Type 2 iodothyronine deiodinase is highly expressed in human thyroid

Journal of Clinical Investigation

Volumn 98, Issue 4, 1996, Pages 962-968

  Salvatore, Domenico ^a   Tu, Helen ^a   Harney, John W ^a   Larsen, P Reed ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

deiodinase; iodide peroxidase; selenium; selenocysteine; thyroid

Indexed keywords

LIOTHYRONINE; MESSENGER RNA; PROPYLTHIOURACIL; THIAMAZOLE; THYROTROPIN; THYROXINE; THYROXINE DEIODINASE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME MECHANISM; GRAVES DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; IODINE DEFICIENCY; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; THYROID ADENOMA; THYROID FOLLICLE CELL; THYROID FUNCTION;

EID: 0029832961     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118880     Document Type: Article

References (42)

1. Berry, M.J., L. Banu, and P.R. Larsen. 1991. Type I iodothyronine deiodinase is a selenocysteine-containing enzyme. Nature (Lond.). 349:438-440.
2. Larsen, P.R., J.E. Silva, and M.M. Kaplan. 1981. Relationships between circulating and intracellular thyroid hormones: physiological and clinical implications. Endocr. Rev. 2:87-102.
3. Leonard, J.L., and T.J. Visser. 1986. Biochemistry of deiodination. In Thyroid Hormone Metabolism. G. Hennemann, editor. Marcel Dekker Inc., New York. 189-229.
4. Berry, M.J., J.D. Kieffer, J.W. Harney, and P.R. Larsen. 1991. Selenocysteine confers the biochemical properties of the type I iodothyronine deiodinase. J. Biol Chem. 266:14155-14158.
5. Silva, J.E., and P.R. Larsen. 1977. Pituitary nuclear 3,5,3′-triiodothyronine and thyrotropin secretion: an explanation for the effect of thyroxine. Science (Wash. DC). 198:617-619.
6. Cheron, R.G., M.M. Kaplan, and P.R. Larsen. 1979. Physiological and pharmacologic influences on thyroxine to 3,5,3′-triiodothyronine conversion and nuclear 3,5,3′-triiodothyronine binding in rat anterior pituitary. J. Clin. Invest. 64:1402-1414.
7. Visser, T.J., J.L. Leonard, M.M. Kaplan, and P.R. Larsen. 1982. Kinetic evidence suggesting two mechanisms for iodothyronine 5′-deiodination in rat cerebral cortex. Proc. Natl. Acad. Sci. USA. 79:5080-5084.
8. Visser, T.J., M.M. Kaplan, J.L. Leonard, and P.R, Larsen. 1983. Evidence for two pathways of iodothyronine 5′-deiodination in rat pituitary that differ in kinetics, propylthyiouracil sensitivity, and response to hypothyroidism. J. Clin. Invest. 71:992-1002.
9. Larsen, P.R. 1996. Thyroid hormone transport, cellular uptake, metabolism, and molecular action. In The Thyroid and its Diseases. L.J. DeGroot, P.R. Larsen, and G. Hennemann, editors. Churchill Livingstone Inc., New York. 61-111.
10. Itagaki, Y., K Yoshida, H. Ikede, K. Kaise, N. Kaise, M. Yamamoto, T. Sakurada, and K. Yoshinaga. 1990. Thyroxine 5′-deiodinase in human anterior pituitary tumors. J. Clin. Endocrinol. Metab. 71:340-344.
11. Davey, J.C., K.B. Becker, M.J. Schneider, D.L. St.Germain, and V.A. Galton. 1995. Cloning of a cDNA for the type II iodothyronine deiodinase. J. Biol. Chem. 270:26786-26789.
12. Salvatore, D., T. Bartha, J.W. Harney, and P.R. Larsen. 1996. Molecular biological and biochemical characterization of the human Type 2 selenodeiodinase. Endocrinology. 137:3308-3315.
13. Silva, J.E., and P.R. Larsen. 1985. The potential of brown adipose tissue type II T4 5′-deiodinase as a local and systemic source of T3 in rats. J. Clin. Invest. 76:2296-2305.
14. LoPresti, J.S., A. Eigen, E. Kaplein, K.P. Anderson, CA. Spencer, and J.T. Nicoloff. 1989. Alteration in 3,3′,5′-triiodothyronine metabolism in response to propylthiouracil, dexamethasone, and thyroxine administration in man. J. Clin. Invest. 84:1650-1656.
15. Kaplan, M.M., C. Pan, P.R. Gordon, J.K. Lee, and B.A. Gilchrest. 1988. Human epidermal keratinocytes in culture convert thyroxine to 3,5,3′-triiodothyronine by type II iodothyronine deiodination: a novel endocrine function of the skin. J. Clin. Endocrinol. Metab. 66:815-822.
16. Izumi, M., and P.R. Larsen. 1977. Triiodothyronine, thyroxine and iodine in purified thyroglobulin from patients with Graves' disease. J. Clin. Invest. 59:1105-1112.
17. Ausubel, F.M., R. Brent, R.E. Kingston, D.D. Moore, J.G. Seidman, J.A. Smith, and K. Struhl. 1987. Current Protocols in Molecular Biology. John Wiley & Sons Inc., New York.
18. Salvatore, D., S.C. Low, M.J. Berry, A.L. Maia, J.W. Harney, W. Croteau, D.L. St.Germain, and P.R. Larsen. 1995. Type 3 iodothyronine deiodinase: cloning, in vitro expression and functional analysis of the placental selenoenzyme. J. Clin. Invest. 95:2421-2430.
19. Berry, M.J., L. Banu, J.W. Harney, and P.R. Larsen. 1993. Functional characterization of the eukaryotic SECIS elements which direct selenocysteine insertion at UGA codons. Eur. Mol. Biol. Org. J. 12:3315-3322.
20. Brent, G.A., P.R. Larsen, J.W. Harney, R.J. Koenig, and D.D. Moore. 1989. Functional characterization of the rat growth hormone promoter elements required for induction by thyroid hormone with and without a co-transfected beta type thyroid hormone receptor. J. Biol. Chem. 264:178-182.
21. Mandel, S.J., M.J. Berry, J.D. Kieffer, J.W. Harney, R.L. Warne, and P.R. Larsen. 1992. Cloning and in vitro expression of the human selenoprotein, type I iodothyronine deiodinase. J. Clin. Endocrinol. Metab. 75:1133-1139.
22. Visser, T.J., E. Kaptein, O.T. Terpstra, and E.P. Krenning. 1988. Deiodination of thyroid hormone by human liver. J. Clin. Endocrinol. Metab. 67:17-24.
23. Toyoda, N., J.W. Harney, M.J. Berry, and P.R. Larsen. 1994. Identification of critical amino acids for 3,5′,3′-triiodothyronine deiodination by human type 1 deiodinase based on comparative functional-structural analyses of the human, dog, and rat enzymes. J. Biol. Chem. 269:20329-20334.
24. Berry, M.J., A.L. Kates, and P.R. Larsen. 1990. Thyroid hormone regulates type I deiodinase messenger RNA in rat liver. Mol. Endocrinol. 4:743-748.
25. Mol, J.A., R. Docter, G. Hennemann, and T.J. Visser. 1984. Modification of rat liver iodothyronine 5′-deiodinase activity with diethylpyrocarbonate and rose bengal: evidence for an active site histidine residue. Biochem. Biophys. Res. Commun. 120:28-36.
26. Toyoda, N., M. Nishikawa, Y. Mori, M. Yoshimura, H. Masaki, A. Gondou, T. Yonemoto, and M. Inada. 1992. Identification of a 27-kilodalton protein with the properties of Type I iodothyronine 5′-deiodinase in human thyroid gland. J. Clin. Endocrinol. Metab. 74:533-538.
27. Silva, J.E., and P.R. Larsen. 1983. Adrenergic activation of triiodothyronine production in brown adipose tissue. Nature (Lond.). 305:712-713.
28. Laurberg, P. 1984. Mechanisms governing the relative proportions of thyroxine and 3,5,3′-triiodothyronine in thyroid secretion. Metab. Clin. Exp. 33: 379-392.
29. Larsen, P.R., and SH. Ingbar. 1992. The thyroid. In Textbook of Endocrinology. J.D. Wilson and D.W. Foster, editors. W.B. Saunders, Co., Philadelphia. 357-487.
30. Goswami, A., and I.N. Rosenberg. 1984. Iodothyronine 5′-deiodinase in rat kidney microsomes: Kinetic behavior at low substrate concentrations. J. Clin. Invest. 74:2097-2106.
31. Silva, J.E., S.A. Mellen, and P.R. Larsen. 1987. Comparison of kidney and brown adipose tissue iodothyronine 5′-deiodinases. Endocrinology. 121: 650-656.
32. Berry, M.J., A.L. Maia, J.D. Kieffer, J.W. Harney, and P.R. Larsen. 1992. Substitution of cysteine for selenocysteine in type I iodothyronine deiodinase reduces the catalytic efficiency of the protein but enhances its translation. Endocrinology. 131:1848-1852.
33. Mol, J.A., and T.J. Visser. 1985. Rapid and selective inner ring deiodination of thyronine sulfale by rat liver deiodinase. Endocrinology. 117:8-12.
34. Borges, M., S.H. Ingbar, and J.E. Silva. 1990. Iodothyronine deiodinase activities in FRTL5 cells: predominance of type I 5′-deiodinase. Endocrinology. 126:3059-3068.
35. Leonard, J.L., J.E. Silva, M.M. Kaplan, S.A. Meilen, T.J. Visser, and P.R. Larsen. 1984. Acute post-transcriptional regulation of cerebrocortical and pituitary iodothyroinine 5′-deiodinase by thyroid hormone. Endocrinology. 114:998-1004.
36. Barge, R.M., I. Mills, J.E. Silva, and P.R. Larsen. 1988. The regional hypothyalamic distribution of Type II 5′-monodeiodinase in euthyroid and hypothyroid rats. Brain Res. E323-E327.
37. Mills, I., A. Raasmaja, N. Moolten, G. Lemack, J.E. Silva, and P.R. Larsen. 1989. Effect of thyroid status on catecholamine stimulation of thyroxine 5′-deiodinase in isolated brown adipocytes. Am. J. Physiol. 256:E74-E79.
38. Raasmaja, A., and P.R. Larsen. 1989. α1-and β-adrenergic agents cause synergistic stimulation of the iodothyronine deiodinase in rat brown adipocytes. Endocrinology. 125:2502-2509.
39. Dumont, J.E., F. Lamy, P. Roger, and C. Maenhaut. 1992. Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors. Physiol. Rev. 72:667-697.
40. Larsen, P.R., and M.J. Berry. 1995. Nutritional and hormonal regulation of thyroid hormone deiodinases. Annu. Rev. Nutr. 15:323-352.
41. Abuid, J., and P.R. Larsen. 1974. Triiodothyronine and thyroxine in hyperthyroidism. J. Clin. Invest. 54:201-208.
42. Laurberg, P., and N. Boye. 1984. Propylthiouracil, ipodate, dexamethasone and periods of fasting induce different variations in serum rT3 in dogs. Metab. Clin. Exp. 33:323-325.