New imidazolidinedione derivatives as antimalarial agents

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 4, 2011, Pages 1541-1549

  Zhang, Liang ^a   Sathunuru, Ramadas ^a   Luong, Thulan ^a   Melendez, Victor ^a   Kozar, Michael P ^a   Lin, Ai J ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

Antimalarials; Imidazolidinedione; Metabolic stability; Preparation

Indexed keywords

[6 [N' (3,4 DICHLOROPHENYL) N'' (1 ISOPROPYL 4,5 DIOXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL)GUANIDINO]HEXYL]CARBAMIC ACID TERT BUTYL ESTER; ANTIMALARIAL AGENT; ATOVAQUONE PLUS PROGUANIL; CHLOROQUINE; IMIDAZOLIDINE DERIVATIVE; IMIDAZOLIDINEDIONE DERIVATIVE; N (3,4 DICHLOROPHENYL) N' (1 ISOPROPYL 4,5 DIOXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL) N'' (2 ADAMANTYL)GUANIDINE; N (3,4 DICHLOROPHENYL) N' (1 ISOPROPYL 4,5 DIOXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL) N'' (2 PYRROLIDIN 1 YLETHYL)GUANIDINE; N (3,4 DICHLOROPHENYL) N' (1 ISOPROPYL 4,5 DIOXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL) N'' (4 PYRROLIDIN 1 YLBUTYL)GUANIDINE; N (3,4 DICHLOROPHENYL) N' (1 ISOPROPYL 4,5 DIOXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL) N'' ALLYLOXYGUANIDINE; N (3,4 DICHLOROPHENYL) N' (1 ISOPROPYL 4,5 DIOXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL) N'' BENZYLGUANIDINE; N (3,4 DICHLOROPHENYL) N' (1 ISOPROPYL 4,5 DIOXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL) N'' BENZYLOXYGUANIDINE; N (3,4 DICHLOROPHENYL) N' (1 ISOPROPYL 4,5 DIOXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL) N'' ETHOXYGUANIDINE; N (3,4 DICHLOROPHENYL) N' (1 ISOPROPYL 4,5 DIOXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL) N'' ETHYLGUANIDINE; N (3,4 DICHLOROPHENYL) N' (1 ISOPROPYL 4,5 DIOXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL) N'' ISOPROPYLGUANIDINE; N (3,4 DICHLOROPHENYL) N' (1 ISOPROPYL 4,5 DIOXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL) N'' METHOXYGUANIDINE; N (3,4 DICHLOROPHENYL) N' (1 ISOPROPYL 4,5 DIOXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL) N'' METHYLGUANIDINE; N (3,4 DICHLOROPHENYL) N' (1 ISOPROPYL 4,5 DIOXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL) N'' PHENYLGUANIDINE; N (3,4 DICHLOROPHENYL) N' (1 ISOPROPYL 4,5 DIOXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL) N'' TERT BUTOXYGUANIDINE; N (3,4 DICHLOROPHENYL) N' (1 ISOPROPYL 4,5 DIOXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL) N'' TERT BUTYLGUANIDINE; N (3,4 DICHLOROPHENYL) N' (1 ISOPROPYL 4,5 DIOXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL) N'',N HEXYLGUANIDINE; N (3,4 DICHLOROPHENYL) N' (2 DIETHYLAMINOETHYL) N'' (1 ISOPROPYL 4,5 DIOXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL)GUANIDINE; N (3,4 DICHLOROPHENYL) N' (2 DIMETHYLAMINOETHYL) N'' (1 ISOPROPYL 4,5 DIOXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL)GUANIDINE; N (3,4 DICHLOROPHENYL) N' (2,2 DIMETHYLPROPYL) N'' (1 ISOPROPYL 4,5 DIOXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL)GUANIDINE; N (3,4 DICHLOROPHENYL) N' (3 DIMETHYLAMINOPROPYL) N'' (1 ISOPROPYL 4,5 DIOXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL)GUANIDINE; PRIMAQUINE; TAFENOQUINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; BENZYLATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG METABOLISM; DRUG STABILITY; DRUG SYNTHESIS; MALARIA; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; RHESUS MONKEY; SPOROZOITE;

ANIMALS; ANTIMALARIALS; HUMANS; IMIDAZOLIDINES; MACACA MULATTA; MICE; MOLECULAR STRUCTURE; PLASMODIUM BERGHEI; PLASMODIUM CYNOMOLGI; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

MACACA MULATTA; MUS; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM;

EID: 79951553515     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.12.028     Document Type: Article

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