Small molecule clearance in ultrafiltration/diafiltration in relation to protein interactions: Study of citrate binding to a fab

Biotechnology and Bioengineering

Volumn 102, Issue 6, 2009, Pages 1718-1722

  Harinarayan, C ^a   Skidmore, K ^a   Kao, Y ^a   Zydney, A L ^b   Van Reis, R ^a  

^a GENENTECH INC   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Binding; Citrate; Clearance; Diafiltration; Formulation; NMR; Proteins; Small molecules; Ultrafiltration

Indexed keywords

BINDING; CITRATE; CLEARANCE; DIAFILTRATION; FORMULATION; NMR; SMALL MOLECULES;

MONOCLONAL ANTIBODIES; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEINS; PURIFICATION; ULTRAFILTRATION;

MOLECULES;

CITRIC ACID; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN;

ANTIGEN BINDING; ARTICLE; DIAFILTRATION; EQUILIBRIUM CONSTANT; FILTRATION; MATHEMATICAL MODEL; MATHEMATICAL PARAMETERS; PH; PROTEIN PURIFICATION; ULTRAFILTRATION;

ACETATES; ALGORITHMS; CITRIC ACID; HEPES; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; MODELS, CHEMICAL; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECOMBINANT PROTEINS; TROMETHAMINE; ULTRAFILTRATION;

EID: 65349103957     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22196     Document Type: Article

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