Analysis of K-ras, BRAF, and PIK3CA mutations in laterally-spreading tumors of the colorectum

Journal of Gastroenterology and Hepatology (Australia)

Volumn 26, Issue 3, 2011, Pages 599-607

  Kaji, Eisuke ^a   Kato, Jun ^a   Suzuki, Hideyuki ^a   Akita, Mitsuhiro ^a   Horii, Joichiro ^a   Saito, Shunsuke ^a   Higashi, Reiji ^a   Ishikawa, Shin ^a   Kuriyama, Motoaki ^a   Hiraoka, Sakiko ^a   Uraoka, Toshio ^b   Yamamoto, Kazuhide ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b OKAYAMA UNIVERSITY HOSPITAL   (Japan)

Author keywords

BRAF; K ras; Laterally spreading tumor; Phosphoinositide 3 kinase catalytic polypeptide

Indexed keywords

B RAF KINASE; K RAS PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE CATALYTIC ALPHA POLYPEPTIDE; UNCLASSIFIED DRUG;

ADULT; ADVANCED CANCER; AGED; ARTICLE; COLON ADENOMA; COLON CANCER; COLORECTAL TUMOR; CONTROLLED STUDY; ENZYME BLOOD LEVEL; FEMALE; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN TISSUE; LATERALLY SPREADING TUMOR; MAJOR CLINICAL STUDY; MALE; METASTASIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TUMOR VOLUME;

EID: 79951658258     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2010.06485.x     Document Type: Article

References (32)

1. Kudo S, Kashida H, Nakajima T, Tamura S, Nakajo K. Endoscopic diagnosis and treatment of early colorectal cancer. World J. Surg. 1997; 21: 694-701.
2. Hurlstone DP, Sanders DS, Cross SS etal. Colonoscopic resection of lateral spreading tumours: a prospective analysis of endoscopic mucosal resection. Gut 2004; 53: 1334-9.
3. Kudo S. Endoscopic mucosal resection of flat and depressed type of early colorectal cancer. Endoscopy 1993; 25: 455-61.
4. Yamagata S, Muto T, Uchida Y etal. Polypoid growth and K-ras codon 12 mutation in colorectal cancer. Cancer 1995; 75: 953-7.
5. Chiang JM, Chou YH, Chou TB. K-ras codon 12 mutation determines the polypoid growth of colorectal cancer. Cancer Res. 1998; 58: 3289-93.
6. Davies H, Bignell GR, Cox C etal. Mutations of the BRAF gene in human cancer. Nature 2002; 417: 949-54.
7. Rajagopalan H, Bardelli A, Lengauer C, Kinzler KW, Vogelstein B, Velculescu VE. Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature 2002; 418: 934.
8. Yuen ST, Davies H, Chan TL etal. Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia. Cancer Res. 2002; 62: 5.
9. Kambara T, Simms LA, Whitehall VL etal. BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum. Gut 2004; 53: 1137-44.
10. Samuels Y, Velculescu VE. Oncogenic mutations of PIK3CA in human cancers. Cell Cycle 2004; 3: 1221-4.
11. Samuels Y, Wang Z, Bardelli A etal. High frequency of mutations of the PIK3CA gene in human cancers. Science 2004; 304: 554.
12. Velho S, Oliveira C, Ferreira A etal. The prevalence of PIK3CA mutations in gastric and colon cancer. Eur. J. Cancer 2005; 41: 1649-54.
13. Kato S, Iida S, Higuchi T etal. PIK3CA mutation is predictive of poor survival in patients with colorectal cancer. Int. J. Cancer 2007; 121: 1771-8.
14. Nosho K, Kawasaki T, Ohnishi M etal. PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations. Neoplasia 2008; 10: 534-41.
15. Uraoka T, Saito Y, Matsubara T etal. Endoscopic indications for endoscopic mucosal resection of laterally spreading tumours in the colorectum. Gut 2006; 55: 1592-97.
16. Yashiro M, Carethers JM, Laghi L etal. Genetic pathways in the evolution of morphologically distinct colorectal neoplasms. Cancer Res. 2001; 61: 2676-83.
17. Sakamoto N, Terai T, Ajioka Y etal. Frequent hypermethylation of RASSF1A in early flat-type colorectal tumors. Oncogene 2004; 23: 8900-7.
18. Hiraoka S, Kato J, Tatsukawa M etal. Laterally spreading type of colorectal adenoma exhibits a unique methylation phenotype and K-ras mutations. Gastroenterology 2006; 131: 379-89.
19. Harada K, Hiraoka S, Kato J etal. Genetic and epigenetic alterations of Ras signalling pathway in colorectal neoplasia: analysis based on tumour clinicopathological features. Br. J. Cancer 2007; 97: 1425-31.
20. Jhawer M, Goel S, Wilson AJ etal. PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab. Cancer Res. 2008; 68: 1953-61.
21. Barry ELR, Baron JA, Grau MV, Wallace K, Haile RW. K-ras mutations in incident sporadic colorectal adenomas. Cancer 2006; 106: 1036-40.
22. Einspahr JG, Martinez ME, Jiang R etal. Associations of Ki-ras proto-oncogene mutation and p53 gene overexpression in sporadic colorectal adenomas with demographic and clinicopathologic characteristics. Cancer Epidemiol. Biomarkers Prev. 2006; 15: 1443-50.
23. Samowitz WS, Curtin K, Schaffer D, Robertson M, Leppert M, Slattery ML. Relationship of Ki-ras mutations in colon cancers to tumor location, stage, and survival: a population-based study. Cancer Epidemiol. Biomarkers Prev. 2000; 9: 1193-7.
24. Andreyev HJ, Norman AR, Cunningham D, Oates JR, Clarke PA. Kirsten ras mutations in patients with colorectal cancer: the multicenter 'RASCAL' study. J. Natl. Cancer Inst. 1998; 90: 675-84.
25. Andreyev HJ, Norman AR, Cunningham D etal. Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. Br. J. Cancer 2001; 85: 692-6.
26. Fujimori T, Satonaka K, Yamamura-Idei Y, Nagasako K, Maeda S. Non-involvement of ras mutations in flat colorectal adenomas and carcinomas. Int. J. Cancer 1994; 57: 51-5.
27. Mukawa K, Fujii S, Takeda J etal. Analysis of K-ras mutations and expression of cyclooxygenase-2 and gastrin protein in laterally spreading tumors. J. Gastroenterol. Hepatol. 2005; 20: 1584-90.
28. Toyota M, Ahuja N, Ohe-Toyota M, Herman JG, Baylin SB, Issa JPJ. CpG island methylator phenotype in colorectal cancer. Proc. Natl. Acad. Sci. U. S. A. 1999; 96: 8681-6.
29. Shen L, Toyota M, Kondo Y etal. Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer. Proc. Natl. Acad. Sci. U. S. A. 2007; 104: 18654-9.
30. Kobayashi N, Saito Y, Uraoka T, Matsuda T, Suzuki H, Fujii T. Treatment strategy for laterally spreading tumors in Japan: before and after the introduction of endoscopic submucosal dissection. J. Gastroenterol. Hepatol. 2009; 24: 1387-92.
31. Mikami M, Nosho K, Yamamoto H etal. Mutational analysis of β-catenin and the RAS-RAF signaling pathway in early flat-type colorectal tumours. Eur. J. Cancer 2006; 42: 3065-72.
32. Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell 2007; 129: 1261-74.