Variation in mutation rates caused by RB69pol fidelity mutants can be rationalized on the basis of their kinetic behavior and crystal structures

Journal of Molecular Biology

Volumn 406, Issue 4, 2011, Pages 558-570

  Xia, Shuangluo ^a   Wang, Mina ^a   Lee, Harold R ^a,b   Sinha, Arjun ^a,c   Blaha, Gregor ^a   Christian, Thomas ^a   Wang, Jimin ^a   Konigsberg, William ^a  

^a YALE UNIVERSITY   (United States)

^b PACIFIC BIOSCIENCES   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

crystal structures; DNA polymerase; kinetics; mutation rates; mutation spectra

Indexed keywords

DNA POLYMERASE; PRIMER DNA; RB69 DNA POLYMERASE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL PARAMETERS; CRYSTAL STRUCTURE; GENE INSERTION; GENETIC VARIABILITY; IN VITRO STUDY; IN VIVO STUDY; KINETICS; MUTATION; PRIORITY JOURNAL; STEADY STATE;

EID: 79951677675     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2010.12.033     Document Type: Article

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