Zaprinast, an inhibitor of cGMP-selective phosphodiesterases, enhances the secretion of TNF-α and IL-1β and the expression of iNOS and MHC class II molecules in rat microglial cells

Journal of Neuroscience Research

Volumn 67, Issue 3, 2002, Pages 411-421

  Choi, Sang Hyun ^a   Choi, Dong Hee ^a   Song, Kwang Seon ^a   Shin, Kyung Ho ^a   Chun, Boe Gwun ^a  

^a Korea University College of Medicine   (South Korea)

Author keywords

Astrocytes; Interferon ; KT5823; Lipopolysaccharide; ODQ

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE INHIBITOR; GUANYLATE CYCLASE; INTERLEUKIN 1BETA; KT 5823; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHODIESTERASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; ZAPRINAST;

ARTICLE; ASTROCYTE; AUTOCRINE EFFECT; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MICROGLIA; NERVE CELL CULTURE; PARACRINE SIGNALING; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; ASTROCYTES; CELLS, CULTURED; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; CYCLIC GMP; HISTOCOMPATIBILITY ANTIGENS CLASS II; INTERFERON TYPE II; INTERLEUKIN-1; MICROGLIA; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; PURINONES; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036469877     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10102     Document Type: Article

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