Prophylactic, prandial rofecoxib treatment lacks efficacy against acute PTZ-induced seizure generation and kindling acquisition

Epilepsia

Volumn 52, Issue 2, 2011, Pages 273-283

  Claycomb, Robert J ^a   Hewett, Sandra J ^a   Hewett, James A ^a  

^a UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

Author keywords

Cyclooxgenase 2; Epilepsy; Epileptogenesis; Kindling; Pentylenetetrazole; Seizures

Indexed keywords

CYCLOOXYGENASE 2; PENTETRAZOLE; ROFECOXIB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMOPROPHYLAXIS; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; CONVULSION; DISEASE SEVERITY; DRUG BLOOD LEVEL; DRUG EFFICACY; HIPPOCAMPUS; KINDLING; MALE; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RATING SCALE; SEIZURE; UPREGULATION;

ANIMALS; ANTICONVULSANTS; BEHAVIOR, ANIMAL; CELL DEATH; CONVULSANTS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; EXTINCTION, PSYCHOLOGICAL; FOOD-DRUG INTERACTIONS; IMMUNOHISTOCHEMISTRY; KAINIC ACID; KINDLING, NEUROLOGIC; LACTONES; MALE; MICE; PENTYLENETETRAZOLE; SEIZURES; SULFONES;

EID: 79951597425     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2010.02889.x     Document Type: Article

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