LRRK2 mutations in Parkinson disease

Neurology

Volumn 65, Issue 5, 2005, Pages 738-740

  Farrer, Matthew ^a   Stone, J ^a   Mata, I F ^a   Lincoln, S ^a   Kachergus, J ^a   Hulihan, M ^a   Strain, K J ^b   Maraganore, D M ^b  

^a MAYO CLINIC   (United States)

^b Mayo Clinic   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEUCINE RICH REPEAT KINASE 2; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

ADULT; ALLELE; ARTICLE; BRADYKINESIA; CLINICAL ARTICLE; FAMILY HISTORY; FEMALE; GENE; GENE MUTATION; GENOTYPE; HUMAN; IDIOPATHIC DISEASE; LRRK2 GENE; MALE; PARKINSON DISEASE; PRIORITY JOURNAL; RIGIDITY; TREMOR;

EID: 24644497562     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.WNL.0000169023.51764.b0     Document Type: Article

References (10)

1. Di Monte DA. The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins? Lancet Neurol 2003;2:531-538.
2. Vila M, Przedborski S. Genetic clues to the pathogenesis of Parkinson's disease. Nat Med 2004;10:S58-62.
3. Paisan-Ruiz C, Jain S, Evans EW, et al. Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron 2004; 44:595-600.
4. Zimprich A, Biskup S, Leitner P, et al. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 2004;44:601-607.
5. Di Fonzo A, Rohe CF, Ferreira J, et al. A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease. Lancet 2005;365:412-415.
6. Gilks WP, Abou-Sleiman PM, Gandhi S, et al. A common LRRK2 mutation in idiopathic Parkinson's disease. Lancet 2005;365:415-416.
7. Kachergus J, Mata IF, Hulihan M, et al. Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism; evidence for a common founder across European populations. Am J Hum Genet 2005.
8. Nichols WC, Pankratz N, Hernandez D, et al. Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease. Lancet 2005;365:410-412.
9. Bower JH, Maraganore DM, McDonnell SK, Rocca WA. Incidence and distribution of parkinsonism in Olmsted County, Minnesota, 1976-1990. Neurology 1999;52:1214-1220.
10. Wang LH, Besirli CG, Johnson EM, Jr. Mixed-lineage kinases: a target for the prevention of neurodegeneration. Annu Rev Pharmacol Toxicol 2004;44:451-474.