Synthesis and anticonvulsant activities of N-benzyl (2R)-2-acetamido-3-oxysubstituted propionamide derivatives

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 19, 2008, Pages 8968-8975

  Morieux, Pierre ^a   Stables, James P ^b   Kohn, Harold ^a,c  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c University of North Carolina at Chapel Hill   (United States)

Author keywords

Amino acid N benzylamides; Anticonvulsants; Aziridine ring opening; Diethoxytriphenylphosphorane; Structure activity relationship

Indexed keywords

2 ACETAMIDO N BENZYL 3 [2 (2 METHOXYETHOXY)ETHOXY]PROPIONAMIDE; 2 ACETAMIDO N BENZYL 3 ETHOXYPROPIONAMIDE; 2 ACETAMIDO N BENZYL 3 ISOPROPOXYPROPIONAMIDE; 2 ACETAMIDO N BENZYL 3 PHENOXYPROPIONAMIDE; 2 ACETAMIDO N BENZYL 3 TERT BUTOXYPROPIONAMIDE; HARKOSERIDE; PHENOBARBITAL; PHENYTOIN; PROPIONAMIDE DERIVATIVE; UNCLASSIFIED DRUG; VALPROIC ACID; VIMPAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; MOUSE; NONHUMAN; RAT; REACTION ANALYSIS; SEIZURE; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

ACETAMIDES; ANIMALS; ANTICONVULSANTS; BINDING SITES; MALE; MICE; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 52949086431     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.08.055     Document Type: Article

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