Some Binding-Related Drug Properties are Dependent on Thermodynamic Signature

Chemical Biology and Drug Design

Volumn 77, Issue 3, 2011, Pages 161-165

  Schön, Arne ^a   Madani, Navid ^b,c   Smith, Amos B ^d   Lalonde, Judith M ^e   Freire, Ernesto ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e BRYN MAWR COLLEGE   (United States)

Author keywords

Binding affinity; Enthalpy; Entropy; Isothermal titration calorimetry; Thermodynamic optimization

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CD4 ANTIGEN PLUS GLYCOPROTEIN GP 120 INHIBITOR; NBD 556; SURROGATE IMMUNOGLOBULIN LIGHT CHAIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG BINDING; DRUG CONFORMATION; ENTHALPY; ENTROPY; HUMAN IMMUNODEFICIENCY VIRUS 1; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; THERMODYNAMICS; VIRUS ENTRY; VIRUS INFECTIVITY;

ANTIGENS, CD4; HIV; HIV ENVELOPE PROTEIN GP120; HIV FUSION INHIBITORS; HUMANS; OXALATES; PIPERIDINES; PROTEIN BINDING; THERMODYNAMICS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 79551704622     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2010.01075.x     Document Type: Article

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