Prevention of clinical and histological signs of proteolipid protein (PLP)-induced experimental allergic encephalomyelitis (EAE) in mice by the water-soluble carbon monoxide-releasing molecule (CORM)-A1

Clinical and Experimental Immunology

Volumn 163, Issue 3, 2011, Pages 368-374

  Fagone, P ^a   Mangano, K ^a   Quattrocchi, C ^a   Motterlini, R ^c   Di Marco, R ^d   Magro, G ^b   Penacho, N ^e   Romao, C C ^e,f   Nicoletti, F ^a  

^a School of Medicine   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

^c ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^d UNIVERSITY OF MOLISE   (Italy)

^e Alfama Lda ^*  (Italy)

^f INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

Author keywords

Animal models; Carbon monoxide releasing molecules; CORM A1; Experimental allergic encephalomyelitis; SJL mice

Indexed keywords

ALF 421; ANTIINFLAMMATORY AGENT; CARBON MONOXIDE; CARBON MONOXIDE RELEASING MOLECULE A1; DEXAMETHASONE; PROTEOLIPID PROTEIN; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD LEVEL; BODY WEIGHT; CONTROLLED STUDY; DISEASE DURATION; FEMALE; HISTOPATHOLOGY; INFLAMMATORY INFILTRATE; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; SCORING SYSTEM; SPINAL CORD;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BODY WEIGHT; BORANES; CARBON MONOXIDE; CARBONATES; DEXAMETHASONE; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; MICE; MYELIN PROTEOLIPID PROTEIN; NEUTROPHILS; PEPTIDE FRAGMENTS; SPINAL CORD;

EID: 79551718102     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2010.04303.x     Document Type: Article

References (43)

1. Motterlini R, Otterbein LE. The therapeutic potential of carbon monoxide. Nat Rev Drug Discov 2010; 9:728-43.
2. Ryter SW, Choi AM. Heme oxygenase-1/carbon monoxide: from metabolism to molecular therapy. Am J Respir Cell Mol Biol 2009; 41:251-60.
3. Poss KD, Tonegawa S. Heme oxygenase 1 is required for mammalian iron reutilization. Proc Natl Acad Sci USA 1997; 94:10919-24.
4. Yachie A, Niida Y, Wada T etal. Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest 1999; 103:129-35.
5. Sarady JK, Zuckerbraun BS, Bilban M etal. Carbon monoxide protection against endotoxic shock involves reciprocal effects on iNOS in the lung and liver. FASEB J 2004; 18:854-6.
6. Mizuguchi S, Stephen J, Bihari R etal. CORM-3-derived CO modulates polymorphonuclear leukocyte migration across the vascular endothelium by reducing levels of cell surface-bound elastase. Am J Physiol Heart Circ Physiol 2009; 297:H920-9.
7. Tsoyi K, Lee TY, Lee YS etal. Heme-oxygenase-1 induction and carbon monoxide-releasing molecule inhibit lipopolysaccharide (LPS)-induced high-mobility group box 1 release in vitro and improve survival of mice in LPS- and cecal ligation and puncture-induced sepsis model in vivo. Mol Pharmacol 2009; 76:173-82.
8. Lancel S, Hassoun SM, Favory R, Decoster B, Motterlini R, Neviere R. Carbon monoxide rescues mice from lethal sepsis by supporting mitochondrial energetic metabolism and activating mitochondrial biogenesis. J Pharmacol Exp Ther 2009; 329:641-8.
9. Desmard M, Davidge KS, Bouvet O etal. J. A carbon monoxide-releasing molecule (CORM-3) exerts bactericidal activity against Pseudomonas aeruginosa and improves survival in an animal model of bacteraemia. FASEB J 2009; 23:1023-31.
10. Chen P, Sun B, Chen H etal. Effects of carbon monoxide releasing molecule-liberated CO on severe acute pancreatitis in rats. Cytokine 2010; 49:15-23.
11. Goebel U, Mecklenburg A, Siepe M etal. Protective effects of inhaled carbon monoxide in pig lungs during cardiopulmonary bypass are mediated via an induction of the heat shock response. Br J Anaesth 2009; 103:173-84.
12. Hoetzel A, Dolinay T, Vallbracht S etal. Carbon monoxide protects against ventilator-induced lung injury via PPAR-gamma and inhibition of Egr-1. Am J Respir Crit Care Med 2008; 177:1223-32.
13. Hoetzel A, Schmidt R, Vallbracht S etal. Carbon monoxide prevents ventilator-induced lung injury via caveolin-1. Crit Care Med 2009; 37:1708-15.
14. Sun B, Sun H, Liu C, Shen J, Chen Z, Chen X. Role of CO-releasing molecules liberated CO in attenuating leukocytes sequestration and inflammatory responses in the lung of thermally injured mice. J Surg Res 2007; 139:128-35.
15. Nemzek JA, Fry C, Abatan O. Low-dose carbon monoxide treatment attenuates early pulmonary neutrophil recruitment after acid aspiration. Am J Physiol Lung Cell Mol Physiol 2008; 294:L644-53.
16. Otterbein LE, Zuckerbraun BS, Haga M etal. Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury. Nat Med 2003; 9:183-90.
17. Bani-Hani MG, Greenstein D, Mann BE, Green CJ, Motterlini R. A carbon monoxide-releasing molecule (CORM-3) attenuates lipopolysaccharide- and interferon-gamma-induced inflammation in microglia. Pharmacol Rep 2006; 58 (Suppl.):132-44.
18. Chora AA, Fontoura P, Cunha A etal. Heme oxygenase-1 and carbon monoxide suppress autoimmune neuroinflammation. J Clin Invest 2007; 117:438-47.
19. Yamauchi T, Lin Y, Sharp FR, Noble-Haeusslein LJ. Hemin induces heme oxygenase-1 in spinal cord vasculature and attenuates barrier disruption and neutrophil infiltration in the injured murine spinal cord. J Neurotrauma 2004; 21:1017-30.
20. Mayr FB, Spiel A, Leitner J etal. Effects of carbon monoxide inhalation during experimental endotoxemia in humans. Am J Respir Crit Care Med 2005; 171:354-60.
21. Motterlini R, Mann BE, Foresti R. Therapeutic applications of carbon monoxide-releasing molecules. Exp Opin Invest Drugs 2005; 14:1305-18.
22. Motterlini R, Sawle P, Hammad J etal. CORM-A1: a new pharmacologically active carbon monoxide-releasing molecule. FASEB J 2005; 19:284-6.
23. Sandouka A, Fuller BJ, Mann BE, Green CJ, Foresti R, Motterlini R. Treatment with CO-RMs during cold storage improves renal function at reperfusion. Kidney Int 2006; 69:239-47.
24. Ryan MJ, Jernigan NL, Drummond HA etal. Renal vascular responses to CORM-A1 in the mouse. Pharmacol Res 2006; 54:24-9.
25. Parfenova H, Basuroy S, Bhattacharya S etal. Glutamate induces oxidative stress and apoptosis in cerebral vascular endothelial cells: contributions of HO-1 and HO-2 to cytoprotection. Am J Physiol Cell Physiol 2006; 290:C1399-410.
26. St Louis J, Uniyal S, Xu L etal. Tolerance induction by acylated peptides: suppression of EAE in the mouse with palmitoylated PLP peptides. J Neuroimmunol 2001; 115:79-90.
27. Vreman HJ, Wong RJ, Kadotani T, Stevenson DK. Determination of carbon monoxide (CO) in rodent tissue: effect of heme administration and environmental CO exposure. Anal Biochem 2005; 341:280-9.
28. Donia M, Mangano K, Quattrocchi C etal. Specific and strain-independent effects of dexamethasone in the prevention and treatment of experimental autoimmune encephalomyelitis in rodents. Scand J Immunol 2010; 72:396-407.
29. Furlan R, Poliani PL, Galbiati F etal. Central nervous system delivery of interleukin 4 by a nonreplicative herpes simplex type 1 viral vector ameliorates autoimmune demyelination. Hum Gene Ther 1998; 9:2605-17.
30. Sun X, Minohara M, Kikuchi H etal. The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis. J Neuroimmunol 2006; 180:126-34.
31. Soilu-Hanninen M, Epa R, Shipham K etal. Treatment of experimental autoimmune encephalomyelitis with antisense oligonucleotides against the low affinity neurotrophin receptor. J Neurosci Res 2000; 59:712-21.
32. Rooman R, Koster G, Bloemen R, Gresnigt R, van Buul-Offers SC. The effect of dexamethasone on body and organ growth of normal and IGF-II-transgenic mice. J Endocrinol 1999; 163:543-52.
33. Zimmermann A, Leffler CW, Tcheranova D, Fedinec AL, Parfenova H. Cerebroprotective effects of the CO-releasing molecule CORM-A1 against seizure-induced neonatal vascular injury. Am J Physiol Heart Circ Physiol 2007; 293:H2501-7.
34. Ferrandiz ML, Maicas N, Garcia-Arnandis I etal. Treatment with a CO-releasing molecule (CORM-3) reduces joint inflammation and erosion in murine collagen-induced arthritis. Ann Rheum Dis 2008; 67:1211-17.
35. Maicas N, Ferrandiz ML, Devesa I etal. The CO-releasing molecule CORM-3 protects against articular degradation in the K/BxN serum transfer arthritis model. Eur J Pharmacol 2010; 634:184-91.
36. Remy S, Blancou P, Tesson L etal. Carbon monoxide inhibits TLR-induced dendritic cell immunogenicity. J Immunol 2009; 182:1877-84.
37. Pae HO, Oh GS, Choi BM etal. Carbon monoxide produced by heme oxygenase-1 suppresses T cell proliferation via inhibition of IL-2 production. J Immunol 2004; 172:4744-51.
38. Otterbein LE, Bach FH, Alam J etal. Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med 2000; 6:422-8.
39. Takagi T, Naito Y, Inoue M etal. Inhalation of carbon monoxide ameliorates collagen-induced arthritis in mice and regulates the articular expression of IL-1beta and MCP-1. Inflammation 2009; 32:83-8.
40. George JF, Braun A, Brusko TM etal. Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells. Am J Pathol 2008; 173:154-60.
41. Lee IT, Luo SF, Lee CW etal. Overexpression of HO-1 protects against TNF-alpha-mediated airway inflammation by down-regulation of TNFR1-dependent oxidative stress. Am J Pathol 2009; 175:519-32.
42. Foresti R, Bani-Hani MG, Motterlini R. Use of carbon monoxide as a therapeutic agent: promises and challenges. Intens Care Med 2008; 34:649-58.
43. Niino M, Sasaki H. Update on the treatment options for multiple sclerosis. Exp Rev Clin Immunol 2010; 6:77-88.