Anticancer and antimetastatic activities of renieramyein M, a marine tetrahydroisoquinoline alkaloid, in human non-small cell lung cancer cells

Anticancer Research

Volumn 31, Issue 1, 2011, Pages 193-201

  Halim, Hasseri ^a   Chunhacha, Preedakorn ^a   Suwanborirux, Khanit ^b   Chanvorachote, Pithi ^b  

^a Pharmaceutical Technology (International) Program   (Thailand)

^b CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

Anoikis; Invasion; Lung cancer cells; Metastasis; Migration; Renieramycin M

Indexed keywords

ALKALOID; ANTINEOPLASTIC AGENT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN MCL 1; PROTEIN P53; RENIERAMYCIN M; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ANOIKIS; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL INVASION; CELL MIGRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG ISOLATION; DRUG MECHANISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; METASTASIS INHIBITION; PRIORITY JOURNAL; SENSITIZATION; XESTOSPONGIA;

ALKALOIDS; ANIMALS; ANOIKIS; APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, NON-SMALL-CELL LUNG; CELL ADHESION; CELL MOVEMENT; CELL PROLIFERATION; COLONY-FORMING UNITS ASSAY; HUMANS; LUNG NEOPLASMS; PORIFERA; PROTO-ONCOGENE PROTEINS C-BCL-2; TETRAHYDROISOQUINOLINES; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; WOUND HEALING;

EID: 79851470014     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Hanahan D and Weinberg RA: The hallmarks of cancer. Cell 100: 57-70, 2000. (Pubitemid 30046295)
2. Frisch SM and Francis H: Disruption of epithelial cell matrix interactions induces apoptosis. J Cell Biol 124: 619-626, 1994. (Pubitemid 24064472)
3. Suwanborirux K, Amnuoypol S, Plubrukarn A, Pummangura S, Kubo A, Tanaka C and Saito NJ: Chemistry of renieramycins. Part 3. Isolation and structure of stabilized renieramycin type derivatives possessing antitumor activity from Thai sponge Xestospongia species, pretreated with potassium cyanide. Nat Protocol 66: 1441-1446, 2003.
4. Scott JD and Williams RM: Chemistry and biology of the tetrahydroisoquinoline antitumor antibiotics. Chem Rev 105(5): 1669-1730, 2002. (Pubitemid 35377652)
5. Cuevas C and Francesch A: Development of Yondelis (trabectedin, ET-743). A semisynthetic process solves the supply problem. Nat Prod Rep 26: 322-337, 2009.
6. Saito N, Tanaka C, Koizumi Y, Suwanborirux K, Amnuoypol S, Pummangura S and Kubo A: Chemistry of renieramycins. Part 6: Transformation of renieramycin M into jorumycin and renieramycin J including oxidative degradation products, mimosamycin, renierone, and renierol acetate. Tetrahedron 60: 3873-3881, 2004.
7. Amnuoypol S, Suwanborirux K, Pummangura S, Kubo A, Tanaka C and Saito N: Chemistry of renieramycins. Part 5. Structure elucidation of renieramycin-type derivatives O, Q, R, and S from Thai marine sponge Xestospongia species pretreated with potassium cyanide. J Nat Prod 67: 1023-1028, 2004. (Pubitemid 38823338)
8. Charupant K, Suwanborirux K, Amnuoypol S, Saito E, Kubo A and Saito N: Jorunnamycins A-C, new stabilized renieramycin-type bistetrahydroisoquinolines isolated from the Thai nudibranch Jorunna funebris. Chem Pharm Bull 55: 81-86, 2007. (Pubitemid 46067587)
9. Charupant K, Daikuhara N, Saito E, Amnuoypol S, Suwanborirux K, Owa T and Saito N: Chemistry of renieramycins. Part 8: Synthesis and cytotoxicity evaluation of renieramycin M-jorunnamycin A analogues. Bioorg Med Chem 17: 4548-4558, 2009.
10. Weigelt B, Peterse JL and van't Veer LJ: Breast cancer metastasis: markers and models. Nat Rev Cancer 5: 591-602, 2005. (Pubitemid 41081385)
11. Tudor G, Aguilera A, Halverson DO, Laing ND and Sausville EA: Susceptibility to drug-induced apoptosis correlates with differential modulation of Bad, Bcl-2 and Bcl-XL protein levels. Cell Death Differ 7: 574-586, 2000. (Pubitemid 30303613)
12. Erba E, Bergamashi D, Bassano L, Damia G, Ronzoni S, Faircloth GT and D'Incalci M: Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action. Eur J Cancer 37: 97-105, 2001. (Pubitemid 32119366)
13. Martinez EJ, Corey EJ and Owa T: Antitumor activity- and gene expression-based profiling of ecteinascidin Et743 and phthalascidin Pt 650. Chem Biol 8: 1151-1160, 2001. (Pubitemid 34029884)
14. Barinaga M: Cell suicide: by ICE, not fire. Science 263: 754-756, 1994.
15. Miyashita T, Harigai M, Hanada M and Reed JC: Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer Res 54: 3131-3135, 1994. (Pubitemid 24208916)
16. Brunelle JK and Letai A: Control of mitochondrial apoptosis by the bcl-2 family. J Cell Sci 122: 437-441, 2009.
17. Strasser A, O'Connor L and Dixit VM: Apoptosis signaling. Annu Rev Biochem 69: 217-245, 2000.
18. Danial NN and Korsmeyer SJ: Cell death: critical control points. Cell 116: 205-219, 2004. (Pubitemid 38167313)
19. Green DR and Reed JC: Mitochondria and apoptosis. Science 281: 1309-1312, 1998. (Pubitemid 28406816)
20. Kim SH, Ricci MS and El-Deiry WS: Mcl-1: A gateway to TRAIL sensitization. Cancer Res 68(7): 2062-2064, 2008.
21. Woods NT, Yamaguchi H, Lee FY, Bhalla KN and Wang HG: Anoikis, initiated by Mcl-1 degradation and Bim induction, is deregulated during oncogenesis. Cancer Res 67(22): 10744-10752, 2007.
22. Song L, Coppola D, Livingston S, Cress D and Haura EB: Mcl-1 regulates survival and sensitivity to diverse apoptotic stimuli in human non-small cell lung cancer cells. Cancer Biol Ther 4(3): 267-276, 2005. (Pubitemid 41351285)
23. Wacheck V, Cejka D, Sieghart W, Losert D, Strammer S, Crevenna R, Monia BP and Selzer E: Mcl-1 is a relevant molecular target for antisense oligonucleotide strategies in gastric cancer cells. Canc Biol Ther 5(10): 1348-1354, 2006. (Pubitemid 44772262)
24. Moulding DA, Giles RV, Spiller DG, White MRH, Tidd DM and Edwards SW: Apoptosis is rapidly triggered by antisense depletion of Mcl-1 in differentiating U937 cells. Blood 96(5): 1756-1763, 2000. (Pubitemid 30661059)
25. Ikegaki N, Katsumata M and Minna J: Expression of bCL-2 in small cell lung carcinoma cells. Cancer Res 54: 6-8, 1994. (Pubitemid 24042076)
26. Ben-Ezra JM, Kornstein MJ and Grimes MM: Small cell carcinomas of the lung express the BCL-2 protein. Am J Pathol 145: 1036-1040, 1994. (Pubitemid 24345651)
27. Chanvorachote P, Nimmannit U, Stehlik C, Wang L, Ongpipatanakul B and Rojanakul Y: Nitric oxide regulates cell sensitivity to cisplatin-induced apoptosis through S-nitrosylation and inhibition of BCL-2 ubiquitination. Cancer Res 66: 6353-6360, 2006.