K-ras codon 12 mutation determines the polypoid growth of colorectal cancer

Cancer Research

Volumn 58, Issue 15, 1998, Pages 3289-3293

  Chiang, Jy Ming ^a   Chou, Yah Huei Wu ^a   Chou, Tze Bin ^b  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CANCER GROWTH; CHROMOSOME 17P; CHROMOSOME 18Q; CHROMOSOME 5Q; COLON CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENETIC SCREENING; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; ONCOGENE K RAS; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

CODON; COLORECTAL NEOPLASMS; GENES, APC; GENES, DCC; GENES, P53; GENES, RAS; GENES, RETINOBLASTOMA; HUMANS; MUTATION;

EID: 0032146177     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Vogelstein, B., Fearon, E. R., Hamilton, S. R., Kern, S., Preisinger, A. C., Leppert, M., Nakamura, Y., White, R., Smits, A. M. W., and Box, J. L. Genetic alterations during colorectal tumor development. N. Engl. J. Med., 319: 525-532, 1988.
2. Fearon, E. R., and Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell, 61: 759-767, 1990.
3. Morson, B. C. The polyp-cancer sequence in the large bowel. Proc. R. Soc. Med., 67: 451-457, 1974.
4. Muto, T., Bussey, H. J. R., and Morson, B. C. The evolution of cancer of colon and rectum. Cancer (Phila.), 36: 2251-2270, 1975.
5. Kuramoto, S., and Oohara, T. How do colorectal cancer develop? Cancer (Phila.), 75: 1534-1538, 1995.
6. Yamagata, S., Muto, T., Uchida, Y., Masaki, T., Higuchi, Y., Sawada, T., and Hirooka, T. Polypoid growth and k-ras codon 12 mutation in colorectal cancer. Cancer (Phila.), 75: 953-957, 1995.
7. Yuasa, Y., Srivastava, S. K., and Dunn, C. Y. Acquisition of transforming properties by alternative point mutations within c-base has human proto-oncogenes. Nature (Lond.), 303: 775-779, 1983.
8. Levi, S., Urbano-Ispizua, A., Gill, R., Thomas, D. M., Gi, J., Foster, C., and Marshall, C. J. Multiple k-ras codon 12 mutations in cholangiocarcinoma demonstrated with a sensitive polymerase chain reaction technique. Cancer Res., 51: 3497-3502, 1991.
9. Kahn, S. M., Jiang, W., Gulbertson, T. A., Weinstein, I. B., Williams, G. M., Tomita, N., and Ronai, Z. Rapid and sensitive nonradioactive detection of mutant k-ras genes via enriched PCR amplification. Oncogene, 6: 1079-1083, 1991.
10. Hsieh, L. L, Hsia, C. F., Wang, L. Y., Chen C. J., and Ho, Y. S. p53 gene mutations in brain tumors in Taiwan. Cancer Lett., 78: 25-32, 1994.
11. Spinardi, L., Mazars, R, and Theillet, C. Protocols for an improved detection of point mutations by SSCP. Nucleic Acids Res., 19: 4009, 1991.
12. Vogelstein, B., Fearon, E. R., Kern, S. E., Hamilton, S. R., Preisinger, A. C., Nakamura, Y., and White, R. Allelotype of colorectal carcinomas. Science (Washington DC), 244: 207-211, 1989.
13. Bos, J. L., Fearon, E. R., Hamilton, S. R., and Vogelstein, B. Prevalence of ras gene mutations in human colorectal cancers. Nature (Lond.), 327: 293-296, 1987.
14. Sasaki, M., Sugio, K., and Sasazuki, T. K-ras activation in colorectal tumors from patients with familial polyposis coli. Cancer (Phila.), 65: 2576-2579, 1990.
15. Losi, L., De Leon, M. P., Jiricny, J., Di Gregorio, C., Benatti, P., Percesepe, A., Fante, R., Roncucci, L., Pedroni, M., and Benhattar, J. K-ras and p53 mutation in hereditary non-polyposis colorectal cancer. Int. J. Cancer, 74: 94-96, 1997.
16. Finkelstein, S. D., Sayegh, R., Christensen, S., and Swalsky, P. A. Determination of tumor aggressiveness in colorectal cancer by k-ras-2 analysis. Arch. Surg., 128: 526-532, 1993.
17. Moerkerk, P., Arends, J. W., Driel, M. V., d'Bruine, A., d'Goeij, A., and Kate, J. T. Type and number of ki-ras point mutations related to stage of human colorectal cancer. Cancer Res., 54: 3376-3378, 1984.
18. Bennett, M. A., Kay, E. W., Mucahy, H., O'Flaherty, L., O'Donoghue, D. P., Leader, M., and Croke, D. T. Ras and p53 in the prediction of survival in Dukes' stage B colorectal carcinoma. J. Clin. Pathol. Mol. Pathol., 48: 310-315, 1995.
19. Bell, S. M., Kelly, S. A., Hoyle, J. A., Lewis, F. A., Taylor, G. R., Thompson, H., Dixon, M. F., and Quirke, P. C-ki-ras gene mutations in dysplasia and carcinomas complicating ulcerative colitis gene mutations in dysplasia and carcinomas complicating ulcerative colitis. Br. J. Cancer, 64: 174-178, 1991.
20. Kern, S. E., Redston, M., Seymour, A. B., Caldas, C., Powell, S. E., Komachi, S., and Kinzler, K. W. Molecular genetic profiles of colitis-associated neoplasms. Gastroenterology, 107: 420-428, 1994.
21. Tsuda, T., Mochizuki, M., and Wakasa, H. Detection of K-ras gene mutation and expression of p21 protein in dysplasias and carcinomas complicating ulcerative colitis. J. Gastroenterol., 30: 30-32, 1995.
22. Minamoto, T., Sawaguchi, K., Mai, M., Yamashita, N., Sugimura, T., and Esumi, H. Infrequent K-ras activation in superficial-type colorectal adenomas and adenocarcinomas. Cancer Res., 54: 2841-2844, 1994.
23. Ohmura, M., and Hattor, T. A possible multiclonal development in human colonic carcinomas. J. Cancer Res. Clin. Oncol., 121: 321-326, 1995.
24. Balmain, A., and Brown, K. Oncogene activation in chemical carcinogenesis. Adv. Cancer Res., 51: 147-182, 1988.
25. Cerny, W. L., Mangold, K. A., and Scarpelli, D. G. K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster. Cancer Res., 52: 4507-4513, 1992.
26. Newcomb, E., Bayona, W., and Pisharody, S. N-methylnitrourea-induced ki-ras condon 12 mutation: early events in mouse thymic lymphoma. Mol. Carcinog., 13: 89-95, 1995.
27. Tachino, N., Hayashi, R., Liew, C., Bailey, G., and Dashwood, R. Evidence for ras gene mutation in 2-amino-3-methylimidazo(4,5-f)quinoline-induced colonic aberrant crypts in the rat. Mol Carcinog., 12: 187-192, 1995.
28. Van Kranen, H. J., de Gruijl, E. R., de Vries, A, Sontag, Y., Wester, P. W., Senden, H. C. M., Rozemuller, E., and van Kreijl, C. F. Frequent p53 alterations but low incidence of ras mutations in UV-B-induced skin tumors of hairless mice. Carcinogenesis (Lond.), 16: 1141-1147, 1995.
29. Zhuang, S. M., Cochran, C., Goodrow, T., Wiseman, R. W., and Saderkvist, P. Genetic alterations of p53 and ras genes in 1,3-butadiene- and 2′,3′-diodeoxycytidine-induced lymphomas. Cancer Res., 57: 2710-2714, 19967.
30. Sidransky, D., Tokino, T., and Hamilton, S. Identification of ras oncogene mutations in the stool of patients with curable colorectal tumor. Science (Washington DC), 256: 102, 1992.
31. Smith-Ravin, J., England, J., Talbot, I. C., and Bodmer, W. Detection of c-ki-ras mutations in faecal samples from sporadic colorectal cancer patients. Gut., 36: 81-86, 1995.
32. Fearon, E. R. K-ras gene mutation as a pathogenic and diagnostic marker in human cancer. J. Natl. Cancer Inst. (Bethesda), 85: 1978-1980, 1993.
33. Pricolo, V. E., Finkelstein, S. D., Wu, T. T., Bakker, A., Swalsky, P. A., and Bland, K. I. Prognostic value of TP53 and k-ras-2 mutational analysis in stage III carcinoma of the colon. Am. J. Surg., 171: 41-46, 1996.
34. Larcher, F. I., Robles, A., Duran, H., Murillas, R., Quintanilla, M., Cano, A. J., Conti, C., and Jorcano, J. L. Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels. Cancer Res., 56: 5391-5396, 1996.
35. Arends, M. J., McGregor, A. H., and Wyllie, A. H. Apoptosis is inversely related to necrosis and determines net growth in tumors bearing constitutively expressed myc, ras, and HPV oncogenes. Am. J. Pathol., 144: 1045-1057, 1994.
36. Shirasawa, S. Altered growth of human colon cancer cell lines disrupted at activated ki-ras. Science (Washington DC), 260: 85-88, 1993.
37. Spirio, L., Joslyn, G., Nelson, L., Leppert, M., and White, R. A. CA repeat 30-70 kb downstream from the adenomatous polyposis coli (APC) gene. Nucleic Acids Res., 19: 6348, 1991.
38. Oliphant, A. R. Dinucleotide repeat polymorphism at the D17s513 locus. Nucleic Acids Res., 19: 4794, 1991.
39. Futreal, P. A., Barrett, J. C., and Wiseman, R. W. An Ala polymorphism intragenic to the TP53 gene. Nucleic Acids Res., 19: 6977, 1991.
40. Weber, J. L., and May, P. E. Dinucleotide repeat polymorphism at the D18S35 locus. Nucleic Acids Res., 18: 6465, 1990.
41. Weber, J. L., and May, P. E. Dinucleotide repeat polymorphism at the D18S34 locus. Nucleic Acids Res., 18: 3431, 1990.
42. Scholnick, S. B., Sun, P. C., Shaw, M. E., and Haughey, B. H. El-Mofty sky frequent loss of heterozygosity for Rb, TP53 and chromosome Arm 3P, but not NME 1 in squamous cell carcinomas of the supraglottic larynx. Cancer (Phila.), 73: 2472-2480, 1994.
43. Gumbiner, B. M. Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell, 84: 345-357, 1996.
44. Schlaepfer, D. D., Hanks, S. K., Hunter, T., and vander Geer, P. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature (Lond.), 372: 786-791, 1994.
45. Zhu, X., and Assoian, R. K. Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation. Mol. Biol. Cell, 6: 273-282, 1995.
46. Hamilton, S. R. Pathologic features of colorectal cancer. In: Cohen, A. M., Winawer, S. J., Friedman, M. A., and Gunderson, L. L. (eds.), Cancer of the Colon, Rectum, and Anus, pp. 189-191. New York: McGraw-Hill, 1995.