Unambiguous synthesis and prophylactic antimalarial activities of imidazolidinedione derivatives

Journal of Medicinal Chemistry

Volumn 48, Issue 20, 2005, Pages 6472-6481

  Zhang, Quan ^a   Guan, Jian ^a   Sacci, John ^a   Ager, Arba ^b   Ellis, William ^a   Milhous, Wilbur ^a   Kyle, Dennis ^a   Lin, Ai J ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b UNIVERSITY OF MIAMI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEETHER; CARBAMIC ACID DERIVATIVE; CHLOROQUINE; CHLORPROGUANIL; IMIDAZOLIDINE DERIVATIVE; MEFLOQUINE; N (3,4 DICHLOROPHENYL) N' (1 ISOPROPYL 4,5 DIOXOIMIDAZOLIDIN 2 YLIDENE)GUANIDINE; N [1 (3,4 DICHLOROPHENYL) 4,5 DIOXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL] N' ISOPROPYLGUANIDINE; OXALIC ACID; PRIMAQUINE; TAFENOQUINE; UNCLASSIFIED DRUG; WR 182393; WR 283246; WR 288568;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; MOUSE; NONHUMAN; PLASMODIUM; PLASMODIUM CYNOMOLGI; PLASMODIUM YOELII; PROPHYLAXIS; RHESUS MONKEY; SCHIZONT;

ADMINISTRATION, ORAL; ANIMALS; ANTIMALARIALS; CARBAMATES; GUANIDINES; IMIDAZOLES; IMIDAZOLIDINES; MALARIA; MALE; MICE; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 26444469915     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0504252     Document Type: Article

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