GJ, Benitez J.: Deep sequencing of target linkage assay-identified regions in familial breast cancer: methods, analysis pipeline and troubleshooting. PLoS One 5:e9976, 2010.
59. Rosa-Rosa JM, Pita G., Urioste M., Llort G., Brunet J., Lazaro C., Blanco I., Ramon y Cajal T., Diez O., de la Hoya M., Caldes T., Tejada MI, Gonzalez-Neira A., Benitez J.: Genome-wide linkage scan reveals three putative breast-cancer-susceptibility loci. Am J Hum Genet 84:115-122, 2009.
60. Rungsipipat A., Tateyama S., Yamaguchi R., Uchida K., Miyoshi N., Hayashi T.: Immunohistochemical analysis of c-yes and c-erbB-2 oncogene products and p53 tumor suppressor protein in canine mammary tumors. J Vet Med Sci 61:27-32, 1999.
61. Salmon Hillbertz NH, Isaksson M., Karlsson EK, Hellmen E., Pielberg GR, Savolainen P., Wade CM, von Euler H., Gustafson U., Hedhammar A., Nilsson M., Lindblad-Toh K., Andersson L., Andersson G.: Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridge-back dogs. Nat Genet 39:1318-1320, 2007.
62. Schneider KA, DiGianni LM, Patenaude AF, Klar N., Stopfer JE, Calzone KA, Li FP, Weber BL, Garber JE: Accuracy of cancer family histories: comparison of two breast cancer syndromes. Genet Test 8:222-228, 2004.
63. Slamon DJ, Clark GM: Amplification of c-erbB-2 and aggressive human breast tumors? Science 240:1795-1798, 1988.
64. Stacey SN, Manolescu A., Sulem P., Rafnar T., Gudmundsson J., Gudjonsson SA, Masson G., Jakobsdottir M., Thorlacius S., Helgason A., Aben KK, Strobbe LJ, Albers-Akkers MT, Swinkels DW, Henderson BE, Kolonel LN, Le Marchand L., Millastre E., Andres R., Godino J., Garcia-Prats MD, Polo E., Tres A., Mouy M., Saemundsdottir J., Backman VM, Gudmundsson L., Kristjansson K., Bergthorsson JT, Kostic J., Frigge ML, Geller F., Gudbjartsson D., Sigurdsson H., Jonsdottir T., Hrafnkelsson J., Johannsson J., Sveinsson T., Myrdal G., Grimsson HN, Jonsson T., von Holst S., Werelius B., Margolin S., Lindblom A., Mayordomo JI, Haiman CA, Kiemeney LA, Johannsson OT, Gulcher JR, Thorsteinsdottir U., Kong A., Stefansson K.: Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. Nat Genet 39:865-869, 2007.
65. Szabo CI, Wagner LA, Francisco LV, Roach JC, Argonza R., King MC, Ostrander EA: Human, canine and murine BRCA1 genes: sequence comparison among species. Hum Mol Genet 5:1289-1298, 1996.
66. Teschendorff AE, Miremadi A., Pinder SE, Ellis IO, Caldas C.: An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer. Genome Biol 8:R157, 2007.
67. Turner NC, Reis-Filho JS, Russell AM, Springall RJ, Ryder K., Steele D., Savage K., Gillett CE, Schmitt FC, Ashworth A., Tutt AN: BRCA1 dysfunction in sporadic basal-like breast cancer. Oncogene 26:2126-2132, 2007.
68. Uva P., Aurisicchio L., Watters J., Loboda A., Kulkarni A., Castle J., Palombo F., Viti V., Mesiti G., Zappulli V., Marconato L., Abramo F., Ciliberto G., Lahm A., La Monica N., de Rinaldis E.: Comparative expression pathway analysis of human and canine mammary tumors. BMC Genomics 10:135, 2009.
69. van Riggelen J., Buchwalter G., Soto U., De-Castro Arce J., Hausen HZ, Wasylyk B., Rosl F.: Loss of net as repressor leads to constitutive increased c-fos transcription in cervical cancer cells. J Biol Chem 280:3286-3294, 2005.
70. van't Veer LJ, Dai H., van de Vijver MJ, He YD, Hart AA, Mao M., Peterse HL, van der Kooy K., Marton MJ, Witteveen AT, Schreiber GJ, Kerkhoven RM, Roberts C., Linsley PS, Bernards R., Friend SH: Gene expression profiling predicts clinical outcome of breast cancer. Nature 415:530-536, 2002.
71. Vasen HF, Morreau H., Nortier JW: Is breast cancer part of the tumor spectrum of hereditary nonpolyposis colorectal cancer? Am J Hum Genet 68:1533-1535, 2001.
72. Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M., Evans CA, Holt RA, Gocayne JD, Amanatides P., Ballew RM, Huson DH, Wortman JR, Zhang Q., Kodira CD, Zheng XH, Chen L., Skupski M., Subramanian G., Thomas PD, Zhang J., Gabor Miklos GL, Nelson C., Broder S., Clark AG, Nadeau J., McKusick VA, Zinder N., Levine AJ, Roberts RJ, Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian AE, Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman TJ, Higgins ME, Ji RR, Ke Z., Ketchum KA, Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov GV, Milshina N., Moore HM, Naik AK, Narayan VA, Neelam B., Nusskern D., Rusch DB, Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng ML, Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers YH, Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint NN, Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril JF, Guigo R., Campbell MJ, Sjolander KV, Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang YH, Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.: The sequence of the human genome. Science 291:1304-1351, 2001.
73. Vinothini G., Balachandran C., Nagini S.: Evaluation of molecular markers in canine mammary tumors: correlation with histological grading. Oncol Res 18:193-201, 2009.
74. von Euler H., Khoshnoud R., He Q., Khoshnoud A., Fornander T., Rutqvist LE, Skog S.: Time-dependent RNA degradation affecting cDNA array quality in spontaneous canine tumours sampled using standard surgical procedures. Int J Mol Med 16:979-985, 2005.
75. Wacholder S., Hartge P., Prentice R., Garcia-Closas M., Feigelson HS, Diver WR, Thun MJ, Cox DG, Hankinson SE, Kraft P., Rosner B., Berg CD, Brinton LA, Lissowska J., Sherman ME, Chlebowski R., Kooperberg C., Jackson RD, Buckman DW, Hui P., Pfeiffer R., Jacobs KB, Thomas GD, Hoover RN, Gail MH, Chanock SJ, Hunter DJ: Performance of common genetic variants in breast-cancer risk models. N Engl J Med 362:986-993, 2010.
76. Walsh T., Casadei S., Coats KH, Swisher E., Stray SM, Higgins J., Roach KC, Mandell J., Lee MK, Ciernikova S., Foretova L., Soucek P., King MC: Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer. JAMA 295:1379-1388, 2006.
77. Weigelt B., Mackay A., A'Hern R., Natrajan R., Tan DS, Dowsett M., Ashworth A., Reis-Filho JS: Breast cancer molecular profiling with single sample predictors: a retrospective analysis. Lancet Oncol 11:339-349, 2010.
78. Wensman H., Goransson H., Leuchowius KJ, Stromberg S., Ponten F., Isaksson A., Rutteman GR, Heldin NE, Pejler G., Hellmen E.: Extensive expression of craniofacial related homeobox genes in canine mammary sarcomas. Breast Cancer Res Treat 118:333-343, 2009.
79. Wheeler DA, Srinivasan M., Egholm M., Shen Y., Chen L., McGuire A., He W., Chen YJ, Makhijani V., Roth GT, Gomes X., Tartaro K., Niazi F., Turcotte CL, Irzyk GP, Lupski JR, Chinault C., Song XZ, Liu Y., Yuan Y., Nazareth L., Qin X., Muzny DM, Margulies M., Weinstock GM, Gibbs RA, Rothberg JM: The complete genome of an individual by massively parallel DNA sequencing. Nature 452:872-876, 2008.
80. Willems PJ: Susceptibility genes in breast cancer: more is less? Clin Genet 72:493-496, 2007.
81. Wooster R., Bignell G., Lancaster J., Swift S., Seal S., Mangion J., Collins N., Gregory S., Gumbs C., Micklem G.: Identification of the breast cancer susceptibility gene BRCA2. Nature 378:789-792, 1995.
82. Wooster R., Neuhausen SL, Mangion J., Quirk Y., Ford D., Collins N., Nguyen K., Seal S., Tran T., Averill D.: Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. Science 265:2088-2090, 1994.