Cultured adult porcine astrocytes and microglia express functional interferon-γ receptors and exhibit toxicity towards SH-SY5Y cells

Brain Research Bulletin

Volumn 84, Issue 3, 2011, Pages 244-251

  Ionescu, Vlad A ^a   Villanueva, Erika B ^a   Hashioka, Sadayuki ^b   Bahniwal, Manpreet ^a   Klegeris, Andis ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Aging; In vitro culture model; Neurodegenerative diseases; Neuroinflammation; Neurotoxicity; Pig glia

Indexed keywords

CD14 ANTIGEN; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; LIPOPOLYSACCHARIDE; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN; CELL CULTURE; CELL STRAIN SH SY5Y; CELL VIABILITY; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; GLIA CELL; IN VITRO STUDY; METHODOLOGY; MICROGLIA; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SWINE;

ANIMALS; ASTROCYTES; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELL LINEAGE; CELLS, CULTURED; HUMANS; MICROGLIA; RECEPTORS, INTERFERON; SUS SCROFA;

EID: 79951675381     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2010.12.011     Document Type: Article

References (54)

1. Allen D.D., Caviedes R., Cardenas A.M., Shimahara T., Segura-Aguilar J., Caviedes P.A. Cell lines as in vitro models for drug screening and toxicity studies. Drug Dev. Ind. Pharm. 2005, 8:757-768.
2. Arciszewski M., Pierzynowski S., Ekblad E. Lipopolysaccharide induces cell death in cultured porcine myenteric neurons. Digest. Dis. Sci. 2005, 9:1661-1668.
3. Auwerx J. The human leukemia cell line, THP-1: a multifacetted model for the study of monocyte-macrophage differentiation. Experientia 1991, 1:22-31.
4. Bal-Price A., Brown G.C. Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity. J. Neurosci. 2001, 17:6480-6491.
5. Barnes K., Kenny A.J., Turner A.J. Localization of aminopeptidase N and dipeptidyl peptidase IV in pig striatum and in neuronal and glial cell cultures. Eur. J. Neurosci. 1994, 4:531-537.
6. Block M.L., Zecca L., Hong J.S. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat. Rev. Neurosci. 2007, 1:57-69.
7. Bowman C.C., Rasley A., Tranguch S.L., Marriott I. Cultured astrocytes express toll-like receptors for bacterial products. Glia 2003, 3:281-291.
8. Chao C.C., Hu S., Sheng W.S., Bu D., Bukrinsky M.I., Peterson P.K. Cytokine-stimulated astrocytes damage human neurons via a nitric oxide mechanism. Glia 1996, 3:276-284.
9. Choi S.H., Choi D.H., Song K.S., Shin K.H., Chun B.G. Zaprinast, an inhibitor of cGMP-selective phosphodiesterases, enhances the secretion of TNF-alpha and IL-1beta and the expression of iNOS and MHC class II molecules in rat microglial cells. J. Neurosci. Res. 2002, 3:411-421.
10. da Silva Correia J., Soldau K., Christen U., Tobias P.S., Ulevitch R.J. Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. Transfer from CD14 to TLR4 and MD-2. J. Biol. Chem. 2001, 24:21129-21135.
11. Deli M.A., Abraham C.S., Kataoka Y., Niwa M. Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharmacology. Cell. Mol. Neurobiol. 2005, 1:59-127.
12. Dooldeniya M.D., Warrens A.N. Xenotransplantation: where are we today?. J. R. Soc. Med. 2003, 3:111-117.
13. Downen M., Amaral T.D., Hua L.L., Zhao M.L., Lee S.C. Neuronal death in cytokine-activated primary human brain cell culture: role of tumor necrosis factor-alpha. Glia 1999, 2:114-127.
14. Filipovic R., Zecevic N. Neuroprotective role of minocycline in co-cultures of human fetal neurons and microglia. Exp. Neurol. 2008, 1:41-51.
15. Floden A.M., Combs C.K. Microglia repetitively isolated from in vitro mixed glial cultures retain their initial phenotype. J. Neurosci. Methods 2007, 2:218-224.
16. Gao H.M., Hong J.S. Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression. Trends Immunol. 2008, 8:357-365.
17. Giulian D., Baker T.J. Characterization of ameboid microglia isolated from developing mammalian brain. J. Neurosci. 1986, 8:2163-2178.
18. Glass C.K., Saijo K., Winner B., Marchetto M.C., Gage F.H. Mechanisms underlying inflammation in neurodegeneration. Cell 2010, 6:918-934.
19. Guo G., Bhat N.R. Hypoxia/reoxygenation differentially modulates NF-kappaB activation and iNOS expression in astrocytes and microglia. Antioxid. Redox Signal. 2006, 5-6:911-918.
20. Hashioka S., Klegeris A., Schwab C., McGeer P.L. Interferon-gamma-dependent cytotoxic activation of human astrocytes and astrocytoma cells. Neurobiol. Aging 2009, 12:1924-1935.
21. Hellendall R.P., Ting J.P. Differential regulation of cytokine-induced major histocompatibility complex class II expression and nitric oxide release in rat microglia and astrocytes by effectors of tyrosine kinase, protein kinase C, and cAMP. J. Neuroimmunol. 1997, 1-2:19-29.
22. Hu S., Chao C.C., Khanna K.V., Gekker G., Peterson P.K., Molitor T.W. Cytokine and free radical production by porcine microglia. Clin. Immunol. Immunopathol. 1996, 1:93-96.
23. Hu S., Sheng W.S., Peterson P.K., Chao C.C. Differential regulation by cytokines of human astrocyte nitric oxide production. Glia 1995, 4:491-494.
24. Jack C.S., Arbour N., Manusow J., Montgrain V., Blain M., McCrea E., Shapiro A., Antel J.P. TLR signaling tailors innate immune responses in human microglia and astrocytes. J. Immunol. 2005, 7:4320-4330.
25. Jeliazkova-Mecheva V.V., Bobilya D.J. A porcine astrocyte/endothelial cell co-culture model of the blood-brain barrier. Brain Res. Brain Res. Protoc. 2003, 2:91-98.
26. Klegeris A., Bissonnette C.J., McGeer P.L. Modulation of human microglia and THP-1 cell toxicity by cytokines endogenous to the nervous system. Neurobiol. Aging 2005, 5:673-682.
27. Klegeris A., Li J., Bammler T.K., Jin J., Zhu D., Kashima D.T., Pan S., Hashioka S., Maguire J., McGeer P.L., Zhang J. Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial and THP-1 cell neurotoxicity. Glia 2008, 6:675-685.
28. Klegeris A., McGeer P.L. Non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory agents in the treatment of neurodegenerative disease. Curr. Alzheimer Res. 2005, 3:355-365.
29. Klegeris A., Walker D.G., McGeer P.L. Toxicity of human THP-1 monocytic cells towards neuron-like cells is reduced by non-steroidal anti-inflammatory drugs (NSAIDs). Neuropharmacology 1999, 7:1017-1025.
30. Lafortune L., Nalbantoglu J., Antel J.P. Expression of tumor necrosis factor alpha (TNF alpha) and interleukin 6 (IL-6) mRNA in adult human astrocytes: comparison with adult microglia and fetal astrocytes. J. Neuropath. Exp. Neurol. 1996, 5:515-521.
31. Le W., Rowe D., Xie W., Ortiz I., He Y., Appel S.H. Microglial activation and dopaminergic cell injury: an in vitro model relevant to Parkinson's disease. J. Neurosci. 2001, 21:8447-8455.
32. Lee S.C., Liu W., Brosnan C.F., Dickson D.W. GM-CSF promotes proliferation of human fetal and adult microglia in primary cultures. Glia 1994, 4:309-318.
33. Lee Y.B., Schrader J.W., Kim S.U. p38 Map kinase regulates TNF-alpha production in human astrocytes and microglia by multiple mechanisms. Cytokine 2000, 7:874-880.
34. Lipovsky M.M., Gekker G., Anderson W.R., Molitor T.W., Peterson P.K., Hoepelman A.I. Phagocytosis of nonopsonized Cryptococcus neoformans by swine microglia involves CD14 receptors. Clin. Immunol. Immunopathol. 1997, 2:208-211.
35. Liu Y., Qin L., Li G., Zhang W., An L., Liu B., Hong J.S. Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation. J. Pharmacol. Exp. Ther. 2003, 1:212-218.
36. Lue L.F., Brachova L., Walker D.G., Rogers J. Characterization of glial cultures from rapid autopsies of Alzheimer's and control patients. Neurobiol. Aging 1996, 3:421-429.
37. Lue L.F., Walker D.G., Rogers J. Modeling microglial activation in Alzheimer's disease with human postmortem microglial cultures. Neurobiol. Aging 2001, 6:945-956.
38. Metzger B.T., Barnes D.M., Reed J.D. Purple carrot (Daucus carota L.) polyacetylenes decrease lipopolysaccharide-induced expression of inflammatory proteins in macrophage and endothelial cells. J. Agric. Food. Chem. 2008, 10:3554-3560.
39. Mizuno T., Kuno R., Nitta A., Nabeshima T., Zhang G., Kawanokuchi J., Wang J., Jin S., Takeuchi H., Suzumura A. Protective effects of nicergoline against neuronal cell death induced by activated microglia and astrocytes. Brain Res. 2005, 1-2:78-85.
40. Nakagawa T., Schwartz J.P. Gene expression patterns in in vivo normal adult astrocytes compared with cultured neonatal and normal adult astrocytes. Neurochem. Int. 2004, 2-3:203-242.
41. Peterson P.K., Gekker G., Hu S., Anderson W.B., Teichert M., Chao C.C., Molitor T.W. Multinucleated giant cell formation of swine microglia induced by Mycobacterium bovis. J. Infect. Dis. 1996, 5:1194-1201.
42. Pilon C., Meurens F., Dauba A., Salmon H., Velge-Roussel F., Lebranchu Y., Baron C. Induction of porcine regulatory cells by mycophenolic acid-treated dendritic cells. Transplant Proc. 2009, 2:700-702.
43. Qin L., Liu Y., Wang T., Wei S.J., Block M.L., Wilson B., Liu B., Hong J.S. NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia. J. Biol. Chem. 2004, 2:1415-1421.
44. Rothkotter H.J., Sowa E., Pabst R. The pig as a model of developmental immunology. Human Exp. Toxicol. 2002, 9-10:533-536.
45. Sak K., Illes P. Neuronal and glial cell lines as model systems for studying P2Y receptor pharmacology. Neurochem. Int. 2005, 6:401-412.
46. Salmina A.B. Neuron-glia interactions as therapeutic targets in neurodegeneration. J. Alzheimer Dis. 2009, 3:485-502.
47. Sawada M., Sawada H., Nagatsu T. Effects of aging on neuroprotective and neurotoxic properties of microglia in neurodegenerative diseases. Neurodegener. Dis. 2008, 3-4:254-256.
48. Sowa G., Gekker G., Lipovsky M.M., Hu S., Chao C.C., Molitor T.W., Peterson P.K. Inhibition of swine microglial cell phagocytosis of Cryptococcus neoformans by femtomolar concentrations of morphine. Biochem. Pharmacol. 1997, 6:823-828.
49. Tambuyzer B.R., Lambrichts I., Lenjou M., Nouwen E.J. Effects of the pig renal epithelial cell line LLC-PK1 and its conditioned medium on the phenotype of porcine microglia in vitro. Eur. J. Cell Biol. 2007, 4:221-232.
50. Tambuyzer B.R., Nouwen E.J. Inhibition of microglia multinucleated giant cell formation and induction of differentiation by GM-CSF using a porcine in vitro model. Cytokine 2005, 4:270-279.
51. Walter L., Neumann H. Role of microglia in neuronal degeneration and regeneration. Semin. Immunopathol. 2009, 4:513-525.
52. Williams K., Bar-Or A., Ulvestad E., Olivier A., Antel J.P., Yong V.W. Biology of adult human microglia in culture: comparisons with peripheral blood monocytes and astrocytes. J. Neuropathol. Exp. Neurol. 1992, 5:538-549.
53. Xie Z., Wei M., Morgan T.E., Fabrizio P., Han D., Finch C.E., Longo V.D. Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia. J. Neurosci. 2002, 9:3484-3492.
54. Yang P., Chen L., Zwart R., Kijlstra A. Immune cells in the porcine retina: distribution, characterization and morphological features. Invest. Ophthalmol. Vis. Sci. 2002, 5:1488-1492.