Inhibitory effects of ginsenoside Rb1 on atopic dermatitis-like skin lesions in mice

Journal of Ginseng Research

Volumn 34, Issue 4, 2010, Pages 363-368

  Park, Hye Jin ^a   Byeon, Hye Eun ^a   Choi, Ko Woon ^a   Rhee, Dong Kwon ^a   Lee, Kang Ro ^a   Pyo, Suhkneung ^a  

^a Sungkyunkwan University   (South Korea)

Author keywords

Atopic dermatitis; Ginsenoside Rb1; Interleukin 4; Scratching behaviors

Indexed keywords

MUS;

EID: 79951799592     PISSN: 12268453     EISSN: None     Source Type: Journal    
DOI: 10.5142/jgr.2010.34.4.363     Document Type: Article

References (23)

1. Joo SS, Kim SG, Choi SE, Kim YB, Park HY, Seo SJ, Choi YW, Lee MW, Lee DI. Suppression of T cell activation by hirsutenone, isolated from the bark of Alnus japonica, and its therapeutic advantages for atopic dermatitis. Eur J Pharmacol 2009;614:98-105.
2. Furrie E. Probiotics and allergy. Proc Nutr Soc 2005;64:465-469. (Pubitemid 41705446)
3. Maggi E, Del Prete G, Macchia D, Parronchi P, Tiri A, Chrétien I, Ricci M, Romagnani S. Profiles of lymphokine activities and helper function for IgE in human T cell clones. Eur J Immunol 1988;18:1045-1050.
4. Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989;7:145-173. (Pubitemid 19138011)
5. Romagnani S. Type 1 T helper and type 2 T helper cells: functions, regulation and role in protection and disease. Int J Clin Lab Res 1991;21:152-158.
6. Yoshimoto T, Mizutani H, Tsutsui H, Noben-Trauth N, Yamanaka K, Tanaka M, Izumi S, Okamura H, Paul WE, Nakanishi K. IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6. Nat Immunol 2000;1:132-137.
7. Park J, Chung SW, Kim SH, Kim TS. Up-regulation of interleukin-4 production via NF-AT/AP-1 activation in T cells by biochanin A, a phytoestrogen and its metabolites. Toxicol Appl Pharmacol 2006;212:188-199.
8. Cron RQ, Bort SJ, Wang Y, Brunvand MW, Lewis DB. T cell priming enhances IL-4 gene expression by increasing nuclear factor of activated T cells. J Immunol 1999;162:860-870. (Pubitemid 29035410)
9. Luo C, Burgeon E, Carew JA, McCaffrey PG, Badalian TM, Lane WS, Hogan PG, Rao A. Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes. Mol Cell Biol 1996;16:3955-3966. (Pubitemid 26199915)
10. Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol 1999;58:1685-1693. (Pubitemid 29505408)
11. Lü JM, Yao Q, Chen C. Ginseng compounds: an update on their molecular mechanisms and medical applications. Curr Vasc Pharmacol 2009;7:293-302.
12. Park EK, Choo MK, Han MJ, Kim DH. Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities. Int Arch Allergy Immunol 2004;133:113-120. (Pubitemid 38314642)
13. Nakata H, Kikuchi Y, Tode T, Hirata J, Kita T, Ishii K, Kudoh K, Nagata I, Shinomiya N. Inhibitory effects of ginsenoside Rh2 on tumor growth in nude mice bearing human ovarian cancer cells. Jpn J Cancer Res 1998;89:733-740. (Pubitemid 28401159)
14. Yun JW, Kim H, Kang HJ, Koh JY, Kim BH. Comparative evaluation of animal models for atopic dermatitis in NC/Nga mice. Lab Anim Res 2008;24:59-66.
15. Lee HU, Bae EA, Han MJ, Kim NJ, Kim DH. Hepatoprotective effect of ginsenoside Rb1 and compound K on tert-butyl hydroperoxide-induced liver injury. Liver Int 2005;25:1069-1073. (Pubitemid 41404031)
16. Izuhara K, Yanagihara Y, Hamasaki N, Shirakawa T, Hopkin JM. Atopy and the human IL-4 receptor alpha chain. J Allergy Clin Immunol 2000;106(1 Pt 2): S65-S71. (Pubitemid 30482837)
17. Laouini D, Alenius H, Bryce P, Oettgen H, Tsitsikov E, Geha RS. IL-10 is critical for Th2 responses in a murine model of allergic dermatitis. J Clin Invest 2003;112:1058-1066. (Pubitemid 38056321)
18. Lester MR, Hofer MF, Gately M, Trumble A, Leung DY. Down-regulating effects of IL-4 and IL-10 on the IFN-gamma response in atopic dermatitis. J Immunol 1995;154:6174-6181.
19. Blumenthal MN. The role of genetics in the development of asthma and atopy. Curr Opin Allergy Clin Immunol 2005;5:141-145. (Pubitemid 40434463)
20. Halbert AR, Weston WL, Morelli JG. Atopic dermatitis: is it an allergic disease? J Am Acad Dermatol 1995;33:1008-1018.
21. Yagi R, Nagai H, Iigo Y, Akimoto T, Arai T, Kubo M. Development of atopic dermatitis-like skin lesions in STAT6-deficient NC/Nga mice. J Immunol 2002;168:2020-2027. (Pubitemid 34135806)
22. Lim CP, Cao X. Structure, function, and regulation of STAT proteins. Mol Biosyst 2006;2:536-550. (Pubitemid 44583902)
23. Cao S, Liu J, Song L, Ma X. The protooncogene c-Maf is an essential transcription factor for IL-10 gene expression in macrophages. J Immunol 2005;174:3484-3492. (Pubitemid 40354056)