The MC3 receptor binding affinity of melanocortins correlates with the nitric oxide production inhibition in mice brain inflammation model

Peptides

Volumn 27, Issue 6, 2006, Pages 1443-1450

  Muceniece, Ruta ^a   Zvejniece, Liga ^a,b   Liepinsh, Edgars ^a,b   Kirjanova, Olga ^b   Baumane, Larisa ^b   Petrovska, Ramona ^c   Mutulis, Felikss ^c   Mutule, Ilze ^c   Kalvinsh, Ivars ^b   Wikberg, Jarl E S ^c   Dambrova, Maija ^b  

^a UNIVERSITY OF LATVIA   (Latvia)

^b LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

Brain inflammation; MC receptors; Melanocortins; Nitric oxide

Indexed keywords

ACETYLSERYLTYROSYLSERYLMETHIONYLGLUTAMYLHISTIDYLPHENYLALANYLARGINYLASPARTYLGLYCYLLEUCYLSERYLASPARTYLAMIDE; ACETYLSERYLTYROSYLSERYLMETHIONYLGLUTAMYLHISTIDYLPHENYLALANYLARGINYLASPARTYLGLYCYLLYSYLPROLYLVALINAMIDE; ACETYLSERYLTYROSYLSERYLMETHIONYLGLUTAMYLHISTIDYLPHENYLALANYLARGINYLTRYPTOPHANYLGLYCYLLEUCYLCYSTEINYLASPARTYLAMIDE; ACETYLSERYLTYROSYLSERYLMETHIONYLGLUTAMYLHISTIDYLPHENYLALANYLARGINYLTRYPTOPHANYLGLYCYLLEUCYLSERYLASPARTYLAMIDE; ALANYLGLUTAMYLLYSYLLYSYLASPARTYLGLUTAMYLGLYCYLPROLYLTYROSYLARGINYLMETHIONYLGLUTAMYLHISTIDYLPHENYLALANYLARGINYLASPARTYLGLYCYLSERYLPROLYLPROLYLLYSYLASPARTYLAMIDE; ALPHA INTERMEDIN; BETA INTERMEDIN; INTERMEDIN; LIPOPOLYSACCHARIDE; MELANOCORTIN; MELANOCORTIN 1 RECEPTOR; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN 5 RECEPTOR; NITRIC OXIDE; RADIOLIGAND; RECOMBINANT HORMONE; SERYLSERYLISOLEUCYLISOLEUCYLSERYLHISTIDYLPHENYLALANYLARGINYLTRYPTOPHANYLGLYCYLLYSYLPROLYLVALINAMIDE; TYROSYLVALYLMETHIONYLGLYCYLHISTIDYLPHENYLALANYLARGINYLTRYPTOPHANYLASPARTYLARGINYLGLYCYLHYDROXIDE; TYROSYLVALYLMETHIONYLGLYCYLHISTIDYLPHENYLALANYLARGINYLTRYPTOPHANYLASPARTYLARGINYLPHENYLALANINAMIDE; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; MELANOCORTIN RECEPTOR; PEPTIDE;

ACETYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; DRUG SCREENING; DRUG SYNTHESIS; ENCEPHALITIS; FOREBRAIN; HORMONE STRUCTURE; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; ANIMAL; CENTRAL NERVOUS SYSTEM; CHEMISTRY; DRUG ANTAGONISM; ELECTRON SPIN RESONANCE; INFLAMMATION; INSECT; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; PATHOLOGY; PROTEIN BINDING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CENTRAL NERVOUS SYSTEM; ELECTRON SPIN RESONANCE SPECTROSCOPY; INFLAMMATION; INSECTS; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED ICR; NITRIC OXIDE; PEPTIDES; PROTEIN BINDING; RECEPTOR, MELANOCORTIN, TYPE 3; RECEPTORS, MELANOCORTIN;

EID: 33646793986     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2005.12.002     Document Type: Article

References (31)

1. Benjannet S., Rondeau N., Day R., Chretien M., and Seidah N.G. PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues. Proc Natl Acad Sci USA 88 (1991) 3564-3568
2. Bhardwaj R.S., Schwarz A., Becher E., Mahnke K., Aragane Y., Schwarz T., et al. Pro-opiomelanocortin-derived peptides induce IL-10 production in human monocytes. J Immunol 156 (1996) 2517-2521
3. Caruso C., Mohn C., Karara A.L., Rettori V., Watanobe H., Schioth H.B., et al. Alpha-melanocyte-stimulating hormone through melanocortin-4 receptor inhibits nitric oxide synthase and cyclooxygenase expression in the hypothalamus of male rats. Neuroendocrinology 79 (2004) 278-286
4. Catania A., Gatti S., Colombo G., and Lipton J.M. Targeting melanocortin receptors as a novel strategy to control inflammation. Pharmacol Rev 56 (2004) 1-29
5. Chhajlani V. Distribution of cDNA for melanocortin receptor subtypes in human tissues. Biochem Mol Biol Int 38 (1996) 73-80
6. Cragnolini A.B., Perello M., Schioth H.B., and Scimonelli T.N. alpha-MSH and gamma-MSH inhibit IL-1beta induced activation of the hypothalamic-pituitary-adrenal axis through central melanocortin receptors. Regul Pept 122 (2004) 185-190
7. Delgado R., Carlin A., Airaghi L., Demitri M.T., Meda L., Galimberti D., et al. Melanocortin peptides inhibit production of proinflammatory cytokines and nitric oxide by activated microglia. J Leukoc Biol 63 (1998) 740-745
8. Galimberti D., Baron P., Meda L., Prat E., Scarpini E., Delgado R., et al. Alpha-MSH peptides inhibit production of nitric oxide and tumor necrosis factor-alpha by microglial cells activated with beta-amyloid and interferon gamma. Biochem Biophys Res Commun 263 (1999) 251-256
9. Gantz I., Miwa H., Konda Y., Shimoto Y., Tashiro T., Watson S.J., et al. Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. J Biol Chem 268 (1993) 15174-15179
10. Getting S.J., Gibbs L., Clark A.J., Flower R.J., and Perretti M. POMC gene-derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation. J Immunol 162 (1999) 7446-7453
11. Getting S.J., and Perretti M. MC3-R as a novel target for antiinflammatory therapy. Drug News Perspect 13 (2000) 19-27
12. Getting S.J., Schioth H.B., and Perretti M. Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides. J Pharmacol Exp Ther 306 (2003) 631-637
13. 2 at the mouse melanocortin receptors. 4. Modifications at the Trp position. J Med Chem 45 (2002) 5736-5744
14. Ichiyama T., Sakai T., Catania A., Barsh G.S., Furukawa S., and Lipton J.M. Systemically administered alpha-melanocyte-stimulating peptides inhibit NF-kappaB activation in experimental brain inflammation. Brain Res 836 (1999) 31-37
15. Kask A., Mutulis F., Muceniece R., Pahkla R., Mutule I., Wikberg J.E., et al. Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology 139 (1998) 5006-5014
16. Lam C.W., and Getting S.J. Melanocortin receptor type 3 as a potential target for anti-inflammatory therapy. Curr Drug Targets Inflamm Allergy 3 (2004) 311-315
17. Lipton J.M., Catania A., and Ichiyama T. Marshaling the anti-inflammatory influence of the neuroimmunomodulator alpha-MSH. News Physiol Sci 15 (2000) 192-195
18. Mandrika I., Muceniece R., and Wikberg J.E. Effects of melanocortin peptides on lipopolysaccharide/interferon-gamma-induced NF-kappaB DNA binding and nitric oxide production in macrophage-like RAW 264.7 cells: evidence for dual mechanisms of action. Biochem Pharmacol 61 (2001) 613-621
19. Muceniece R., Zvejniece L., Kirjanova O., Liepinsh E., Krigere L., Baumane L., et al. Beta- and gamma-melanocortins inhibit lipopolysaccharide induced nitric oxide production in mice brain. Brain Res 995 (2004) 7-13
20. Muceniece R., Zvejniece L., Kirjanova O., Liepinsh E., Krigere L., Vilskersts R., et al. Beta-MSH inhibits brain inflammation via MC(3)/(4) receptors and impaired NF-kappaB signaling. J Neuroimmunol 169 (2005) 13-19
21. Neumann A.G., Nagaeva O., Mandrika I., Petrovska R., Muceniece R., Mincheva-Nilsson L., et al. MC(1) receptors are constitutively expressed on leucocyte subpopulations with antigen presenting and cytotoxic functions. Clin Exp Immunol 126 (2001) 441-446
22. Peng P.J., Sahm U.G., Doherty R.V., Kinsman R.G., Moss S.H., and Pouton C.W. Binding and biological activity of C-terminally modified melanocortin peptides: a comparison between their actions at rodent MC1 and MC3 receptors. Peptides 18 (1997) 1001-1008
23. Schioth H.B., Kuusinen A., Muceniece R., Szardenings M., Keinanen K., and Wikberg J.E. Expression of functional melanocortin 1 receptors in insect cells. Biochem Biophys Res Commun 221 (1996) 807-814
24. Schioth H.B., Muceniece R., Mutulis F., Bouifrouri A.A., Mutule I., and Wikberg J.E. Further pharmacological characterization of the selective melanocortin 4 receptor antagonist HS014: comparison with SHU9119. Neuropeptides 33 (1999) 191-196
25. Schioth H.B., Muceniece R., Wikberg J.E., and Chhajlani V. Characterisation of melanocortin receptor subtypes by radioligand binding analysis. Eur J Pharmacol 288 (1995) 311-317
26. Star R.A., Rajora N., Huang J., Stock R.C., Catania A., and Lipton J.M. Evidence of autocrine modulation of macrophage nitric oxide synthase by alpha-melanocyte-stimulating hormone. Proc Natl Acad Sci USA 92 (1995) 8016-8020
27. Szardenings M., Muceniece R., Mutule I., Mutulis F., and Wikberg J.E. New highly specific agonistic peptides for human melanocortin MC(1) receptor. Peptides 21 (2000) 239-243
28. Vanin A.F., Huisman A., and van Faassen E.E. Iron dithiocarbamate as spin trap for nitric oxide detection: pitfalls and successes. Meth Enzymol 359 (2002) 27-42
29. Wikberg J.E., Muceniece R., Mandrika I., Prusis P., Lindblom J., Post C., et al. New aspects on the melanocortins and their receptors. Pharmacol Res 42 (2000) 393-420
30. Xia Y., Wikberg J.E., and Chhajlani V. Expression of melanocortin 1 receptor in periaqueductal gray matter. Neuroreport 6 (1995) 2193-2196
31. Zohar M., and Salomon Y. Mechanism of action of melanocortin peptides. Possible role in astrocyte regulation. J Mol Neurosci 4 (1993) 55-62