Synthesis and biological assay of 4-aryl-6-chloro-quinoline derivatives as novel non-nucleoside anti-HBV agents

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 4, 2011, Pages 1400-1408

  Guo, Rui Hua ^a,b   Zhang, Quan ^a   Ma, Yun Bao ^a   Huang, Xiao Yan ^a   Luo, Jie ^a   Wang, Li Jun ^a,b   Geng, Chang An ^a,b   Zhang, Xue Mei ^a   Zhou, Jun ^a   Jiang, Zhi Yong ^a   Chen, Ji Jun ^a  

^a KUNMING INSTITUTE OF BOTANY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

4 Aryl 6 chloro quinoline; Derivatives; Hepatitis B virus; Synthesis

Indexed keywords

12 (2,6 DIFLUOROBENZYLOXY) 3 [2 (TERT BUTYLDIPHENYLSILYLOXY)ETHYL] 6 CHLORO 4 (2 CHLOROPHENYL)QUINOLINE; 2 (2,6 DICHLORO 4 (2 CHLOROPHENYL)QUINOLIN 3 YL)ETHYLACETIC ACID; 2 (2,6 DICHLOROBENZYLOXY) 3 [2 (TERT BUTYLDIPHENYLSILYLOXY)ETHYL] 6 CHLORO 4 (2 CHLOROPHENYL)QUINOLINE; 2 (6 CHLORO 4 (2 CHLOROPHENYL) 2 (PIPERAZIN 1 YL)QUINOLIN 3 YL)ETHANOL; 2 [2 (1H BENZO[D][1,2,3]TRIAZOL 1 YLAMINO) 6 CHLORO 4 (2 CHLOROPHENYL)QUINOLIN 3 YL]ETHANOL; 2 [2 (2,6 DICHLOROBENZYLOXY) 6 CHLORO 4 (2 CHLOROPHENYL)QUINOLIN 3 YL]ETHANOL; 2 [2 (2,6 DIFLUOROBENZYLOXY) 6 CHLORO 4 (2 CHLOROPHENYL)QUINOLIN 3 YL]ETHANOL; 2 [2,6 DICHLORO 4 (2 CHLOROPHENYL)QUINOLIN 3 YL]ETHANOL; 2 [2,6 DICHLORO 4 (2 CHLOROPHENYL)QUINOLIN 3 YL]ETHYLMETHANESULFONIC ACID; 2 [6 CHLORO 4 (2 CHLOROPHENYL) 2 (METHYLSULFONYLOXY)QUINOLIN 3 YL]ETHYLMETHANESULFONIC ACID; 2 [6 CHLORO 4 (2 CHLOROPHENYL) 2 (PIPERIDIN 1 YL)QUINOLIN 3 YL]ETHANOL; 2 [6 CHLORO 4 (2 CHLOROPHENYL) 2 METHOXYQUINOLIN 3 YL]ETHANOL; 2 [6 CHLORO 4 (2 CHLOROPHENYL) 2 MORPHOLINOQUINOLIN 3 YL]ETHANOL; 2 [6 CHLORO 4 (2 CHLOROPHENYL) 2 OXO 1,2 DIHYDROQUINOLIN 3 YL]ETHYLACETIC ACID; 2 AZIDO 3 (2 AZIDOETHYL) 6 CHLORO 4 (2 CHLOROPHENYL)QUINOLINE; 2,6 DICHLORO 3 (2 CHLOROETHYL) 4 (2 CHLOROPHENYL)QUINOLINE; 3 (2 AZIDOETHYL) 2,6 DICHLORO 4 (2 CHLOROPHENYL)QUINOLINE; 3 [2 (TERT BUTYLDIPHENYLSILYLOXY)ETHYL] 6 CHLORO 4 (2 CHLOROPHENYL) 2 (PIPERAZIN 1 YL)QUINOLINE; 3 [2 (TERT BUTYLDIPHENYLSILYLOXY)ETHYL] 6 CHLORO 4 (2 CHLOROPHENYL) 2 (PIPERIDIN 1 YL)QUINOLINE; 3 [2 (TERT BUTYLDIPHENYLSILYLOXY)ETHYL] 6 CHLORO 4 (2 CHLOROPHENYL)QUINOLIN 2 YLTRIFLUOROMETHANESULFONIC ACID; 3 [2 (TERT BUTYLDIPHENYLSILYLOXY)ETHYL] 6 CHLORO 4 (2 CHLOROPHENYL)QUINOLIN 2(1H) ONE; 4 [3 [2 (TERT BUTYLDIPHENYLSILYLOXY)ETHYL] 6 CHLORO 4 (2 CHLOROPHENYL)QUINOLIN 2 YL]MORPHOLINE; 6 CHLORO 4 (2 CHLOROPHENYL) 3 (2 HYDROXYETHYL)QUINOLIN 2(1H) ONE; 6 CHLOROQUINOLINE DERIVATIVE; ANTIVIRUS AGENT; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; N (1H BENZO[D][1,2,3]TRIAZOL 1 YL) 3 [2 (TERT BUTYLDIPHENYLSILYLOXY)ETHYL] 6 CHLORO 4 (2 CHLOROPHENYL)QUINOLIN 2 AMINE; QUINOLINE DERIVATIVE; TENOFOVIR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CELL STRAIN HEPG2; CYTOTOXICITY; DRUG SYNTHESIS; HEPATITIS B VIRUS; IC 50; VIRUS REPLICATION;

ANTIVIRAL AGENTS; DNA REPLICATION; DNA, VIRAL; HEPATITIS B VIRUS; MOLECULAR STRUCTURE; QUINOLINES;

HEPATITIS B VIRUS;

EID: 79951557683     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.01.006     Document Type: Article

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