Physical and mechanical properties of PMMA bone cement reinforced with nano-sized titania fibers

Journal of Biomaterials Applications

Volumn 25, Issue 6, 2011, Pages 515-537

  Khaled, S M Z ^a   Charpentier, Paul A ^a   Rizkalla, Amin S ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b WESTERN UNIVERSITY   (Canada)

Author keywords

acrylic cement; mechanical properties; radiopacity; rheology; titania nanofibers

Indexed keywords

BIFUNCTIONAL MONOMERS; CEMENT MANTLE; CEMENT MATRIX; COMPLEX VISCOSITY; CONTRAST MEDIUM; DETRIMENTAL EFFECTS; FIBER CONTENTS; FLEXURAL MODULUS; FLEXURAL STRENGTH; FUNCTIONALIZED; HANDLING PROPERTIES; IMPLANT LOOSENING; IN-VITRO; INTERFACIAL INTERACTION; LOAD TRANSFER; METHACRYLIC ACIDS; NANO-SIZED; NANOSTRUCTURED TITANIA; PHYSICAL AND MECHANICAL PROPERTIES; PMMA BONE CEMENT; PMMA MATRICES; POLYMERIZATION TEMPERATURE; RADIOPACITY; REINFORCING PHASE; SETTING TIME; TIO; TITANIA; TITANIA FIBERS;

BENDING STRENGTH; BIOCOMPATIBILITY; BONE; CEMENTS; CONTRAST MEDIA; ELASTICITY; FIBERS; FRACTURE; FRACTURE TOUGHNESS; MECHANICAL PROPERTIES; NANOFIBERS; REINFORCED PLASTICS; RHEOLOGY; TITANIUM DIOXIDE; VISCOSITY;

BONE CEMENT;

BIOMATERIAL; BONE CEMENT; NANOFIBER; POLY(METHYL METHACRYLATE); TITANIUM; TITANIUM DIOXIDE;

ANIMAL; ARTICLE; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; FLOW KINETICS; MATERIALS TESTING; METHODOLOGY; OSTEOBLAST; POLYMERIZATION; RAT; SCANNING ELECTRON MICROSCOPY; TEMPERATURE; TENSILE STRENGTH; ULTRASTRUCTURE;

ANIMALS; BIOCOMPATIBLE MATERIALS; BONE CEMENTS; CELL PROLIFERATION; MATERIALS TESTING; MICROSCOPY, ELECTRON, SCANNING; NANOFIBERS; OSTEOBLASTS; POLYMERIZATION; POLYMETHYL METHACRYLATE; RATS; RHEOLOGY; TEMPERATURE; TENSILE STRENGTH; TITANIUM;

EID: 79951607913     PISSN: 08853282     EISSN: 15308022     Source Type: Journal    
DOI: 10.1177/0885328209356944     Document Type: Article

References (55)

1. Haboush, E. A New Operation for Arthroplasty of the Hip Based on Biomechanics Photoelasticity, Fast-setting Dental Acrylic and Other Considerations, Bull. Hosp. Joint. Dis. Orthop. Inst., 1953: 14: 242-250.
2. Pascual, B., Vtiquez, B., Gurruchaga, M. et al. New Aspects of the Effect of Size and Size Distribution on the Setting Parameters and Mechanical Properties of Acrylic Bone Cements, Biomaterials, 1996: 17: 509-516. (Pubitemid 26058534)
3. Deb, S., Abdulghani, S. and Behiri, J.C. Radiopacity in Bone Cements Using an Organo-bismuth Compound, Biomaterials, 2002: 23: 3387-3393. (Pubitemid 34615645)
4. Lewis, G. Fatigue Testing and Performance of Acrylic Bone-Cement Materials: State-of-the-Art Review, J. Biomed. Mater. Res. B Appl. Biomater., 2003: 66B: 457-486. (Pubitemid 37522441)
5. Lewis, G. Properties of Acrylic Bone Cement: State-of-the-Art Review, J. Biomed. Mater. Res. (Appl. Biomater.), 1997: 38: 155-182. (Pubitemid 27233104)
6. Deb, S. A Review of Improvements in Acrylic Bone Cements, J. Biomater. Appl., 1999: 14: 16-46.
7. Lewis, G. and Bhattaram, A. Influence of a Pre-blended Antibiotic (Gentamicin Sulfate Powder) on Various Mechanical, Thermal, and Physical Properties of Three Acrylic Bone Cements, J. Biomater. Appl., 2006: 20: 377-408.
8. Hill, J., Orr, J. and Dunne, N. In Vitro Study Investigating the Mechanical Properties of Acrylic Bone Cement Containing Calcium Carbonate Nanoparticles, J. Mater. Sci. Mater. Med., 2008: 19: 3327-3333.
9. Abboud, M., Vol, S., Duguet, E. and Fontanille, M. PMMA-Based Composite Materials with Reactive Ceramic Fillers Part III: Radiopacifying Particle-reinforced Bone Cements, J. Mater. Sci. Mater. Med., 2000: 11: 295-300. (Pubitemid 30316282)
10. Goto, K., Tamura, J. and Shinzato, S. Bioactive Bone Cements Containing Nano-sized Titania Particles for Use as Bone Substitutes, Biomaterials, 2005: 26: 6496-6505. (Pubitemid 41021744)
11. Goto, K., Hashimoto, M., Fujibayashi, S., Kokubo, T. and Nakamura, T. New Bioactive Bone Cement Containing Nano-sized Titania Particles, Key Eng. Mat., 2005: 284-286: 97-100. (Pubitemid 46780317)
12. Kuhn, K.-D. (2000). Bone Cements: Up-to-Date Comparison of Physical and Chemical Properties of Commercial Materials, Berlin, Springer, pp. 246-247.
13. Kotha, S., Li, C., Schmid, S. and Mason, J. Fracture Toughness of Steel-fibre-reinforced Bone Cement, J. Biomed. Mater. Res. A., 2004: 70: 514-521. (Pubitemid 39145252)
14. Bowman, A. and Manley, T. The Elimination of Breakages in Upper Dentures by Reinforcement with Carbon Fibre, Br. Dent. J., 1984: 156: 87-89.
15. Stipho, H. Effect of Glass Fiber Reinforcement on Some Mechanical Properties of Autopolymerizing Polymethyl Methacrylate, J. Prosthet. Dent., 1998: 79: 580-584.
16. Vallittu, P. Dimensional Accuracy and Stability of Polymethyl Methacrylate Reinforced with Metal Wire or with Continuous Glass Fibre, J. Prosthet. Dent., 1996: 75: 617-621. (Pubitemid 126653673)
17. Manley, T., Bowman, A. and Cook, M. Denture Bases Reinforced with Carbon Fibres, Br. Dent. J., 1979: 146: 25-30.
18. Saha, S. and Pal, S. Mechanical Characterization of Commercially Made Carbon-fibre-reinforced Polymethylmethacrylate, J. Biomed. Mater. Res., 1986: 20: 817-826.
19. Pourdeyhimi, B. and Wagner, H. Elastic and Ultimate Properties of Acrylic Bone Cement Reinforced with Ultrahigh Molecular Weight Polyethylene Fibers, J. Biomed. Mater. Res., 1989: 23: 63-80. (Pubitemid 19031253)
20. Topoleski, L., Ducheyne, P. and Cuckler, J. The Fracture Toughness of Titanium-fibre-reinforced Bone Cement, J. Biomed. Mater. Res., 1992: 26: 1599-1617.
21. Marrs, B., Andrews, R., Rantell, T. and Pienkowski, D. Augmentation of Acrylic Bone Cement with Multiwall Carbon Nanotubes, J. Biomed. Mater. Res., 2006: 77A: 269-276. (Pubitemid 47233528)
22. Njuguna, J. and Pielichowski, K. Polymer Nanocomposites for Aerospace Applications: Characterization, Adv. Eng. Mater., 2004: 6: 204-210.
23. Jordan, J., Jacob, K.I., Tannenbaum, R., Sharaf, M.A. and Jasiuk, I. Experimental Trends in Polymer Nanocomposites - A Review, Mater. Sci. Eng. A., 2005: 393: 1-11. (Pubitemid 40198591)
24. Service, F. Nanotechnology Grows Up, Science, 2004: 304: 1732-1734.
25. Wang, J.-H., Young, T.-H., Lin, D.-J., et al. Preparation of Clay/PMMA Nanocomposites with Intercalated or Exfoliated Structure for Bone Cement Synthesis, Macromol. Mater. Eng., 2006: 291: 661-669. (Pubitemid 43973083)
26. Gomoll, A.H., Fitz, W., Scott, R.D., Thornhill, T.S. and Bellare, A. Nanoparticulate Fillers Improve the Mechanical Strength of Bone Cement, Act. Orthop., 2008: 79: 421-427. (Pubitemid 352009340)
27. Abboud, M., Casaubieilh, L., Morvan, F., Fontanille, M. and Duguet, E. PMMA-Based Composite Materials with Reactive Ceramic Fillers: IV. Radiopacifying Particles Embedded in PMMA Beads for Acrylic Bone Cements, J. Biomed. Mater. Res., 2000: 53: 728-736.
28. San Roman, J., Vazquez Lasa, B., Aguilar, M.R. and Boesel, L.F. (2008). Modifications of Bone Cements, In: Sanjukta, D. (ed.), Orthropaedic Bone Cements, Boca Raton, USA, CRC Press, pp. 332-349.
29. Khaled, S.M., Sui, R., Charpentier, P.A. and Rizkalla, A.S. Synthesis of TiO2-PMMA Nanocomposite: Using Methacrylic Acid as a Coupling Agent, Langmuir, 2007: 23: 3988-3995. (Pubitemid 46581932)
30. Lam, C.W., James, J.T., McCluskey, R. and Hunter, R.L. Pulmonary Toxicity of Single-wall Carbon Nanotubes in Mice 7 and 90 Days after Intratracheal Instillation, Toxicol. Sci., 2004: 77: 126-134. (Pubitemid 38128652)
31. Sui, R., Rizkalla, A.S. and Charpentier, P.A. Formation of Titania Nanofibers: A Direct Sol-Gel Route in Supercritical CO2, Langmuir, 2005: 21: 6150-6153. (Pubitemid 41006423)
32. Zhang, H. and Banfield, J.F. Thermodynamic Analysis of Phase Stability of Nanocrystalline Titania, J. Mater. Chem., 1998: 8: 2073-2076. (Pubitemid 128701661)
33. ISO 5833. Implants for Surgery - Acrylic Resin Cements, IHS - ISO 5833, 2002.
34. Khaled, S.M., Miron, R.J., Hamilton, D.W., Charpentier, P.A. and Rizkalla, A.S. Reinforcement of Resin Based Cement with Titania Nanotubes, Dent. Mater., Online First, 14 November 2009 (doi: 10.1016/j.dental.2009.09.011).
35. Ruse, N.D., Troczynski, T., MacEntee, M.I. and Feduik, D. Novel Fracture Toughness Test Using a Notchless Triangular Prism (NTP) Specimen, J. Biomed. Mater. Res., 1996: 31: 457-463. (Pubitemid 26250988)
36. ASTM B771-87 (1997). Standard Test Method for Short Rod Fracture Toughness of Cemented Carbides, In: Annual Book of ASTM Standards, West Conshohocken, Pennsylvania, American Society for Testing Materials.
37. Lewis, G. Effect of Lithotriptor Treatment on the Fracture Toughness of Acrylic Bone Cement, Biomaterials, 1991: 13: 225-230.
38. Bellows, C. and Aubin, J. Determination of Numbers of Osteoprogenitors Present in Isolated Fetal Rat Calvaria Cells In Vitro, Dev. Biol., 1989: 133: 8-13. (Pubitemid 19118468)
39. Zheng, K., Chen, L., Li, Y. and Cui, P. Preparation and Thermal Properties of Silica-Graft Acrylonitrile-Butadiene-Styrene Nanocomposites, Polym. Eng. Sci., 2004: 44: 1077-1082.
40. Huang, J.Y., Park, B.H., Jan, D., et al. High-resolution Transmission Electron Microscopy Study of Defects and Interfaces in Epitaxial TiO2 Films on Sapphire and LaAlO3, Philos. Mag. A., 2002: 82: 735-749. (Pubitemid 35393241)
41. Zhao, Q. and Samulski, E.T. A Comparative Study of Poly(Methyl methacrylate) and Polystyrene/Clay Nanocomposites Prepared in Supercritical Carbon Dioxide, Polym. Test., 2006: 47: 663-671. (Pubitemid 43053268)
42. Kashiwagi, T., Inaba, A., Brown, J.E., et al. Effects of Weak Linkages on the Thermal and Oxidative Degradation of Poly(Methyl methacrylates), Macromol., 1986: 19: 2160-2168.
43. Haas, S., Brauer, G. and Dickson, G. A Characterization of Polymethylmethacrylate Bone Cement, J. Bone Joint Surg., 1975: 57: 380-391.
44. Meyer, P.R., Lautenschlager, E.P. and Moore, B.K. On the Setting Properties of Acrylic Bone Cement, J. Bone Joints Surg., 1973: 55: 149-156.
45. Puska, M.A., Lassila, L.V., Aho, A.J., et al. Exothermal Characteristics and Release of Residual Monomers from Fibre-reinforced Oligomer-modified Acrylic Bone Cement, J. Biomater. Appl., 2005: 20: 51-64. (Pubitemid 41250079)
46. Hernandez, L., Gurruchaga, M. and Goni, I. Influence of Powder Particle Size Distribution on Complex Viscosity and Other Properties of Acrylic Bone Cement for Vertebroplasty and Kyphoplasty, J. Biomed. Mater. Res. B Appl. Biomater., 2006: 77B: 98-103.
47. Nicholas, M.K.D., Waters, M.G.J., Holford, K.M. and Adusei, G. Analysis of Rheological Properties of Bone Cements, J. Mater. Sci. Mater. Med., 2007: 18: 1407-1412. (Pubitemid 47007605)
48. Farrar, D.F. and Rose, J. Rheological Properties of PMMA Bone Cements During Curing, Biomaterials, 2001: 22: 3005-3013. (Pubitemid 32768708)
49. Lewis, G. and Carroll, M. Rheological Properties of Acrylic Bone Cement During Curing and the Role of the Size of the Powder Particles, J. Biomed. Mater. Res. B. Appl. Biomater., 2002: 63: 191-199. (Pubitemid 34263864)
50. Lewis, G. Alternative Acrylic Bone Cement Formulations for Cemented Arthroplasties: Present Status, Key Issues, and Future Prospects, J. Biomed. Mater. Res. B. Appl. Biomater., 2008: 84B: 301-319. (Pubitemid 351147783)
51. Kurtz, S.M., Villarraga, M.L., Zhao, K. and Edidin, A.A. Static and Fatigue Mechanical Behavior of Bone Cement with Elevated Barium Sulfate Content for Treatment of Vertebral Compression Fractures, Biomaterials, 2005: 26: 3699-3712. (Pubitemid 40038165)
52. Michler, G.H. (2005). Micromechanical Mechanisms of Toughness Enhancement in Nanostructured Amorphous and Semicrystalline Polymers, In: Michler, G.H. and Calleja, F.J. (eds), Mechanical Properties of Polymers Based on Nanostructure and Morphology, Boca Raton, Taylor & Francis, pp. 391-395.
53. Segerström, S. and Ruyter, I.E. Effect of Thermal Cycling on Flexural Properties of Carbon-Graphite Fiber-reinforced Polymers, Dent. Mater., 2009: 25: 845-851.
54. Kotha, S.P., Chaodi, L., Schmid, S. and Mason, J. Reinforcement of Bone Cement using Zirconia Fibers With and Without Acrylic Coating, J. Biomed. Mater. Res., 2008: 88A: 898-906.
55. Topoleski, L.D., Ducheyene, P. and Cuckler, J.M. A Fractographic Analysis of In Vivo Poly(methyl methacrylate) Bone Cement Failure Mechanisms, J. Biomed. Mater. Res., 1990: 24: 135-154. (Pubitemid 20123719)