TLR4 as a risk factor for periodontal disease: A reappraisal

Journal of Clinical Periodontology

Volumn 36, Issue 4, 2009, Pages 279-286

  Ozturk, Ayla ^a,b   Vieira, Alexandre R ^a,c  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b ONDOKUZ MAYIS UNIVERSITY   (Turkey)

^c UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Association; Meta analysis; Periodontal diseases; Polymorphisms

Indexed keywords

ASPARTIC ACID; GLYCINE; ISOLEUCINE; THREONINE; TLR4 PROTEIN, HUMAN; TOLL LIKE RECEPTOR 4;

ALLELE; ARTICLE; CHRONIC PERIODONTITIS; GENE FREQUENCY; GENETIC MARKER; GENETIC PREDISPOSITION; GENETICS; HUMAN; IMMUNOLOGY; META ANALYSIS; PERIODONTITIS; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

AGGRESSIVE PERIODONTITIS; ALLELES; ASPARTIC ACID; CHRONIC PERIODONTITIS; GENE FREQUENCY; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GLYCINE; HUMANS; ISOLEUCINE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; THREONINE; TOLL-LIKE RECEPTOR 4;

EID: 63049120043     PISSN: 03036979     EISSN: 1600051X     Source Type: Journal    
DOI: 10.1111/j.1600-051X.2009.01370.x     Document Type: Article

References (53)

1. Arbour, N. C., Lorenz, E., Schutte, B. C., Zabner, J., Kline, J. N., Jones, M., Frees, K., Watt, J. L. Schwartz, D. A. (2000) TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nature Genetics 25, 187 191.
2. Begg, C. B. Mazumdar, M. (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50, 1088 1101.
3. Berdeli, A., Emingil, G., Han Saygan, B., Gurkan, A., Atilla, G., Kose, T. Baylas, H. (2007) TLR2 Arg753Gly, TLR4 Asp299Gly and Thr399Ile gene polymorphisms are not associated with chronic periodontitis in a Turkish population. Journal of Clinical Periodontology 34, 551 557.
4. Brennan, P. (2002) Gene-environment interaction and aetiology of cancer: what does it mean and how can we measure it? Carcinogenesis 23, 381 387.
5. Brett, P. M., Zygogianni, P., Griffiths, G. S., Tomaz, M., Parkar, M., D'Aiuto, F. Tonetti, M. (2005) Functional gene polymorphisms in aggressive and chronic periodontitis. Journal of Dental Research 84, 1149 1153.
6. Cochran, W. (1954) The combination of estimates from different experiments. Biometrics 10, 101 129.
7. Cooper, H. Hedges, L. V. (1994) The Handbook of Research Synthesis, 1st edition, p. 573. NY : Russell Sage Foundation.
8. D'Aiuto, F., Parkar, M., Brett, P. M., Ready, D. Tonetti, M. S. (2004) Gene polymorphisms in pro-inflammatory cytokines are associated with systemic inflammation in patients with severe periodontal infections. Cytokine 28, 29 34.
9. DerSimonian, R. Laird, N. (1986) Meta-analysis in clinical trials. Controlled Clinical Trials 7, 177 188.
10. Egger, M., Davey Smith, G., Schneider, M. Minder, C. (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315, 629 634.
11. Egger, M. Smith, G. D. (1998) Bias in location and selection of studies. BMJ 316, 61 66.
12. Emahazion, T., Feuk, L., Jobs, M., Sawyer, S. L., Fredman, D., St Clair, D., Prince, J. A. Brookes, A. J. (2001) SNP association studies in Alzheimer's disease highlight problems for complex disease analysis. Trends in Genetics 17, 407 413.
13. Emingil, G., Berdeli, A., Baylas, H., Saygan, B. H., Gurkan, A., Kose, T. Atilla, G. (2007) Toll-like receptor 2 and 4 gene polymorphisms in generalized aggressive periodontitis. Journal of Periodontology 78, 1968 1977.
14. Ferwerda, B., McCall, M. B., Alonso, S., Giamarellos-Bourboulis, E. J., Mouktaroudi, M., Izagirre, N., Syafruddin, D., Kibiki, G., Cristea, T., Hijmans, A., Hamann, L., Israel, S., ElGhazali, G., Troye-Blomberg, M., Kumpf, O., Maiga, B., Dolo, A., Doumbo, O., Hermsen, C. C., Stalenhoef, A. F., van Crevel, R., Brunner, H. G., Oh, D. Y., Schumann, R. R., de la Rua, C., Sauerwein, R., Kullberg, B. J., van der Ven, A. J., van der Meer, J. W. Netea, M. G. (2007) TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans. Proceedings of the National Academy of Sciences of the United States of America 104, 16645 16650.
15. Folwaczny, M., Glas, J., Torok, H. P., Limbersky, O. Folwaczny, C. (2004) Toll-like receptor (TLR) 2 and 4 mutations in periodontal disease. Clinical and Experimental Immunology 135, 330 335.
16. Fukusaki, T., Ohara, N., Hara, Y., Yoshimura, A. Yoshiura, K. (2007) Evidence for association between a Toll-like receptor 4 gene polymorphism and moderate/severe periodontitis in the Japanese population. Journal of Periodontal Research 42, 541 545.
17. Greenstein, G. Hart, T. C. (2002a) Clinical utility of a genetic susceptibility test for severe chronic periodontitis: a critical evaluation. J Am Dent Assoc 133, 452 459 quiz 492-453.
18. Greenstein, G. Hart, T. C. (2002b) A critical assessment of interleukin-1 (IL-1) genotyping when used in a genetic susceptibility test for severe chronic periodontitis. Journal of Periodontology 73, 231 247.
19. Hajishengallis, G., Sharma, A., Russell, M. W. Genco, R. J. (2002) Interactions of oral pathogens with toll-like receptors: possible role in atherosclerosis. Annals of Periodontology 7, 72 78.
20. Harbord, R. M., Egger, M. Sterne, J. A. (2006) A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints. Statistics in Medicine 25, 3443 3457.
21. Higgins, J. P. Thompson, S. G. (2004) Controlling the risk of spurious findings from meta-regression. Statistics in Medicine 23, 1663 1682.
22. Higgins, J. P., Thompson, S. G., Deeks, J. J. Altman, D. G. (2003) Measuring inconsistency in meta-analyses. BMJ 327, 557 560.
23. Ioannidis, J. P., Contopoulos-Ioannidis, D. G., Chew, P. Lau, J. (2001a) Meta-analysis of randomized controlled trials on the comparative efficacy and safety of azithromycin against other antibiotics for upper respiratory tract infections. Journal of Antimicrobial Chemotherapy 48, 677 689.
24. Ioannidis, J. P., Ntzani, E. E., Trikalinos, T. A. Contopoulos-Ioannidis, D. G. (2001b) Replication validity of genetic association studies. Nature Genetics 29, 306 309.
25. Ioannidis, J. P., Trikalinos, T. A. Khoury, M. J. (2006) Implications of small effect sizes of individual genetic variants on the design and interpretation of genetic association studies of complex diseases. American Journal of Epidemiology 164, 609 614.
26. Izakovicova Holla, L., Buckova, D., Fassmann, A., Roubalikova, L. Vanek, J. (2007) Lack of association between chronic periodontitis and the Toll-like receptor 4 gene polymorphisms in a Czech population. Journal of Periodontal Research 42, 340 344.
27. James, J. A., Poulton, K. V., Haworth, S. E., Payne, D., McKay, I. J., Clarke, F. M., Hughes, F. J. Linden, G. J. (2007) Polymorphisms of TLR4 but not CD14 are associated with a decreased risk of aggressive periodontitis. Journal of Clinical Periodontology 34, 111 117.
28. Janeway Jr., C. A. Medzhitov, R. (2002) Innate immune recognition. Annual Review of Immunology 20, 197 216.
29. Kaisho, T. Akira, S. (2001) Bug detectors. Nature 414, 701 703.
30. Kinane, D. F., Peterson, M. Stathopoulou, P. G. (2006a) Environmental and other modifying factors of the periodontal diseases. Periodontology 2000 40, 107 119.
31. Kinane, D. F., Shiba, H., Stathopoulou, P. G., Zhao, H., Lappin, D. F., Singh, A., Eskan, M. A., Beckers, S., Waigel, S., Alpert, B. Knudsen, T. B. (2006b) Gingival epithelial cells heterozygous for Toll-like receptor 4 polymorphisms Asp299Gly and Thr399ile a're hypo-responsive to Porphyromonas gingivalis. Genes and Immunity 7, 190 200.
32. Laine, M. L., Morre, S. A., Murillo, L. S., van Winkelhoff, A. J. Pena, A. S. (2005) CD14 and TLR4 gene polymorphisms in adult periodontitis. Journal of Dental Research 84, 1042 1046.
33. Lau, J., Ioannidis, J. P. Schmid, C. H. (1997) Quantitative synthesis in systematic reviews. Annals of Internal Medicine 127, 820 826.
34. Lau, J., Ioannidis, J. P. Schmid, C. H. (1998) Summing up evidence: one answer is not always enough. Lancet 351, 123 127.
35. Lohmueller, K. E., Pearce, C. L., Pike, M., Lander, E. S. Hirschhorn, J. N. (2003) Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nature Genetics 33, 177 182.
36. Loos, B. G., John, R. P. Laine, M. L. (2005) Identification of genetic risk factors for periodontitis and possible mechanisms of action. Journal of Clinical Periodontology 32 (Suppl. 6), 159 179.
37. Michalowicz, B. S., Diehl, S. R., Gunsolley, J. C., Sparks, B. S., Brooks, C. N., Koertge, T. E., Califano, J. V., Burmeister, J. A. Schenkein, H. A. (2000) Evidence of a substantial genetic basis for risk of adult periodontitis. Journal of Periodontology 71, 1699 1707.
38. Mori, Y., Yoshimura, A., Ukai, T., Lien, E., Espevik, T. Hara, Y. (2003) Immunohistochemical localization of Toll-like receptors 2 and 4 in gingival tissue from patients with periodontitis. Oral Microbiology and Immunology 18, 54 58.
39. Poltorak, A., He, X., Smirnova, I., Liu, M. Y., Van Huffel, C., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., Freudenberg, M., Ricciardi-Castagnoli, P., Layton, B. Beutler, B. (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282, 2085 2088.
40. Qureshi, S. T., Lariviere, L., Leveque, G., Clermont, S., Moore, K. J., Gros, P. Malo, D. (1999) Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). Journal of Experimental Medicine 189, 615 625.
41. Ren, L., Leung, W. K., Darveau, R. P. Jin, L. (2005) The expression profile of lipopolysaccharide-binding protein, membrane-bound CD14, and toll-like receptors 2 and 4 in chronic periodontitis. Journal of Periodontology 76, 1950 1959.
42. Schaid, D. J. (2004) Evaluating associations of haplotypes with traits. Genetic Epidemiology 27, 348 364.
43. Schröder, N. W., Meister, D., Wolff, V., Christan, C., Kaner, D., Haban, V., Purucker, P., Hermann, C., Moter, A., Gobel, U. B. Schumann, R. R. (2005) Chronic periodontal disease is associated with single-nucleotide polymorphisms of the human TLR-4 gene. Genes and Immunity 6, 448 451.
44. Sterne, J. A., Gavaghan, D. Egger, M. (2000) Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature. Journal of Clinical Epidemiology 53, 1119 1129.
45. Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K. Akira, S. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11, 443 451.
46. Todd, J. A. (1999) Interpretation of results from genetic studies of multifactorial diseases. Lancet 354 (Suppl. 1), SI15 SI16.
47. Travis, J. (2001) Immunity's Eyes Science News: biologists reveal the proteins that first see dangarous microbes. Science News 160, 152 158.
48. Trikalinos, T. A., Karassa, F. B. Ioannidis, J. P. (2001) Meta-analysis of the association between low-affinity Fcgamma receptor gene polymorphisms and hematologic and autoimmune disease. Blood 98, 1634 1635.
49. Walker, C. Karpinia, K. (2002) Rationale for use of antibiotics in periodontics. Journal of Periodontology 73, 1186 1196.
50. Wang, P. L., Azuma, Y., Shinohara, M. Ohura, K. (2000) Toll-like receptor 4-mediated signal pathway induced by Porphyromonas gingivalis lipopolysaccharide in human gingival fibroblasts. Biochemical and Biophysical Research Communications 273, 1161 1167.
51. Wang, P. L., Ohura, K., Fujii, T., Oido-Mori, M., Kowashi, Y., Kikuchi, M., Suetsugu, Y. Tanaka, J. (2003) DNA microarray analysis of human gingival fibroblasts from healthy and inflammatory gingival tissues. Biochemical and Biophysical Research Communications 305, 970 973.
52. Zhu, G., Li, C., Cao, Z., Corbet, E. F. Jin, L. (2008) Toll-like receptors 2 and 4 gene polymorphisms in a Chinese population with periodontitis. Quintessence International 39, 217 226.
53. Zintzaras, E. Ioannidis, J. P. (2005) HEGESMA: genome search meta-analysis and heterogeneity testing. Bioinformatics 21, 3672 3673.