메뉴 건너뛰기




Volumn 101, Issue 6, 2007, Pages 416-420

Functional evaluation of THIQ, a melanocortin 4 receptor agonist, in models of food intake and inflammation

Author keywords

[No Author keywords available]

Indexed keywords

HORMONE RECEPTOR STIMULATING AGENT; LIPOPOLYSACCHARIDE; MELANOTAN 2; NITRIC OXIDE; TETRAHYDROISOQUINOLINE; UNCLASSIFIED DRUG;

EID: 36248932522     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2007.00133.x     Document Type: Article
Times cited : (16)

References (25)
  • 1
    • 1542347163 scopus 로고    scopus 로고
    • Targeting melanocortin receptors as a novel strategy to control inflammation
    • Catania A, Gatti S, Colombo G, Lipton JM. Targeting melanocortin receptors as a novel strategy to control inflammation. Pharmacol Rev 2004 56 : 1 29.
    • (2004) Pharmacol Rev , vol.56 , pp. 1-29
    • Catania, A.1    Gatti, S.2    Colombo, G.3    Lipton, J.M.4
  • 2
    • 0033736084 scopus 로고    scopus 로고
    • New aspects on the melanocortins and their receptors
    • Wikberg JE, Muceniece R, Mandrika I et al. New aspects on the melanocortins and their receptors. Pharmacol Res 2000 42 : 393 420.
    • (2000) Pharmacol Res , vol.42 , pp. 393-420
    • Wikberg, J.E.1    Muceniece, R.2    Mandrika, I.3
  • 3
    • 25144524533 scopus 로고    scopus 로고
    • Feeding effects of melanocortin ligands: A historical perspective
    • Irani BG, Haskell-Luevano C. Feeding effects of melanocortin ligands: a historical perspective. Peptides 2005 26 : 1788 99.
    • (2005) Peptides , vol.26 , pp. 1788-99
    • Irani, B.G.1    Haskell-Luevano, C.2
  • 4
    • 19044393779 scopus 로고    scopus 로고
    • The role of melanocortins in body weight regulation: Opportunities for the treatment of obesity
    • MacNeil DJ, Howard AD, Guan X et al. The role of melanocortins in body weight regulation: opportunities for the treatment of obesity. Eur J Pharmacol 2002 450 : 93 109.
    • (2002) Eur J Pharmacol , vol.450 , pp. 93-109
    • MacNeil, D.J.1    Howard, A.D.2    Guan, X.3
  • 5
    • 2442497286 scopus 로고    scopus 로고
    • Melanocortin receptors and erectile function
    • Martin WJ, MacIntyre DE. Melanocortin receptors and erectile function. Eur Urol 2004 45 : 706 13.
    • (2004) Eur Urol , vol.45 , pp. 706-13
    • Martin, W.J.1    MacIntyre, D.E.2
  • 6
    • 27344437618 scopus 로고    scopus 로고
    • Beta-MSH inhibits brain inflammation via MC(3)/(4) receptors and impaired NF-kappaB signaling
    • Muceniece R, Zvejniece L, Kirjanova O et al. Beta-MSH inhibits brain inflammation via MC(3)/(4) receptors and impaired NF-kappaB signaling. J Neuroimmunol 2005 169 : 13 9.
    • (2005) J Neuroimmunol , vol.169 , pp. 13-9
    • Muceniece, R.1    Zvejniece, L.2    Kirjanova, O.3
  • 7
    • 33749043482 scopus 로고    scopus 로고
    • Expression of melanocortin-4 receptor by rat parabrachial neurons responsive to immune and aversive stimuli
    • Paues J, Mackerlova L, Blomqvist A. Expression of melanocortin-4 receptor by rat parabrachial neurons responsive to immune and aversive stimuli. Neuroscience 2006 141 : 287 97.
    • (2006) Neuroscience , vol.141 , pp. 287-97
    • Paues, J.1    MacKerlova, L.2    Blomqvist, A.3
  • 9
    • 0037057558 scopus 로고    scopus 로고
    • Design and pharmacology of N-[(3R)-1-4-tetrahydroisoquinolinium-3- ylcarbonyl]-(1R)-1-(4-chlorobenzyl)-2-[4-cyclohexyl-4-(1H-1,2, 4-triazol-1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor agonist
    • Sebhat IK, Martin WJ, Ye Z et al. Design and pharmacology of N-[(3R)-1-4-tetrahydroisoquinolinium-3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl) -2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor agonist. J Med Chem 2002 45 : 4589 93.
    • (2002) J Med Chem , vol.45 , pp. 4589-93
    • Sebhat, I.K.1    Martin, W.J.2    Ye, Z.3
  • 10
    • 0036842081 scopus 로고    scopus 로고
    • Activation of melanocortin MC(4) receptors increases erectile activity in rats ex copula
    • Martin WJ, McGowan E, Cashen DE et al. Activation of melanocortin MC(4) receptors increases erectile activity in rats ex copula. Eur J Pharmacol 2002 454 : 71 9.
    • (2002) Eur J Pharmacol , vol.454 , pp. 71-9
    • Martin, W.J.1    McGowan, E.2    Cashen, D.E.3
  • 12
    • 31544470058 scopus 로고    scopus 로고
    • Cardiovascular responses to melanocortin 4-receptor stimulation in conscious unrestrained normotensive rats
    • Nordheim U, Nicholson JR, Dokladny K, Dunant P, Hofbauer KG. Cardiovascular responses to melanocortin 4-receptor stimulation in conscious unrestrained normotensive rats. Peptides 2006 27 : 438 43.
    • (2006) Peptides , vol.27 , pp. 438-43
    • Nordheim, U.1    Nicholson, J.R.2    Dokladny, K.3    Dunant, P.4    Hofbauer, K.G.5
  • 13
    • 1842453288 scopus 로고    scopus 로고
    • Assessment of a small molecule melanocortin-4 receptor-specific agonist on energy homeostasis
    • Cepoi D, Phillips T, Cismowski M et al. Assessment of a small molecule melanocortin-4 receptor-specific agonist on energy homeostasis. Brain Res 2004 1000 : 64 71.
    • (2004) Brain Res , vol.1000 , pp. 64-71
    • Cepoi, D.1    Phillips, T.2    Cismowski, M.3
  • 14
    • 33646793986 scopus 로고    scopus 로고
    • The MC3 receptor binding affinity of melanocortins correlates with the nitric oxide production inhibition in mice brain inflammation model
    • Muceniece R, Zvejniece L, Liepinsh E et al. The MC3 receptor binding affinity of melanocortins correlates with the nitric oxide production inhibition in mice brain inflammation model. Peptides 2006 27 : 1443 50.
    • (2006) Peptides , vol.27 , pp. 1443-50
    • Muceniece, R.1    Zvejniece, L.2    Liepinsh, E.3
  • 15
    • 4143067936 scopus 로고    scopus 로고
    • New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of 'THIQ'
    • Mutulis F, Yahorava S, Mutule I et al. New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of 'THIQ'. J Med Chem 2004 47 : 4613 26.
    • (2004) J Med Chem , vol.47 , pp. 4613-26
    • Mutulis, F.1    Yahorava, S.2    Mutule, I.3
  • 17
    • 0242506759 scopus 로고    scopus 로고
    • Iron dithiocarbamate as spin trap for nitric oxide detection: Pitfalls and successes
    • Vanin AF, Huisman A, van Faassen EE. Iron dithiocarbamate as spin trap for nitric oxide detection: pitfalls and successes. Meth Enzymol 2002 359 : 27 42.
    • (2002) Meth Enzymol , vol.359 , pp. 27-42
    • Vanin, A.F.1    Huisman, A.2    Van Faassen, E.E.3
  • 18
    • 0344440819 scopus 로고    scopus 로고
    • Beta- and gamma-melanocortins inhibit lipopolysaccharide induced nitric oxide production in mice brain
    • Muceniece R, Zvejniece L, Kirjanova O et al. Beta- and gamma-melanocortins inhibit lipopolysaccharide induced nitric oxide production in mice brain. Brain Res 2004 995 : 7 13.
    • (2004) Brain Res , vol.995 , pp. 7-13
    • Muceniece, R.1    Zvejniece, L.2    Kirjanova, O.3
  • 19
    • 0036235171 scopus 로고    scopus 로고
    • Increased synthesis of nitric oxide in rat brain cortex due to halogenated volatile anesthetics confirmed by EPR spectroscopy
    • Baumane L, Dzintare M, Zvejniece L et al. Increased synthesis of nitric oxide in rat brain cortex due to halogenated volatile anesthetics confirmed by EPR spectroscopy. Acta Anaesthesiol Scand 2002 46 : 378 83.
    • (2002) Acta Anaesthesiol Scand , vol.46 , pp. 378-83
    • Baumane, L.1    Dzintare, M.2    Zvejniece, L.3
  • 20
    • 0031914232 scopus 로고    scopus 로고
    • Central infusion of melanocortin agonist MTII in rats: Assessment of c-Fos expression and taste aversion
    • Thiele TE, van DG, Yagaloff KA et al. Central infusion of melanocortin agonist MTII in rats: assessment of c-Fos expression and taste aversion. Am J Physiol 1998 274 : R248 R254.
    • (1998) Am J Physiol , vol.274
    • Thiele, T.E.1    Van, D.G.2    Yagaloff, K.A.3
  • 21
    • 19444381366 scopus 로고    scopus 로고
    • Functional selectivity of melanocortin 4 receptor peptide and nonpeptide agonists: Evidence for ligand-specific conformational states
    • Nickolls SA, Fleck B, Hoare SR, Maki RA. Functional selectivity of melanocortin 4 receptor peptide and nonpeptide agonists: evidence for ligand-specific conformational states. J Pharmacol Exp Ther 2005 313 : 1281 8.
    • (2005) J Pharmacol Exp Ther , vol.313 , pp. 1281-8
    • Nickolls, S.A.1    Fleck, B.2    Hoare, S.R.3    Maki, R.A.4
  • 22
    • 0031786114 scopus 로고    scopus 로고
    • Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): Evaluation in vitro and in vivo
    • Kask A, Mutulis F, Muceniece R et al. Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology 1998 139 : 5006 14.
    • (1998) Endocrinology , vol.139 , pp. 5006-14
    • Kask, A.1    Mutulis, F.2    Muceniece, R.3
  • 23
    • 0035157351 scopus 로고    scopus 로고
    • Natural and synthetic agonists of the melanocortin receptor type 3 possess anti-inflammatory properties
    • Getting SJ, Allcock GH, Flower R, Perretti M. Natural and synthetic agonists of the melanocortin receptor type 3 possess anti-inflammatory properties. J Leukoc Biol 2001 69 : 98 104.
    • (2001) J Leukoc Biol , vol.69 , pp. 98-104
    • Getting, S.J.1    Allcock, G.H.2    Flower, R.3    Perretti, M.4
  • 24
    • 33845664425 scopus 로고    scopus 로고
    • Melanocortin 3 receptors control crystal-induced inflammation
    • Getting SJ, Lam CW, Chen AS, Grieco P, Perretti M. Melanocortin 3 receptors control crystal-induced inflammation. FASEB J 2006 20 : 2234 41.
    • (2006) FASEB J , vol.20 , pp. 2234-41
    • Getting, S.J.1    Lam, C.W.2    Chen, A.S.3    Grieco, P.4    Perretti, M.5
  • 25
    • 0242418191 scopus 로고    scopus 로고
    • Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2 induces penile erection via brain and spinal melanocortin receptors
    • Wessells H, Hruby VJ, Hackett J, Han G, Balse-Srinivasan P, Vanderah TW. Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2 induces penile erection via brain and spinal melanocortin receptors. Neuroscience 2003 118 : 755 62.
    • (2003) Neuroscience , vol.118 , pp. 755-62
    • Wessells, H.1    Hruby, V.J.2    Hackett, J.3    Han, G.4    Balse-Srinivasan, P.5    Vanderah, T.W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.