Expression of hsp 90 in the human kidney and in proximal tubule cells exposed to heat, sodium arsenite and cadmium chloride

Toxicology Letters

Volumn 133, Issue 2-3, 2002, Pages 241-254

  Somji, Seema ^a,b   Ann Sens, Mary ^a   Garrett, Scott H ^a   Gurel, Volkan ^a   Todd, John H ^a   Sens, Donald A ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cadmium; Cell culture; Gene expression; Heat shock; Heat shock protein 90; Hsp 90 ; Hsp 90 ; Immunohistochemistry; Metal toxicity; Microdissection; Proximal tubule; RT PCR; Sodium arsenite

Indexed keywords

ARSENITE SODIUM; CADMIUM CHLORIDE; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90ALPHA; HEAT SHOCK PROTEIN 90BETA; MESSENGER RNA; UNCLASSIFIED DRUG;

ARTICLE; BLASTEMA; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EXPOSURE; GENE EXPRESSION; GLOMERULUS; HEAT SHOCK RESPONSE; HENLE LOOP; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KIDNEY COLLECTING TUBULE; KIDNEY DISTAL TUBULE; KIDNEY MEDULLA; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; LETHALITY; PHYSICAL STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RNA ANALYSIS; RNA ISOLATION; STAINING; THERMAL EXPOSURE; TIME;

ARSENITES; BLOTTING, WESTERN; CADMIUM; CELL SURVIVAL; CELLS, CULTURED; HEAT; HSP90 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; ISOMERISM; KIDNEY; KIDNEY TUBULES, PROXIMAL; PARAFFIN EMBEDDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

GLOMERULUS;

EID: 0037151249     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(02)00205-9     Document Type: Article

References (26)

1. Hsp 90 & Co. - A holding for folding
2. Heat shock proteins and molecular chaperones: Mediators of protein conformation and turnover in the cell
3. The 90-kDa molecular chaperone family: Structure, function, and clinical applications. A comprehensive review
4. Differential expression of human metallothionein isoform I mRNAs in human proximal tubule cells exposed to metals
5. +2 induces metallothionein protein accumulation, but not metallothionein isoform 2 mRNA
6. Metallothionein isoform 1 and 2 gene expression in the human prostate: Downregulation of MT-1X in advanced prostate cancer
7. Role of the major heat shock proteins as molecular chaperones
8. Stress protein synthesis induced by cadmium-cysteine in rat kidney
9. Stress protein synthesis induced in rat liver by cadmium precedes hepatotoxicity
10. Binding of heat shock proteins to the avian progesterone receptor
11. Quantitation and intracellular localization of the 85K heat shock protein by using monoclonal and polyclonal antibodies
12. Heat-shock proteins and molecular chaperones; Implications for pathogenesis, diagnostics, and therapeutics
13. Localization of 90-kDa heat shock protein in the kidney
14. Murine 86- and 84-kDa heat shock proteins, cDNA sequences, chromosome assignments, and evolutionary origin
15. Calreticulin functions as a molecular chaperone in the biosynthesis of myeloperoxidase
16. Induction and intracellular localization of 90-kilodalton heat-shock protein in rat kidneys with acute gentamicin nephropathy
17. Stressor-specific activation of heat shock genes in H35 rat hepatoma cells
18. Relationship between cadmium-induced expression of heat shock genes, inhibition of protein synthesis and cell death
19. How the cell copes with stress and the function of heat shock proteins
20. Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70
21. 2
22. 2
23. 2
24. Enzymatic isolation and serum-free culture of human renal cells retaining properties of proximal tubule cells
25. Mice lacking hsp90β fail to develop a placental labyrinth
26. Stressor-specific induction of heat shock proteins in rat hepatoma cells