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Volumn 178, Issue 2, 2011, Pages 548-571

Phosphoproteomic analysis of signaling pathways in head and neck squamous cell carcinoma patient samples

Author keywords

[No Author keywords available]

Indexed keywords

CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; EUKARYOTIC TRANSLATION INITIATION FACTOR 4E BINDING PROTEIN 1; I KAPPA B ALPHA; I KAPPA B KINASE INHIBITOR; INITIATION FACTOR 4E; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN BAD; PROTEIN KINASE C; PROTEIN KINASE LKB1; SMAD2 PROTEIN; STAT3 PROTEIN; UNCLASSIFIED DRUG;

EID: 79951838654     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2010.10.044     Document Type: Article
Times cited : (39)

References (64)
  • 1
    • 0035888074 scopus 로고    scopus 로고
    • Estimating the world cancer burden: Globocan 2000
    • Parkin DM, Bray F, Ferlay J, Pisani P: Estimating the world cancer burden: globocan 2000. Int J Cancer 2001, 94:153-156
    • (2001) Int J Cancer , vol.94 , pp. 153-156
    • Parkin, D.M.1    Bray, F.2    Ferlay, J.3    Pisani, P.4
  • 3
    • 37249003928 scopus 로고    scopus 로고
    • Oncogene addiction: Setting the stage for molecularly targeted cancer therapy
    • DOI 10.1101/gad.1609907
    • Sharma SV, Settleman J: Oncogene addiction: setting the stage for molecularly targeted cancer therapy. Genes Dev 2007, 21:3214-3231 (Pubitemid 350277749)
    • (2007) Genes and Development , vol.21 , Issue.24 , pp. 3214-3231
    • Sharma, S.V.1    Settleman, J.2
  • 4
    • 0037392444 scopus 로고    scopus 로고
    • Issues and progress with protein kinase inhibitors for cancer treatment
    • Dancey J, Sausville EA: Issues and progress with protein kinase inhibitors for cancer treatment. Nat Rev Drug Discov 2003, 2:296-313 (Pubitemid 37361688)
    • (2003) Nature Reviews Drug Discovery , vol.2 , Issue.4 , pp. 296-313
    • Dancey, J.1    Sausville, E.A.2
  • 5
    • 0029831041 scopus 로고    scopus 로고
    • Quantitative immunohistochemical analysis of transforming growth factor- α and epidermal growth factor receptor in patients with squamous cell carcinoma of the head and neck
    • DOI 10.1002/(SICI)1097-0142(19960915)78:6<1284::AID-CNCR17>3.0. CO;2-X
    • Rubin GJ, Melhem MF, Barnes EL, Tweardy DJ: Quantitative immunohistochemical analysis of transforming growth factor-alpha and epidermal growth factor receptor in patients with squamous cell carcinoma of the head and neck. Cancer 1996, 78:1284-1292 (Pubitemid 26303896)
    • (1996) Cancer , vol.78 , Issue.6 , pp. 1284-1292
    • Grandis, J.R.1    Melhem, M.F.2    Barnes, E.L.3    Tweardy, D.J.4
  • 6
    • 18544387934 scopus 로고    scopus 로고
    • Expression of epidermal growth factor receptor in head and neck cancers correlates with clinical progression: A multicentre immunohistochemical study in the Asia-Pacific region
    • DOI 10.1046/j.1365-2559.2002.01436.x
    • Putti TC, To KF, Hsu HC, Chan AT, Lai GM, Tse G, Lee YS, Whang-Peng J, Millward M, Lin L, Lin X, Lee CS: Expression of epidermal growth factor receptor in head and neck cancers correlates with clinical progression: a multicentre immunohistochemical study in the Asia-Pacific region. Histopathology 2002, 41:144-151 (Pubitemid 34985187)
    • (2002) Histopathology , vol.41 , Issue.2 , pp. 144-151
    • Putti, T.C.1    To, K.F.2    Hsu, H.C.3    Chan, A.T.C.4    Lai, G.M.5    Tse, G.6    Lee, Y.S.7    Whang-Peng, J.8    Millward, M.9    Lin, L.10    Lin, X.11    Lee, C.S.12
  • 8
    • 34250155320 scopus 로고    scopus 로고
    • Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer
    • DOI 10.1200/JCO.2006.06.6605
    • Temam S, Kawaguchi H, El-Naggar AK, Jelinek J, Tang H, Liu DD, Lang W, Issa JP, Lee JJ, Mao L: Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer. J Clin Oncol 2007, 25:2164-2170 (Pubitemid 46954638)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.16 , pp. 2164-2170
    • Temam, S.1    Kawaguchi, H.2    El-Naggar, A.K.3    Jelinek, J.4    Tang, H.5    Liu, D.D.6    Lang, W.7    Issa, J.-P.8    Lee, J.J.9    Mao, L.10
  • 9
    • 23044482678 scopus 로고    scopus 로고
    • Epidermal growth factor receptor - Its expression and copy numbers of EGFR gene in patients with head and neck squamous cell carcinomas
    • Mrhalova M, Plzak J, Betka J, Kodet R: Epidermal growth factor receptor: its expression and copy numbers of EGFR gene in patients with head and neck squamous cell carcinomas. Neoplasma 2005, 52:338-343 (Pubitemid 41076203)
    • (2005) Neoplasma , vol.52 , Issue.4 , pp. 338-343
    • Mrhalova, M.1    Plzak, J.2    Betka, J.3    Kodet, R.4
  • 11
    • 0346645692 scopus 로고    scopus 로고
    • The role of epidermal growth factor receptor in head and neck squamous cell carcinoma
    • Pomerantz RG, Grandis JR: The role of epidermal growth factor receptor in head and neck squamous cell carcinoma. Curr Oncol Rep 2003, 5:140-146 (Pubitemid 38898776)
    • (2003) Current Oncology Reports , vol.5 , Issue.2 , pp. 140-146
    • Pomerantz, R.G.1    Grandis, J.R.2
  • 13
    • 49649123885 scopus 로고    scopus 로고
    • The role of inhibitors of the epidermal growth factor in management of head and neck cancer
    • Brockstein B, Lacouture M, Agulnik M: The role of inhibitors of the epidermal growth factor in management of head and neck cancer. J Natl Compr Canc Netw 2008, 6:696-706
    • (2008) J Natl Compr Canc Netw , vol.6 , pp. 696-706
    • Brockstein, B.1    Lacouture, M.2    Agulnik, M.3
  • 14
    • 58149234368 scopus 로고    scopus 로고
    • The role of cetuximab for the treatment of squamous cell carcinoma of the head and neck
    • Mehra R, Cohen RB, Burtness BA: The role of cetuximab for the treatment of squamous cell carcinoma of the head and neck. Clin Adv Hematol Oncol 2008, 6:742-750
    • (2008) Clin Adv Hematol Oncol , vol.6 , pp. 742-750
    • Mehra, R.1    Cohen, R.B.2    Burtness, B.A.3
  • 16
    • 33847271170 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 receptor and ligand targeting in head and neck squamous cell carcinoma
    • DOI 10.1016/j.canlet.2006.08.004, PII S0304383506004976
    • Slomiany MG, Black LA, Kibbey MM, Tingler MA, Day TA, Rosenzweig SA: Insulin-like growth factor-1 receptor and ligand targeting in head and neck squamous cell carcinoma. Cancer Lett 2007, 248: 269-279 (Pubitemid 46330562)
    • (2007) Cancer Letters , vol.248 , Issue.2 , pp. 269-279
    • Slomiany, M.G.1    Black, L.A.2    Kibbey, M.M.3    Tingler, M.A.4    Day, T.A.5    Rosenzweig, S.A.6
  • 17
    • 35848956117 scopus 로고    scopus 로고
    • Upregulation of IGF-2 and IGF-1 receptor expression in oral cancer cell lines
    • Brady G, Crean SJ, Naik P, Kapas S: Upregulation of IGF-2 and IGF-1 receptor expression in oral cancer cell lines. Int J Oncol 2007, 31: 875-881
    • (2007) Int J Oncol , vol.31 , pp. 875-881
    • Brady, G.1    Crean, S.J.2    Naik, P.3    Kapas, S.4
  • 19
    • 0036569522 scopus 로고    scopus 로고
    • Activation of Stat-3 as one of the early events in tobacco chewing-mediated oral carcinogenesis
    • DOI 10.1002/cncr.10499
    • Nagpal JK, Mishra R, Das BR: Activation of Stat-3 as one of the early events in tobacco chewing-mediated oral carcinogenesis. Cancer 2002, 94:2393-2400 (Pubitemid 34457120)
    • (2002) Cancer , vol.94 , Issue.9 , pp. 2393-2400
    • Nagpal, J.K.1    Mishra, R.2    Das, B.R.3
  • 20
    • 0037096876 scopus 로고    scopus 로고
    • Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma
    • Masuda M, Suzui M, Yasumatu R, Nakashima T, Kuratomi Y, Azuma K, Tomita K, Komiyama S, Weinstein IB: Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma. Cancer Res 2002, 62:3351-3355 (Pubitemid 34651376)
    • (2002) Cancer Research , vol.62 , Issue.12 , pp. 3351-3355
    • Masuda, M.1    Suzui, M.2    Yasumatu, R.3    Nakashima, T.4    Kuratomi, Y.5    Azuma, K.6    Tomita, K.7    Komiyama, S.8    Weinstein, I.B.9
  • 21
    • 0032885434 scopus 로고    scopus 로고
    • Constitutive activation of transcription factors NF-(kappa)B, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines
    • Ondrey FG, Dong G, Sunwoo J, Chen Z, Wolf JS, Crowl-Bancroft CV, Mukaida N, Van Waes C: Constitutive activation of transcription factors NF-(kappa)B, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines. Mol Carcinog 1999, 26:119-129
    • (1999) Mol Carcinog , vol.26 , pp. 119-129
    • Ondrey, F.G.1    Dong, G.2    Sunwoo, J.3    Chen, Z.4    Wolf, J.S.5    Crowl-Bancroft, C.V.6    Mukaida, N.7    Van Waes, C.8
  • 22
    • 0035840790 scopus 로고    scopus 로고
    • Enhanced IkappaB kinase activity is responsible for the augmented activity of NF-kappaB in human head and neck carcinoma cells
    • DOI 10.1016/S0304-3835(01)00611-5, PII S0304383501006115
    • Tamatani T, Azuma M, Aota K, Yamashita T, Bando T, Sato M: Enhanced IkappaB kinase activity is responsible for the augmented activity of NF-kappaB in human head and neck carcinoma cells. Cancer Lett 2001, 171:165-172 (Pubitemid 32772803)
    • (2001) Cancer Letters , vol.171 , Issue.2 , pp. 165-172
    • Tamatani, T.1    Azuma, M.2    Aota, K.3    Yamashita, T.4    Bando, T.5    Sato, M.6
  • 23
    • 0035892777 scopus 로고    scopus 로고
    • High expression levels of nuclear factor kappaB, IkappaB kinase α and akt kinase in squamous cell carcinoma of the oral cavity
    • DOI 10.1002/1097-0142(20011215)92:12<3037::AID-CNCR10171>3.0.CO;2-#
    • Nakayama H, Ikebe T, Beppu M, Shirasuna K: High expression levels of nuclear factor kappaB: IkappaB kinase alpha and Akt kinase in squamous cell carcinoma of the oral cavity. Cancer 2001, 92:3037-3044 (Pubitemid 33136198)
    • (2001) Cancer , vol.92 , Issue.12 , pp. 3037-3044
    • Nakayama, H.1    Ikebe, T.2    Beppu, M.3    Shirasuna, K.4
  • 25
    • 23844442112 scopus 로고    scopus 로고
    • Nuclear factor-kappaB pathway as a therapeutic target in head and neck squamous cell carcinoma: Pharmaceutical and molecular validation in human cell lines using Velcade and siRNA/NF-kappaB
    • Lun M, Zhang PL, Pellitteri PK, Law A, Kennedy TL, Brown RE: Nuclear factor-kappaB pathway as a therapeutic target in head and neck squamous cell carcinoma: pharmaceutical and molecular validation in human cell lines using Velcade and siRNA/NF-kappaB. Ann Clin Lab Sci 2005, 35:251-258 (Pubitemid 41176783)
    • (2005) Annals of Clinical and Laboratory Science , vol.35 , Issue.3 , pp. 251-258
    • Lun, M.1    Zhang, P.L.2    Pellitteri, P.K.3    Law, A.4    Kennedy, T.L.5    Brown, R.E.6
  • 26
    • 4043111378 scopus 로고    scopus 로고
    • Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling
    • DOI 10.1002/ijc.20333
    • Aggarwal S, Takada Y, Singh S, Myers JN, Aggarwal BB: Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling. Int J Cancer 2004, 111:679-692 (Pubitemid 39062889)
    • (2004) International Journal of Cancer , vol.111 , Issue.5 , pp. 679-692
    • Aggarwal, S.1    Takada, Y.2    Singh, S.3    Myers, J.N.4    Aggarwal, B.B.5
  • 31
    • 54449101189 scopus 로고    scopus 로고
    • Akt pathway as a target for therapeutic intervention in HNSCC
    • Moral M, Paramio JM: Akt pathway as a target for therapeutic intervention in HNSCC. Histol Histopathol 2008, 23:1269-1278
    • (2008) Histol Histopathol , vol.23 , pp. 1269-1278
    • Moral, M.1    Paramio, J.M.2
  • 32
  • 37
    • 0027377043 scopus 로고
    • Immunohistochemical determination of estrogen and progesterone receptor content in human breast cancer: Computer assisted image analysis (QIC score) vs. subjective grading (IRS)
    • Remmele W, Schicketanz KH: Immunohistochemical determination of estrogen and progesterone receptor content in human breast cancer: computer-assisted image analysis (QIC score) vs. subjective grading (IRS). Pathol Res Pract 1993, 189:862-866 (Pubitemid 23308006)
    • (1993) Pathology Research and Practice , vol.189 , Issue.8 , pp. 862-866
    • Remmele, W.1    Schicketanz, K.-H.2
  • 38
    • 34547110110 scopus 로고    scopus 로고
    • Quantitative phosphoproteomics of early elicitor signaling in Arabidopsis
    • DOI 10.1074/mcp.M600429-MCP200
    • Benschop JJ, Mohammed S, O'Flaherty M, Heck AJ, Slijper M, Menke FL, Benschop JJ, Mohammed S, O'Flaherty M, Heck AJR, Slijper M, Menke FLH: Quantitative phosphoproteomics of early elicitor signaling in Arabidopsis. Mol Cell Proteomics 2007, 6:1198-1214 (Pubitemid 47099230)
    • (2007) Molecular and Cellular Proteomics , vol.6 , Issue.7 , pp. 1198-1214
    • Benschop, J.J.1    Mohammed, S.2    O'Flaherty, M.3    Heck, A.J.R.4    Slijper, M.5    Menke, F.L.H.6
  • 39
    • 26444555647 scopus 로고    scopus 로고
    • Clinical proteomics: From biomarker discovery and cell signaling profiles to individualized personal therapy
    • DOI 10.1007/s10540-005-2851-3
    • Calvo KR, Liotta LA, Petricoin EF: Clinical proteomics: from biomarker discovery and cell signaling profiles to individualized personal therapy. Biosci Rep 2005, 25:107-125 (Pubitemid 41437713)
    • (2005) Bioscience Reports , vol.25 , Issue.1-2 , pp. 107-125
    • Calvo, K.R.1    Liotta, L.A.2    Petricoin, E.F.3
  • 40
    • 25444531988 scopus 로고    scopus 로고
    • Atypical protein kinase Ciota is an oncogene in human non-small cell lung cancer
    • DOI 10.1158/0008-5472.CAN-05-2372
    • Regala RP, Weems C, Jamieson L, Khoor A, Edell ES, Lohse CM, Fields AP, Regala RP, Weems C, Jamieson L, Khoor A, Edell ES, Lohse CM, Fields AP: Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer. Cancer Res 2005, 65:8905-8911 (Pubitemid 41377380)
    • (2005) Cancer Research , vol.65 , Issue.19 , pp. 8905-8911
    • Regala, R.P.1    Weems, C.2    Jamieson, L.3    Khoor, A.4    Edell, E.S.5    Lohse, C.M.6    Fields, A.P.7
  • 42
    • 34147206546 scopus 로고    scopus 로고
    • Specific role of Chk1 phosphorylations in cell survival and checkpoint activation
    • DOI 10.1128/MCB.01611-06
    • Niida H, Katsuno Y, Banerjee B, Hande MP, Nakanishi M: Specific role of Chk1 phosphorylations in cell survival and checkpoint activation. Mol Cell Biol 2007, 27:2572-2581 (Pubitemid 46581348)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.7 , pp. 2572-2581
    • Niida, H.1    Katsuno, Y.2    Banerjee, B.3    Hande, M.P.4    Nakanishi, M.5
  • 43
    • 0034617281 scopus 로고    scopus 로고
    • A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta) and PKC- Related kinase 2 by PDK1
    • DOI 10.1074/jbc.M000421200
    • Balendran A, Biondi RM, Cheung PC, Casamayor A, Deak M, Alessi DR, Balendran A, Biondi RM, Cheung PC, Casamayor A, Deak M, Alessi DR: A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta) and PKC-related kinase 2 by PDK1. J Biol Chem 2000, 275:20806-20813 (Pubitemid 30457673)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.27 , pp. 20806-20813
    • Balendran, A.1    Biondi, R.M.2    Cheung, P.C.F.3    Casamayor, A.4    Deak, M.5    Alessi, D.R.6
  • 45
    • 0032566691 scopus 로고    scopus 로고
    • Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
    • DOI 10.1126/science.281.5385.2042
    • Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ, Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ: Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science 1998, 281:2042-2045 (Pubitemid 28475494)
    • (1998) Science , vol.281 , Issue.5385 , pp. 2042-2045
    • Le, G.J.A.1    Ziegler, W.H.2    Parekh, D.B.3    Alessi, D.R.4    Cohen, P.5    Parker, P.J.6
  • 46
    • 0036969141 scopus 로고    scopus 로고
    • Amplification of the 3q26.3 locus is associated with progression to invasive cancer and is a negative prognostic factor in head and neck squamous cell carcinomas
    • Singh B, Stoffel A, Gogineni S, Poluri A, Pfister DG, Shaha AR, Pathak A, Bosl G, Cordon-Cardo C, Shah JP, Rao PH, Singh B, Stoffel A, Gogineni S, Poluri A, Pfister DG, Shaha AR, Pathak A, Bosl G, Cordon-Cardo C, Shah JP, Rao PH: Amplification of the 3q26.3 locus is associated with progression to invasive cancer and is a negative prognostic factor in head and neck squamous cell carcinomas. Am J Pathol 2002, 161:365-371 (Pubitemid 36142144)
    • (2002) American Journal of Pathology , vol.161 , Issue.2 , pp. 365-371
    • Singh, B.1    Stoffel, A.2    Gogineni, S.3    Poluri, A.4    Pfister, D.G.5    Shaha, A.R.6    Pathak, A.7    Bosl, G.8    Cordon-Cardo, C.9    Shah, J.P.10    Rao, P.H.11
  • 47
    • 70350074501 scopus 로고    scopus 로고
    • Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation
    • Justilien V, Fields AP: Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation. Oncogene 2009, 28: 3597-3607
    • (2009) Oncogene , vol.28 , pp. 3597-3607
    • Justilien, V.1    Fields, A.P.2
  • 48
    • 0033151533 scopus 로고    scopus 로고
    • Constitutive activation of extracellular signal-regulated kinase in human acute leukemias: Combined role of activation of MEK, hyperexpression of extracellular signal-regulated kinase, and downregulation of a phosphatase
    • Kim SC, Hahn JS, Min YH, Yoo NC, Ko YW, Lee WJ: Constitutive activation of extracellular signal-regulated kinase in human acute leukemias: combined role of activation of MEK, hyperexpression of extracellular signal-regulated kinase, and downregulation of a phosphatase. PAC1 Blood 1999, 93:3893-3899
    • (1999) PAC1 Blood , vol.93 , pp. 3893-3899
    • Kim, S.C.1    Hahn, J.S.2    Min, Y.H.3    Yoo, N.C.4    Ko, Y.W.5    Lee, W.J.6
  • 51
    • 0037287298 scopus 로고    scopus 로고
    • Protein kinase C lambda/iota PKClambda/iota: A PKC isotype essential for the development of multicellular organisms
    • DOI 10.1093/jb/mvg018
    • Suzuki A, Akimoto K, Ohno S: Protein kinase C lambda/iota (PKClambda/iota): a PKC isotype essential for the development of multicellular organisms. J Biochem 2003, 133:9-16 (Pubitemid 36240973)
    • (2003) Journal of Biochemistry , vol.133 , Issue.1 , pp. 9-16
    • Suzuki, A.1    Akimoto, K.2    Ohno, S.3
  • 52
    • 38449103501 scopus 로고    scopus 로고
    • Role of activated nuclear factor-kappaB in the pathogenesis and therapy of squamous cell carcinoma of the head and neck
    • Allen CT, Ricker JL, Chen Z, Van Waes C: Role of activated nuclear factor-kappaB in the pathogenesis and therapy of squamous cell carcinoma of the head and neck. Head Neck 2007, 29:959-971
    • (2007) Head Neck , vol.29 , pp. 959-971
    • Allen, C.T.1    Ricker, J.L.2    Chen, Z.3    Van Waes, C.4
  • 53
    • 27144459692 scopus 로고    scopus 로고
    • Phosphorylation of Re1A/p65 on serine 536 defines an IkappaBalpha- Independent NF-kappaB pathway
    • DOI 10.1074/jbc.M504943200
    • Sasaki CY, Barberi TJ, Ghosh P, Longo DL: Phosphorylation of RelA/ p65 on serine 536 defines an I{kappa}B{alpha}-independent NF-{kappa}B pathway. J Biol Chem 2005, 280:34538-34547 (Pubitemid 41504584)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.41 , pp. 34538-34547
    • Sasaki, C.Y.1    Barberi, T.J.2    Ghosh, P.3    Longo, D.L.4
  • 54
    • 0036118391 scopus 로고    scopus 로고
    • Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways
    • DOI 10.1038/sj/neo/7900219
    • Tian H, Faje AT, Lee SL, Jorgensen TJ: Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways. Neoplasia 2002, 4:171-180 (Pubitemid 34218685)
    • (2002) Neoplasia , vol.4 , Issue.2 , pp. 171-180
    • Tian, H.1    Faje, A.T.2    Lee, S.L.3    Jorgensen, T.J.4
  • 58
    • 3242880578 scopus 로고    scopus 로고
    • Constitutively active DNA damage checkpoint pathways as the driving force for the high frequency of p53 mutations in human cancer
    • review
    • Halazonetis TD: Constitutively active DNA damage checkpoint pathways as the driving force for the high frequency of p53 mutations in human cancer [review]. DNA Repair 2004, 3:1057-1062
    • (2004) DNA Repair , vol.3 , pp. 1057-1062
    • Halazonetis, T.D.1
  • 59
    • 34247481285 scopus 로고    scopus 로고
    • Targeting checkpoint kinase 1 in cancer therapeutics
    • DOI 10.1158/1078-0432.CCR-06-2793
    • Tse AN, Carvajal R, Schwartz GK: Targeting checkpoint kinase 1 in cancer therapeutics. Clin Cancer Res 2007, 13:1955-1960 (Pubitemid 46649860)
    • (2007) Clinical Cancer Research , vol.13 , Issue.7 , pp. 1955-1960
    • Tse, A.N.1    Carvajal, R.2    Schwartz, G.K.3
  • 60
    • 2342489456 scopus 로고    scopus 로고
    • EIF-4E expression and its role in malignancies and metastases
    • DOI 10.1038/sj.onc.1207545
    • De Benedetti A, Graff JR: eIF-4E expression and its role in malignancies and metastases. Oncogene 2004, 23:3189-3199 (Pubitemid 38638830)
    • (2004) Oncogene , vol.23 , Issue.18 , pp. 3189-3199
    • De, B.A.1    Graff, J.R.2
  • 61
    • 61749103876 scopus 로고    scopus 로고
    • Stability of eukaryotic translation initiation factor 4E mRNA is regulated by HuR, and this activity is dysregulated in cancer
    • Topisirovic I, Siddiqui N, Orolicki S, Skrabanek LA, Tremblay M, Hoang T, Borden KL: Stability of eukaryotic translation initiation factor 4E mRNA is regulated by HuR, and this activity is dysregulated in cancer. Mol Cell Biol 2009, 29:1152-1162
    • (2009) Mol Cell Biol , vol.29 , pp. 1152-1162
    • Topisirovic, I.1    Siddiqui, N.2    Orolicki, S.3    Skrabanek, L.A.4    Tremblay, M.5    Hoang, T.6    Borden, K.L.7
  • 62
    • 73449136900 scopus 로고    scopus 로고
    • Understanding and targeting the eukaryotic translation initiation factor eIF4E in head and neck cancer
    • Culjkovic B, Borden KL: Understanding and targeting the eukaryotic translation initiation factor eIF4E in head and neck cancer. J Oncol 2009, 2009:981679
    • (2009) J Oncol , vol.2009 , pp. 981679
    • Culjkovic, B.1    Borden, K.L.2
  • 64
    • 33745699726 scopus 로고    scopus 로고
    • Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase
    • Cohen EE, Lingen MW, Zhu B, Zhu H, Straza MW, Pierce C, Martin LE, Rosner MR: Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase. Cancer Res 2006, 66:6296-6303
    • (2006) Cancer Res , vol.66 , pp. 6296-6303
    • Cohen, E.E.1    Lingen, M.W.2    Zhu, B.3    Zhu, H.4    Straza, M.W.5    Pierce, C.6    Martin, L.E.7    Rosner, M.R.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.