Structure-activity studies for a novel series of N-(arylethyl)-N- (1,2,3,4-tetrahydronaphthalen-1-ylmethyl)-N-methylamines possessing dual 5- HT uptake inhibiting and α2-antagonistic activities

Journal of Medicinal Chemistry

Volumn 40, Issue 7, 1997, Pages 1049-1062

  Meyer, Michael D ^a   Hancock, Arthur A ^a   Tietje, Karin ^a   Sippy, Kevin B ^a   Prasad, Rajnandan ^a   Stout, David M ^a   Arendsen, David L ^a   Donner, B Greg ^a   Carroll, William A ^a  

^a Neuroscience Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIDEPRESSANT AGENT; SEROTONIN UPTAKE INHIBITOR; TETRALIN DERIVATIVE;

ARTICLE; CHEMICAL MODIFICATION; DEPRESSION; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; CEREBRAL CORTEX; MAGNETIC RESONANCE SPECTROSCOPY; METHYLAMINES; RATS; RECEPTORS, ADRENERGIC, ALPHA-2; SEROTONIN UPTAKE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030890290     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960723m     Document Type: Article

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