-
1
-
-
0035888074
-
Estimating the world cancer burden: Globocan 2000
-
Parkin DM, Bray F, Ferlay J, Pisani P: Estimating the world cancer burden: globocan 2000. Int J Cancer 2001, 94:153-156
-
(2001)
Int J Cancer
, vol.94
, pp. 153-156
-
-
Parkin, D.M.1
Bray, F.2
Ferlay, J.3
Pisani, P.4
-
2
-
-
67650874081
-
Cancer statistics, 2009
-
Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ: Cancer statistics, 2009. CA Cancer J Clin 2009, 59:225-249
-
(2009)
CA Cancer J Clin
, vol.59
, pp. 225-249
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
Hao, Y.4
Xu, J.5
Thun, M.J.6
-
3
-
-
37249003928
-
Oncogene addiction: Setting the stage for molecularly targeted cancer therapy
-
DOI 10.1101/gad.1609907
-
Sharma SV, Settleman J: Oncogene addiction: setting the stage for molecularly targeted cancer therapy. Genes Dev 2007, 21:3214-3231 (Pubitemid 350277749)
-
(2007)
Genes and Development
, vol.21
, Issue.24
, pp. 3214-3231
-
-
Sharma, S.V.1
Settleman, J.2
-
4
-
-
0037392444
-
Issues and progress with protein kinase inhibitors for cancer treatment
-
Dancey J, Sausville EA: Issues and progress with protein kinase inhibitors for cancer treatment. Nat Rev Drug Discov 2003, 2:296-313 (Pubitemid 37361688)
-
(2003)
Nature Reviews Drug Discovery
, vol.2
, Issue.4
, pp. 296-313
-
-
Dancey, J.1
Sausville, E.A.2
-
5
-
-
0029831041
-
Quantitative immunohistochemical analysis of transforming growth factor- α and epidermal growth factor receptor in patients with squamous cell carcinoma of the head and neck
-
DOI 10.1002/(SICI)1097-0142(19960915)78:6<1284::AID-CNCR17>3.0. CO;2-X
-
Rubin GJ, Melhem MF, Barnes EL, Tweardy DJ: Quantitative immunohistochemical analysis of transforming growth factor-alpha and epidermal growth factor receptor in patients with squamous cell carcinoma of the head and neck. Cancer 1996, 78:1284-1292 (Pubitemid 26303896)
-
(1996)
Cancer
, vol.78
, Issue.6
, pp. 1284-1292
-
-
Grandis, J.R.1
Melhem, M.F.2
Barnes, E.L.3
Tweardy, D.J.4
-
6
-
-
18544387934
-
Expression of epidermal growth factor receptor in head and neck cancers correlates with clinical progression: A multicentre immunohistochemical study in the Asia-Pacific region
-
DOI 10.1046/j.1365-2559.2002.01436.x
-
Putti TC, To KF, Hsu HC, Chan AT, Lai GM, Tse G, Lee YS, Whang-Peng J, Millward M, Lin L, Lin X, Lee CS: Expression of epidermal growth factor receptor in head and neck cancers correlates with clinical progression: a multicentre immunohistochemical study in the Asia-Pacific region. Histopathology 2002, 41:144-151 (Pubitemid 34985187)
-
(2002)
Histopathology
, vol.41
, Issue.2
, pp. 144-151
-
-
Putti, T.C.1
To, K.F.2
Hsu, H.C.3
Chan, A.T.C.4
Lai, G.M.5
Tse, G.6
Lee, Y.S.7
Whang-Peng, J.8
Millward, M.9
Lin, L.10
Lin, X.11
Lee, C.S.12
-
7
-
-
49749113623
-
Expression and mutation analysis of epidermal growth factor receptor in head and neck squamous cell carcinoma
-
Sheikh Ali MA, Gunduz M, Nagatsuka H, Gunduz E, Cengiz B, Fukushima K, Beder LB, Demircan K, Fujii M, Yamanaka N, Shimizu K, Grenman R, Nagai N: Expression and mutation analysis of epidermal growth factor receptor in head and neck squamous cell carcinoma. Cancer Sci 2008, 99:1589-1594
-
(2008)
Cancer Sci
, vol.99
, pp. 1589-1594
-
-
Sheikh Ali, M.A.1
Gunduz, M.2
Nagatsuka, H.3
Gunduz, E.4
Cengiz, B.5
Fukushima, K.6
Beder, L.B.7
Demircan, K.8
Fujii, M.9
Yamanaka, N.10
Shimizu, K.11
Grenman, R.12
Nagai, N.13
-
8
-
-
34250155320
-
Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer
-
DOI 10.1200/JCO.2006.06.6605
-
Temam S, Kawaguchi H, El-Naggar AK, Jelinek J, Tang H, Liu DD, Lang W, Issa JP, Lee JJ, Mao L: Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer. J Clin Oncol 2007, 25:2164-2170 (Pubitemid 46954638)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.16
, pp. 2164-2170
-
-
Temam, S.1
Kawaguchi, H.2
El-Naggar, A.K.3
Jelinek, J.4
Tang, H.5
Liu, D.D.6
Lang, W.7
Issa, J.-P.8
Lee, J.J.9
Mao, L.10
-
9
-
-
23044482678
-
Epidermal growth factor receptor - Its expression and copy numbers of EGFR gene in patients with head and neck squamous cell carcinomas
-
Mrhalova M, Plzak J, Betka J, Kodet R: Epidermal growth factor receptor: its expression and copy numbers of EGFR gene in patients with head and neck squamous cell carcinomas. Neoplasma 2005, 52:338-343 (Pubitemid 41076203)
-
(2005)
Neoplasma
, vol.52
, Issue.4
, pp. 338-343
-
-
Mrhalova, M.1
Plzak, J.2
Betka, J.3
Kodet, R.4
-
10
-
-
33748653109
-
Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas
-
DOI 10.1200/JCO.2006.07.2587
-
Chung CH, Ely K, McGavran L, Varella-Garcia M, Parker J, Parker N, Jarrett C, Carter J, Murphy BA, Netterville J, Burkey BB, Sinard R, Cmelak A, Levy S, Yarbrough WG, Slebos RJ, Hirsch FR: Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas. J Clin Oncol 2006, 24:4170-4176 (Pubitemid 46622295)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.25
, pp. 4170-4176
-
-
Chung, C.H.1
Ely, K.2
McGavran, L.3
Varella-Garcia, M.4
Parker, J.5
Parker, N.6
Jarrett, C.7
Carter, J.8
Murphy, B.A.9
Netterville, J.10
Burkey, B.B.11
Sinard, R.12
Cmelak, A.13
Levy, S.14
Yarbrough, W.G.15
Slebos, R.J.C.16
Hirsch, F.R.17
-
11
-
-
0346645692
-
The role of epidermal growth factor receptor in head and neck squamous cell carcinoma
-
Pomerantz RG, Grandis JR: The role of epidermal growth factor receptor in head and neck squamous cell carcinoma. Curr Oncol Rep 2003, 5:140-146 (Pubitemid 38898776)
-
(2003)
Current Oncology Reports
, vol.5
, Issue.2
, pp. 140-146
-
-
Pomerantz, R.G.1
Grandis, J.R.2
-
12
-
-
67349108318
-
Dysregulated molecular networks in head and neck carcinogenesis
-
Molinolo AA, Amornphimoltham P, Squarize CH, Castilho RM, Patel V, Gutkind JS: Dysregulated molecular networks in head and neck carcinogenesis. Oral Oncol 2009, 45:324-334
-
(2009)
Oral Oncol
, vol.45
, pp. 324-334
-
-
Molinolo, A.A.1
Amornphimoltham, P.2
Squarize, C.H.3
Castilho, R.M.4
Patel, V.5
Gutkind, J.S.6
-
13
-
-
49649123885
-
The role of inhibitors of the epidermal growth factor in management of head and neck cancer
-
Brockstein B, Lacouture M, Agulnik M: The role of inhibitors of the epidermal growth factor in management of head and neck cancer. J Natl Compr Canc Netw 2008, 6:696-706
-
(2008)
J Natl Compr Canc Netw
, vol.6
, pp. 696-706
-
-
Brockstein, B.1
Lacouture, M.2
Agulnik, M.3
-
14
-
-
58149234368
-
The role of cetuximab for the treatment of squamous cell carcinoma of the head and neck
-
Mehra R, Cohen RB, Burtness BA: The role of cetuximab for the treatment of squamous cell carcinoma of the head and neck. Clin Adv Hematol Oncol 2008, 6:742-750
-
(2008)
Clin Adv Hematol Oncol
, vol.6
, pp. 742-750
-
-
Mehra, R.1
Cohen, R.B.2
Burtness, B.A.3
-
15
-
-
52949133777
-
EGFR inhibition as a therapy for head and neck squamous cell carcinoma
-
Loeffler-Ragg J, Schwentner I, Sprinzl GM, Zwierzina H: EGFR inhibition as a therapy for head and neck squamous cell carcinoma. Expert Opin Investig Drugs 2008, 17:1517-1531
-
(2008)
Expert Opin Investig Drugs
, vol.17
, pp. 1517-1531
-
-
Loeffler-Ragg, J.1
Schwentner, I.2
Sprinzl, G.M.3
Zwierzina, H.4
-
16
-
-
33847271170
-
Insulin-like growth factor-1 receptor and ligand targeting in head and neck squamous cell carcinoma
-
DOI 10.1016/j.canlet.2006.08.004, PII S0304383506004976
-
Slomiany MG, Black LA, Kibbey MM, Tingler MA, Day TA, Rosenzweig SA: Insulin-like growth factor-1 receptor and ligand targeting in head and neck squamous cell carcinoma. Cancer Lett 2007, 248: 269-279 (Pubitemid 46330562)
-
(2007)
Cancer Letters
, vol.248
, Issue.2
, pp. 269-279
-
-
Slomiany, M.G.1
Black, L.A.2
Kibbey, M.M.3
Tingler, M.A.4
Day, T.A.5
Rosenzweig, S.A.6
-
17
-
-
35848956117
-
Upregulation of IGF-2 and IGF-1 receptor expression in oral cancer cell lines
-
Brady G, Crean SJ, Naik P, Kapas S: Upregulation of IGF-2 and IGF-1 receptor expression in oral cancer cell lines. Int J Oncol 2007, 31: 875-881
-
(2007)
Int J Oncol
, vol.31
, pp. 875-881
-
-
Brady, G.1
Crean, S.J.2
Naik, P.3
Kapas, S.4
-
18
-
-
12944272024
-
Constitutive activation of stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo
-
DOI 10.1073/pnas.97.8.4227
-
Grandis JR, Drenning SD, Zeng Q, Watkins SC, Melhem MF, Endo S, Johnson DE, Huang L, He Y, Kim JD: Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc Natl Acad Sci U S A 2000, 97:4227-4232 (Pubitemid 30226115)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.8
, pp. 4227-4232
-
-
Grandis, J.R.1
Drenning, S.D.2
Zeng, Q.3
Watkins, S.C.4
Melhem, M.F.5
Endo, S.6
Johnson, D.E.7
Huang, L.8
He, Y.9
Kim, J.D.10
-
19
-
-
0036569522
-
Activation of Stat-3 as one of the early events in tobacco chewing-mediated oral carcinogenesis
-
DOI 10.1002/cncr.10499
-
Nagpal JK, Mishra R, Das BR: Activation of Stat-3 as one of the early events in tobacco chewing-mediated oral carcinogenesis. Cancer 2002, 94:2393-2400 (Pubitemid 34457120)
-
(2002)
Cancer
, vol.94
, Issue.9
, pp. 2393-2400
-
-
Nagpal, J.K.1
Mishra, R.2
Das, B.R.3
-
20
-
-
0037096876
-
Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma
-
Masuda M, Suzui M, Yasumatu R, Nakashima T, Kuratomi Y, Azuma K, Tomita K, Komiyama S, Weinstein IB: Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma. Cancer Res 2002, 62:3351-3355 (Pubitemid 34651376)
-
(2002)
Cancer Research
, vol.62
, Issue.12
, pp. 3351-3355
-
-
Masuda, M.1
Suzui, M.2
Yasumatu, R.3
Nakashima, T.4
Kuratomi, Y.5
Azuma, K.6
Tomita, K.7
Komiyama, S.8
Weinstein, I.B.9
-
21
-
-
0032885434
-
Constitutive activation of transcription factors NF-(kappa)B, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines
-
Ondrey FG, Dong G, Sunwoo J, Chen Z, Wolf JS, Crowl-Bancroft CV, Mukaida N, Van Waes C: Constitutive activation of transcription factors NF-(kappa)B, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines. Mol Carcinog 1999, 26:119-129
-
(1999)
Mol Carcinog
, vol.26
, pp. 119-129
-
-
Ondrey, F.G.1
Dong, G.2
Sunwoo, J.3
Chen, Z.4
Wolf, J.S.5
Crowl-Bancroft, C.V.6
Mukaida, N.7
Van Waes, C.8
-
22
-
-
0035840790
-
Enhanced IkappaB kinase activity is responsible for the augmented activity of NF-kappaB in human head and neck carcinoma cells
-
DOI 10.1016/S0304-3835(01)00611-5, PII S0304383501006115
-
Tamatani T, Azuma M, Aota K, Yamashita T, Bando T, Sato M: Enhanced IkappaB kinase activity is responsible for the augmented activity of NF-kappaB in human head and neck carcinoma cells. Cancer Lett 2001, 171:165-172 (Pubitemid 32772803)
-
(2001)
Cancer Letters
, vol.171
, Issue.2
, pp. 165-172
-
-
Tamatani, T.1
Azuma, M.2
Aota, K.3
Yamashita, T.4
Bando, T.5
Sato, M.6
-
23
-
-
0035892777
-
High expression levels of nuclear factor kappaB, IkappaB kinase α and akt kinase in squamous cell carcinoma of the oral cavity
-
DOI 10.1002/1097-0142(20011215)92:12<3037::AID-CNCR10171>3.0.CO;2-#
-
Nakayama H, Ikebe T, Beppu M, Shirasuna K: High expression levels of nuclear factor kappaB: IkappaB kinase alpha and Akt kinase in squamous cell carcinoma of the oral cavity. Cancer 2001, 92:3037-3044 (Pubitemid 33136198)
-
(2001)
Cancer
, vol.92
, Issue.12
, pp. 3037-3044
-
-
Nakayama, H.1
Ikebe, T.2
Beppu, M.3
Shirasuna, K.4
-
25
-
-
23844442112
-
Nuclear factor-kappaB pathway as a therapeutic target in head and neck squamous cell carcinoma: Pharmaceutical and molecular validation in human cell lines using Velcade and siRNA/NF-kappaB
-
Lun M, Zhang PL, Pellitteri PK, Law A, Kennedy TL, Brown RE: Nuclear factor-kappaB pathway as a therapeutic target in head and neck squamous cell carcinoma: pharmaceutical and molecular validation in human cell lines using Velcade and siRNA/NF-kappaB. Ann Clin Lab Sci 2005, 35:251-258 (Pubitemid 41176783)
-
(2005)
Annals of Clinical and Laboratory Science
, vol.35
, Issue.3
, pp. 251-258
-
-
Lun, M.1
Zhang, P.L.2
Pellitteri, P.K.3
Law, A.4
Kennedy, T.L.5
Brown, R.E.6
-
26
-
-
4043111378
-
Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling
-
DOI 10.1002/ijc.20333
-
Aggarwal S, Takada Y, Singh S, Myers JN, Aggarwal BB: Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling. Int J Cancer 2004, 111:679-692 (Pubitemid 39062889)
-
(2004)
International Journal of Cancer
, vol.111
, Issue.5
, pp. 679-692
-
-
Aggarwal, S.1
Takada, Y.2
Singh, S.3
Myers, J.N.4
Aggarwal, B.B.5
-
27
-
-
3042531148
-
Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: A potential target for UCN-01
-
DOI 10.1158/1078-0432.CCR-03-0249
-
Amornphimoltham P, Sriuranpong V, Patel V, Benavides F, Conti CJ, Sauk J, Sausville EA, Molinolo AA, Gutkind JS: Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01. Clin Cancer Res 2004, 10:4029-4037 (Pubitemid 38812478)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.12 I
, pp. 4029-4037
-
-
Amornphimoltham, P.1
Sriuranpong, V.2
Patel, V.3
Benavides, F.4
Conti, C.J.5
Sauk, J.6
Sausville, E.A.7
Molinolo, A.A.8
Gutkind, J.S.9
-
28
-
-
33645085614
-
The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck
-
Mandal M, Younes M, Swan EA, Jasser SA, Doan D, Yigitbasi O, McMurphey A, Ludwick J, El-Naggar AK, Bucana C, Mills GB, Myers JN: The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck. Oral Oncol 2006, 42:430-439
-
(2006)
Oral Oncol
, vol.42
, pp. 430-439
-
-
Mandal, M.1
Younes, M.2
Swan, E.A.3
Jasser, S.A.4
Doan, D.5
Yigitbasi, O.6
McMurphey, A.7
Ludwick, J.8
El-Naggar, A.K.9
Bucana, C.10
Mills, G.B.11
Myers, J.N.12
-
29
-
-
13244265590
-
Frequent genetic and biochemical alterations of the PI 3-K/AKT/PTEN pathway in head and neck squamous cell carcinoma
-
DOI 10.1002/ijc.20711
-
Pedrero JM, Carracedo DG, Pinto CM, Zapatero AH, Rodrigo JP, Nieto CS, Gonzalez MV: Frequent genetic and biochemical alterations of the PI 3-K/AKT/PTEN pathway in head and neck squamous cell carcinoma. Int J Cancer 2005, 114:242-248 (Pubitemid 40194293)
-
(2005)
International Journal of Cancer
, vol.114
, Issue.2
, pp. 242-248
-
-
Garcia, P.J.M.1
Garcia, C.D.2
Munoz, P.C.3
Herrero, Z.A.4
Rodrigo, J.P.5
Suarez, N.C.6
Gonzalez, M.V.7
-
30
-
-
19944430106
-
AKT, protein kinase C, and mitogen-activated protein kinase phosphorylation status in head and neck squamous cell carcinoma
-
DOI 10.1002/hed.20120
-
Tosi L, Rinaldi E, Carinci F, Farina A, Pastore A, Pelucchi S, Cassano L, Evangelisti R, Carinci P, Volinia S: Akt, protein kinase C, and mitogen-activated protein kinase phosphorylation status in head and neck squamous cell carcinoma. Head Neck 2005, 27:130-137 (Pubitemid 40194689)
-
(2005)
Head and Neck
, vol.27
, Issue.2
, pp. 130-137
-
-
Tosi, L.1
Rinaldi, E.2
Carinci, F.3
Farina, A.4
Pastore, A.5
Pelucchi, S.6
Cassano, L.7
Evangelisti, R.8
Carinci, P.9
Volinia, S.10
-
31
-
-
54449101189
-
Akt pathway as a target for therapeutic intervention in HNSCC
-
Moral M, Paramio JM: Akt pathway as a target for therapeutic intervention in HNSCC. Histol Histopathol 2008, 23:1269-1278
-
(2008)
Histol Histopathol
, vol.23
, pp. 1269-1278
-
-
Moral, M.1
Paramio, J.M.2
-
32
-
-
33846038402
-
Proteomic analysis reveals successive aberrations in protein expression from healthy mucosa to invasive head and neck cancer
-
DOI 10.1038/sj.onc.1209770, PII 1209770
-
Roesch-Ely M, Nees M, Karsai S, Ruess A, Bogumil R, Warnken U, Schnolzer M, Dietz A, Plinkert PK, Hofele C, Bosch FX: Proteomic analysis reveals successive aberrations in protein expression from healthy mucosa to invasive head and neck cancer. Oncogene 2007, 26:54-64 (Pubitemid 46067331)
-
(2007)
Oncogene
, vol.26
, Issue.1
, pp. 54-64
-
-
Roesch-Ely, M.1
Nees, M.2
Karsai, S.3
Ruess, A.4
Bogumil, R.5
Warnken, U.6
Schnolzer, M.7
Dietz, A.8
Plinkert, P.K.9
Hofele, C.10
Bosch, F.X.11
-
33
-
-
20844437570
-
Proteome-wide analysis of head and neck squamous cell carcinomas using laser-capture microdissection and tandem mass spectrometry
-
DOI 10.1016/j.oraloncology.2004.08.009, PII S1368837504001903
-
Baker H, Patel V, Molinolo AA, Shillitoe EJ, Ensley JF, Yoo GH, Meneses-Garcia A, Myers JN, El-Naggar AK, Gutkind JS, Hancock WS: Proteome-wide analysis of head and neck squamous cell carcinomas using laser-capture microdissection and tandem mass spectrometry. Oral Oncol 2005, 41:183-199 (Pubitemid 40202885)
-
(2005)
Oral Oncology
, vol.41
, Issue.2
, pp. 183-199
-
-
Baker, H.1
Patel, V.2
Molinolo, A.A.3
Shillitoe, E.J.4
Ensley, J.F.5
Yoo, G.H.6
Meneses-Garcia, A.7
Myers, J.N.8
El-Naggar, A.K.9
Gutkind, J.S.10
Hancock, W.S.11
-
34
-
-
39749160439
-
Proteomic analysis of laser-captured paraffin-embedded tissues: A molecular portrait of head and neck cancer progression
-
DOI 10.1158/1078-0432.CCR-07-1497
-
Patel V, Hood BL, Molinolo AA, Lee NH, Conrads TP, Braisted JC, Krizman DB, Veenstra TD, Gutkind JS: Proteomic analysis of laser-captured paraffin-embedded tissues: a molecular portrait of head and neck cancer progression. Clin Cancer Res 2008, 14:1002-1014 (Pubitemid 351302545)
-
(2008)
Clinical Cancer Research
, vol.14
, Issue.4
, pp. 1002-1014
-
-
Patel, V.1
Hood, B.L.2
Molinolo, A.A.3
Lee, N.H.4
Conrads, T.P.5
Braisted, J.C.6
Krizman, D.B.7
Veenstra, T.D.8
Gutkind, J.S.9
-
35
-
-
38049184430
-
Signal pathway profiling of epithelial and stromal compartments of colonic carcinoma reveals epithelial-mesenchymal transition
-
Sheehan KM, Gulmann C, Eichler GS, Weinstein JN, Barrett HL, Kay EW, Conroy RM, Liotta LA, Petricoin EF III, Sheehan KM, Gulmann C, Eichler GS, Weinstein JN, Barrett HL, Kay EW, Conroy RM, Liotta LA, Petricoin EF: Signal pathway profiling of epithelial and stromal compartments of colonic carcinoma reveals epithelial-mesenchymal transition. Oncogene 2008, 27:323-331
-
(2008)
Oncogene
, vol.27
, pp. 323-331
-
-
Sheehan, K.M.1
Gulmann, C.2
Eichler, G.S.3
Weinstein, J.N.4
Barrett, H.L.5
Kay, E.W.6
Conroy, R.M.7
Liotta, L.A.8
Petricoin III, E.F.9
Sheehan, K.M.10
Gulmann, C.11
Eichler, G.S.12
Weinstein, J.N.13
Barrett, H.L.14
Kay, E.W.15
Conroy, R.M.16
Liotta, L.A.17
Petricoin, E.F.18
-
36
-
-
45549107510
-
Multiplexed cell signaling analysis of human breast cancer applications for personalized therapy
-
Wulfkuhle JD, Speer R, Pierobon M, Laird J, Espina V, Deng J, Mammano E, Yang SX, Swain SM, Nitti D, Esserman LJ, Belluco C, Liotta LA, Petricoin EF III: Multiplexed cell signaling analysis of human breast cancer applications for personalized therapy. J Proteome Res 2008, 7:1508-1517
-
(2008)
J Proteome Res
, vol.7
, pp. 1508-1517
-
-
Wulfkuhle, J.D.1
Speer, R.2
Pierobon, M.3
Laird, J.4
Espina, V.5
Deng, J.6
Mammano, E.7
Yang, S.X.8
Swain, S.M.9
Nitti, D.10
Esserman, L.J.11
Belluco, C.12
Liotta, L.A.13
Petricoin III, E.F.14
-
37
-
-
0027377043
-
Immunohistochemical determination of estrogen and progesterone receptor content in human breast cancer: Computer assisted image analysis (QIC score) vs. subjective grading (IRS)
-
Remmele W, Schicketanz KH: Immunohistochemical determination of estrogen and progesterone receptor content in human breast cancer: computer-assisted image analysis (QIC score) vs. subjective grading (IRS). Pathol Res Pract 1993, 189:862-866 (Pubitemid 23308006)
-
(1993)
Pathology Research and Practice
, vol.189
, Issue.8
, pp. 862-866
-
-
Remmele, W.1
Schicketanz, K.-H.2
-
38
-
-
34547110110
-
Quantitative phosphoproteomics of early elicitor signaling in Arabidopsis
-
DOI 10.1074/mcp.M600429-MCP200
-
Benschop JJ, Mohammed S, O'Flaherty M, Heck AJ, Slijper M, Menke FL, Benschop JJ, Mohammed S, O'Flaherty M, Heck AJR, Slijper M, Menke FLH: Quantitative phosphoproteomics of early elicitor signaling in Arabidopsis. Mol Cell Proteomics 2007, 6:1198-1214 (Pubitemid 47099230)
-
(2007)
Molecular and Cellular Proteomics
, vol.6
, Issue.7
, pp. 1198-1214
-
-
Benschop, J.J.1
Mohammed, S.2
O'Flaherty, M.3
Heck, A.J.R.4
Slijper, M.5
Menke, F.L.H.6
-
39
-
-
26444555647
-
Clinical proteomics: From biomarker discovery and cell signaling profiles to individualized personal therapy
-
DOI 10.1007/s10540-005-2851-3
-
Calvo KR, Liotta LA, Petricoin EF: Clinical proteomics: from biomarker discovery and cell signaling profiles to individualized personal therapy. Biosci Rep 2005, 25:107-125 (Pubitemid 41437713)
-
(2005)
Bioscience Reports
, vol.25
, Issue.1-2
, pp. 107-125
-
-
Calvo, K.R.1
Liotta, L.A.2
Petricoin, E.F.3
-
40
-
-
25444531988
-
Atypical protein kinase Ciota is an oncogene in human non-small cell lung cancer
-
DOI 10.1158/0008-5472.CAN-05-2372
-
Regala RP, Weems C, Jamieson L, Khoor A, Edell ES, Lohse CM, Fields AP, Regala RP, Weems C, Jamieson L, Khoor A, Edell ES, Lohse CM, Fields AP: Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer. Cancer Res 2005, 65:8905-8911 (Pubitemid 41377380)
-
(2005)
Cancer Research
, vol.65
, Issue.19
, pp. 8905-8911
-
-
Regala, R.P.1
Weems, C.2
Jamieson, L.3
Khoor, A.4
Edell, E.S.5
Lohse, C.M.6
Fields, A.P.7
-
41
-
-
20444447110
-
Stability of phosphoprotein as a biological marker of tumor signaling
-
Baker AF, Dragovich T, Ihle NT, Williams R, Fenoglio-Preiser C, Powis G, Baker AF, Dragovich T, Ihle NT, Williams R, Fenoglio-Preiser C, Powis G: Stability of phosphoprotein as a biological marker of tumor signaling. Clin Cancer Res 2005, 11:4338-4340
-
(2005)
Clin Cancer Res
, vol.11
, pp. 4338-4340
-
-
Baker, A.F.1
Dragovich, T.2
Ihle, N.T.3
Williams, R.4
Fenoglio-Preiser, C.5
Powis, G.6
Baker, A.F.7
Dragovich, T.8
Ihle, N.T.9
Williams, R.10
Fenoglio-Preiser, C.11
Powis, G.12
-
42
-
-
34147206546
-
Specific role of Chk1 phosphorylations in cell survival and checkpoint activation
-
DOI 10.1128/MCB.01611-06
-
Niida H, Katsuno Y, Banerjee B, Hande MP, Nakanishi M: Specific role of Chk1 phosphorylations in cell survival and checkpoint activation. Mol Cell Biol 2007, 27:2572-2581 (Pubitemid 46581348)
-
(2007)
Molecular and Cellular Biology
, vol.27
, Issue.7
, pp. 2572-2581
-
-
Niida, H.1
Katsuno, Y.2
Banerjee, B.3
Hande, M.P.4
Nakanishi, M.5
-
43
-
-
0034617281
-
A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta) and PKC- Related kinase 2 by PDK1
-
DOI 10.1074/jbc.M000421200
-
Balendran A, Biondi RM, Cheung PC, Casamayor A, Deak M, Alessi DR, Balendran A, Biondi RM, Cheung PC, Casamayor A, Deak M, Alessi DR: A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta) and PKC-related kinase 2 by PDK1. J Biol Chem 2000, 275:20806-20813 (Pubitemid 30457673)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.27
, pp. 20806-20813
-
-
Balendran, A.1
Biondi, R.M.2
Cheung, P.C.F.3
Casamayor, A.4
Deak, M.5
Alessi, D.R.6
-
44
-
-
0032563936
-
Regulation of protein kinase C zeta by PI 3-kinase and PDK-1
-
Chou MM, Hou W, Johnson J, Graham LK, Lee MH, Chen CS, Newton AC, Schaffhausen BS, Toker A: Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. Curr Biol 1998, 8:1069-1077 (Pubitemid 28451031)
-
(1998)
Current Biology
, vol.8
, Issue.19
, pp. 1069-1077
-
-
Chou, M.M.1
Hou, W.2
Johnson, J.3
Graham, L.K.4
Lee, M.H.5
Chen, C.-S.6
Newton, A.C.7
Schaffhausen, B.S.8
Toker, A.9
-
45
-
-
0032566691
-
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
-
DOI 10.1126/science.281.5385.2042
-
Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ, Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ: Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science 1998, 281:2042-2045 (Pubitemid 28475494)
-
(1998)
Science
, vol.281
, Issue.5385
, pp. 2042-2045
-
-
Le, G.J.A.1
Ziegler, W.H.2
Parekh, D.B.3
Alessi, D.R.4
Cohen, P.5
Parker, P.J.6
-
46
-
-
0036969141
-
Amplification of the 3q26.3 locus is associated with progression to invasive cancer and is a negative prognostic factor in head and neck squamous cell carcinomas
-
Singh B, Stoffel A, Gogineni S, Poluri A, Pfister DG, Shaha AR, Pathak A, Bosl G, Cordon-Cardo C, Shah JP, Rao PH, Singh B, Stoffel A, Gogineni S, Poluri A, Pfister DG, Shaha AR, Pathak A, Bosl G, Cordon-Cardo C, Shah JP, Rao PH: Amplification of the 3q26.3 locus is associated with progression to invasive cancer and is a negative prognostic factor in head and neck squamous cell carcinomas. Am J Pathol 2002, 161:365-371 (Pubitemid 36142144)
-
(2002)
American Journal of Pathology
, vol.161
, Issue.2
, pp. 365-371
-
-
Singh, B.1
Stoffel, A.2
Gogineni, S.3
Poluri, A.4
Pfister, D.G.5
Shaha, A.R.6
Pathak, A.7
Bosl, G.8
Cordon-Cardo, C.9
Shah, J.P.10
Rao, P.H.11
-
47
-
-
70350074501
-
Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation
-
Justilien V, Fields AP: Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation. Oncogene 2009, 28: 3597-3607
-
(2009)
Oncogene
, vol.28
, pp. 3597-3607
-
-
Justilien, V.1
Fields, A.P.2
-
48
-
-
0033151533
-
Constitutive activation of extracellular signal-regulated kinase in human acute leukemias: Combined role of activation of MEK, hyperexpression of extracellular signal-regulated kinase, and downregulation of a phosphatase
-
Kim SC, Hahn JS, Min YH, Yoo NC, Ko YW, Lee WJ: Constitutive activation of extracellular signal-regulated kinase in human acute leukemias: combined role of activation of MEK, hyperexpression of extracellular signal-regulated kinase, and downregulation of a phosphatase. PAC1 Blood 1999, 93:3893-3899
-
(1999)
PAC1 Blood
, vol.93
, pp. 3893-3899
-
-
Kim, S.C.1
Hahn, J.S.2
Min, Y.H.3
Yoo, N.C.4
Ko, Y.W.5
Lee, W.J.6
-
49
-
-
0028046339
-
Ras Mutations and expression in head and neck squamous cell carcinomas
-
Yarbrough WG, Shores C, Witsell DL, Weissler MC, Fidler ME, Gilmer TM: ras mutations and expression in head and neck squamous cell carcinomas. Laryngoscope 1994, 104(pt 1):1337-1347 (Pubitemid 24346961)
-
(1994)
Laryngoscope
, vol.104
, Issue.11 I
, pp. 1337-1347
-
-
Yarbrough, W.G.1
Shores, C.2
Witsell, D.L.3
Weissler, M.C.4
Fidler, M.E.5
Gilmer, T.M.6
-
50
-
-
0028500793
-
Immunohistochemical detection of the H-ras, K-ras, and N-ras oncogenes in squamous cell carcinoma of the head and neck
-
McDonald JS, Jones H, Pavelic ZP, Pavelic LJ, Stambrook PJ, Gluckman JL: Immunohistochemical detection of the H-ras, K-ras, and N-ras oncogenes in squamous cell carcinoma of the head and neck. J Oral Pathol Med 1994, 23:342-346 (Pubitemid 2150698)
-
(1994)
Journal of Oral Pathology and Medicine
, vol.23
, Issue.8
, pp. 342-346
-
-
McDonald, J.S.1
Jones, H.2
Pavelic, Z.P.3
Pavelic, L.J.4
Stambrook, P.J.5
Gluckman, J.L.6
-
51
-
-
0037287298
-
Protein kinase C lambda/iota PKClambda/iota: A PKC isotype essential for the development of multicellular organisms
-
DOI 10.1093/jb/mvg018
-
Suzuki A, Akimoto K, Ohno S: Protein kinase C lambda/iota (PKClambda/iota): a PKC isotype essential for the development of multicellular organisms. J Biochem 2003, 133:9-16 (Pubitemid 36240973)
-
(2003)
Journal of Biochemistry
, vol.133
, Issue.1
, pp. 9-16
-
-
Suzuki, A.1
Akimoto, K.2
Ohno, S.3
-
52
-
-
38449103501
-
Role of activated nuclear factor-kappaB in the pathogenesis and therapy of squamous cell carcinoma of the head and neck
-
Allen CT, Ricker JL, Chen Z, Van Waes C: Role of activated nuclear factor-kappaB in the pathogenesis and therapy of squamous cell carcinoma of the head and neck. Head Neck 2007, 29:959-971
-
(2007)
Head Neck
, vol.29
, pp. 959-971
-
-
Allen, C.T.1
Ricker, J.L.2
Chen, Z.3
Van Waes, C.4
-
53
-
-
27144459692
-
Phosphorylation of Re1A/p65 on serine 536 defines an IkappaBalpha- Independent NF-kappaB pathway
-
DOI 10.1074/jbc.M504943200
-
Sasaki CY, Barberi TJ, Ghosh P, Longo DL: Phosphorylation of RelA/ p65 on serine 536 defines an I{kappa}B{alpha}-independent NF-{kappa}B pathway. J Biol Chem 2005, 280:34538-34547 (Pubitemid 41504584)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.41
, pp. 34538-34547
-
-
Sasaki, C.Y.1
Barberi, T.J.2
Ghosh, P.3
Longo, D.L.4
-
54
-
-
0036118391
-
Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways
-
DOI 10.1038/sj/neo/7900219
-
Tian H, Faje AT, Lee SL, Jorgensen TJ: Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways. Neoplasia 2002, 4:171-180 (Pubitemid 34218685)
-
(2002)
Neoplasia
, vol.4
, Issue.2
, pp. 171-180
-
-
Tian, H.1
Faje, A.T.2
Lee, S.L.3
Jorgensen, T.J.4
-
55
-
-
33750340969
-
DNA damage-induced cell cycle regulation and function of novel Chk2 phosphoresidues
-
DOI 10.1128/MCB.00534-06
-
Buscemi G, Carlessi L, Zannini L, Lisanti S, Fontanella E, Canevari S, Delia D: DNA damage-induced cell cycle regulation and function of novel Chk2 phosphoresidues. Mol Cell Biol 2006, 26:7832-7845 (Pubitemid 44630985)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.21
, pp. 7832-7845
-
-
Buscemi, G.1
Carlessi, L.2
Zannini, L.3
Lisanti, S.4
Fontanella, E.5
Canevari, S.6
Delia, D.7
-
56
-
-
17244367849
-
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
-
DOI 10.1038/nature03482
-
Bartkova J, Horejsi Z, Koed K, Kramer A, Tort F, Zieger K, Guldberg P, Sehested M, Nesland JM, Lukas C, Orntoft T, Lukas J, Bartek J: DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005, 434:864-870 (Pubitemid 40558993)
-
(2005)
Nature
, vol.434
, Issue.7035
, pp. 864-870
-
-
Bartkova, J.1
Horejsi, Z.2
Koed, K.3
Kramer, A.4
Tort, F.5
Zleger, K.6
Guldberg, P.7
Sehested, M.8
Nesland, J.M.9
Lukas, C.10
Orntoft, T.11
Lukas, J.12
Bartek, J.13
-
57
-
-
43749120045
-
DNA repair deficiency as a therapeutic target in cancer
-
DOI 10.1016/j.gde.2008.01.016, PII S0959437X0800021X
-
Martin SA, Lord CJ, Ashworth A: DNA repair deficiency as a therapeutic target in cancer. Curr Opin Genet Dev 2008, 18:80-86 (Pubitemid 351694447)
-
(2008)
Current Opinion in Genetics and Development
, vol.18
, Issue.1
, pp. 80-86
-
-
Martin, S.A.1
Lord, C.J.2
Ashworth, A.3
-
58
-
-
3242880578
-
Constitutively active DNA damage checkpoint pathways as the driving force for the high frequency of p53 mutations in human cancer
-
review
-
Halazonetis TD: Constitutively active DNA damage checkpoint pathways as the driving force for the high frequency of p53 mutations in human cancer [review]. DNA Repair 2004, 3:1057-1062
-
(2004)
DNA Repair
, vol.3
, pp. 1057-1062
-
-
Halazonetis, T.D.1
-
59
-
-
34247481285
-
Targeting checkpoint kinase 1 in cancer therapeutics
-
DOI 10.1158/1078-0432.CCR-06-2793
-
Tse AN, Carvajal R, Schwartz GK: Targeting checkpoint kinase 1 in cancer therapeutics. Clin Cancer Res 2007, 13:1955-1960 (Pubitemid 46649860)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.7
, pp. 1955-1960
-
-
Tse, A.N.1
Carvajal, R.2
Schwartz, G.K.3
-
60
-
-
2342489456
-
EIF-4E expression and its role in malignancies and metastases
-
DOI 10.1038/sj.onc.1207545
-
De Benedetti A, Graff JR: eIF-4E expression and its role in malignancies and metastases. Oncogene 2004, 23:3189-3199 (Pubitemid 38638830)
-
(2004)
Oncogene
, vol.23
, Issue.18
, pp. 3189-3199
-
-
De, B.A.1
Graff, J.R.2
-
61
-
-
61749103876
-
Stability of eukaryotic translation initiation factor 4E mRNA is regulated by HuR, and this activity is dysregulated in cancer
-
Topisirovic I, Siddiqui N, Orolicki S, Skrabanek LA, Tremblay M, Hoang T, Borden KL: Stability of eukaryotic translation initiation factor 4E mRNA is regulated by HuR, and this activity is dysregulated in cancer. Mol Cell Biol 2009, 29:1152-1162
-
(2009)
Mol Cell Biol
, vol.29
, pp. 1152-1162
-
-
Topisirovic, I.1
Siddiqui, N.2
Orolicki, S.3
Skrabanek, L.A.4
Tremblay, M.5
Hoang, T.6
Borden, K.L.7
-
62
-
-
73449136900
-
Understanding and targeting the eukaryotic translation initiation factor eIF4E in head and neck cancer
-
Culjkovic B, Borden KL: Understanding and targeting the eukaryotic translation initiation factor eIF4E in head and neck cancer. J Oncol 2009, 2009:981679
-
(2009)
J Oncol
, vol.2009
, pp. 981679
-
-
Culjkovic, B.1
Borden, K.L.2
-
63
-
-
34250755685
-
Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation
-
Mamane Y, Petroulakis E, Martineau Y, Sato TA, Larsson O, Rajasekhar VK, Sonenberg N: Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation. PLoS One 2007, 2:e242
-
(2007)
PLoS One
, vol.2
-
-
Mamane, Y.1
Petroulakis, E.2
Martineau, Y.3
Sato, T.A.4
Larsson, O.5
Rajasekhar, V.K.6
Sonenberg, N.7
-
64
-
-
33745699726
-
Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase
-
Cohen EE, Lingen MW, Zhu B, Zhu H, Straza MW, Pierce C, Martin LE, Rosner MR: Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase. Cancer Res 2006, 66:6296-6303
-
(2006)
Cancer Res
, vol.66
, pp. 6296-6303
-
-
Cohen, E.E.1
Lingen, M.W.2
Zhu, B.3
Zhu, H.4
Straza, M.W.5
Pierce, C.6
Martin, L.E.7
Rosner, M.R.8
|