Benznidazole treatment attenuates liver NF-κB activity and MAPK in a cecal ligation and puncture model of sepsis

Molecular Immunology

Volumn 48, Issue 6-7, 2011, Pages 867-873

  Ronco, María Teresa ^a   Manarin, Romina ^a,b   Francés, Daniel ^a   Serra, Esteban ^a   Revelli, Silvia ^b   Carnovale, Cristina ^a  

^a UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

^b FACULTAD DE CIENCIAS MÉDICAS   (Argentina)

Author keywords

Chagas' disease; Immunomodulation; Liver; NF B; Sepsis

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BENZNIDAZOLE; I KAPPA B ALPHA; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CECUM; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; GENE EXPRESSION; HEPATITIS; IMMUNOMODULATION; INTESTINE INJURY; LEUKOCYTE COUNT; LIVER DYSFUNCTION; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPSIS;

ANIMALS; CECUM; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; EXUDATES AND TRANSUDATES; GENE EXPRESSION REGULATION; LEUKOCYTE COUNT; LIGATION; LIVER; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; NITROIMIDAZOLES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PUNCTURES; RNA, MESSENGER; SEPSIS; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

MUS; TRYPANOSOMA CRUZI;

EID: 79951552809     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2010.12.021     Document Type: Article

References (39)

1. Angus D.C., Linde-Zwirble W.T., Clermont G., Griffin M.F., Clark R.H. Epidemiology of neonatal respiratory failure in the United States: projections from California and New York. Am. J. Respir. Crit Care Med. 2001, 164:1154-1160.
2. Astiz M.E., Rackow E.C. Septic shock. Lancet 1998, 351:1501-1505.
3. Baker C.C., Chaudry I.H., Gaines H.O., Baue A.E. Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model. Surgery 1983, 94:331-335.
4. Bone R.C., Grodzin C.J., Balk R.A. Sepsis: a new hypothesis for pathogenesis of the disease process. Chest 1997, 112:235-243.
5. Boveris A., Alvarez S., Navarro A. The role of mitochondrial nitric oxide synthase in inflammation and septic shock. Free Radic. Biol. Med. 2002, 33:1186-1193.
6. Brochner A.C., Toft P. Pathophysiology of the systemic inflammatory response after major accidental trauma. Scand. J. Trauma Resusc. Emerg. Med. 2009, 17:43.
7. Brown M.A., Jones W.K. NF-kappaB action in sepsis: the innate immune system and the heart. Front Biosci. 2004, 9:1201-1217.
8. Burch P.T., Scott M.J., Wortz G.N., Peyton J.C., Cheadle W.G. Mortality in murine peritonitis correlates with increased Escherichia coli adherence to the intestinal mucosa. Am. Surg. 2004, 70:333-341.
9. Cohen J. The immunopathogenesis of sepsis. Nature 2002, 420:885-891.
10. Eum H.A., Park S.W., Lee S.M. Role of nitric oxide in the expression of hepatic vascular stress genes in response to sepsis. Nitric Oxide 2007, 17:126-133.
11. Gallos G., Jones D.R., Nasr S.H., Emala C.W., Lee H.T. Local anesthetics reduce mortality and protect against renal and hepatic dysfunction in murine septic peritonitis. Anesthesiology 2004, 101:902-911.
12. Joshi V.D., Kalvakolanu D.V., Cross A.S. Simultaneous activation of apoptosis and inflammation in pathogenesis of septic shock: a hypothesis. FEBS Lett. 2003, 555:180-184.
13. Kosai K., Matsumoto K., Funakoshi H., Nakamura T. Hepatocyte growth factor prevents endotoxin-induced lethal hepatic failure in mice. Hepatology 1999, 30:151-159.
14. Lewis S.A., Pavord I.D., Stringer J.R., Knox A.J., Weiss S.T., Britton J.R. The relation between peripheral blood leukocyte counts and respiratory symptoms, atopy, lung function, and airway responsiveness in adults. Chest 2001, 119:105-114.
15. Liu S.F., Malik A.B. NF-kappa B activation as a pathological mechanism of septic shock and inflammation. Am. J. Physiol. Lung Cell Mol. Physiol. 2006, 290:L622-L645.
16. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
17. Manarin R., Bottasso E., Bottasso O., Serra E., Revelli S. Beneficial effects of benznidazole during an infectious-based situation of systemic inflammatory response: cecal ligation and puncture. Am. J. Trop. Med. Hyg. 2008, 79:793-796.
18. Manarin R., Pascutti M.F., Ruffino J.P., De Las H.B., Bosca L., Bottasso O., Revelli S., Serra E. Benznidazole blocks NF-kappaB activation but not AP-1 through inhibition of IKK. Mol. Immunol. 2010, 47:2485-2491.
19. Moreno S.E., Alves-Filho J.C., Alfaya T.M., da Silva J.S., Ferreira S.H., Liew F.Y. IL-12, but not IL-18, is critical to neutrophil activation and resistance to polymicrobial sepsis induced by cecal ligation and puncture. J. Immunol. 2006, 177:3218-3224.
20. O'Sullivan A.W., Wang J.H., Redmond H.P. NF-kappaB and p38 MAPK inhibition improve survival in endotoxin shock and in a cecal ligation and puncture model of sepsis in combination with antibiotic therapy. J. Surg. Res. 2009, 152:46-53.
21. Obata T., Brown G.E., Yaffe M.B. MAP kinase pathways activated by stress: the p38 MAPK pathway. Crit. Care Med. 2000, 28:N67-N77.
22. Pascutti M.F., Pitashny M., Nocito A.L., Guermonprez P., Amigorena S., Wietzerbin J., Serra E., Bottasso O., Revelli S. Benznidazole, a drug used in Chagas' disease, ameliorates LPS-induced inflammatory response in mice. Life Sci. 2004, 76:685-697.
23. Piaggio E., Sanceau J., Revelli S., Bottasso O., Wietzerbin J., Serra E. Trypanocidal drug benznidazole impairs lipopolysaccharide induction of macrophage nitric oxide synthase gene transcription through inhibition of NF-kappaB activation. J. Immunol. 2001, 167:3422-3426.
24. Ramnath R.D., Ng S.W., Guglielmotti A., Bhatia M. Role of MCP-1 in endotoxemia and sepsis. Int. Immunopharmacol. 2008, 8:810-818.
25. Revelli S., Le P.C., Piaggio E., Wietzerbin J., Bottasso O. Benznidazole, a drug employed in the treatment of Chagas' disease, down-regulates the synthesis of nitrite and cytokines by murine stimulated macrophages. Clin. Exp. Immunol. 1999, 118:271-277.
26. Rittirsch D., Huber-Lang M.S., Flierl M.A., Ward P.A. Immunodesign of experimental sepsis by cecal ligation and puncture. Nat. Protoc. 2009, 4:31-36.
27. Ronco M.T., Alvarez M.L., Monti J.A., Carrillo M.C., Pisani G.B., Lugano M.C., Carnovale C.E. Role of nitric oxide increase on induced programmed cell death during early stages of rat liver regeneration. Biochim. Biophys. Acta 2004, 1690:70-76.
28. Ronco M.T., Frances D.E., Ingaramo P.I., Quiroga A.D., Alvarez M.L., Pisani G.B., Revelli S.S., Carnovale C.E. Tumor necrosis factor alpha induced by Trypanosoma cruzi infection mediates inflammation and cell death in the liver of infected mice. Cytokine 2010, 49:64-72.
29. Salkowski C.A., Detore G., Franks A., Falk M.C., Vogel S.N. Pulmonary and hepatic gene expression following cecal ligation and puncture: monophosphoryl lipid A prophylaxis attenuates sepsis-induced cytokine and chemokine expression and neutrophil infiltration. Infect. Immun. 1998, 66:3569-3578.
30. Smith S.J., Fenwick P.S., Nicholson A.G., Kirschenbaum F., Finney-Hayward T.K., Higgins L.S., Giembycz M.A., Barnes P.J., Donnelly L.E. Inhibitory effect of p38 mitogen-activated protein kinase inhibitors on cytokine release from human macrophages. Br. J. Pharmacol. 2006, 149:393-404.
31. Song G.Y., Chung C.S., Chaudry I.H., Ayala A. MAPK p38 antagonism as a novel method of inhibiting lymphoid immune suppression in polymicrobial sepsis. Am. J. Physiol. Cell Physiol. 2001, 281:C662-C669.
32. Tsiotou A.G., Sakorafas G.H., Anagnostopoulos G., Bramis J. Septic shock; current pathogenetic concepts from a clinical perspective. Med. Sci. Monit. 2005, 11:RA76-RA85.
33. van den Berg R., Haenen G.R., van den Berg H., Bast A. Transcription factor NF-kappaB as a potential biomarker for oxidative stress. Br. J. Nutr. 2001, 86(Suppl 1):S121-S127.
34. Victor V.M., Rocha M., De la Fuente M. Immune cells: free radicals and antioxidants in sepsis. Int. Immunopharmacol. 2004, 4:327-347.
35. Wheeler A.P., Bernard G.R. Treating patients with severe sepsis. N. Engl. J. Med. 1999, 340:207-214.
36. Wheeler D.S., Zingarelli B., Wheeler W.J., Wong H.R. Novel pharmacologic approaches to the management of sepsis: targeting the host inflammatory response. Recent Pat. Inflamm. Allergy Drug Discov. 2009, 3:96-112.
37. Xie X.Q., Shinozawa Y., Sasaki J., Takuma K., Akaishi S., Yamanouchi S., Endo T., Nomura R., Kobayashi M., Kudo D., Hojo N. The effects of arginine and selective inducible nitric oxide synthase inhibitor on pathophysiology of sepsis in a CLP model. J. Surg. Res. 2008, 146:298-303.
38. Zhang F., Wu R., Qiang X., Zhou M., Wang P. Antagonism of alpha2A-adrenoceptor: a novel approach to inhibit inflammatory responses in sepsis. J. Mol. Med. 2010, 88:289-296.
39. Zhang H., Moochhala S.M., Bhatia M. Endogenous hydrogen sulfide regulates inflammatory response by activating the ERK pathway in polymicrobial sepsis. J. Immunol. 2008, 181:4320-4331.