Distribution and quantitation of the anti-trypanosomal diamidine 2,5-bis(4-amidinophenyl)furan (DB75) and its N-methoxy prodrug DB289 in murine brain tissue

Acta Tropica

Volumn 91, Issue 2, 2004, Pages 131-143

  Sturk, Lisa M ^a   Brock, Jacqueline L ^b   Bagnell, C Robert ^a   Hall, James E ^a,b   Tidwell, Richard R ^a  

^a Rm 805 Brinkhous Bullitt Bldg S ^*  (United States)

^b Sch P   (United States)

Author keywords

African; Brain; Diamidine; Fluorescence; Prodrug; Trypanosomiasis

Indexed keywords

2,5 BIS(4 AMIDINOPHENYL)FURAN; 2,5 BIS(4 AMIDINOPHENYL)FURAN BIS O METHYLAMIDOXIME; DB 289; FURAN DERIVATIVE; OXIME DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG;

TRYPANOSOMIASIS;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AFRICAN TRYPANOSOMIASIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG EFFICACY; FLUORESCENCE MICROSCOPY; MALE; MOUSE; NONHUMAN; PNEUMOCYSTIS PNEUMONIA; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS;

ADMINISTRATION, ORAL; ANIMALS; BENZAMIDINES; BLOOD-BRAIN BARRIER; BRAIN; INJECTIONS, INTRAVENOUS; MALE; MICE; MICROSCOPY, FLUORESCENCE; PRODRUGS; TISSUE DISTRIBUTION; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI GAMBIENSE; TRYPANOSOMIASIS, AFRICAN;

ANIMALIA; MURINAE; PNEUMOCYSTIS CARINII;

EID: 3242663162     PISSN: 0001706X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actatropica.2004.03.010     Document Type: Article

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