Single nucleotide polymorphisms of pattern recognition receptors and chronic periodontitis

Journal of Periodontal Research

Volumn 46, Issue 2, 2011, Pages 184-192

  Sahingur, S E ^a   Xia, X J ^a   Gunsolley, J ^a   Schenkein, H A ^a   Genco, R J ^b,c   De Nardin, E ^b,c  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

CD14; Genetics; Periodontitis; Polymorphisms; Toll like receptors

Indexed keywords

ADENINE; CD14 ANTIGEN; CYTOSINE; GUANINE; THYMINE; TLR2 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN; TLR9 PROTEIN, HUMAN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9;

ARTICLE; CHRONIC PERIODONTITIS; COMPARATIVE STUDY; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HOMOZYGOTE; HUMAN; MALE; MIDDLE AGED; PERIODONTAL DISEASE; PERIODONTAL POCKET; PERIODONTICS; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; TOOTH PLAQUE;

ADENINE; ANTIGENS, CD14; CHRONIC PERIODONTITIS; CYTOSINE; DENTAL PLAQUE INDEX; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GUANINE; HOMOZYGOTE; HUMANS; MALE; MIDDLE AGED; PERIODONTAL ATTACHMENT LOSS; PERIODONTAL INDEX; PERIODONTAL POCKET; POLYMORPHISM, SINGLE NUCLEOTIDE; SMOKING; THYMINE; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 9; TOLL-LIKE RECEPTORS;

EID: 79951873674     PISSN: 00223484     EISSN: 16000765     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2010.01327.x     Document Type: Article

References (67)

1. Taubman MA, Valverde P, Han X, Kawai T. Immune response: the key to bone resorption in periodontal disease. J Periodontol 2005;76:2033-2041.
2. Cochran DL. Inflammation and bone loss in periodontal disease. J Periodontol 2008;79:1569-1576.
3. Michalowicz BS, Diehl SR, Gunsolley JC et al. Evidence of a substantial genetic basis for risk of adult periodontitis. J Periodontol 2000;71:1699-1707.
4. Schenkein HA. Finding genetic risk factors for periodontal diseases: is the climb worth the view? Periodontol 2000 2002;30:79-90.
5. Laine ML, Loos BG, Crielaard W. Gene polymorphisms in chronic periodontitis. Int J Dent 2000;2010:324719.
6. Mahanonda R, Pichyangkul S. Toll-like receptors and their role in periodontal health and disease. Periodontol 2000 2007;43:41-55.
7. Schwartz DA, Cook DN. Polymorphisms of the Toll-like receptors and human disease. Clin Infect Dis 2005;41(Suppl 7):S403-407.
8. Janeway CA Jr, Medzhitov R. Lipoproteins take their toll on the host. Curr Biol 1999;9:R879-882.
9. Arbour NC, Lorenz E, Schutte BC et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 2000;25:187-191.
10. Michel O, LeVan TD, Stern D et al. Systemic responsiveness to lipopolysaccharide and polymorphisms in the toll-like receptor 4 gene in human beings. J Allergy Clin Immunol 2003;112:923-929.
11. Ferwerda B, McCall MB, Verheijen K et al. Functional consequences of toll-like receptor 4 polymorphisms. Mol Med 2008;14:346-352.
12. Karoly E, Fekete A, Banki NF et al. Heat shock protein 72 (HSPA1B) gene polymorphism and Toll-like receptor (TLR) 4 mutation are associated with increased risk of urinary tract infection in children. Pediatr Res 2007;61:371-374.
13. Mandelberg A, Tal G, Naugolny L et al. Lipopolysaccharide hyporesponsiveness as a risk factor for intensive care unit hospitalization in infants with respiratory syncitial virus bronchiolitis. Clin Exp Immunol 2006;144:48-52.
14. Tulic MK, Hurrelbrink RJ, Prele CM et al. TLR4 polymorphisms mediate impaired responses to respiratory syncytial virus and lipopolysaccharide. J Immunol 2007;179:132-140.
15. Pabst S, Baumgarten G, Stremmel A et al. Toll-like receptor (TLR) 4 polymorphisms are associated with a chronic course of sarcoidosis. Clin Exp Immunol 2006;143:420-426.
16. Schroder NW, Meister D, Wolff V et al. Chronic periodontal disease is associated with single-nucleotide polymorphisms of the human TLR-4 gene. Genes Immun 2005;6:448-451.
17. Fukusaki T, Ohara N, Hara Y, Yoshimura A, Yoshiura K. Evidence for association between a Toll-like receptor 4 gene polymorphism and moderate/severe periodontitis in the Japanese population. J Periodontal Res 2007;42:541-545.
18. Folwaczny M, Glas J, Torok HP, Limbersky O, Folwaczny C. Toll-like receptor (TLR) 2 and 4 mutations in periodontal disease. Clin Exp Immunol 2004;135:330-335.
19. Laine ML, Morre SA, Murillo LS, van Winkelhoff AJ, Pena AS. CD14 and TLR4 gene polymorphisms in adult periodontitis. J Dent Res 2005;84:1042-1046.
20. James JA, Poulton KV, Haworth SE et al. Polymorphisms of TLR4 but not CD14 are associated with a decreased risk of aggressive periodontitis. J Clin Periodontol 2007;34:111-117.
21. Kinane DF, Shiba H, Stathopoulou PG et al. Gingival epithelial cells heterozygous for Toll-like receptor 4 polymorphisms Asp299Gly and Thr399ile are hypo-responsive to Porphyromonas gingivalis. Genes Immun 2006;7:190-200.
22. Ozturk A, Vieira AR. TLR4 as a risk factor for periodontal disease: a reappraisal. J Clin Periodontol 2009;36:279-286.
23. Akashi-Takamura S, Miyake K. TLR accessory molecules. Curr Opin Immunol 2008;20:420-425.
24. Cleveland MG, Gorham JD, Murphy TL, Tuomanen E, Murphy KM. Lipoteichoic acid preparations of gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway. Infect Immun 1996;64:1906-1912.
25. LeVan TD, Bloom JW, Bailey TJ et al. A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity. J Immunol 2001;167:5838-5844.
26. Vainas T, Stassen FR, Bruggeman CA et al. Synergistic effect of Toll-like receptor 4 and CD14 polymorphisms on the total atherosclerosis burden in patients with peripheral arterial disease. J Vasc Surg 2006;44:326-332.
27. Smit LA, Bongers SI, Ruven HJ et al. Atopy and new-onset asthma in young Danish farmers and CD14, TLR2, and TLR4 genetic polymorphisms: a nested case-control study. Clin Exp Allergy 2007;37:1602-1608.
28. Donati M, Berglundh T, Hytonen AM, Hahn-Zoric M, Hanson LA, Padyukov L. Association of the -159 CD14 gene polymorphism and lack of association of the -308 TNFA and Q551R IL-4RA polymorphisms with severe chronic periodontitis in Swedish Caucasians. J Clin Periodontol 2005;32:474-479.
29. Folwaczny M, Glas J, Torok HP, Fricke K, Folwaczny C. The CD14 -159C-to-T promoter polymorphism in periodontal disease. J Clin Periodontol 2004;31:991-995.
30. Yamazaki K, Ueki-Maruyama K, Oda T et al. Single-nucleotide polymorphism in the CD14 promoter and periodontal disease expression in a Japanese population. J Dent Res 2003;82:612-616.
31. Tervonen T, Raunio T, Knuuttila M, Karttunen R. Polymorphisms in the CD14 and IL-6 genes associated with periodontal disease. J Clin Periodontol 2007;34:377-383.
32. Holla LI, Buckova D, Fassmann A, Halabala T, Vasku A, Vacha J. Promoter polymorphisms in the CD14 receptor gene and their potential association with the severity of chronic periodontitis. J Med Genet 2002;39:844-848.
33. Raunio T, Knuuttila M, Karttunen R, Vainio O, Tervonen T. Serum sCD14, polymorphism of CD14(-260) and periodontal infection. Oral Dis 2009;15:484-489.
34. Nicu EA, Laine ML, Morre SA, Van der Velden U, Loos BG. Soluble CD14 in periodontitis. Innate Immun 2009;15:121-128.
35. Hajishengallis G, Wang M, Harokopakis E, Triantafilou M, Triantafilou K. Porphyromonas gingivalis fimbriae proactively modulate beta2 integrin adhesive activity and promote binding to and internalization by macrophages. Infect Immun 2006;74:5658-5666.
36. Darveau RP, Pham TT, Lemley K et al. Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4. Infect Immun 2004;72:5041-5051.
37. Onishi S, Honma K, Liang S et al. Toll-like receptor 2-mediated interleukin-8 expression in gingival epithelial cells by the Tannerella forsythia leucine-rich repeat protein BspA. Infect Immun 2008;76:198-205.
38. Kutukculer N, Yeniay BS, Aksu G, Berdeli A. Arg753Gln polymorphism of the human toll-like receptor-2 gene in children with recurrent febrile infections. Biochem Genet 2007;45:507-514.
39. Berdeli A, Celik HA, Ozyurek R, Dogrusoz B, Aydin HH. TLR-2 gene Arg753Gln polymorphism is strongly associated with acute rheumatic fever in children. J Mol Med 2005;83:535-541.
40. Ogus AC, Yoldas B, Ozdemir T et al. The Arg753GLn polymorphism of the human toll-like receptor 2 gene in tuberculosis disease. Eur Respir J 2004;23:219-223.
41. Krediet TG, Wiertsema SP, Vossers MJ et al. Toll-like receptor 2 polymorphism is associated with preterm birth. Pediatr Res 2007;62:474-476.
42. Tsui FW, Xi N, Rohekar S et al. Toll-like receptor 2 variants are associated with acute reactive arthritis. Arthritis Rheum 2008;58:3436-3438.
43. Imamura Y, Fujigaki Y, Oomori Y, Kuno T, Ota N, Wang PL. Polymorphism of genes encoding toll-like receptors and inflammatory cytokines in periodontal disease in the Japanese population. J Int Acad Periodontol 2008;10:95-102.
44. Akira S. Innate immunity to pathogens: diversity in receptors for microbial recognition. Immunol Rev 2009;227:5-8.
45. Nonnenmacher C, Dalpke A, Zimmermann S, Flores-De-Jacoby L, Mutters R, Heeg K. DNA from periodontopathogenic bacteria is immunostimulatory for mouse and human immune cells. Infect Immun 2003;71:850-856.
46. Sahingur SE, Xia XJ, Alamgir S, Honma K, Sharma A, Schenkein HA. DNA from Porphyromonas gingivalis and Tannerella forsythia induce cytokine production in human monocytic cell lines. Mol Oral Microbiol 2010;25:123-135.
47. Kajita K, Honda T, Amanuma R et al. Quantitative messenger RNA expression of Toll-like receptors and interferon-alpha1 in gingivitis and periodontitis. Oral Microbiol Immunol 2007;22:398-402.
48. Beklen A, Hukkanen M, Richardson R, Konttinen YT. Immunohistochemical localization of Toll-like receptors 1-10 in periodontitis. Oral Microbiol Immunol 2008;23:425-431.
49. Hamann L, Glaeser C, Hamprecht A, Gross M, Gomma A, Schumann RR. Toll-like receptor (TLR)-9 promotor polymorphisms and atherosclerosis. Clin Chim Acta 2006;364:303-307.
50. Lazarus R, Klimecki WT, Raby BA et al. Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studies. Genomics 2003;81:85-91.
51. Torok HP, Glas J, Tonenchi L, Bruennler G, Folwaczny M, Folwaczny C. Crohn's disease is associated with a toll-like receptor-9 polymorphism. Gastroenterology 2004;127:365-366.
52. Torok HP, Glas J, Endres I et al. Epistasis between Toll-like receptor-9 polymorphisms and variants in NOD2 and IL23R modulates susceptibility to Crohn's disease. Am J Gastroenterol 2009;104:1723-1733.
53. Novak N, Yu CF, Bussmann C et al. Putative association of a TLR9 promoter polymorphism with atopic eczema. Allergy 2007;62:766-772.
54. Velez DR, Wejse C, Stryjewski ME et al. Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans. Hum Genet 2010;127:65-73.
55. Davis SM, Clark EA, Nelson LT, Silver RM. The association of innate immune response gene polymorphisms and puerperal group A streptococcal sepsis. Am J Obstet Gynecol 2010;202:308 e301-308.
56. Mollaki V, Georgiadis T, Tassidou A et al. Polymorphisms and haplotypes in TLR9 and MYD88 are associated with the development of Hodgkin's lymphoma: a candidate-gene association study. J Hum Genet 2009;54:655-659.
57. Tao K, Fujii M, Tsukumo S et al. Genetic variations of Toll-like receptor 9 predispose to systemic lupus erythematosus in Japanese population. Ann Rheum Dis 2007;66:905-909.
58. Holla LI, Vokurka J, Hrdlickova B, Augustin P, Fassmann A. Association of Toll-like receptor 9 haplotypes with chronic periodontitis in Czech population. J Clin Periodontol 2009;37:152-159.
59. Hong J, Leung E, Fraser AG, Merriman TR, Vishnu P, Krissansen GW. TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort. J Gastroenterol Hepatol 2007;22:1760-1766.
60. * in the 5' flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. Am J Respir Cell Mol Biol 1999;20:976-983.
61. Jin L, Darveau RP. Soluble CD14 levels in gingival crevicular fluid of subjects with untreated adult periodontitis. J Periodontol 2001;72:634-640.
62. Jin L, Ren L, Leung WK, Darveau RP. The in vivo expression of membrane-bound CD14 in periodontal health and disease. J Periodontol 2004;75:578-585.
63. Buduneli N, Bicakci N, Keskinoglu A. Flow-cytometric analysis of lymphocyte subsets and mCD14 expression in patients with various periodontitis categories. J Clin Periodontol 2001;28:419-424.
64. Schulz S, Zissler N, Altermann W et al. Impact of genetic variants of CD14 and TLR4 on subgingival periodontopathogens. Int J Immunogenet 2008;35:457-464.
65. De Nardo D, De Nardo CM, Nguyen T, Hamilton JA, Scholz GM. Signaling crosstalk during sequential TLR4 and TLR9 activation amplifies the inflammatory response of mouse macrophages. J Immunol 2009;183:8110-8118.
66. Hajishengallis G, Lambris JD. Crosstalk pathways between Toll-like receptors and the complement system. Trends Immunol 2010;31:154-163.
67. O'Neill LA. When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction. Immunity 2008;29:12-20.