A comparative analysis of oncofetal fibronectin and tenascin-C incorporation in tumour vessels using human recombinant SIP format antibodies

Histochemistry and Cell Biology

Volumn 133, Issue 4, 2010, Pages 467-475

  Berndt, Alexander ^a   Köllner, Robert ^a   Richter, Petra ^a   Franz, Marcus ^a   Voigt, Astrid ^a   Berndt, Angela ^b   Borsi, Laura ^c   Giavazzi, Raffaella ^d   Neri, Dario ^e   Kosmehl, Hartwig ^f  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

^c UNIVERSITY OF GENOA   (Italy)

^d MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^e ETH ZURICH   (Switzerland)

^f HELIOS KLINIKUM ERFURT   (Germany)

Author keywords

Extracellular matrix; Fibronectin; Stratification; Tenascin C; Tumour vessels; Vascular basement membrane

Indexed keywords

FIBRONECTIN; TENASCIN;

ANGIOGENESIS; ARTICLE; BASEMENT MEMBRANE; BIOTINYLATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENETIC HETEROGENEITY; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN STRUCTURE; STROMA CELL; STRUCTURE ANALYSIS; TISSUE DISTRIBUTION; XENOGRAFT;

BASEMENT MEMBRANE; BLOOD VESSELS; CARCINOMA, RENAL CELL; FIBRONECTINS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; KIDNEY NEOPLASMS; LAMININ; NEOPLASMS; PROTEIN ISOFORMS; TENASCIN; URINARY BLADDER NEOPLASMS;

EID: 77952239376     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00418-010-0685-y     Document Type: Article

References (63)

1. F Ahmed JC Steele JM Herbert NM Steven R Bicknell 2008 Tumor stroma as a target in cancer Curr Cancer Drug Targets 8 447 453 10.2174/156800908785699360 1:CAS:528:DC%2BD1cXhtVGqu7%2FO 18781891
2. S Astrof RO Hynes 2009 Fibronectins in vascular morphogenesis Angiogenesis 12 165 175 10.1007/s10456-009-9136-6 1:CAS:528:DC%2BD1MXnt12ntLk%3D 19219555
3. VL Ballard A Sharma I Duignan JM Holm A Chin R Choi KA Hajjar SC Wong JM Edelberg 2006 Vascular tenascin-C regulates cardiac endothelial phenotype and neovascularization FASEB J 20 717 719 1:CAS:528:DC%2BD28XjtlGqs7o%3D 16461331
4. E Balza A Siri M Ponassi F Caocci A Linnala I Virtanen L Zardi 1993 Production and characterization of monoclonal antibodies specific for different epitopes of human tenascin FEBS Lett 332 39 43 10.1016/0014-5793(93)80479-E 1:CAS:528:DyaK3sXmsVOls7s%3D 7691659 (Pubitemid 23295894)
5. SC Bell JH Pringle DJ Taylor TM Malak 1999 Alternatively spliced tenascin-C mRNA isoforms in human fetal membranes Mol Hum Reprod 5 1066 1076 10.1093/molehr/5.11.1066 1:CAS:528:DyaK1MXnvVKhsLk%3D 10541570 (Pubitemid 29518912)
6. A Berndt H Kosmehl U Mandel U Gabler X Luo D Celeda L Zardi D Katenkamp 1995 TGF beta and bFGF synthesis and localization in Dupuytren's disease (nodular palmar fibromatosis) relative to cellular activity, myofibroblast phenotype and oncofetal variants of fibronectin Histochem J 27 1014 1020 1:STN:280:DyaK28zotFeqsg%3D%3D 8789403
7. A Berndt L Borsi X Luo L Zardi D Katenkamp H Kosmehl 1998 Evidence of ED-B+ fibronectin synthesis in human tissues by non-radioactive RNA in situ hybridization. Investigations on carcinoma (oral squamous cell and breast carcinoma), chronic inflammation (rheumatoid synovitis) and fibromatosis (Morbus Dupuytren) Histochem Cell Biol 109 249 255 10.1007/s004180050224 1:CAS:528:DyaK1cXos1ynsQ%3D%3D 9541473 (Pubitemid 28114289)
8. A Berndt L Borsi P Hyckel H Kosmehl 2001 Fibrillary co-deposition of laminin-5 and large unspliced tenascin-C in the invasive front of oral squamous cell carcinoma in vivo and in vitro J Cancer Res Clin Oncol 127 286 292 10.1007/s004320000205 1:CAS:528:DC%2BD3MXisVaksbw%3D 11355143 (Pubitemid 32662328)
9. A Berndt K Anger P Richter L Borsi S Brack M Silacci M Franz H Wunderlich M Gajda L Zardi D Neri H Kosmehl 2006 Differential expression of tenascin-C splicing domains in urothelial carcinomas of the urinary bladder J Cancer Res Clin Oncol 132 537 546 10.1007/s00432-006-0106-8 1:CAS:528:DC%2BD28XmtVaktrc%3D 16788848 (Pubitemid 43938338)
10. L Borsi B Carnemolla G Nicolo B Spina G Tanara L Zardi 1992 Expression of different tenascin isoforms in normal, hyperplastic and neoplastic human breast tissues Int J Cancer 52 688 692 10.1002/ijc.2910520504 1:STN:280: DyaK3s%2Flt1ymsA%3D%3D 1385335
11. L Borsi E Balza B Carnemolla F Sassi P Castellani A Berndt H Kosmehl A Biro A Siri P Orecchia J Grassi D Neri L Zardi 2003 Selective targeted delivery of TNFalpha to tumor blood vessels Blood 102 4384 4392 10.1182/blood-2003-04- 1039 1:CAS:528:DC%2BD3sXpslGrsL8%3D 12933583 (Pubitemid 37494099)
12. SS Brack M Silacci M Birchler D Neri 2006 Tumor-targeting properties of novel antibodies specific to the large isoform of tenascin-C Clin Cancer Res 12 3200 3208 10.1158/1078-0432.CCR-05-2804 1:CAS:528:DC%2BD28Xks1Chsro%3D 16707621 (Pubitemid 43837370)
13. M Cai K Onoda M Takao IY Kyoko H Shimpo T Yoshida I Yada 2002 Degradation of tenascin-C and activity of matrix metalloproteinase-2 are associated with tumor recurrence in early stage non-small cell lung cancer Clin Cancer Res 8 1152 1156 1:CAS:528:DC%2BD38XjsF2lt7o%3D 11948127
14. A Caporale UM Cosenza AR Vestri A Giuliani U Costi G Galati C Cannaviello F Franchi 2001 Has desmoplastic response extent protective action against tumor aggressiveness in gastric carcinoma? J Exp Clin Cancer Res 20 21 24 1:STN:280:DC%2BD3M3nsFSmsA%3D%3D 11370824
15. P Castellani G Viale A Dorcaratto G Nicolo J Kaczmarek G Querze L Zardi 1994 The fibronectin isoform containing the ED-B oncofetal domain: a marker of angiogenesis Int J Cancer 59 612 618 10.1002/ijc.2910590507 1:STN:280: DyaK2M%2FkvVyqug%3D%3D 7525495 (Pubitemid 24358583)
16. CY Chung L Zardi HP Erickson 1995 Binding of tenascin-C to soluble fibronectin and matrix fibrils J Biol Chem 270 29012 29017 10.1074/jbc.270.48. 29012 1:CAS:528:DyaK2MXpslOjurc%3D 7499434
17. JA Eble S Niland 2009 The extracellular matrix of blood vessels Curr Pharm Des 15 1385 1400 10.2174/138161209787846757 1:CAS:528:DC%2BD1MXmtValtrk%3D 19355976
18. E El-Emir JL Dearling A Huhalov MP Robson G Boxer D Neri GA van Dongen E Trachsel RH Begent RB Pedley 2007 Characterisation and radioimmunotherapy of L19-SIP, an anti-angiogenic antibody against the extra domain B of fibronectin, in colorectal tumour models Br J Cancer 96 1862 1870 10.1038/sj.bjc.6603806 1:CAS:528:DC%2BD2sXmtlyqtbs%3D 17519905 (Pubitemid 46912019)
19. HP Erickson JL Inglesias 1984 A six-armed oligomer isolated from cell surface fibronectin preparations Nature 311 267 269 10.1038/311267a0 1:CAS:528:DyaL2cXls1Grtr4%3D 6482952
20. M Franz T Hansen P Richter L Borsi FD Bohmer P Hyckel P Schleier D Katenkamp L Zardi H Kosmehl A Berndt 2006 Complex formation of the laminin-5 gamma2 chain and large unspliced tenascin-C in oral squamous cell carcinoma in vitro and in situ: implications for sequential modulation of extracellular matrix in the invasive tumor front Histochem Cell Biol 126 125 131 10.1007/s00418-005-0126-5 1:CAS:528:DC%2BD28XlsFCjsrw%3D 16344911 (Pubitemid 43882546)
21. M Franz T Hansen L Borsi C Geier P Hyckel P Schleier P Richter A Altendorf-Hofmann H Kosmehl A Berndt 2007 A quantitative co-localization analysis of large unspliced tenascin-C(L) and laminin-5/gamma2-chain in basement membranes of oral squamous cell carcinoma by confocal laser scanning microscopy J Oral Pathol Med 36 6 11 1:CAS:528:DC%2BD2sXitlOmsrg%3D 17181735
22. MA Ghert WN Qi HP Erickson JA Block SP Scully 2001 Tenascin-C splice variant adhesive/anti-adhesive effects on chondrosarcoma cell attachment to fibronectin Cell Struct Funct 26 179 187 10.1247/csf.26.179 1:CAS:528: DC%2BD3MXntVKhur4%3D 11565810 (Pubitemid 32894084)
23. C Halin S Rondini F Nilsson A Berndt H Kosmehl L Zardi D Neri 2002 Enhancement of the antitumor activity of interleukin-12 by targeted delivery to neovasculature Nat Biotechnol 20 264 269 10.1038/nbt0302-264 1:CAS:528:DC%2BD38XhvVWjt7g%3D 11875427 (Pubitemid 34205419)
24. W Hindermann A Berndt L Borsi X Luo P Hyckel D Katenkamp H Kosmehl 1999 Synthesis and protein distribution of the unspliced large tenascin-C isoform in oral squamous cell carcinoma J Pathol 189 475 480 10.1002/(SICI)1096- 9896(199912)189:4<475::AID-PATH462>3.0.CO;2-V 1:CAS:528: DC%2BD3cXltlSltg%3D%3D 10629546
25. V Hofmeister D Schrama JC Becker 2008 Anti-cancer therapies targeting the tumor stroma Cancer Immunol Immunother 57 1 17 10.1007/s00262-007-0365-5 1:CAS:528:DC%2BD2sXht1aqs77L 17661033 (Pubitemid 350043655)
26. K Katenkamp A Berndt W Hindermann H Wunderlich KM Haas L Borsi L Zardi H Kosmehl 2004 mRNA expression and protein distribution of the unspliced tenascin-C isoform in prostatic adenocarcinoma J Pathol 203 771 779 10.1002/path.1589 1:CAS:528:DC%2BD2cXmtFSmt7c%3D 15221936 (Pubitemid 38961563)
27. MG Kellermann LM Sobral SD da Silva KG Zecchin E Graner MA Lopes I Nishimoto LP Kowalski RD Coletta 2007 Myofibroblasts in the stroma of oral squamous cell carcinoma are associated with poor prognosis Histopathology 51 849 853 10.1111/j.1365-2559.2007.02873.x 1:STN:280:DC%2BD2sjgsFCktw%3D%3D 18042073 (Pubitemid 350179411)
28. MN Kirstein MM Moore AZ Dudek 2006 Review of selected patents for cancer therapy targeting tumor angiogenesis Recent Pat Anticancer Drug Discov 1 153 161 10.2174/157489206777442269 1:CAS:528:DC%2BD28XmsVOjurw%3D 18221033
29. H Kosmehl A Berndt D Katenkamp U Mandel R Bohle U Gabler D Celeda 1995 Differential expression of fibronectin splice variants, oncofetal glycosylated fibronectin and laminin isoforms in nodular palmar fibromatosis Pathol Res Pract 191 1105 1113 1:STN:280:DyaK28vhvFeguw%3D%3D 8822112
30. H Kosmehl A Berndt D Katenkamp 1996 Molecular variants of fibronectin and laminin: structure, physiological occurrence and histopathological aspects Virchows Arch 429 311 322 10.1007/BF00198435 1:CAS:528:DyaK2sXktFeluw%3D%3D 8982375
31. AV Ljubimov M Saghizadeh KS Spirin HL Khin SL Lewin L Zardi MA Bourdon MC Kenney 1998 Expression of tenascin-C splice variants in normal and bullous keratopathy human corneas Invest Ophthalmol Vis Sci 39 1135 1142 1:STN:280:DyaK1c3otFersA%3D%3D 9620072 (Pubitemid 28247347)
32. AJ Lyons J Jones 2007 Cell adhesion molecules, the extracellular matrix and oral squamous carcinoma Int J Oral Maxillofac Surg 36 671 679 10.1016/j.ijom.2007.04.002 1:STN:280:DC%2BD2svkt1amsg%3D%3D 17643963 (Pubitemid 47091508)
33. EMM Manders FJ Verbeek JA Aten 1993 Measurement of Colocalization of Objects in Dual-Color Confocal Images J Microscopy-Oxford 169 375 382
34. AJ Mighell J Thompson WJ Hume AF Markham PA Robinson 1997 Human tenascin-C: identification of a novel type III repeat in oral cancer and of novel splice variants in normal, malignant and reactive oral mucosae Int J Cancer 72 236 240 10.1002/(SICI)1097-0215(19970717)72:2<236::AID-IJC6>3.0. CO;2-S 1:CAS:528:DyaK2sXkslylsbg%3D 9219826 (Pubitemid 27314878)
35. D Neri R Bicknell 2005 Tumour vascular targeting Nat Rev Cancer 5 436 446 10.1038/nrc1627 1:CAS:528:DC%2BD2MXks1Gmsrw%3D 15928674 (Pubitemid 40791486)
36. F Nilsson H Kosmehl L Zardi D Neri 2001 Targeted delivery of tissue factor to the ED-B domain of fibronectin, a marker of angiogenesis, mediates the infarction of solid tumors in mice Cancer Res 61 711 716 1:CAS:528: DC%2BD3MXht1Gmtrg%3D 11212273
37. G Orend R Chiquet-Ehrismann 2006 Tenascin-C induced signaling in cancer Cancer Lett 244 143 163 10.1016/j.canlet.2006.02.017 1:CAS:528: DC%2BD28XhtVGitrjP 16632194 (Pubitemid 44508708)
38. A Ostman M Augsten 2009 Cancer-associated fibroblasts and tumor growth-bystanders turning into key players Curr Opin Genet Dev 19 67 73 10.1016/j.gde.2009.01.003 19211240
39. M Pedretti A Soltermann S Arni W Weder D Neri S Hillinger 2009 Comparative immunohistochemistry of L19 and F16 in non-small cell lung cancer and mesothelioma: two human antibodies investigated in clinical trials in patients with cancer Lung Cancer 64 28 33 10.1016/j.lungcan.2008.07.013 18799229
40. N Petäjäniemi M Korhonen J Kortesmaa K Tryggvason K Sekiguchi H Fujiwara L Sorokin LE Thornell Z Wondimu D Assefa M Patarroyo I Virtanen 2002 Localization of laminin alpha4-chain in developing and adult human tissues J Histochem Cytochem 50 1113 1130 12133914
41. K Pietras K Rubin T Sjoblom E Buchdunger M Sjoquist CH Heldin A Ostman 2002 Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy Cancer Res 62 5476 5484 1:CAS:528:DC%2BD38Xnsl2lsL4%3D 12359756
42. D Ribatti B Nico A Vacca L Roncali PH Burri V Djonov 2001 Chorioallantoic membrane capillary bed: a useful target for studying angiogenesis and anti-angiogenesis in vivo Anat Rec 264 317 324 10.1002/ar.10021 1:CAS:528:DC%2BD38XitFelug%3D%3D 11745087 (Pubitemid 33097031)
43. Richter P, Tost M, Franz M, Altendorf-Hofmann A, Junker K, Borsi L, Neri D, Kosmehl H, Wunderlich H, Berndt A (2009) B and C domain containing tenascin-C: urinary markers for invasiveness of urothelial carcinoma of the urinary bladder? J Cancer Res Clin Oncol
44. Y Saito Y Shiota M Nishisaka T Owaki M Shimamura F Fukai 2008 Inhibition of angiogenesis by a tenascin-c peptide which is capable of activating beta1-integrins Biol Pharm Bull 31 1003 1007 10.1248/bpb.31.1003 1:CAS:528:DC%2BD1cXotF2mtLY%3D 18451535 (Pubitemid 351731977)
45. T Sangai G Ishii K Kodama S Miyamoto Y Aoyagi T Ito J Magae H Sasaki T Nagashima M Miyazaki A Ochiai 2005 Effect of differences in cancer cells and tumor growth sites on recruiting bone marrow-derived endothelial cells and myofibroblasts in cancer-induced stroma Int J Cancer 115 885 892 10.1002/ijc.20969 1:CAS:528:DC%2BD2MXltlWrsL4%3D 15729726 (Pubitemid 40791828)
46. S Sauer PA Erba M Petrini A Menrad L Giovannoni C Grana B Hirsch L Zardi G Paganelli G Mariani D Neri H Durkop HD Menssen 2009 Expression of the oncofetal ED-B-containing fibronectin isoform in hematologic tumors enables ED-B-targeted 131I-L19SIP radioimmunotherapy in Hodgkin lymphoma patients Blood 113 2265 2274 10.1182/blood-2008-06-160416 1:CAS:528:DC%2BD1MXjt12ntLk%3D 19131554
47. S Schenk R Chiquet-Ehrismann EJ Battegay 1999 The fibrinogen globe of tenascin-C promotes basic fibroblast growth factor-induced endothelial cell elongation Mol Biol Cell 10 2933 2943 1:CAS:528:DyaK1MXmtFeksbg%3D 10473637
48. C Schliemann A Palumbo K Zuberbuhler A Villa M Kaspar E Trachsel W Klapper HD Menssen D Neri 2009 Complete eradication of human B-cell lymphoma xenografts using rituximab in combination with the immunocytokine L19-IL2 Blood 113 2275 2283 10.1182/blood-2008-05-160747 1:CAS:528:DC%2BD1MXjt12ntLY%3D 19005180
49. JE Schwarzbauer 1991 Alternative splicing of fibronectin: three variants, three functions Bioessays 13 527 533 10.1002/bies.950131006 1:CAS:528:DyaK38XitlGk 1755828
50. M Silacci SS Brack N Spath A Buck S Hillinger S Arni W Weder L Zardi D Neri 2006 Human monoclonal antibodies to domain C of tenascin-C selectively target solid tumors in vivo Protein Eng Des Sel 19 471 478 10.1093/protein/ gzl033 1:CAS:528:DC%2BD28Xps1yhurY%3D 16928692 (Pubitemid 44408907)
51. A Siri V Knauper N Veirana F Caocci G Murphy L Zardi 1995 Different susceptibility of small and large human tenascin-C isoforms to degradation by matrix metalloproteinases J Biol Chem 270 8650 8654 10.1074/jbc.270.15.8650 1:CAS:528:DyaK2MXltVOgurc%3D 7536739
52. LM Sorokin F Pausch M Frieser S Kroger E Ohage R Deutzmann 1997 Developmental regulation of the laminin alpha5 chain suggests a role in epithelial and endothelial cell maturation Dev Biol 189 285 300 10.1006/dbio.1997.8668 1:CAS:528:DyaK2sXmsVGrt7g%3D 9299121 (Pubitemid 27428370)
53. L Tarli E Balza F Viti L Borsi P Castellani D Berndorff L Dinkelborg D Neri L Zardi 1999 A high-affinity human antibody that targets tumoral blood vessels Blood 94 192 198 1:CAS:528:DyaK1MXktlOks74%3D 10381513
54. Tijink BM, Perk LR, Budde M, Stigter-van Walsum M, Visser GW, Kloet RW, Dinkelborg LM, Leemans CR, Neri D, van Dongen GA (2009) (124) I-L19-SIP for immuno-PET imaging of tumour vasculature and guidance of (131) I-L19-SIP radioimmunotherapy. Eur J Nucl Med Mol Imaging
55. TD Tlsty LM Coussens 2006 Tumor stroma and regulation of cancer development Annu Rev Pathol 1 119 150 10.1146/annurev.pathol.1.110304.100224 1:CAS:528:DC%2BD28XktVOitb0%3D 18039110
56. E Trachsel D Neri 2006 Antibodies for angiogenesis inhibition, vascular targeting and endothelial cell transcytosis Adv Drug Deliv Rev 58 735 754 10.1016/j.addr.2005.11.002 1:CAS:528:DC%2BD28XoslKrsbo%3D 16822576 (Pubitemid 44247228)
57. T Tsujino I Seshimo H Yamamoto CY Ngan K Ezumi I Takemasa M Ikeda M Sekimoto N Matsuura M Monden 2007 Stromal myofibroblasts predict disease recurrence for colorectal cancer Clin Cancer Res 13 2082 2090 10.1158/1078-0432.CCR-06-2191 1:CAS:528:DC%2BD2sXjs12rt78%3D 17404090 (Pubitemid 46649876)
58. JA Tuxhorn SJ McAlhany F Yang TD Dang DR Rowley 2002 Inhibition of transforming growth factor-beta activity decreases angiogenesis in a human prostate cancer-reactive stroma xenograft model Cancer Res 62 6021 6025 1:CAS:528:DC%2BD38XosF2nu7o%3D 12414622
59. A Villa E Trachsel M Kaspar C Schliemann R Sommavilla JN Rybak C Rosli L Borsi D Neri 2008 A high-affinity human monoclonal antibody specific to the alternatively spliced EDA domain of fibronectin efficiently targets tumor neo-vasculature in vivo Int J Cancer 122 2405 2413 10.1002/ijc.23408 1:CAS:528:DC%2BD1cXltlaitbs%3D 18271006 (Pubitemid 351590471)
60. F Viti L Tarli L Giovannoni L Zardi D Neri 1999 Increased binding affinity and valence of recombinant antibody fragments lead to improved targeting of tumoral angiogenesis Cancer Res 59 347 352 1:CAS:528: DyaK1MXntFKqtg%3D%3D 9927045
61. D Zagzag B Shiff GI Jallo MA Greco C Blanco H Cohen J Hukin JC Allen DR Friedlander 2002 Tenascin-C promotes microvascular cell migration and phosphorylation of focal adhesion kinase Cancer Res 62 2660 2668 1:CAS:528:DC%2BD38XjtlGrt7s%3D 11980665
62. L Zardi B Carnemolla A Siri TE Petersen G Paolella G Sebastio FE Baralle 1987 Transformed human cells produce a new fibronectin isoform by preferential alternative splicing of a previously unobserved exon EMBO J 6 2337 2342 1:CAS:528:DyaL1cXmvF2qtw%3D%3D 2822387
63. X Zhou RG Rowe N Hiraoka JP George D Wirtz DF Mosher I Virtanen MA Chernousov SJ Weiss 2008 Fibronectin fibrillogenesis regulates three-dimensional neovessel formation Genes Dev 22 1231 1243 10.1101/gad.1643308 1:CAS:528:DC%2BD1cXlslCqs7w%3D 18451110 (Pubitemid 351656581)