-
1
-
-
0036065039
-
Benefit of an extract of Tripterygium wilfordii Hook F in patients with rheumatoid arthritis: A double-blind, placebo-controlled study
-
DOI 10.1002/art.10411
-
Tao X, Younger J, Fan FZ, Wang B and Lipsky PE: Benefit of an extract of Tripterygium wilfordii Hook F in patients with rheumatoid arthritis: a double-blind, placebo-controlled study. Arthritis Rheum 46: 1735-1743, 2002. (Pubitemid 34774504)
-
(2002)
Arthritis and Rheumatism
, vol.46
, Issue.7
, pp. 1735-1743
-
-
Tao, X.1
Younger, J.2
Fan, F.Z.3
Wang, B.4
Lipsky, P.E.5
-
2
-
-
0034909663
-
Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F
-
Chen BJ: Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F. Leuk Lymphoma 42: 253-265, 2001.
-
(2001)
Leuk Lymphoma
, vol.42
, pp. 253-265
-
-
Chen, B.J.1
-
3
-
-
77951732252
-
Triptolide induces anti-inflammatory cellular responses
-
Matta R, Wang XX, Ge H, Ray W, Nelin LD and Liu Y: Triptolide induces anti-inflammatory cellular responses. Am J Transi Res 1: 267-282, 2009.
-
(2009)
Am J Transi Res
, vol.1
, pp. 267-282
-
-
Matta, R.1
Wang, X.X.2
Ge, H.3
Ray, W.4
Nelin, L.D.5
Liu, Y.6
-
4
-
-
77951932747
-
RNA polymerase - An important molecular target of triptolide in cancer cells
-
Pan JX: RNA polymerase - an important molecular target of triptolide in cancer cells. Cancer Lett 292: 149-52, 2010.
-
(2010)
Cancer Lett
, vol.292
, pp. 149-152
-
-
Pan, J.X.1
-
5
-
-
77955496813
-
Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways
-
Mujumdar N, MacKenzie T, Dudeja V, Chugh R, Antonoff MB, Borja-Cacho D, Sangwan V, Dawra R, Vickers SM, Saluja AK: Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways. Gastroenterology 139: 598-608, 2010.
-
(2010)
Gastroenterology
, vol.139
, pp. 598-608
-
-
Mujumdar, N.1
MacKenzie, T.2
Dudeja, V.3
Chugh, R.4
Antonoff, M.B.5
Borja-Cacho, D.6
Sangwan, V.7
Dawra, R.8
Vickers, S.M.9
Saluja, A.K.10
-
6
-
-
63649086487
-
Targeting the ubiquitin system in cancer therapy
-
Hoeller D and Dikic I: Targeting the ubiquitin system in cancer therapy. Nature 458: 438-444, 2009.
-
(2009)
Nature
, vol.458
, pp. 438-444
-
-
Hoeller, D.1
Dikic, I.2
-
7
-
-
0033178142
-
Proteasome inhibitors as potential novel anticancer agents
-
DOI 10.1054/drup.1999.0095
-
Dou QP and Li B: Proteasome inhibitors as potential novel anticancer agents. Drug Resist Updat 2: 215-223, 1999. (Pubitemid 29526245)
-
(1999)
Drug Resistance Updates
, vol.2
, Issue.4
, pp. 215-223
-
-
Dou, Q.P.1
Li, B.2
-
8
-
-
0029071646
-
Functions of the proteasome: The lysis at the end of the tunnel
-
Goldberg AL: Functions of the proteasome: the lysis at the end of the tunnel. Science 268: 522-523, 1995.
-
(1995)
Science
, vol.268
, pp. 522-523
-
-
Goldberg, A.L.1
-
9
-
-
0030004897
-
Site-specific phosphorylation of IκBa by a novel ubiquitination- Dependent protein kinase activity
-
DOI 10.1016/S0092-8674(00)81064-8
-
Chen ZJ, Parent L and Maniatis T: Site-specific phosphorylation of IκBa by a novel ubiquitination-dependent protein kinase activity. Cell 84: 853-862, 1996. (Pubitemid 26106855)
-
(1996)
Cell
, vol.84
, Issue.6
, pp. 853-862
-
-
Chen, Z.J.1
Parent, L.2
Maniatis, T.3
-
10
-
-
0036240701
-
The proteasome: A target novel for cancer chemotherapy
-
DOI 10.1038/sj/leu/2402417
-
Almond JB and Cohen GM: The proteasome: a novel target for cancer chemotherapy. Leukemia 16: 433-443, 2002. (Pubitemid 34449723)
-
(2002)
Leukemia
, vol.16
, Issue.4
, pp. 433-443
-
-
Almond, J.B.1
Cohen, G.M.2
-
11
-
-
64249097600
-
Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo
-
Yang HJ, Zhou P, Huang HB, Chen D, Ma N, Cui QC, Shen S, Dong W, Zhang X, Lian W, Wang X, Dou QP and Liu J: Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo. Int J Cancer 124: 2450-2459, 2009.
-
(2009)
Int J Cancer
, vol.124
, pp. 2450-2459
-
-
Yang, H.J.1
Zhou, P.2
Huang, H.B.3
Chen, D.4
Ma, N.5
Cui, Q.C.6
Shen, S.7
Dong, W.8
Zhang, X.9
Lian, W.10
Wang, X.11
Dou, Q.P.12
Liu, J.13
-
12
-
-
14644437010
-
Exploiting the ubiquitin-proteasome pathway for anticancer drug discovery: Unanswered questions and future directions
-
Smith DM, Daniel KG and Dou QP: Exploiting the ubiquitin-proteasome pathway for anticancer drug discovery: unanswered questions and future directions. Lett Drug Des Discov 2: 77-84, 2005.
-
(2005)
Lett Drug des Discov
, vol.2
, pp. 77-84
-
-
Smith, D.M.1
Daniel, K.G.2
Dou, Q.P.3
-
13
-
-
2342667387
-
The development of proteasome inhibitors as anticancer drugs
-
Adam J: The development of proteasome inhibitors as anticancer drugs. Cancer Cell 5: 417-421, 2004.
-
(2004)
Cancer Cell
, vol.5
, pp. 417-421
-
-
Adam, J.1
-
14
-
-
0032429122
-
Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts
-
An B, Goldfarb RH, Siman R and Dou QP: Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts. Cell Death Differ 5: 1062-1075, 1998.
-
(1998)
Cell Death Differ
, vol.5
, pp. 1062-1075
-
-
An, B.1
Goldfarb, R.H.2
Siman, R.3
Dou, Q.P.4
-
15
-
-
18044383342
-
Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells
-
DOI 10.1016/j.bcp.2005.02.022
-
Chen D, Daniel KG, Chen MS, Kuhn DJ, Landis-Piwowar KR and Dou QP: Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells. Biochem Pharmacol 69: 1421-1432, 2005. (Pubitemid 40602442)
-
(2005)
Biochemical Pharmacology
, vol.69
, Issue.10
, pp. 1421-1432
-
-
Chen, D.1
Daniel, K.G.2
Chen, M.S.3
Kuhn, D.J.4
Landis-Piwowar, K.R.5
Dou, Q.P.6
-
16
-
-
3042717275
-
A natural musaceas plant extract inhibits proteasome activity and induces apoptosis selectively in human tumor and transformed, but not normal and non-transformed cells
-
Kazi A, Urbizu DA, Kuhn DJ, Acebo AL, Jackson ER, Greenfelder GP, Kumar NB and Dou QP: A natural musaceas plant extract inhibits proteasome activity and induces apoptosis selectively in human tumor and transformed, but not normal and non-transformed cells. Int J Mol Med 6: 879-887, 2003.
-
(2003)
Int J Mol Med
, vol.6
, pp. 879-887
-
-
Kazi, A.1
Urbizu, D.A.2
Kuhn, D.J.3
Acebo, A.L.4
Jackson, E.R.5
Greenfelder, G.P.6
Kumar, N.B.7
Dou, Q.P.8
-
17
-
-
33646406554
-
Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice
-
Yang HJ, Chen D, Cui QC, Xiao Y and Dou QP: Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res 66: 4758-4764, 2006.
-
(2006)
Cancer Res
, vol.66
, pp. 4758-4764
-
-
Yang, H.J.1
Chen, D.2
Cui, Q.C.3
Xiao, Y.4
Dou, Q.P.5
-
18
-
-
33846454701
-
The tumor proteasome is a primary target for the natural anticancer compound Withaferin a isolated from 'Indian winter cherry'
-
Yang HJ, Shi GQ and Dou QP: The tumor proteasome is a primary target for the natural anticancer compound Withaferin A isolated from 'Indian winter cherry'. Mol Pharmacol 71: 426-437, 2007.
-
(2007)
Mol Pharmacol
, vol.71
, pp. 426-437
-
-
Yang, H.J.1
Shi, G.Q.2
Dou, Q.P.3
-
19
-
-
54749132655
-
Curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo
-
Milacic V, Banerjee S, Landis KR, Sarkar FH, Majumdar AP and Dou QP: Curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo. Cancer Res 68: 7283-7292, 2008.
-
(2008)
Cancer Res
, vol.68
, pp. 7283-7292
-
-
Milacic, V.1
Banerjee, S.2
Landis, K.R.3
Sarkar, F.H.4
Majumdar, A.P.5
Dou, Q.P.6
-
20
-
-
63849258626
-
A small molecule triptolide suppresses angiogenesis and invasion of human anaplastic thyroid carcinoma cells via down-regulation of NF-kappa B pathway
-
Zhu W, Ou Y, Li Y, Xiao R, Shu M, Zhou Y, Xie J, He S, Qiu P and Yan G: A small molecule triptolide suppresses angiogenesis and invasion of human anaplastic thyroid carcinoma cells via down-regulation of NF-kappa B pathway. Mol Pharmacol 75: 812-819, 2009.
-
(2009)
Mol Pharmacol
, vol.75
, pp. 812-819
-
-
Zhu, W.1
Ou, Y.2
Li, Y.3
Xiao, R.4
Shu, M.5
Zhou, Y.6
Xie, J.7
He, S.8
Qiu, P.9
Yan, G.10
-
21
-
-
0033532177
-
Immunosuppressant PG490 (Triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kB transcriptional activation
-
Qiu DM, Zhao GH, Aoki YS, Shi L, Uyei A, Nazarian S, Ng JC and Kao PN: Immunosuppressant PG490 (Triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kB transcriptional activation. J Biol Chem 274: 13443-13450, 1999
-
(1999)
J Biol Chem
, vol.274
, pp. 13443-13450
-
-
Qiu, D.M.1
Zhao, G.H.2
Aoki, Y.S.3
Shi, L.4
Uyei, A.5
Nazarian, S.6
Ng, J.C.7
Kao, P.N.8
-
22
-
-
58149185984
-
L-glutamine schiff base copper complex as a proteasome inhibitor and an apoptosis inducer in human cancer cells
-
Yan X, Bi CF, Fan YH, Cui C, Zhang X and Dou QP: L-glutamine schiff base copper complex as a proteasome inhibitor and an apoptosis inducer in human cancer cells. Int J Oncol 33: 1073-1079, 2008.
-
(2008)
Int J Oncol
, vol.33
, pp. 1073-1079
-
-
Yan, X.1
Bi, C.F.2
Fan, Y.H.3
Cui, C.4
Zhang, X.5
Dou, Q.P.6
-
23
-
-
35148887169
-
Inhibition of the proteasome activity by gallium(III) complexes contributes to their anti-prostate tumor effects
-
DOI 10.1158/0008-5472.CAN-07-1813
-
Chen Di, Frezza M, Shakya R, Cui QC, Milacic V, Verani CN and Dou QP: Inhibition of the proteasome activity by gallium(III) complexes contributes to their anti-prostate tumor effects. Cancer Res 67: 9258-9265, 2007. (Pubitemid 47535914)
-
(2007)
Cancer Research
, vol.67
, Issue.19
, pp. 9258-9265
-
-
Chen, D.1
Frezza, M.2
Shakya, R.3
Cui, Q.C.4
Milacic, V.5
Verani, C.N.6
Dou, Q.P.7
-
24
-
-
0035918278
-
Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo
-
Nam S, Smith DM and Dou QP: Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo. J Biol Chem 276: 13322-13330, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 13322-13330
-
-
Nam, S.1
Smith, D.M.2
Dou, Q.P.3
-
25
-
-
0015494046
-
Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii
-
Kupchan SM, Court WA, Dailey RG Jr., Gilmore CJ and Bryan RF: Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii. J Am Chem Soc 94: 7194-7195, 1972.
-
(1972)
J Am Chem Soc
, vol.94
, pp. 7194-7195
-
-
Kupchan, S.M.1
Court, W.A.2
Dailey Jr., R.G.3
Gilmore, C.J.4
Bryan, R.F.5
-
26
-
-
43549107334
-
Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5
-
Carter BZ, Mak DH, Schober WD, Dietrich MF, Pinilla C, Vassilev LT, Reed JC and Andreeff M: Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5. Blood 111: 3742-3750, 2008.
-
(2008)
Blood
, vol.111
, pp. 3742-3750
-
-
Carter, B.Z.1
Mak, D.H.2
Schober, W.D.3
Dietrich, M.F.4
Pinilla, C.5
Vassilev, L.T.6
Reed, J.C.7
Andreeff, M.8
-
27
-
-
33744832401
-
United States Food and Drug Administration approval summary: Bortezomib for the treatment of progressive multiple myeloma after one prior therapy
-
DOI 10.1158/1078-0432.CCR-06-0170
-
Dou KR, Farrell AT, Sridhara R and Pazdur R: United States Food and Drug Administration approval summary: bortezomib for the treatment of progressive multiple myeloma after one prior therapy. Clin Cancer Res 12: 2955-2960, 2006. (Pubitemid 43837337)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.10
, pp. 2955-2960
-
-
Kane, R.C.1
Farrell, A.T.2
Sridhara, R.3
Pazdur, R.4
-
28
-
-
53749093009
-
Triptolide inhibits COX-2 expression and PGE2 release by suppressing the activity of NF-kappaB and JNK in LPS-treated microglia
-
Gong Y, Xue B, Jiao J, Jing L and Wang X: Triptolide inhibits COX-2 expression and PGE2 release by suppressing the activity of NF-kappaB and JNK in LPS-treated microglia. J Neurochem 107: 779-788, 2008.
-
(2008)
J Neurochem
, vol.107
, pp. 779-788
-
-
Gong, Y.1
Xue, B.2
Jiao, J.3
Jing, L.4
Wang, X.5
-
29
-
-
70349454064
-
Triptolide-induced suppression of phospholipase D expression inhibits proliferation of MDA-MB-231 breast cancer cells
-
Kang DW, Lee JY, Oh DH, Park SY, Woo TM, Kim MK, Park MH, Jang YH and Min do S: Triptolide-induced suppression of phospholipase D expression inhibits proliferation of MDA-MB-231 breast cancer cells. Exper Mol Med 41: 678-685, 2009.
-
(2009)
Exper Mol Med
, vol.41
, pp. 678-685
-
-
Kang, D.W.1
Lee, J.Y.2
Oh, D.H.3
Park, S.Y.4
Woo, T.M.5
Kim, M.K.6
Park, M.H.7
Jang, Y.H.8
Min Do, S.9
-
30
-
-
35848963616
-
Resveratrol: From basic science to the clinic
-
Cucciolla V, Borriello A, Oliva A, Galletti P, Zappia V, Della Ragione F: Resveratrol: from basic science to the clinic. Cell Cycle 6: 2495-2510, 2007. (Pubitemid 350058668)
-
(2007)
Cell Cycle
, vol.6
, Issue.20
, pp. 2495-2510
-
-
Cucciolla, V.1
Borriello, A.2
Oliva, A.3
Galletti, P.4
Zappia, V.5
Della, R.F.6
-
31
-
-
0036023433
-
Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells
-
Kiviharju TM, Lecane PS, Sellers RG and Peehl DM: Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells. Clin Cancer Res 8: 2666-2674, 2002. (Pubitemid 34856355)
-
(2002)
Clinical Cancer Research
, vol.8
, Issue.8
, pp. 2666-2674
-
-
Kiviharju, T.M.1
Lecane, P.S.2
Sellers, R.G.3
Peehl, D.M.4
|