Cu2+-cyclen as probe to identify conformational states in guanine nucleotide binding proteins

Journal of the American Chemical Society

Volumn 133, Issue 7, 2011, Pages 2048-2051

  Meierhofer, Tanja ^a   Rosnizeck, Ina C ^a   Graf, Thorsten ^a   Reiss, Kerstin ^a   König, Burkhard ^a   Kalbitzer, Hans Robert ^a   Spoerner, Michael ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CONFORMATIONAL EQUILIBRIUM; CONFORMATIONAL STATE; DIRECT DETECTION; GUANINE NUCLEOTIDE-BINDING PROTEINS; MILLIMOLAR CONCENTRATIONS; NMR SPECTROSCOPY; PHYSIOLOGICAL PROPERTIES; TWO-STATE;

CHEMICAL DETECTION; CHEMICAL SHIFT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDES; POSITIVE IONS; PROBES; PROTEINS;

CONFORMATIONS;

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR 1; COPPER; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE TRIPHOSPHATE; RAN PROTEIN; RAS PROTEIN; 1,4,7,10 TETRAAZACYCLODODECANE; HETEROCYCLIC COMPOUND;

ARTICLE; CONFORMATIONAL TRANSITION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PROTON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; PROTEIN BINDING; PROTEIN CONFORMATION;

CATALYTIC DOMAIN; GTP-BINDING PROTEINS; HETEROCYCLIC COMPOUNDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 79951836689     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja108779j     Document Type: Article

References (26)

1. (a) Wennerberg, K.; Rossmann, K. L.; Der, C. J. Science 2005, 118, 843-846.
2. (b) Vetter, I. R.; Wittinghofer, A. Science 2001, 294, 1299-1304.
3. (a)Geyer,M.; Schweins,T.;Herrmann,C.;Prisner,T.;Wittinghofer, A.; Kalbitzer, H. R. Biochemistry 1996, 35, 10308-10320.
4. (b) Spoerner, M.; Nuehs, A.; Ganser, P.; Herrmann, C.; Wittinghofer, A.; Kalbitzer, H. R. Biochemistry 2005, 44, 2225-2236.
5. Geyer, M.; Assheuer, R.; Klebe, C.; Kuhlmann, J.; Becker, J.; Wittinghofer, A.; Kalbitzer, H. R. Biochemistry 1999, 38, 11250-11260.
6. (a) Kremer, W.; Steiner, G.; Béraud-Dufour, S.; Kalbitzer, H. R. J. Biol. Chem. 2004, 279, 17004-17012.
7. (b) Kiel, C.; Filchtinski, D.; Spoerner, M.; Schreiber, G.; Kalbitzer, H. R.; Herrmann, C. J. Biol. Chem. 2009, 284, 31893-31902.
8. (c) Ford, B.; Skowronek, K.; Boykevisch, S.; Bar-Sagi, D.; Nassar, N. J. Biol. Chem. 2005, 280, 25697-25705.
9. (d) Fenwick, R. B.; Prasannan, S.; Campbell, L. J.; Nietlispach, D.; Evetts, K. A.; Camonis, J.; Mott, H. R.; Owen, D. Biochemistry 2009, 48, 2192-2206.
10. (e) Phillips, M. J.; Calero, G.; Chan, B.; Ramachandran, S.; Cerione, R. A. J. Biol. Chem. 2008, 283, 14153-14164.
11. (f) Seidel, R. D., III; Amor, J. C.; Kahn, R. A.; Prestegard, J. H. J. Biol. Chem. 2004, 279, 48307-48318.
12. Shima, F.; Ijiri, Y.; Muraoka, S.; Liao, J.; Ye, M.; Araki, M.; Matsumoto, K.; Yamamoto, N.; Sugimoto, T.; Yoshikawa, Y.; Kumasaka, T.; Yamamoto, M.; Tamura, A.; Kataoka, T. J. Biol. Chem. 2010, 285, 22696-22705.
13. Spoerner,M.;Herrmann,C.; Vetter, I.; Kalbitzer, H. R.;Wittinghofer, A. Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 4944-4949.
14. (a) Spoerner, M.; Wittinghofer, A.; Kalbitzer, H. R. FEBS Lett. 2004, 578, 305-310.
15. (b) Geyer, M.; Herrmann, C.; Wohlgemuth, S.; Wittinghofer, A.; Kalbitzer, H. R. Nat. Struct. Biol. 1997, 4, 684-699.
16. (c) Linnemann, T.; Geyer, M.; Jaitner, T.; Block, C.; Kalbitzer, H. R.; Wittinghofer, A.; Herrmann, C. J. Biol. Chem. 1999, 274, 13556-13562.
17. (d) Gronwald, W.; Huber, F.; Grünewald, P.; Spörner, M.; Wohlgemuth, S.; Herrmann, C.; Wittinghofer, A.; Kalbitzer, H. R. Structure 2001, 9, 1029-1041.
18. Kalbitzer, H. R.; Spoerner, M.; Hozsa, C.; Ganser, P.; Kremer, W. J. Am. Chem. Soc. 2009, 131, 16714-16719.
19. Margarit, M.; Sondermann, H.; Hall, B.; Nagar, B.; Hoelz, A.; Pirruccello, M.; Barsagi, D.; Kuriyan, J. Cell 2003, 112, 685-695.
20. (a) For a review, see: Riechers, A.; Schmidt, F.; Stadlbauer, S.; Reichenbach-Klinke, B. R.; König, B. J. Chem. Soc., Dalton Trans. 2002, 121-130.
21. 2+-cyclen based probes for selective staining of phosphorylated proteins, see: König, B. Bioconjugate Chem. 2009, 20, 804-807.
22. (a) Rosnizeck, I. C.; Graf, T.; Spoerner, M.; Tränkle, J.; Filchtinski, D.; Herrmann, C.; Gremer, L.; Vetter, I. R.; Wittinghofer, A.; König, B.; Kalbitzer, H. R. Angew. Chem., Int. Ed. 2010, 49, 3830-3833.
23. (b) Spoerner, M.; Graf, T.; König, B.; Kalbitzer, H. R. Biochem. Biophys. Res. Commun. 2005, 334, 709-713.
24. Spoerner, M.; Nuehs, A.; Herrmann, C.; Steiner, G.; Kalbitzer, H. R. FEBS J. 2007, 274, 1419-1433.
25. Spoerner, M.; Hozsa, C.; Poetzl, J.; Reiss, K.; Ganser, P.; Geyer, M.; Kalbitzer, H. R. J. Biol. Chem. 2010, 285, 39768-39778.
26. Goldberg, J. Cell 1998, 95, 237-248.