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Volumn 37, Issue 10, 2010, Pages 1059-1066

Function of LRRK2 in Parkinson's disease

Author keywords

Functional research; Leucine rich repeat kinase (LRRK2); Parkinson's disease

Indexed keywords


EID: 79951888273     PISSN: 10003282     EISSN: None     Source Type: Journal    
DOI: 10.3724/SP.J.1206.2010.00197     Document Type: Article
Times cited : (1)

References (68)
  • 3
    • 23344453013 scopus 로고    scopus 로고
    • Genetics of Parkinson's disease
    • Gasser T. Genetics of Parkinson's disease. Curr Opin Neurol, 2005, 18(4): 363-369 (Pubitemid 41104797)
    • (2005) Current Opinion in Neurology , vol.18 , Issue.4 , pp. 363-369
    • Gasser, T.1
  • 6
    • 33947247929 scopus 로고    scopus 로고
    • LRRK2: A link between familial and sporadic Parkinson's disease?
    • Lesage S, Durr A, Brice A. LRRK2: a link between familial and sporadic Parkinson's disease?. Pathol Biol(Paris), 2007, 55(2): 107-110
    • (2007) Pathol Biol(Paris) , vol.55 , Issue.2 , pp. 107-110
    • Lesage, S.1    Durr, A.2    Brice, A.3
  • 7
    • 33646151866 scopus 로고    scopus 로고
    • LRRK2 in Parkinson's disease: Protein domains and functional insights
    • Mata I F, Wedemeyer W J, Farrer M J, et al. LRRK2 in Parkinson's disease: protein domains and functional insights. Trends Neurosci, 2006, 29(5): 286-293
    • (2006) Trends Neurosci , vol.29 , Issue.5 , pp. 286-293
    • Mata, I.F.1    Wedemeyer, W.J.2    Farrer, M.J.3
  • 9
    • 0036196860 scopus 로고    scopus 로고
    • A new locus for Parkinson's Disease (PARK8) maps to chromosome 12p11.2-q13.1
    • DOI 10.1002/ana.10113
    • Funayama M, Hasegawa K, Kowa H, et al. A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1. Ann Neurol, 2002, 51(3): 296-301 (Pubitemid 34206285)
    • (2002) Annals of Neurology , vol.51 , Issue.3 , pp. 296-301
    • Funayama, M.1    Hasegawa, K.2    Kowa, H.3    Saito, M.4    Tsuji, S.5    Obata, F.6
  • 11
    • 33644822969 scopus 로고    scopus 로고
    • Type and frequency of mutations in the LRRK2 gene in familial and sporadic Parkinson's disease
    • Berg D, Schweitzer K, Leitner P, et al. Type and frequency of mutations in the LRRK2 gene in familial and sporadic Parkinson's disease. Brain, 2005, 128(Pt 12): 3000-3011
    • (2005) Brain , vol.128 , Issue.PART 12 , pp. 3000-3011
    • Berg, D.1    Schweitzer, K.2    Leitner, P.3
  • 21
    • 33846587090 scopus 로고    scopus 로고
    • A common genetic factor for Parkinson disease in ethnic Chinese population in Taiwan
    • Fung H C, Chen C M, Hardy J, et al. A common genetic factor for Parkinson disease in ethnic Chinese population in Taiwan. BMC Neurol, 2006, 6: 47
    • (2006) BMC Neurol , vol.6 , pp. 47
    • Fung, H.C.1    Chen, C.M.2    Hardy, J.3
  • 23
    • 33745917404 scopus 로고    scopus 로고
    • Distribution of PINK1 and LRRK2 in rat and mouse brain
    • DOI 10.1111/j.1471-4159.2006.03919.x
    • Taymans J M, Van Den Haute C, Baekelandt V. Distribution of PINK1 and LRRK2 in rat and mouse brain. J Neurochem, 2006, 98(3): 951-961 (Pubitemid 44051294)
    • (2006) Journal of Neurochemistry , vol.98 , Issue.3 , pp. 951-961
    • Taymans, J.-M.1    Van Den Haute, C.2    Baekelandt, V.3
  • 24
    • 33644934224 scopus 로고    scopus 로고
    • LRRK2 is expressed in areas affected by Parkinson's disease in the adult mouse brain
    • Simon-Sanchez J, Herranz-Perez V, Olucha-Bordonau F, et al. LRRK2 is expressed in areas affected by Parkinson's disease in the adult mouse brain. Eur J Neurosci, 2006, 23(3): 659-666
    • (2006) Eur J Neurosci , vol.23 , Issue.3 , pp. 659-666
    • Simon-Sanchez, J.1    Herranz-Perez, V.2    Olucha-Bordonau, F.3
  • 25
    • 33646146878 scopus 로고    scopus 로고
    • Anatomical localization of leucine-rich repeat kinase 2 in mouse brain
    • DOI 10.1016/j.neuroscience.2006.01.017, PII S0306452206001175
    • Melrose H, Lincoln S, Tyndall G, et al. Anatomical localization of leucine-rich repeat kinase 2 in mouse brain. Neuroscience, 2006, 139(3): 791-794 (Pubitemid 44308089)
    • (2006) Neuroscience , vol.139 , Issue.3 , pp. 791-794
    • Melrose, H.1    Lincoln, S.2    Tyndall, G.3    Dickson, D.4    Farrer, M.5
  • 26
    • 33645790701 scopus 로고    scopus 로고
    • LRRK2 expression linked to dopamine-innervated areas
    • Galter D, Westerlund M, Carmine A, et al. LRRK2 expression linked to dopamine-innervated areas. Ann Neurol, 2006, 59 (4): 714-719
    • (2006) Ann Neurol , vol.59 , Issue.4 , pp. 714-719
    • Galter, D.1    Westerlund, M.2    Carmine, A.3
  • 36
    • 34548621385 scopus 로고    scopus 로고
    • Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants
    • DOI 10.1111/j.1471-4159.2007.04743.x
    • Li X, Tan Y C, Poulose S, et al. Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants. J Neurochem, 2007, 103(1): 238-247 (Pubitemid 47404210)
    • (2007) Journal of Neurochemistry , vol.103 , Issue.1 , pp. 238-247
    • Li, X.1    Tan, Y.-C.2    Poulose, S.3    Olanow, C.W.4    Huang, X.-Y.5    Yue, Z.6
  • 37
    • 77952391573 scopus 로고    scopus 로고
    • GTPase activity plays a key role in the pathobiology of LRRK2
    • Xiong Y, Coombes C E, Kilaru A, et al. GTPase activity plays a key role in the pathobiology of LRRK2. PLoS Genet, 2010, 6(4): e1000902
    • (2010) PLoS Genet , vol.6 , Issue.4
    • Xiong, Y.1    Coombes, C.E.2    Kilaru, A.3
  • 40
    • 41549124987 scopus 로고    scopus 로고
    • Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons
    • No.3
    • Wang D, Tang B, Zhao G, et al. Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons. Mol Neurodegener, 2008, 3(1): No.3
    • (2008) Mol Neurodegener , vol.3 , Issue.1
    • Wang, D.1    Tang, B.2    Zhao, G.3
  • 41
    • 77952409692 scopus 로고    scopus 로고
    • Deletion of the WD40 domain of LRRK2 in Zebrafish causes Parkinsonism-like loss of neurons and locomotive defect
    • Sheng D, Qu D, Kwok K H, et al. Deletion of the WD40 domain of LRRK2 in Zebrafish causes Parkinsonism-like loss of neurons and locomotive defect. PLoS Genet, 2010, 6(4): e1000914
    • (2010) PLoS Genet , vol.6 , Issue.4
    • Sheng, D.1    Qu, D.2    Kwok, K.H.3
  • 42
    • 67649813448 scopus 로고    scopus 로고
    • Mutant LRRK2 (R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease
    • Li Y, Liu W, Oo T F, et al. Mutant LRRK2 (R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nature Neuroscience, 2009, 12(7): 826-828
    • (2009) Nature Neuroscience , vol.12 , Issue.7 , pp. 826-828
    • Li, Y.1    Liu, W.2    Oo, T.F.3
  • 43
    • 77953090478 scopus 로고    scopus 로고
    • Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of {alpha}-synuclein, and apoptotic cell death in aged mice
    • Tong Y, Yamaguchi H, Giaime E, et al. Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of {alpha}-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci USA, 2010, 107(21): 9879-9884
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.21 , pp. 9879-9884
    • Tong, Y.1    Yamaguchi, H.2    Giaime, E.3
  • 44
    • 34548604567 scopus 로고    scopus 로고
    • The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase thatstimulates kinase activity
    • DOI 10.1016/j.yexcr.2007.07.007, PII S0014482707003345
    • Guo L, Gandhi P N, Wang W, et al. The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity. Exp Cell Res, 2007, 313(16): 3658-3670 (Pubitemid 47404550)
    • (2007) Experimental Cell Research , vol.313 , Issue.16 , pp. 3658-3670
    • Guo, L.1    Gandhi, P.N.2    Wang, W.3    Petersen, R.B.4    Wilson-Delfosse, A.L.5    Chen, S.G.6
  • 45
    • 33846818834 scopus 로고    scopus 로고
    • GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease
    • DOI 10.1021/bi061960m
    • Ito G, Okai T, Fujino G, et al. GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease. Biochemistry, 2007, 46(5): 1380-1388 (Pubitemid 46208485)
    • (2007) Biochemistry , vol.46 , Issue.5 , pp. 1380-1388
    • Ito, G.1    Okai, T.2    Fujino, G.3    Takeda, K.4    Ichijo, H.5    Katada, T.6    Iwatsubo, T.7
  • 47
    • 62449124769 scopus 로고    scopus 로고
    • CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity
    • Ko H S, Bailey R, Smith W W, et al. CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity. Proc Natl Acad Sci USA, 2009, 106(8): 2897-2902
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.8 , pp. 2897-2902
    • Ko, H.S.1    Bailey, R.2    Smith, W.W.3
  • 48
    • 67650164931 scopus 로고    scopus 로고
    • Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP
    • Ding X, Goldberg M S. Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP. PloS One, 2009, 4(6): e5949
    • (2009) PloS One , vol.4 , Issue.6
    • Ding, X.1    Goldberg, M.S.2
  • 49
    • 45549085874 scopus 로고    scopus 로고
    • The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules
    • DOI 10.1002/jnr.21622
    • Gandhi P N, Wang X, Zhu X, et al. The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules. J Neurosci Res, 2008, 86(8): 1711-1720 (Pubitemid 351859422)
    • (2008) Journal of Neuroscience Research , vol.86 , Issue.8 , pp. 1711-1720
    • Gandhi, P.N.1    Wang, X.2    Zhu, X.3    Chen, S.G.4    Wilson-Delfosse, A.L.5
  • 50
    • 68949218403 scopus 로고    scopus 로고
    • Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability - A point of convergence in Parkinsonian neurodegeneration?
    • Gillardon F. Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability - a point of convergence in Parkinsonian neurodegeneration?. J Neurochemistry, 2009, 110(5): 1514-1522
    • (2009) J Neurochemistry , vol.110 , Issue.5 , pp. 1514-1522
    • Gillardon, F.1
  • 51
    • 59649089328 scopus 로고    scopus 로고
    • The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration
    • Ho C C, Rideout H J, Ribe E, et al. The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration. J Neurosci, 2009, 29(4): 1011-1016
    • (2009) J Neurosci , vol.29 , Issue.4 , pp. 1011-1016
    • Ho, C.C.1    Rideout, H.J.2    Ribe, E.3
  • 52
    • 77649328234 scopus 로고    scopus 로고
    • The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation
    • Kumar A, Greggio E, Beilina A, et al. The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation. PLoS One, 2010, 5 (1): e8730
    • (2010) PLoS One , vol.5 , Issue.1
    • Kumar, A.1    Greggio, E.2    Beilina, A.3
  • 53
    • 51949090816 scopus 로고    scopus 로고
    • Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
    • Imai Y, Gehrke S, Wang H Q, et al. Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila. EMBO J, 2008, 27(18): 2432-2443
    • (2008) EMBO J , vol.27 , Issue.18 , pp. 2432-2443
    • Imai, Y.1    Gehrke, S.2    Wang, H.Q.3
  • 54
    • 69249211037 scopus 로고    scopus 로고
    • Interaction of elongation factor 1-alpha with leucine-rich repeat kinase 2 impairs kinase activity and microtubule bundling in vitro
    • Gillardon F. Interaction of elongation factor 1-alpha with leucine-rich repeat kinase 2 impairs kinase activity and microtubule bundling in vitro. Neuroscience, 2009, 163(2): 533-539
    • (2009) Neuroscience , vol.163 , Issue.2 , pp. 533-539
    • Gillardon, F.1
  • 55
    • 46549089664 scopus 로고    scopus 로고
    • LRRK2 regulates synaptic vesicle endocytosis
    • Shin N, Jeong H, Kwon J, et al. LRRK2 regulates synaptic vesicle endocytosis. Exp Cell Res, 2008, 314(10): 2055-2065
    • (2008) Exp Cell Res , vol.314 , Issue.10 , pp. 2055-2065
    • Shin, N.1    Jeong, H.2    Kwon, J.3
  • 56
    • 67651008224 scopus 로고    scopus 로고
    • Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications
    • Qing H, Wong W, McGeer E G, et al. Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications. Biochem Biophys Res Commun, 2009, 387(1): 149-152
    • (2009) Biochem Biophys Res Commun , vol.387 , Issue.1 , pp. 149-152
    • Qing, H.1    Wong, W.2    McGeer, E.G.3
  • 57
    • 67650233672 scopus 로고    scopus 로고
    • Caenorhabditis elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth
    • Samann J, Hegermann J, Gromoff E V, et al. Caenorhabditis elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth. J Biol Chem, 2009, 284: 16482-16491
    • (2009) J Biol Chem , vol.284 , pp. 16482-16491
    • Samann, J.1    Hegermann, J.2    Gromoff, E.V.3
  • 58
    • 77349113121 scopus 로고    scopus 로고
    • MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2
    • Hsu C H, Chan D, Greggio E, et al. MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2. J Neurochem, 2010, 112(6):1593-1604
    • (2010) J Neurochem , vol.112 , Issue.6 , pp. 1593-1604
    • Hsu, C.H.1    Chan, D.2    Greggio, E.3
  • 59
    • 65649142038 scopus 로고    scopus 로고
    • The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro
    • Gloeckner C J, Schumacher A, Boldt K, et al. The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro. J Neurochem, 2009, 109(4): 959-968
    • (2009) J Neurochem , vol.109 , Issue.4 , pp. 959-968
    • Gloeckner, C.J.1    Schumacher, A.2    Boldt, K.3
  • 60
    • 51349166968 scopus 로고    scopus 로고
    • Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway
    • Liou A K, Leak R K, Li L, et al. Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway. Neurobiol Dis, 2008, 32(1): 116-124
    • (2008) Neurobiol Dis , vol.32 , Issue.1 , pp. 116-124
    • Liou, A.K.1    Leak, R.K.2    Li, L.3
  • 61
    • 77951898652 scopus 로고    scopus 로고
    • Leucine-rich repeat kinase 2 induces alpha-synuclein expression via the extracellular signal-regulated kinase pathway
    • Carballo-Carbajal I, Weber-Endress S, Rovelli G, et al. Leucine-rich repeat kinase 2 induces alpha-synuclein expression via the extracellular signal-regulated kinase pathway. Cell Signal, 2010, 22(5):821-827
    • (2010) Cell Signal , vol.22 , Issue.5 , pp. 821-827
    • Carballo-Carbajal, I.1    Weber-Endress, S.2    Rovelli, G.3
  • 62
    • 33751256567 scopus 로고    scopus 로고
    • The Familial Parkinsonism Gene LRRK2 Regulates Neurite Process Morphology
    • DOI 10.1016/j.neuron.2006.10.008, PII S0896627306008075
    • Macleod D, Dowman J, Hammond R, et al. The familial Parkinsonism gene LRRK2 regulates neurite process morphology. Neuron, 2006, 52(4): 587-593 (Pubitemid 44781171)
    • (2006) Neuron , vol.52 , Issue.4 , pp. 587-593
    • MacLeod, D.1    Dowman, J.2    Hammond, R.3    Leete, T.4    Inoue, K.5    Abeliovich, A.6
  • 63
    • 39549117093 scopus 로고    scopus 로고
    • Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells
    • DOI 10.1111/j.1471-4159.2008.05217.x
    • Plowey E D, Cherra S J, Liu Y J, et al. Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells. J Neurochem, 2008, 105(3): 1048-1056 (Pubitemid 351565713)
    • (2008) Journal of Neurochemistry , vol.105 , Issue.3 , pp. 1048-1056
    • Plowey, E.D.1    Cherra III, S.J.2    Liu, Y.-J.3    Chu, C.T.4
  • 64
    • 33947663512 scopus 로고    scopus 로고
    • LRK-1, a C. elegans PARK8-Related Kinase, Regulates Axonal-Dendritic Polarity of SV Proteins
    • DOI 10.1016/j.cub.2007.01.074, PII S0960982207009931
    • Sakaguchi-Nakashima A, Meir J Y, Jin Y, et al. LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins. Curr Biol, 2007, 17(7): 592-598 (Pubitemid 46497793)
    • (2007) Current Biology , vol.17 , Issue.7 , pp. 592-598
    • Sakaguchi-Nakashima, A.1    Meir, J.Y.2    Jin, Y.3    Matsumoto, K.4    Hisamoto, N.5


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