-
1
-
-
0028874049
-
Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus type 1 (HIV-1): interference with early and late events in HIV-1 replication
-
Steinkasserer A, Harrison R, Billich A etal. Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus type 1 (HIV-1): interference with early and late events in HIV-1 replication. J. Virol. 1995; 69: 814-24.
-
(1995)
J. Virol.
, vol.69
, pp. 814-824
-
-
Steinkasserer, A.1
Harrison, R.2
Billich, A.3
-
2
-
-
0142182744
-
Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes
-
Watashi K, Hijikata M, Hosaka M, Yamaji M, Shimotohno K. Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes. Hepatology 2003; 38: 1282-8.
-
(2003)
Hepatology
, vol.38
, pp. 1282-1288
-
-
Watashi, K.1
Hijikata, M.2
Hosaka, M.3
Yamaji, M.4
Shimotohno, K.5
-
3
-
-
14844297023
-
Inhibitory effect of cyclosporine A on hepatitis B virus replication in vitro and its possible mechanisms
-
Xia WL, Shen Y, Zheng SS. Inhibitory effect of cyclosporine A on hepatitis B virus replication in vitro and its possible mechanisms. Hepatobiliary Pancreat. Dis. Int. 2005; 4: 18-22.
-
(2005)
Hepatobiliary Pancreat. Dis. Int.
, vol.4
, pp. 18-22
-
-
Xia, W.L.1
Shen, Y.2
Zheng, S.S.3
-
4
-
-
34548172402
-
Cyclosporine inhibits mouse cytomegalovirus infection via a cyclophilin-dependent pathway specifically in neural stem/progenitor cells
-
Kawasaki H, Mocarski ES, Kosugi I, Tsutsui Y. Cyclosporine inhibits mouse cytomegalovirus infection via a cyclophilin-dependent pathway specifically in neural stem/progenitor cells. J. Virol. 2007; 81: 9013-23.
-
(2007)
J. Virol.
, vol.81
, pp. 9013-9023
-
-
Kawasaki, H.1
Mocarski, E.S.2
Kosugi, I.3
Tsutsui, Y.4
-
5
-
-
13444282326
-
Specific inhibition of the mitochondrial permeability transition prevents lethal reperfusion injury
-
Argaud L, Gateau-Roesch O, Muntean D etal. Specific inhibition of the mitochondrial permeability transition prevents lethal reperfusion injury. J. Mol. Cell. Cardiol. 2005; 38: 367-74.
-
(2005)
J. Mol. Cell. Cardiol.
, vol.38
, pp. 367-374
-
-
Argaud, L.1
Gateau-Roesch, O.2
Muntean, D.3
-
6
-
-
0029845347
-
The use of cyclosporine, FK506, and SDZ NIM811 to prevent CD25-quiescent peripheral blood mononuclear cells from producing human immunodeficiency virus
-
Borvak J, Chou CS, Van Dyke G, Rosenwirth B, Vitetta ES, Ramilo O. The use of cyclosporine, FK506, and SDZ NIM811 to prevent CD25-quiescent peripheral blood mononuclear cells from producing human immunodeficiency virus. J. Infect. Dis. 1996; 174: 850-3.
-
(1996)
J. Infect. Dis.
, vol.174
, pp. 850-853
-
-
Borvak, J.1
Chou, C.S.2
Van Dyke, G.3
Rosenwirth, B.4
Vitetta, E.S.5
Ramilo, O.6
-
7
-
-
34247364125
-
NIM811, a mitochondrial permeability transition inhibitor, prevents mitochondrial depolarization in small-for-size rat liver grafts
-
Zhong Z, Theruvath TP, Currin RT, Waldmeier PC, Lemasters JJ. NIM811, a mitochondrial permeability transition inhibitor, prevents mitochondrial depolarization in small-for-size rat liver grafts. Am. J. Transplant. 2007; 7: 1103-11.
-
(2007)
Am. J. Transplant.
, vol.7
, pp. 1103-1111
-
-
Zhong, Z.1
Theruvath, T.P.2
Currin, R.T.3
Waldmeier, P.C.4
Lemasters, J.J.5
-
8
-
-
0036088518
-
Inhibition of the mitochondrial permeability transition by the nonimmunosuppressive cyclosporin derivative NIM811
-
Waldmeier PC, Feldtrauer JJ, Qian T, Lemasters JJ. Inhibition of the mitochondrial permeability transition by the nonimmunosuppressive cyclosporin derivative NIM811. Mol. Pharmacol. 2002; 62: 22-9.
-
(2002)
Mol. Pharmacol.
, vol.62
, pp. 22-29
-
-
Waldmeier, P.C.1
Feldtrauer, J.J.2
Qian, T.3
Lemasters, J.J.4
-
9
-
-
0037744950
-
Activation and inhibition of cellular calcium and tyrosine kinase signaling pathways identify targets of the HBx protein involved in hepatitis B virus replication
-
Bouchard MJ, Puro RJ, Wang L, Schneider RJ. Activation and inhibition of cellular calcium and tyrosine kinase signaling pathways identify targets of the HBx protein involved in hepatitis B virus replication. J. Virol. 2003; 77: 7713-19.
-
(2003)
J. Virol.
, vol.77
, pp. 7713-7719
-
-
Bouchard, M.J.1
Puro, R.J.2
Wang, L.3
Schneider, R.J.4
-
10
-
-
21244433445
-
Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase
-
Watashi K, Ishii N, Hijikata M etal. Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase. Mol. Cell. 2005; 19: 111-22.
-
(2005)
Mol. Cell.
, vol.19
, pp. 111-122
-
-
Watashi, K.1
Ishii, N.2
Hijikata, M.3
-
11
-
-
57349138389
-
NIM811 (N-methyl-4-isoleucine cyclosporine), a mitochondrial permeability transition inhibitor, attenuates cholestatic liver injury but not fibrosis in mice
-
Rehman H, Ramshesh VK, Theruvath TP etal. NIM811 (N-methyl-4-isoleucine cyclosporine), a mitochondrial permeability transition inhibitor, attenuates cholestatic liver injury but not fibrosis in mice. J. Pharmacol. Exp. Ther. 2008; 327: 699-706.
-
(2008)
J. Pharmacol. Exp. Ther.
, vol.327
, pp. 699-706
-
-
Rehman, H.1
Ramshesh, V.K.2
Theruvath, T.P.3
-
12
-
-
35148889830
-
NIM811, a nonimmunosuppressive cyclosporine analogue, suppresses collagen production and enhances collagenase activity in hepatic stellate cells
-
Kohjima M, Enjoji M, Higuchi N etal. NIM811, a nonimmunosuppressive cyclosporine analogue, suppresses collagen production and enhances collagenase activity in hepatic stellate cells. Liver Int. 2007; 27: 1273-81.
-
(2007)
Liver Int.
, vol.27
, pp. 1273-1281
-
-
Kohjima, M.1
Enjoji, M.2
Higuchi, N.3
-
13
-
-
77953277111
-
Application of tacrolimus and cyclosporine A in HBV-carrying renal transplant recipients
-
Liu XY, Yu LX, Fu SJ etal. Application of tacrolimus and cyclosporine A in HBV-carrying renal transplant recipients. Nan Fang Yi Ke Da Xue Xue Bao 2007; 27: 1090-2.
-
(2007)
Nan Fang Yi Ke Da Xue Xue Bao
, vol.27
, pp. 1090-1092
-
-
Liu, X.Y.1
Yu, L.X.2
Fu, S.J.3
-
14
-
-
16344374690
-
Co-administration of cyclosporine an alleviates thioacetamide-induced liver injury
-
Fan S, Weng CF. Co-administration of cyclosporine an alleviates thioacetamide-induced liver injury. World J. Gastroenterol. 2005; 11: 1411-19.
-
(2005)
World J. Gastroenterol.
, vol.11
, pp. 1411-1419
-
-
Fan, S.1
Weng, C.F.2
-
15
-
-
33748687426
-
NIM811, a cyclophilin inhibitor, exhibits potent in vitro activity against hepatitis C virus alone or in combination with alpha interferon
-
Ma S, Boerner JE, TiongYip C etal. NIM811, a cyclophilin inhibitor, exhibits potent in vitro activity against hepatitis C virus alone or in combination with alpha interferon. Antimicrob. Agents Chemother. 2006; 50: 2976-82.
-
(2006)
Antimicrob. Agents Chemother.
, vol.50
, pp. 2976-2982
-
-
Ma, S.1
Boerner, J.E.2
TiongYip, C.3
-
16
-
-
72949100768
-
Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A
-
Ciesek S, Steinmann E, Wedemeyer H etal. Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A. Hepatology 2009; 50: 1638-45.
-
(2009)
Hepatology
, vol.50
, pp. 1638-1645
-
-
Ciesek, S.1
Steinmann, E.2
Wedemeyer, H.3
-
17
-
-
59149102173
-
Overexpressed cyclophilin B suppresses apoptosis associated with ROS and Ca2+ homeostasis after ER stress
-
Kim J, Choi TG, Ding Y etal. Overexpressed cyclophilin B suppresses apoptosis associated with ROS and Ca2+ homeostasis after ER stress. J. Cell. Sci. 2008; 121: 3636-48.
-
(2008)
J. Cell. Sci.
, vol.121
, pp. 3636-3648
-
-
Kim, J.1
Choi, T.G.2
Ding, Y.3
-
18
-
-
0029807530
-
A cyclophilin function in Hsp90-dependent signal transduction
-
Duina AA, Chang HC, Marsh JA, Lindquist S, Gaber RF. A cyclophilin function in Hsp90-dependent signal transduction. Science 1996; 274: 1713-15.
-
(1996)
Science
, vol.274
, pp. 1713-1715
-
-
Duina, A.A.1
Chang, H.C.2
Marsh, J.A.3
Lindquist, S.4
Gaber, R.F.5
-
19
-
-
0029852712
-
Molecular chaperone machines: chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23
-
Freeman BC, Toft DO, Morimoto RI. Molecular chaperone machines: chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23. Science 1996; 274: 1718-20.
-
(1996)
Science
, vol.274
, pp. 1718-1720
-
-
Freeman, B.C.1
Toft, D.O.2
Morimoto, R.I.3
-
20
-
-
38349006274
-
Cyclophilin B induces integrin-mediated cell adhesion by a mechanism involving CD98-dependent activation of protein kinase C-delta and p44/42 mitogen-activated protein kinases
-
Melchior A, Denys A, Deligny A, Mazurier J, Allain F. Cyclophilin B induces integrin-mediated cell adhesion by a mechanism involving CD98-dependent activation of protein kinase C-delta and p44/42 mitogen-activated protein kinases. Exp. Cell. Res. 2008; 314: 616-28.
-
(2008)
Exp. Cell. Res.
, vol.314
, pp. 616-628
-
-
Melchior, A.1
Denys, A.2
Deligny, A.3
Mazurier, J.4
Allain, F.5
-
21
-
-
61449166638
-
Cyclophilin B stimulates RNA synthesis by the HCV RNA dependent RNA polymerase
-
Heck JA, Meng X, Frick DN. Cyclophilin B stimulates RNA synthesis by the HCV RNA dependent RNA polymerase. Biochem. Pharmacol. 2009; 77: 1173-80.
-
(2009)
Biochem. Pharmacol.
, vol.77
, pp. 1173-1180
-
-
Heck, J.A.1
Meng, X.2
Frick, D.N.3
-
22
-
-
22544457641
-
Cyclophilin B escorts the hepatitis C virus RNA polymerase: a viral Achilles heel?
-
Heitman J, Cullen BR. Cyclophilin B escorts the hepatitis C virus RNA polymerase: a viral Achilles heel? Mol. Cell. 2005; 19: 145-6.
-
(2005)
Mol. Cell.
, vol.19
, pp. 145-146
-
-
Heitman, J.1
Cullen, B.R.2
-
23
-
-
0033950189
-
Oxidative stress and adenine nucleotide control of mitochondrial permeability transition
-
Kantrow SP, Tatro LG, Piantadosi CA. Oxidative stress and adenine nucleotide control of mitochondrial permeability transition. Free Radic. Biol. Med. 2000; 28: 251-60.
-
(2000)
Free Radic. Biol. Med.
, vol.28
, pp. 251-260
-
-
Kantrow, S.P.1
Tatro, L.G.2
Piantadosi, C.A.3
-
24
-
-
37549006050
-
Attenuation of acute mitochondrial dysfunction after traumatic brain injury in mice by NIM811, a non-immunosuppressive cyclosporin A analog
-
Mbye LH, Singh IN, Sullivan PG, Springer JE, Hall ED. Attenuation of acute mitochondrial dysfunction after traumatic brain injury in mice by NIM811, a non-immunosuppressive cyclosporin A analog. Exp. Neurol. 2008; 209: 243-53.
-
(2008)
Exp. Neurol.
, vol.209
, pp. 243-253
-
-
Mbye, L.H.1
Singh, I.N.2
Sullivan, P.G.3
Springer, J.E.4
Hall, E.D.5
-
25
-
-
33645968418
-
Effect of celecoxib on experimental liver fibrosis in rat
-
Hui AY, Leung WK, Chan HL etal. Effect of celecoxib on experimental liver fibrosis in rat. Liver Int. 2006; 26: 125-36.
-
(2006)
Liver Int.
, vol.26
, pp. 125-136
-
-
Hui, A.Y.1
Leung, W.K.2
Chan, H.L.3
-
26
-
-
28844489800
-
Bile salt-induced apoptosis involves NADPH oxidase isoform activation
-
Reinehr R, Becker S, Keitel V, Eberle A, Grether-Beck S, Haussinger D. Bile salt-induced apoptosis involves NADPH oxidase isoform activation. Gastroenterology 2005; 129: 2009-31.
-
(2005)
Gastroenterology
, vol.129
, pp. 2009-2031
-
-
Reinehr, R.1
Becker, S.2
Keitel, V.3
Eberle, A.4
Grether-Beck, S.5
Haussinger, D.6
-
27
-
-
54549111991
-
Oxidative and nitrosative stress and fibrogenic response
-
viii.
-
Urtasun R, Conde de la Rosa L, Nieto N. Oxidative and nitrosative stress and fibrogenic response. Clin. Liver Dis. 2008; 12: 769-90, viii.
-
(2008)
Clin. Liver Dis.
, vol.12
, pp. 769-790
-
-
Urtasun, R.1
Conde de la Rosa, L.2
Nieto, N.3
-
28
-
-
49749084758
-
Newly proposed fibrosis staging criterion for assessing carbon tetrachloride- and albumin complex-induced liver fibrosis in rodents
-
Zhao XY, Wang BE, Li XM, Wang TL. Newly proposed fibrosis staging criterion for assessing carbon tetrachloride- and albumin complex-induced liver fibrosis in rodents. Pathol. Int. 2008; 58: 580-8.
-
(2008)
Pathol. Int.
, vol.58
, pp. 580-588
-
-
Zhao, X.Y.1
Wang, B.E.2
Li, X.M.3
Wang, T.L.4
-
29
-
-
35448974586
-
Prognostic significance of PTEN expression in esophageal squamous cell carcinoma from Linzhou City, a high incidence area of northern China
-
Chang D, Wang TY, Li HC, Wei JC, Song JX. Prognostic significance of PTEN expression in esophageal squamous cell carcinoma from Linzhou City, a high incidence area of northern China. Dis. Esophagus. 2007; 20: 491-6.
-
(2007)
Dis. Esophagus.
, vol.20
, pp. 491-496
-
-
Chang, D.1
Wang, T.Y.2
Li, H.C.3
Wei, J.C.4
Song, J.X.5
-
31
-
-
12044260143
-
Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies
-
Friedman SL. Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N. Engl. J. Med. 1993; 328: 1828-35.
-
(1993)
N. Engl. J. Med.
, vol.328
, pp. 1828-1835
-
-
Friedman, S.L.1
-
32
-
-
0032794576
-
Cytokines and fibrogenesis
-
Friedman SL. Cytokines and fibrogenesis. Semin. Liver Dis. 1999; 19: 129-40.
-
(1999)
Semin. Liver Dis.
, vol.19
, pp. 129-140
-
-
Friedman, S.L.1
-
33
-
-
0034723290
-
Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
-
Friedman SL. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J. Biol. Chem. 2000; 275: 2247-50.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 2247-2250
-
-
Friedman, S.L.1
-
35
-
-
13544268721
-
Antifibrotic therapy in chronic liver disease
-
Rockey DC. Antifibrotic therapy in chronic liver disease. Clin. Gastroenterol. Hepatol. 2005; 3: 95-107.
-
(2005)
Clin. Gastroenterol. Hepatol.
, vol.3
, pp. 95-107
-
-
Rockey, D.C.1
-
36
-
-
0038455747
-
Cirrhosis: new research provides a basis for rational and targeted treatments
-
Iredale JP. Cirrhosis: new research provides a basis for rational and targeted treatments. BMJ 2003; 327: 143-7.
-
(2003)
BMJ
, vol.327
, pp. 143-147
-
-
Iredale, J.P.1
-
37
-
-
0032801286
-
Liver fibrogenesis and the role of hepatic stellate cells: new insights and prospects for therapy
-
Li D, Friedman SL. Liver fibrogenesis and the role of hepatic stellate cells: new insights and prospects for therapy. J. Gastroenterol. Hepatol. 1999; 14: 618-33.
-
(1999)
J. Gastroenterol. Hepatol.
, vol.14
, pp. 618-633
-
-
Li, D.1
Friedman, S.L.2
-
38
-
-
66549109510
-
Antifibrotic activity of anisodamine in vivo is associated with changed intrahepatic levels of matrix metalloproteinase-2 and its inhibitor tissue inhibitors of metalloproteinases-2 and transforming growth factor beta1 in rats with carbon tetrachloride-induced liver injury
-
Luo L, Zhou A. Antifibrotic activity of anisodamine in vivo is associated with changed intrahepatic levels of matrix metalloproteinase-2 and its inhibitor tissue inhibitors of metalloproteinases-2 and transforming growth factor beta1 in rats with carbon tetrachloride-induced liver injury. J. Gastroenterol. Hepatol. 2009; 24: 1070-6.
-
(2009)
J. Gastroenterol. Hepatol.
, vol.24
, pp. 1070-1076
-
-
Luo, L.1
Zhou, A.2
-
39
-
-
31944433741
-
TGF-beta/Smad signaling in the injured liver
-
Breitkopf K, Godoy P, Ciuclan L, Singer MV, Dooley S. TGF-beta/Smad signaling in the injured liver. Z. Gastroenterol. 2006; 44: 57-66.
-
(2006)
Z. Gastroenterol.
, vol.44
, pp. 57-66
-
-
Breitkopf, K.1
Godoy, P.2
Ciuclan, L.3
Singer, M.V.4
Dooley, S.5
-
40
-
-
35948954244
-
Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver
-
Friedman SL. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol. Rev. 2008; 88: 125-72.
-
(2008)
Physiol. Rev.
, vol.88
, pp. 125-172
-
-
Friedman, S.L.1
-
41
-
-
0028965266
-
Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus (HIV) type 1: interference with HIV protein-cyclophilin A interactions
-
Billich A, Hammerschmid F, Peichl P etal. Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus (HIV) type 1: interference with HIV protein-cyclophilin A interactions. J. Virol. 1995; 69: 2451-61.
-
(1995)
J. Virol.
, vol.69
, pp. 2451-2461
-
-
Billich, A.1
Hammerschmid, F.2
Peichl, P.3
-
42
-
-
40949117600
-
The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus
-
Flisiak R, Horban A, Gallay P etal. The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus. Hepatology 2008; 47: 817-26.
-
(2008)
Hepatology
, vol.47
, pp. 817-826
-
-
Flisiak, R.1
Horban, A.2
Gallay, P.3
-
43
-
-
57749190824
-
The anti-inflammatory effect of celecoxib does not prevent liver fibrosis in bile duct-ligated rats
-
Yu J, Hui AY, Chu ES etal. The anti-inflammatory effect of celecoxib does not prevent liver fibrosis in bile duct-ligated rats. Liver Int. 2009; 29: 25-36.
-
(2009)
Liver Int.
, vol.29
, pp. 25-36
-
-
Yu, J.1
Hui, A.Y.2
Chu, E.S.3
|