Analgesic efficacy and haemodynamic effects of nefopam in critically ill patients

British Journal of Anaesthesia

Volumn 106, Issue 3, 2011, Pages 336-343

  Chanques, G ^a   Sebbane, M ^a   Constantin, J M ^b   Ramillon, N ^a   Jung, B ^a   Ciss, M ^a   Lefrant, J Y ^c   Jaber, S ^a  

^a HÔPITAL SAINT ELOI   (France)

^b HÔTEL DIEU   (France)

^c DEPARTMENT OF NEUROLOGY   (France)

Author keywords

adverse drug reaction; analgesia; intensive care unit; nefopam; pain

Indexed keywords

NEFOPAM;

ADULT; AGITATION; AIR CONDITIONING; ANALGESIA; ARTICLE; CLINICAL TRIAL; CRITICALLY ILL PATIENT; DRUG EFFECT; DRUG EFFICACY; FEMALE; HEART OUTPUT; HEART RATE; HEAT SENSATION; HEMODYNAMICS; HUMAN; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; NAUSEA; OXYGEN SATURATION; PAIN ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEDATION; SIDE EFFECT; SWEATING; SYSTEMIC VASCULAR RESISTANCE; VOMITING; XEROSTOMIA;

EID: 79951562118     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aeq375     Document Type: Article

References (54)

1. Chanques G, Sebbane M, Barbotte E, Viel E, Eledjam JJ, Jaber S. A prospective study of pain at rest: incidence and characteristics of an unrecognized symptom in surgical and trauma versus medical intensive care unit patients. Anesthesiology 2007; 107: 858-60 (Pubitemid 351325993)
2. Chanques G, Constantin JM, Sauter M, et al. Discomfort associated with underhumidified high-flow oxygen therapy in critically ill patients. Intensive Care Med 2009; 35: 996-1003
3. Chanques G, Payen JF, Mercier G, et al. Assessing pain in non-intubated critically ill patients unable to self report: an adaptation of the Behavioral Pain Scale. Intensive Care Med 2009; 35: 2060-7
4. Payen JF, Chanques G, Mantz J, et al. Current practices in sedation and analgesia for mechanically ventilated critically ill patients: a prospective multicenter patient-based study. Anesthesiology 2007; 106: 687-95 (Pubitemid 46555612)
5. Novaes M, Knobel E, Bork A, Pavão O, Nogueira-Martins L, Ferraz M. Stressors in ICU: perception of the patient, relatives and health care team. Intensive Care Med 1999; 25: 1421-6 (Pubitemid 30021170)
6. Chanques G, Jaber S, Barbotte E, et al. Impact of systematic evaluation of pain and agitation in an intensive care unit. Crit Care Med 2006; 34: 1691-9 (Pubitemid 43810050)
7. Epstein J, Breslow M. The stress response of critical illness. Crit Care Clin 1999; 15: 17-33 (Pubitemid 29054829)
8. Schelling G, Stoll C, Haller M, et al. Health-related quality of life and posttraumatic stress disorder in survivors of the acute respir-atory distress syndrome. Crit Care Med 1998; 26: 651-9 (Pubitemid 28201410)
9. Garćia Lizana F, Peres Bota D, De Cubber M, Vincent J. Long-term outcome in ICU patients: what about quality of life? Intensive Care Med 2003; 29: 1286-93 (Pubitemid 37041157)
10. Lamer C, Harboun M, Knani L, et al. Quality of life after compli-cated elective surgery requiring intensive care. Intensive Care Med 2004; 30: 1594-601 (Pubitemid 39094961)
11. Dowdy DW, Eid MP, Dennison CR, et al. Quality of life after acute respiratory distress syndrome: a meta-analysis. Intensive Care Med 2006; 32: 1115-24 (Pubitemid 44232405)
12. Recommendations for sedation, analgesia and curarization. Short text. French Society of Anesthesia and Intensive Care. Ann Fr Anesth Reanim 2000; 19: 98-105
13. Jacobi J, Fraser GL, Coursin DB, et al. Clinical practice guidelines for the sustained use ofsedatives and analgesics in the critically ill adult. Crit Care Med 2002; 30: 119-41 (Pubitemid 34112188)
14. Bertolini G, Minelli C, Latronico N, etal. The use ofanalgesic drugs in postoperative patients: the neglected problem of pain control in intensive care units. An observational, prospective, multicenter study in 128 Italian intensive care units. Eur J Clin Pharmacol 2002; 58: 73-7 (Pubitemid 34327998)
15. Freire AX, Afessa B, Cawley P, Phelps S, Bridges L. Characteristics associated with analgesia ordering in the intensive care unit and relationships with outcome. Crit Care Med 2002; 30: 2468-72 (Pubitemid 35351865)
16. Puntillo KA, Wild LR, Morris AB, Stanik-Hutt J, Thompson CL, White C. Practices and predictors ofanalgesic interventions for adults under-going painful procedures. Am J Crit Care 2002; 11: 415-29
17. Vila H, Smith R, Augustyniak M, et al. The efficacy and safety of pain management before and after implementation of hospital-wide pain management standards: is patient safety compro-mised by treatment based solely on numerical pain ratings? Anesth Analg 2005; 101: 474-80 (Pubitemid 41045233)
18. Hamill-Ruth RJ. Use ofanalgesics in the intensive care unit: who says it hurts? Crit Care Med 2002; 30: 2597-8 (Pubitemid 35351888)
19. Vargas E, Terleira A, Hernando F, et al. Effect ofadverse drug reac-tions on length of stay in surgical intensive care units. Crit Care Med 2003; 31: 694-8 (Pubitemid 36379570)
20. Mrozek S, Constantin JM, Futier E, et al. Acetaminophen-induced hypotension in intensive care unit: a prospective study. Ann Fr Anesth Reanim 2009; 28: 448-53
21. Rosland J, Hole K. The effect of nefopam and its enantiomers on the uptake of 5-hydroxytryptamine, noradrenaline and dopamine in crude rat brain synaptosomal preparations. J Pharm Pharmacol 1990; 42: 437-8 (Pubitemid 20313696)
22. Beloeil H, Delage N, Nègre I, Mazoit JX, Benhamou D. The median effective dose of nefopam and morphine administered intrave-nously for postoperative pain after minor surgery: a prospective randomized double-blinded isobolographic study of their analgesic action. Anesth Analg 2004; 98: 395-400 (Pubitemid 38129387)
23. Dordoni P, Della Ventura M, Stefanelli A, et al. Effect of ketorolac, ketoprofen and nefopam on platelet function. Anaesthesia 1994; 49: 1046-9
24. Michael R, Younan N, Aziz M, Mostafa N, Ghobriel A, Gintautas J. Effect of a non-opiate analgesic, nefopam hydrochloride, on stress gastric ulcer in rats. Proc West Pharmacol Soc 2001; 44: 109-11 (Pubitemid 34097424)
25. Fuzier R, Belbachir A, Gall O, Këita H. Postoperative analgesia in 'particular situations'. Practical recommendations. Ann Fr Anesth Reanim 2008; 27: 966-8
26. Heel R, Brogden R, Pakes G, Speight T, Avery G. Nefopam: a review of its pharmacological properties and therapeutic efficacy. Drugs 1980; 19: 249-67 (Pubitemid 10075172)
27. Pillans PI, Woods DJ. Adverse reactions associated with nefopam. N Z Med J 1995; 108: 382-4
28. Mimoz O, Incagnoli P, Josse C, et al. Analgesic efficacy and safety of nefopam vs. propacetamol following hepatic resection. Anaes-thesia 2001; 56: 520-5 (Pubitemid 32529613)
29. Godier A, Babinet A, el Metaoua S, Fulgencio J, Bonnet F. A new cause of postoperative confusion syndrome: nefopam. Ann Fr Anesth Reanim 2002; 21: 538-9 (Pubitemid 34728781)
30. Durrieu G, Olivier P, Bagheri H, Montastruc JL, French Network of Pharmacovigilance C. Overview of adverse reactions to nefopam: an analysis of the French Pharmacovigilance database. Fundam Clin Pharmacol 2007; 21: 555-8 (Pubitemid 47407733)
31. Evans MS, Lysakowski C, Tramèr MR. Nefopam for the prevention of postoperative pain: quantitative systematic review. Br J Anaesth 2008; 101: 610-7
32. Vincent JL, Moreno R, Takala J, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Pro-blems of the European Society of Intensive Care Medicine. Inten-sive Care Med 1996; 22: 707-10
33. Chanques G, Viel E, Constantin JM, et al. The measurement of pain in intensive care unit: comparison of 5 self-report intensity scales. Pain 2010; 151: 711-21
34. Payen JF, Bru O, Bosson JL, et al. Assessing pain in critically ill sedated patients by using a behavioral pain scale. Crit Care Med 2001; 29: 2258-63 (Pubitemid 34038155)
35. Äissaoui Y, Zeggwagh A, Zekraoui A, Abidi K, Abouqal R. Vali-dation of a behavioral pain scale in critically ill, sedated, and mechanically ventilated patients. Anesth Analg 2005; 101: 1470-6 (Pubitemid 41531890)
36. Hamill-Ruth RJ, Marohn ML. Evaluation of pain in the critically ill patient. Crit Care Clin 1999; 15: 35-54 (Pubitemid 29054830)
37. Sessler CN, Gosnell MS, Grap MJ, et al. The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients. Am J Respir Crit Care Med 2002; 166: 1338-44 (Pubitemid 35292699)
38. Ely EW, Truman B, Shintani A, et al. Monitoring sedation status overtime in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS). J Am Med Assoc 2003; 289: 2983-91 (Pubitemid 37430101)
39. Chanques G, Jaber S, Barbotte E, et al. Validation of the French translated Richmond vigilance-agitation scale. Ann Fr Anesth Reanim 2006; 25: 696-701 (Pubitemid 44223919)
40. Vallée F, Richard JC, Mari A, et al. Pulse pressure variations adjusted by alveolar driving pressure to assess fluid responsive-ness. Intensive Care Med 2009; 35: 1004-10
41. Guirimand F, Dupont X, Bouhassira D, Brasseur L, Chauvin M. Nefopam strongly depresses the nociceptive flexion (R(III)) reflex in humans. Pain 1999; 80: 399-404 (Pubitemid 29151726)
42. Mok M, Lippmann M, Steen S. Comparison of intravenous nefopam versus morphine for the relief of postoperative pain. Clin Pharmacol Ther 1979; 25: 237-8 (Pubitemid 9145068)
43. Tigerstedt I, Tammisto T, Leander P. Comparison of the analgesic dose-effect relationships of nefopam and oxycodone in post-operative pain. Acta Anaesthesiol Scand 1979; 23: 555-60 (Pubitemid 10132233)
44. Chanques G, Girard C, Pinzani V, Jaber S. Fatal pristinamycin-induced toxic epidermal necrolysis (Lyell's syndrome): difficulties in attributing causal association in the polymedicated intensive care unit patient. Acta Anaesthesiol Scand 2005; 49: 721-2 (Pubitemid 40593524)
45. McLintock T, Kenny G, Howie J, McArdle C, Lawrie S, Aitken H. Assessment of the analgesic efficacy of nefopam hydrochloride after upper abdominal surgery: a study using patient controlled analgesia. Br J Surg 1988; 75: 779-81
46. Tramoni G, Viale J, Cazals C, Bhageerutty K. Morphine-sparing effect of nefopam by continuous intravenous injection after abdominal surgery by laparotomy. Eur J Anaesthesiol 2003; 20: 990-2 (Pubitemid 37500231)
47. Kröll W, List WF. Pain treatment in the ICU: intravenous, regional or both? Eur J Anaesthesiol 1997; 15: 49-52
48. American Society of Anesthesiologists Task Force on Acute Pain Management. Practice guidelines for acute pain management in the perioperative setting: an updated report by the American Society of Anesthesiologists Task Force on Acute Pain Manage-ment. Anesthesiology 2004; 100: 1573-81
49. White PF, Kehlet H, Neal JM, et al. The role of the anesthesiologist in fast-track surgery: from multimodal analgesia to perioperative medical care. Anesth Analg 2007; 104: 1380-96 (Pubitemid 46791272)
50. Hagemann K, Platte G, Meyer J, Effert S. Haemodynamic effects of nefopam (author's transl). Dtsch Med Wochenschr 1978; 103: 1040-3 (Pubitemid 8362005)
51. Knaus U. Cardiovascular effect of nefopam in nitrous oxide anesthesia. Inaugural dissertation for doctorate of the medical faculty, Zurich, 1977
52. Dabisch PA, Liles JT, Kadowitz PJ. Effect of inhibition of nitric oxide synthase on the vasopressor response to ephedrine. Can J Physiol Pharmacol 2003; 81: 966-71 (Pubitemid 37521834)
53. Pallapies D, Peskar B, Brune K, Zeilhofer H. Modulation of nitric oxide effects by flurbiprofen enantiomers and nefopam and its relation to antinociception. Eur J Pharmacol 1994; 271: 335-40
54. Legall J-R, Lemeshow S, Saulnier F. New Simplified Acute Physi-ology Score (SAPS II) based on a European/North American multi-center study. J Am Med Assoc 1993; 270: 2957-63 (Pubitemid 24000804)