MRNA expression of alpha and beta isoforms of glucocorticoid receptor in peripheral blood mononuclear cells of patients with tuberculosis and its relation with components of the immunoendocrine response

Brain, Behavior, and Immunity

Volumn 25, Issue 3, 2011, Pages 461-467

  D'Attlio, Luciano ^a   Trini, Ernesto ^b   Bongiovanni, Bettina ^a   Dídoli, Griselda ^a   Gardeñez, Walter ^c   Nannini, Luis J ^d   Giri, Adriana ^e   Bottasso, Oscar A ^a   Bay, María Luisa ^a  

^a FACULTAD DE CIENCIAS MÉDICAS   (Argentina)

^b Laboratorio de Estudios Moleculares y Genómica   (Argentina)

^c Hospital Centenario de Rosario   (Argentina)

^d Hospital Eva Peron   (Argentina)

^e UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

Author keywords

Cytokines; Glucocorticoid receptor; Glucocorticoids; Hormones; Immune endocrine interactions; Tuberculosis

Indexed keywords

DIMER; GAMMA INTERFERON; GLUCOCORTICOID RECEPTOR ALPHA; GLUCOCORTICOID RECEPTOR BETA; HYDROCORTISONE; INTERLEUKIN 18; INTERLEUKIN 6; MESSENGER RNA;

ADULT; AGE DISTRIBUTION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; ENDOCRINE FUNCTION; FEMALE; GENE EXPRESSION; HUMAN; IMMUNE RESPONSE; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUBERCULOSIS;

ADULT; CYTOKINES; DEHYDROEPIANDROSTERONE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; HYDROCORTISONE; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; PROTEIN ISOFORMS; RECEPTORS, GLUCOCORTICOID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; STATISTICS, NONPARAMETRIC; TUBERCULOSIS;

EID: 79551690196     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbi.2010.11.006     Document Type: Article

References (43)

1. Arcila M.L., Sánchez M.D., Ortiz B., Barrera L.F., García L.F., Rojas M. Activation of apoptosis, but not necrosis, during Mycobacterium tuberculosis infection correlated with decreased bacterial growth: role of TNF-alpha, IL-10, caspases and phospholipase A2. Cell. Immunol. 2007, 249:80-93.
2. Barnes P.J. Corticosteroid effects on cell signaling. Eur. Respir. J. 2006, 27:413-426.
3. Barnes P.J., Adcock I.M. Glucocorticoid resistance in inflammatory diseases. Lancet 2009, 373:1905-1917.
4. Bartholome B., Spie C.M., Gaber T., Schuchmann S., Berki T., Kunkel D., Bienert M., Radbruch A., Burmester G.-R., Lauster R., Scheffold A., Buttgereit F. Membrane glucocorticoid receptors (mGCR) are expressed in normal human peripheral blood mononuclear cells and up-regulated after in vitro stimulation and in patients with rheumatoid arthritis. FASEB J. 2004, 18:70-80.
5. Bauer M.E. Stress, glucocorticoids and ageing of the immune system. Stress 2005, 8:69-83.
6. Besedovsky H., del Rey A. Immune-neuro-endocrine interactions: facts and hypothesis. Endocr. Rev. 1996, 17:64-95.
7. Bookout A.L., Mangelsdorf D.J. Quantitative real-time PCR protocol for analysis of nuclear receptor signaling pathways. Nucl. Recept. Signaling 2003, 1:e012.
8. Bozza V.V., D'Attilio L., Mahuad C.V., Giri A.A., del Rey A., Besedovsky H., Bottasso O., Bay M.L. Altered cortisol/DHEA ratio in tuberculosis patients and its relationship with abnormalities in the mycobacterial-driven cytokine production by peripheral blood mononuclear cells. Scand. J. Immunol. 2007, 66:97-103.
9. Bozza V., D'Attilio L., Didoli G., Santucci N., Nannini L., Bogue C., Del Rey A., Besedovsky H., Bay M.L., Bottasso O. The adrenal steroid response during tuberculosis and its effects on the mycobacterial-driven IFN-(production of patients and their household contacts. Ann. N.Y. Acad. Sci. 2009, 1153:247-255.
10. Cooper A.M., Adams L.B., Dalton D.K., Appelberg R., Ehlers S. IFN-gamma and NO in mycobacterial disease: new jobs for old hands. Trends Microbiol. 2002, 10:221-226.
11. Cooper A.M. Cell-mediated immune responses in tuberculosis. Annu. Rev. Immunol. 2009, 27:393-422.
12. Croxtall J.D., Chourdhury Q., Flower R.J. Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism. Br. J. Pharmacol. 2000, 130:289-298.
13. del Rey A., Mahuad C.V., Bozza V., Bogue C., Farroni M.A., Bay M.L., Bottasso O.A., Besedovsky H.O. Endocrine and cytokine responses in humans with pulmonary tuberculosis. Brain Behav. Immun. 2007, 2:171-179.
14. Dillon J. Dehydroepiandrosterone, dehydroepiandrosterone sulfate and related steroids: their role in inflammatory, allergic and immunological disorders. Curr. Drug Targets Inflamm. Allergy 2005, 4:377-385.
15. Flynn J.L. Immunology of tuberculosis and implications in vaccine development. Tuberculosis 2004, 84:93-101.
16. Gracie J.A., Robertson S.E., McInnes I.B. Interleukin-18. J. Leukocyte Biol. 2003, 73:213-224.
17. Grad I., Picard D. The glucocorticoid responses are shaped by molecular chaperones. Mol. Cell. Endocrinol. 2007, 274:2-12.
18. Hamid Q.A., Wenzel S.E., Hauk P.J., Tsicopoulos A., Walaert B., Lafitte J.J., Chrousos G.P., Szefler S.J., Leung D.Y.M. Increased glucocorticoid receptor β in airway cells of glucocorticoid-insensitive asthma. Am. J. Respir. Crit. Care Med. 1999, 159:1600-1604.
19. He J.Q., Sandford A.J., Wang I.M., Stepaniants S., Knight D.A., Kicic A., Stick S.M., Paré P.D. Selection of housekeeping genes for real-time PCR in atopic human bronchial epithelial cells. Eur. Respir. J. 2008, 32:755-762.
20. Hoheisel G., Izbicki G., Roth M., Chan C.H., Leung J.C., Reichenberger F., Schauer J., Perruchoud A.P. Compartmentalization of pro-inflammatory cytokines in tuberculous pleurisy. Respir. Med. 1998, 92:14-17.
21. Hollenberg S.M., Weinberger C., Ong E.S., Cerelli G., Oro A., Lebo R., Thompson E.B., Rosenfeld M.G., Evans R.M. Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature 1985, 318:635-641.
22. Hennebold J.D., Daynes R.A. Regulation of macrophage dehydroepiandrosterone sulfate metabolism by inflammatory cytokines. Endocrinology 1994, 135:67-75.
23. Honda M., Orii F., Ayabe T., Imai S., Ashida T., Obara T., Kohgo Y. Expression of glucocorticoid receptor β in lymphocytes of patients with glucocorticoid-resistant ulcerative colitis. Gastroenterology 2000, 118:859-866.
24. Kino T., De Martino M.U., Charmandari E., Mirani M., Chrousos G.P. Tissue glucocorticoid resistance/hypersensitivity syndromes. J. Steroid Biochem. Mol. Biol. 2003, 85:457-467.
25. Ladel C.H., Blum C., Dreher A., Reifenberg K., Kopf M., Kaufmann S.H. Lethal tuberculosis in interleukin-6-deficient mutant mice. Infect. Immun. 1997, 65:4843-4849.
26. Lalvani A. Counting antigen-specific T cells: a new approach for monitoring response to tuberculosis treatment?. Clin. Infect. Dis. 2004, 38:757-759.
27. Lu N.Z., Cidlowski J.A. Glucocorticoid receptor isoforms generate transcription specificity. Trends Cell. Biol. 2006, 16:301-307.
28. Mahuad C., Bay M.L., Farroni M.A., Bozza V., del Rey A., Besedovsky H., Bottasso O.A. Cortisol and dehydroepiandrosterone affect the response of peripheral blood mononuclear cells to mycobacterial antigens during tuberculosis. Scand. J. Immunol. 2004, 60:639-646.
29. Oakley R.H., Sar M., Cidlowski J.A. The human glucocorticoid receptor β isoform: expression, biochemical properties, and putative function. J. Biol. Chem. 1996, 271:9550-9559.
30. Oakley R.H., Jewell C.M., Yudt M.R., Bofetiado D.M., Cidlowski J.A. The dominant negative activity of the human glucocorticoid receptor β isoform. J. Biol. Chem. 1999, 274:27857-27866.
31. Orii F., Ashida T., Nomura M., Maemoto A., Fujiki T., Ayabe T., Imai S., Saitoh Y., Kohgo Y. Quantitative analysis for human glucocorticoid receptor α/β mRNA in IBD. Biochem. Biophys. Res. Commun. 2002, 296:1286-1294.
32. Rook G., Baker R., Walker B., Honour J., Jessop D., Hernandez-Pando R., Arriaga K., Shaw R., Zumla A., Lightman S. Local regulation of glucocorticoid activity in sites of inflammation. Insights from the study of tuberculosis. Ann. N.Y. Acad. Sci. 2000, 917:913-922.
33. Rook G.A., Hernandez-Pando R., Dheda K., Teng Seah G. IL-4 in tuberculosis: implications for vaccine design. Trends Immunol. 2004, 25:483-488.
34. Russell D.G., Cardona P.J., Kim M.J., Allain S., Altare F. Foamy macrophages and the progression of the human tuberculosis granuloma. Nat. Immunol. 2009, 10:943-948.
35. Saunders B.M., Frank A.A., Orme I.M., Cooper A.M. Interleukin-6 induces early gamma interferon production in the infected lung but is not required for generation of specific immunity to Mycobacterium tuberculosis infection. Infect. Immun. 2000, 68:3322-3326.
36. Schneider B., Korbel D., Hagens K., Koch M., Raupach B., Enders J., Kaufmann S.H.E., Mittrucker H.W., Schaible U.E. A role for IL-18 in protective immunity against Mycobacterium tuberculosis. Eur. J. Immunol. 2010, 40:396-405.
37. Stahn C., Buttgereit F. Genomic and nongenomic effects of glucocorticoids. Nat. Clin. Pract. Rheumatol. 2008, 10:525-533.
38. Turnbull A.V., Rivier C.L. Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of action. Physiological Rev. 1999, 79:1-71.
39. Van Heyningen T.K., Collins H.L., Russell D.G. IL-6 produced by macrophages infected with Mycobacterium species suppresses T cell responses. J. Immunol. 1997, 158:330-337.
40. Webster J.C., Oakley R.H., Jewell C.M., Cidlowski J.A. Pro-inflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative β isoform: a mechanism for the generation of glucocorticoid resistance. Proc. Natl. Acad. Sci. USA 2001, 98:6865-6870.
41. Webster J., Tonelli J., Sternberg E.M. Neuroendocrine regulation of immunity. Annu. Rev. Immunol. 2002, 20:125-163.
42. Organization World.Health. Global tuberculosis control-surveillance, planning, financing. WHO/HTM/TB 393 2008, World Health Organization, Geneva.
43. Yudt M.R., Cidlowski J.A. The glucocorticoid receptor: coding a diversity of proteins and responses through a single gene. Mol. Endocrinol. 2002, 16:1719-1726.