Chronic periodontal disease is associated with single-nucleotide polymorphisms of the human TLR-4 gene

Genes and Immunity

Volumn 6, Issue 5, 2005, Pages 448-451

  Schroder N W J ^a,d   Meister, D ^a   Wolff, V ^a   Christan, C ^b   Kaner, D ^a   Haban, V ^a   Purucker, P ^a   Hermann, C ^c   Moter, A ^a   Gobel U B ^a   Schumann, Ralf R ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Zahntechnik Mehrhof   (Germany)

^c UNIVERSITY OF KONSTANZ   (Germany)

^d Cedar Sinai Medical Center   (United States)

Author keywords

Disease susceptibility; Innate immunity; Periodontitis; Single nucleotide polymorphisms; Toll like receptors

Indexed keywords

ARGININE; ASPARAGINE; CYTOKINE; GLYCINE; THREONINE; TOLL LIKE RECEPTOR 4;

ADULT; AGE; AMINO ACID ANALYSIS; ARTICLE; CHRONIC DISEASE; CONNECTIVE TISSUE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; FEMALE; GENETIC SCREENING; GENETIC VARIABILITY; HUMAN; INFLAMMATORY DISEASE; MAJOR CLINICAL STUDY; MALE; PERIODONTAL DISEASE; PERIODONTITIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; AMINO ACID SUBSTITUTION; CHRONIC DISEASE; FEMALE; HUMANS; MALE; MIDDLE AGED; PERIODONTITIS; POLYMORPHISM, SINGLE NUCLEOTIDE; TOLL-LIKE RECEPTOR 4;

EID: 23444437867     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/sj.gene.6364221     Document Type: Article

References (29)

1. Williams RC. Periodontal disease. N Engl J Med 1990; 322: 373-382.
2. Shaw JH. Causes and control of dental caries. N Engl J Med 1987; 317: 996-1004.
3. Papapanou PN. Epidemiology of periodontal diseases: An update. J Int Acad Periodontol 1999; 1: 110-116.
4. Brown LJ, Loe H. Prevalence, extent, severity and progression of periodontal disease. Periodontology 2000 1993; 2: 57-71.
5. American Academy of periodontology. Parameter on aggressive periodontitis. J Periodontol 2000; 71: 867-869.
6. Li L, Messas E, Batista Jr EL, Levine RA, Amar S. Porphyromonas gingivalis infection accelerates the progression of atherosclerosis in a heterozygous apolipoprotein E-deficient murine model. Circulation 2002; 105: 861-867.
7. Nelson KE, Fleischmann RD, DeBoy RT et al. Complete genome sequence of the oral pathogenic Bacterium Porphyromonas gingivalis strain W83. J Bacteriol 2003; 185: 5591-5601.
8. Stashenko P, Jandinski JJ, Fujiyoshi P, Rynar J, Socransky SS. Tissue levels of bone resorptive cytokines in periodontal disease. J Periodontol 1991; 62: 504-509.
9. Stashenko P, Dewhirst FE, Peros WJ, Kent RL, Ago JM. Synergistic interactions between interleukin 1, tumor necrosis factor, and lymphotoxin in bone resorption. J Immunol 1987; 138: 1464-1468.
10. Barton GM, Medzhitov R. Toll-like receptor signaling pathways. Science 2003; 300: 1524-1525.
11. Bainbridge BW, Darveau RP. Porphyromonas gingivalis lipopolysaccharide: an unusual pattern recognition receptor ligand for the innate host defense system. Acta Odontol Scand 2001; 59: 131-138.
12. Darveau RP, Pham TT, Lemley K et al. Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4. Infect Immun 2004; 72: 5041-5051.
13. Kirschning CJ, Schumann RR. TLR2: Cellular sensor for microbial and endogenous molecular patterns. Curr Top Microbiol Immunol 2002; 270: 121-144.
14. Mori Y, Yoshimura A, Ukai T et al. Immunohistochemical localization of Toll-like receptors 2 and 4 in gingival tissue from patients with periodontitis. Oral Microbiol Immunol 2003; 18: 54-58.
15. Hou L, Sasaki H, Stashenko P. Toll-like receptor 4-deficient mice have reduced bone destruction following mixed anaerobic infection. Infect Immun 2000; 68: 4681-4687.
16. Kornman KS, Crane A, Wang HY et al. The interleukin-1 genotype as a severity factor in adult periodontal disease. J Clin Periodontol 1997; 24: 72-77.
17. Parkhill JM, Hennig BJ, Chapple IL, Heasman PA, Taylor JJ. Association of interleukin-1 gene polymorphisms with early-onset periodontitis. J Clin Periodontol 2000; 27: 682-689.
18. Schröder NWJ, Schumann RR. Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease. Lancet Infect Dis 2005; 5: 156-164.
19. Lorenz E, Mira JP, Cornish KL, Arbour NC, Schwartz DA. A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection. Infect Immun 2000; 68: 6398-6401.
20. Schröder NWJ, Hermann C, Hamann L et al. High frequency of polymorphism Arg753Gln of the Toll-like receptor-2 gene detected by a novel allele-specific PCR. J Mol Med 2003; 81: 368-372.
21. Agnese DM, Calvano JE, Hahm SJ et al. Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of Gram-negative infections. J Infect Dis 2002; 186: 1522-1525.
22. Lorenz E, Mira JP, Frees KL, Schwartz DA. Relevance of mutations in the TLR4 receptor in patients with Gram-negative septic shock. Arch Intern Med 2002; 162: 1028-1032.
23. Hawn TR, Verbon V, Janer M et al. Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease. Proc Natl Acad Sci USA 2005; 102: 2487-2489.
24. Smirnova I, Mann N, Dols A et al. Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility. Proc Natl Acad Sci USA 2003; 100: 6075-6080.
25. Folwaczny M, Glas J, Torok HP, Limbersky O, Folwaczny C. Toll-like receptor (TLR) 2 and 4 mutations in periodontal disease. Clin Exp Immunol 2004; 135: 330-335.
26. Hashimoto M, Asai Y, Tamai R et al. Chemical structure and immunobiological activity of lipid A from Prevotella intermedia ATCC 25611 lipopolysaccharide. FEBS Lett 2003; 543: 98-102.
27. Suzuki T, Kobayashi M, Isatsu K et al. Mechanisms involved in apoptosis of human macrophages induced by lipopolysaccharide from Actinobacillus actinomycetemcomitans in the presence of cycloheximide. Infect Immun 2004; 72: 1856-1865.
28. Kornman KS, Page RC, Tonetti MS. The host response to the microbial challenge in periodontitis: Assembling the players. Periodontology 2000 1997; 14: 33-53.
29. Lorenz E, Frees KL, Schwartz DA. Determination of the TLR4 genotype using allele-specific PCR. Biotechniques 2001; 31: 22-24.