8-Prenylkaempferol accelerates osteoblast maturation through bone morphogenetic protein-2/p38 pathway to activate Runx2 transcription

Life Sciences

Volumn 88, Issue 7-8, 2011, Pages 335-342

  Chiou, Wen Fei ^a,b   Lee, Chia Hsin ^b   Liao, Jyh Fei ^b   Chen, Chien Chih ^c  

^a NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c HUNGKUANG UNIVERSITY   (Taiwan)

Author keywords

8 Prenylkaempferol; Bone morphogenetic protein 2; Osteoblastogenesis; Sophora flavescens

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 8 PRENYLKAEMPFEROL; ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 1; FLAVONOID; MESSENGER RNA; NOGGIN; OSTEOCALCIN; OSTEOPONTIN; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; BONE MATURATION; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION; MEDICINAL PLANT; MINERALIZATION; MOUSE; NONHUMAN; OSTEOBLAST; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SOPHORA FLAVESCENS; TRANSCRIPTION INITIATION; UPREGULATION; WESTERN BLOTTING;

ALKALINE PHOSPHATASE; ANIMALS; BLOTTING, WESTERN; BONE MORPHOGENETIC PROTEIN 2; CELL DIFFERENTIATION; CELL LINE; COLLAGEN TYPE I; CORE BINDING FACTOR ALPHA 1 SUBUNIT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; KAEMPFEROLS; MICE; OSTEOBLASTS; OSTEOCALCIN; OSTEOGENESIS; OSTEOPONTIN; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UP-REGULATION;

SOPHORA FLAVESCENS;

EID: 79751526399     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2010.12.009     Document Type: Article

References (30)

1. E. Canalis, A.N. Economides, and E. Gazzerro Bone morphogenetic proteins, their antagonists, and the skeleton Endocrinology 24 2003 218 235 (Pubitemid 36515285)
2. X. Chen, C. Yi, X. Yang, and X. Wang Liquid chromatography of active principles in Sophora flavescens root J Chromatogr B 812 2004 149 163 (Pubitemid 39535407)
3. W.F. Chiou, C.C. Chen, and B.L. Wei 8-Prenylkaempferol suppresses influenza A virus-induced RANTES production in A549 cells via blocking PI3K-mediated transcriptional activation of NF-κB and IRF3 Evid Based Complement Alternat Med 2010 10.1093/ecam/nep066
4. P. Ducy, R. Zhang, V. Geoffroy, A.L. Ridall, and G. Karsenty Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation Cell 89 1997 747 754 (Pubitemid 27516177)
5. J. Guicheux, J. Lemonnier, C. Ghayor, A. Suzuki, G. Palmer, and J. Caverzasio Activation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation J Bone Miner Res 18 2003 2060 2068 (Pubitemid 37377457)
6. P.I. Hillerns, and M. Wink Binding of flavonoids from Sophora flavescens to the rat uterine estrogen receptor Planta Med 71 2005 1065 1068 (Pubitemid 41802878)
7. Y.L. Hsu, J.K. Chang, C.H. Tsai, T.T. Chang-Chien, and P.L. Kuo Myricetin induces human osteoblast differentiation through bone morphogenetic protein-2/p38 mitogen-activated protein kinase pathway Biochem Pharmacol 73 2007 504 514
8. J.S. Hwang, S.A. Lee, S.S. Hong, K.S. Lee, M.K. Lee, and B.Y. Hwang Monoamine oxidase inhibitory components from the roots of Sophora flavescens Arch Pharm Res 28 2005 190 194 (Pubitemid 43073672)
9. J. Jadlowiec, H. Koch, X. Zhang, P.G. Campbell, P.M. Seyedain, and C. Sfeir Phosphophoryn regulates the gene expression and differentiation of NIH3T3, MC3T3-E1, and human mesenchymal stem cells via the integrin/MAPK signaling pathway J Biol Chem 279 2004 53323 53330 (Pubitemid 40051837)
10. H.J. Jung, S.S. Kang, S.K. Hyun, and J.S. Choi In vitro free radical and ONOO- scavengers from Sophora flavescens Arch Pharm Res 28 2005 534 540
11. D.W. Kim, Y.S. Chi, K.H. Son, H.W. Chang, J.S. Kim, and S.S. Kang Effects of sophoraflavanone G, a prenylated flavonoid from Sophora flavescenes, on cyclooxygenase-2 and in vitro inflammatory response Arch Pharm Res 25 2002 329 335 (Pubitemid 43093314)
12. P.L. Kuo, Y.L. Hsu, C.H. Chang, and J.K. Chang Osthole-mediated cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells J Pharmacol Exp Ther 314 2005 1290 1299
13. P.L. Kuo, Y.T. Huang, C.H. Chang, and J.K. Chang Bone morphogenetic protein-2 and -4 (BMP-2 and -4) mediates fraxetin-induced maturation and differentiation in human osteoblast-like cell lines Biol Pharm Bull 29 2006 119 124
14. C.F. Lai, and S.L. Cheng Signal transductions induced by bone morphogenetic protein-2 and transforming growth factor beta in normal human osteoblastic cells J Biol Chem 277 2002 15514 15522
15. J.B. Lian, G.S. Stein, and A. Javed Networks and hubs for the transcriptional control of osteoblastogenesis Rev Endocr Metab Disord 7 2006 1 16 (Pubitemid 46044345)
16. Y.C. Lo, Y.H. Chang, B.L. Wei, Y.L. Huang, and W.F. Chiou Betulinic acid stimulates the differentiation and mineralization of osteoblastic MC3T3-E1 Cells: involvement of BMP/Runx2 and β-catenin signals J Agric Food Chem 58 2010 6643 6649
17. M. Miyake, N. Arai, S. Ushio, K. Iwaki, and M. Ikeda Promoting effect of kaempferol on the differentiation and mineralization of murine pre-osteoblastic cell line MC3T3-E1 Biosci Biotechnol Biochem 63 2003 1199 1205 (Pubitemid 39251812)
18. K. Miyazono, S. Maeda, and T. Imamura BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk Cytokine Growth Factor Rev 16 2005 251 263 (Pubitemid 40910315)
19. N. Okumura, T. Yoshikawa, J. Iida, A. Nonomura, and Y. Takakura Bone formation-promoting effect of genistein on marrow mesenchymal cell culture Biomed Mater Eng 16 2006 23 32 (Pubitemid 43104590)
20. F. Otto, A.P. Thornell, T. Crompton, A. Denzel, K.C. Gilmour, and I.R. Rosewell Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development Cell 30 1997 765 771 (Pubitemid 27516179)
21. M. Prince, C. Banerjee, A. Javed, J. Green, J.B. Lian, and G.S. Stein Expression and regulation of Runx2/Cbfa1 and osteoblast phenotypic markers during the growth and differentiation of human osteoblasts J Cell Biochem 80 2001 424 440 (Pubitemid 32141498)
22. C. Prouillet, J.C. Maziere, C. Maziere, A. Wattel, M. Brazier, and S. Kamel Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway Biochem Pharmacol 67 2004 1307 1313 (Pubitemid 38315096)
23. M. Qiao, P. Shapiro, R. Kumar, and A. Passaniti Insulin-like growth factor-1 regulates endogenous RUNX2 activity in endothelial cells through a phosphatidylinositol 3-kinase/ERK-dependent and Akt-independent signaling pathway J Biol Chem 279 2004 42709 42718 (Pubitemid 39372157)
24. T. Sakou, T. Onishi, T. Yamamoto, T. Nagamine, T. Sampath, and P. Ten-Dijke Localization of Smads, the TGF-beta family intracellular signaling components during endochondral ossification J Bone Miner Res 14 1999 1145 1152 (Pubitemid 29314057)
25. B. Sen, Z. Xie, N. Case, M. Ma, C. Rubin, and J. Rubin Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable β-catenin signal Endocrinology 149 2008 6065 6075
26. G. Xiao, D. Jiang, P. Thomas, M.D. Benson, K. Guan, and G. Karsenty MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1 J Biol Chem 275 2000 4453 4459 (Pubitemid 30094689)
27. G. Xiao, R. Gopalakrishnan, D. Jiang, E. Reith, M.D. Benson, and R.T. Franceschi Bone morphogenetic proteins, extracellular matrix, and mitogen-activated protein kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells J Bone Miner Res 17 2002 101 110 (Pubitemid 33151001)
28. G. Xiao, D. Jiang, R. Gopalakrishnan, and R.T. Franceschi Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2 J Biol Chem 277 2002 36181 36187
29. S. Yang, D. Wei, D. Wang, M. Phimphilai, P.H. Krebsbach, and R.T. Franceschi In vitro and in vivo synergistic interactions between the Runx2/Cbfa1 transcription factor and bone morphogenetic protein-2 in stimulating osteoblast differentiation J Bone Miner Res 18 2003 705 715 (Pubitemid 36899320)
30. W. Zhu, J. Kim, C. Cheng, B.A. Rawlins, O. Boachie-Adjei, and R.G. Crystal Noggin regulation of bone morphogenetic protein (BMP) 2/7 heterodimer activity in vitro Bone 39 2006 61 71 (Pubitemid 43831779)