EAR motif-mediated transcriptional repression in plants: An underlying mechanism for epigenetic regulation of gene expression

Epigenetics

Volumn 6, Issue 2, 2011, Pages 141-146

  Kagale, Sateesh ^a   Rozwadowski, Kevin ^a  

^a SASKATOON RESEARCH CENTRE   (Canada)

Author keywords

Chromatin modification; Co repressors; EAR motif; Epigenetic regulation; HDA19; Histone deacetylation; Phosphorylation; Post translational modification; Repressome; SAP18; TPL; Transcriptional repression

Indexed keywords

ARTICLE; CHROMATIN; CONSENSUS SEQUENCE; EPIGENETICS; ETHYLENE RESPONSIVE ELEMENT BINDING FACTOR ASSOCIATED AMPHIPHILIC REPRESSION; GENE CONTROL; GENE EXPRESSION REGULATION; GENETIC REGULATION; NONHUMAN; PHOSPHORYLATION; PLANT; PROTEIN MOTIF; REPRESSOR GENE; TRANSCRIPTION REGULATION; UBIQUITINATION;

EID: 79951506522     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/epi.6.2.13627     Document Type: Article

References (50)

1. Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 2003; 33:245-54.
2. Luger K, Mader AW, Richmond RK, Sargent DF, Richmond TJ. Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature 1997; 389:251-60.
3. Chinnusamy V, Gong Z, Zhu JK. Abscisic acid-mediated epigenetic processes in plant development and stress responses. J Integr Plant Biol 2008; 50:1187-95.
4. Peterson CL, Laniel MA. Histones and histone modifications. Curr Biol 2004; 14:546-51.
5. Sun ZW, Allis CD. Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Nature 2002; 418:104-8.
6. Berger SL, Kouzarides T, Shiekhattar R, Shilatifard A. An operational definition of epigenetics. Genes Dev 2009; 23:781-3.
7. Hanna-Rose W, Hansen U. Active repression mechanisms of eukaryotic transcription repressors. Trends Genet 1996; 12:229-34.
8. Kagale S, Rozwadowski K. Small yet effective: The Ethylene responsive element binding factor-associated Amphiphilic Repression (EAR) motif. Plant Signal Behav 2010; 5:691-4.
9. Pazin MJ, Kadonaga JT. What's up and down with histone deacetylation and transcription? Cell 1997; 89:325-8.
10. Ohta M, Matsui K, Hiratsu K, Shinshi H, Ohme-Takagi M. Repression domains of class II ERF transcriptional repressors share an essential motif for active repression. Plant Cell 2001; 13:1959-68.
11. Matsui K, Umemura Y, Ohme-Takagi M. AtMYBL2, a protein with a single MYB domain, acts as a negative regulator of anthocyanin biosynthesis in Arabidopsis. Plant J 2008; 55:954-67.
12. Ikeda M, Ohme-Takagi M. A novel group of transcriptional repressors in Arabidopsis. Plant Cell Physiol 2009; 50:970-5.
13. Paponov IA, Teale W, Lang D, Paponov M, Reski R, Rensing SA, et al. The evolution of nuclear auxin signalling. BMC Evol Biol 2009; 9:126.
14. Hiratsu K, Matsui K, Koyama T, Ohme-Takagi M. Dominant repression of target genes by chimeric repressors that include the EAR motif, a repression domain, in Arabidopsis. Plant J 2003; 34:733-9.
15. Hiratsu K, Ohta M, Matsui K, Ohme-Takagi M. The SUPERMAN protein is an active repressor whose carboxy-terminal repression domain is required for the development of normal flowers. FEBS Lett 2002; 514:351-4.
16. Tiwari SB, Hagen G, Guilfoyle TJ. Aux/IAA proteins contain a potent transcriptional repression domain. Plant Cell 2004; 16:533-43.
17. Tsukagoshi H, Morikami A, Nakamura K. Two B3 domain transcriptional repressors prevent sugarinducible expression of seed maturation genes in Arabidopsis seedlings. Proc Natl Acad Sci USA 2007; 104:2543-7.
18. Tsukagoshi H, Saijo T, Shibata D, Morikami A, Nakamura K. Analysis of a sugar response mutant of Arabidopsis identified a novel B3 domain protein that functions as an active transcriptional repressor. Plant Physiol 2005; 138:675-85.
19. Hill K, Wang H, Perry SE. A transcriptional repression motif in the MADS factor AGL15 is involved in recruitment of histone deacetylase complex components. Plant J 2008; 53:172-85.
20. Weigel RR, Pfitzner UM, Gatz C. Interaction of NIMIN1 with NPR1 modulates PR gene expression in Arabidopsis. Plant Cell 2005; 17:1279-91.
21. Szemenyei H, Hannon M, Long JA. TOPLESS mediates auxin-dependent transcriptional repression during Arabidopsis embryogenesis. Science 2008; 319:1384-6.
22. Kagale S, Links MG, Rozwadowski K. Genomewide analysis of ethylene-responsive element binding factor-associated amphiphilic repression motifcontaining transcriptional regulators in Arabidopsis. Plant Physiol 2010; 152:1109-34.
23. Thiel G, Lietz M, Hohl M. How mammalian transcriptional repressors work. Eur J Biochem 2004; 271:2855-62.
24. Wolffe AP. Histone deacetylase: a regulator of transcription. Science 1996; 272:371-2.
25. Song CP, Agarwal M, Ohta M, Guo Y, Halfter U, Wang P, et al. Role of an Arabidopsis AP2/ EREBP-type transcriptional repressor in abscisic acid and drought stress responses. Plant Cell 2005; 17:2384-96.
26. Song CP, Galbraith DW. AtSAP18, an orthologue of human SAP18, is involved in the regulation of salt stress and mediates transcriptional repression in Arabidopsis. Plant Mol Biol 2006; 60:241-57.
27. Hollender C, Liu Z. Histone deacetylase genes in Arabidopsis development. J Integr Plant Biol 2008; 50:875-85.
28. Fujimoto SY, Ohta M, Usui A, Shinshi H, Ohme-Takagi M. Arabidopsis ethylene-responsive element binding factors act as transcriptional activators or repressors of GCC box-mediated gene expression. Plant Cell 2000; 12:393-404.
29. McGrath KC, Dombrecht B, Manners JM, Schenk PM, Edgar CI, Maclean DJ, et al. Repressor-and activator-type ethylene response factors functioning in jasmonate signaling and disease resistance identified via a genome-wide screen of Arabidopsis transcription factor gene expression. Plant Physiol 2005; 139:949-59.
30. Yang Z, Tian L, Latoszek-Green M, Brown D, Wu K. Arabidopsis ERF4 is a transcriptional repressor capable of modulating ethylene and abscisic acid responses. Plant Mol Biol 2005; 58:585-96.
31. Hiratsu K, Mitsuda N, Matsui K, Ohme-Takagi M. Identification of the minimal repression domain of SUPERMAN shows that the DLELRL hexapeptide is both necessary and sufficient for repression of transcription in Arabidopsis. Biochem Biophys Res Commun 2004; 321:172-8.
32. Pauwels L, Barbero GF, Geerinck J, Tilleman S, Grunewald W, Perez AC, et al. NINJA connects the co-repressor TOPLESS to jasmonate signalling. Nature 2010; 464:788-91.
33. Gallavotti A, Long JA, Stanfield S, Yang X, Jackson D, Vollbrecht E, et al. The control of axillary meristem fate in the maize ramosa pathway. Development 2010; 137:2849-56.
34. Long JA, Ohno C, Smith ZR, Meyerowitz EM. TOPLESS regulates apical embryonic fate in Arabidopsis. Science 2006; 312:1520-3.
35. Chen G, Fernandez J, Mische S, Courey AJ. A functional interaction between the histone deacetylase Rpd3 and the corepressor Groucho in Drosophila development. Genes Dev 1999; 13:2218-30.
36. Sekiya T, Zaret KS. Repression by Groucho/TLE/ Grg proteins: genomic site recruitment generates compacted chromatin in vitro and impairs activator binding in vivo. Mol Cell 2007; 28:291-303.
37. Winkler CJ, Ponce A, Courey AJ. Groucho-mediated repression may result from a histone deacetylasedependent increase in nucleosome density. PLoS One 2010; 5:e10166.
38. Zhu Z, Xu F, Zhang Y, Cheng YT, Wiermer M, Li X. Arabidopsis resistance protein SNC1 activates immune responses through association with a transcriptional corepressor. Proc Natl Acad Sci USA 2010; 107:13960-5.
39. Shikata M, Ohme-Takagi M. The utility of transcription factors for manipulation of floral traits. Plant Biotechnol 2008; 25:31-6.
40. Toufighi K, Brady SM, Austin R, Ly E, Provart NJ. The Botany Array Resource: e-northerns, Expression Angling and promoter analyses. Plant J 2005; 43:153-63.
41. Durek P, Schmidt R, Heazlewood JL, Jones A, MacLean D, Nagel A, et al. PhosPhAt: the Arabidopsis thaliana phosphorylation site database. An update. Nucleic Acids Res 2010; 38:828-34.
42. Heazlewood JL, Durek P, Hummel J, Selbig J, Weckwerth W, Walther D, et al. PhosPhAt: a database of phosphorylation sites in Arabidopsis thaliana and a plant-specific phosphorylation site predictor. Nucleic Acids Res 2008; 36:1015-21.
43. Nuthall HN, Husain J, McLarren KW, Stifani S. Role for Hes1-induced phosphorylation in Grouchomediated transcriptional repression. Mol Cell Biol 2002; 22:389-99.
44. Nuthall HN, Joachim K, Stifani S. Phosphorylation of serine 239 of Groucho/TLE1 by protein kinase CK2 is important for inhibition of neuronal differentiation. Mol Cell Biol 2004; 24:8395-407.
45. Buscarlet M, Hermann R, Lo R, Tang Y, Joachim K, Stifani S. Cofactor-activated phosphorylation is required for inhibition of cortical neuron differentiation by Groucho/TLE1. PLoS ONE 2009; 4:e8107.
46. Chico JM, Chini A, Fonseca S, Solano R. JAZ repressors set the rhythm in jasmonate signaling. Curr Opin Plant Biol 2008; 11:486-94.
47. Gray WM, Kepinski S, Rouse D, Leyser O, Estelle M. Auxin regulates SCF(TIR1)-dependent degradation of AUX/IAA proteins. Nature 2001; 414:271-6.
48. Huq E. Degradation of negative regulators: a common theme in hormone and light signaling networks? Trends Plant Sci 2006; 11:4-7.
49. Maraschin Fdos S, Memelink J, Offringa R. Auxininduced, SCF(TIR1)-mediated poly-ubiquitination marks AUX/IAA proteins for degradation. Plant J 2009; 59:100-9.
50. Santner A, Estelle M. The ubiquitin-proteasome system regulates plant hormone signaling. Plant J 2010; 61:1029-40.