Improved binding of Raf to Ras·GDP is correlated with biological activity

Journal of Biological Chemistry

Volumn 284, Issue 46, 2009, Pages 31893-31902

  Kiel, Christina ^a,b   Filchtinski, Daniel ^c   Spoerner, Michael ^d   Schreiber, Gideon ^e   Kalbitzer, Hans Robert ^d   Herrmann, Christian ^c  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^b CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^c RUHR UNIVERSITY BOCHUM   (Germany)

^d UNIVERSITY OF REGENSBURG   (Germany)

^e WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ASSOCIATION KINETICS; BINDING STRENGTH; BIOLOGICAL ACTIVITIES; BOUND STATE; CELLULAR PROCESS; COMPLEX STABILITY; GTP-BINDING PROTEINS; MOLECULAR SWITCHES; NMR SPECTROSCOPY; PHOSPHATIDYLINOSITOL 3-KINASE; PROTEIN DESIGN; REPORTER GENE ASSAYS; SIGNALING ACTIVITY; SIGNALING CASCADES;

COMPUTER CONTROL SYSTEMS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLANTS (BOTANY); SIGNALING;

PROTEINS;

GUANOSINE DIPHOSPHATE; RAF PROTEIN; RAS PROTEIN;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; CORRELATION FUNCTION; MUTATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

COMPUTATIONAL BIOLOGY; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HUMANS; LUCIFERASES; MAGNETIC RESONANCE SPECTROSCOPY; MUTATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS P21(RAS); RAF KINASES; SIGNAL TRANSDUCTION;

EID: 70450265216     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.031153     Document Type: Article

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